{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T13:18:21Z","timestamp":1793971101590,"version":"4.8.0"},"reference-count":153,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2023-MS-165"],"award-info":[{"award-number":["2023-MS-165"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2022-BS-149"],"award-info":[{"award-number":["2022-BS-149"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Despite improvements in modern medical therapies, inflammatory diseases, such as atherosclerosis, diabetes, non-alcoholic fatty liver, chronic kidney diseases, and autoimmune diseases have high incidence rates, still threaten human health, and represent a huge financial burden. N6-methyladenosine (m6A) modification of RNA contributes to the pathogenesis of various diseases. As the most widely discussed m6A methyltransferase, the pathogenic role of METTL3 in inflammatory diseases has become a research hotspot, but there has been no comprehensive review of the topic. Here, we summarize the expression changes, modified target genes, and pathogenesis related to METTL3 in cardiovascular, metabolic, degenerative, immune, and infectious diseases, as well as tumors. In addition to epithelial cells, endothelial cells, and fibroblasts, METTL3 also regulates the function of inflammation-related immune cells, including macrophages, neutrophils, dendritic cells, Th17 cells, and NK cells. Regarding therapeutic applications, METTL3 serves as a target for the treatment of inflammatory diseases with natural plant drug components, such as emodin, cinnamaldehyde, total flavonoids of <jats:italic>Abelmoschus manihot<\/jats:italic>, and resveratrol. This review focuses on recent advances in the initiation, development, and therapeutic application of METTL3 in inflammatory diseases. Knowledge of the specific regulatory mechanisms involving METTL3 can help to deepen understanding of inflammatory diseases and lay the foundation for the development of precisely targeted drugs to address inflammatory processes.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1221609","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T13:36:55Z","timestamp":1692625015000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":79,"title":["Emerging role of METTL3 in inflammatory diseases: mechanisms and therapeutic applications"],"prefix":"10.3389","volume":"14","author":[{"given":"Bimei","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xida","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.006","article-title":"Inflammation 2010: new adventures of an old flame","volume":"140","author":"Medzhitov","year":"2010","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.02.010","article-title":"Homeostasis, inflammation, and disease susceptibility","volume":"160","author":"Kotas","year":"2015","journal-title":"Cell"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/454427a","article-title":"Inflammation","volume":"454","author":"Weiss","year":"2008","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3790","article-title":"A guiding map for inflammation","volume":"18","author":"Netea","year":"2017","journal-title":"Nat Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.03.014","article-title":"The resolution of inflammation: Principles and challenges","volume":"27","author":"Headland","year":"2015","journal-title":"Semin Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat Med"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.151","article-title":"Homeostasis-altering molecular processes as mechanisms of inflammasome activation","volume":"17","author":"Liston","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00160","article-title":"Resolution of inflammation: what controls its onset","volume":"7","author":"Sugimoto","year":"2016","journal-title":"Front Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.670711","article-title":"N6-methyladenosine RNA modification in inflammation: roles, mechanisms, and applications","volume":"9","author":"Luo","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711x(92)90028-y","article-title":"The formation of internal 6-methyladenine residues in eucaryotic messenger RNA","volume":"24","author":"Tuck","year":"1992","journal-title":"Int J Biochem"},{"key":"B13","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1021\/bi00647a024","article-title":"5\u2019-Terminal and internal methylated nucleotide sequences in HeLa cell mRNA","volume":"15","author":"Wei","year":"1976","journal-title":"Biochemistry"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.05.003","article-title":"Comprehensive analysis of mRNA methylation reveals enrichment in 3\u2019 UTRs and near stop codons","volume":"149","author":"Meyer","year":"2012","journal-title":"Cell"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0168-5","article-title":"Reading, writing and erasing mRNA methylation","volume":"20","author":"Zaccara","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B17","article-title":"Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase","volume":"3","author":"Bokar","year":"1997","journal-title":"RNA"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3-METTL14 complex mediates mamMalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Nat Chem Biol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.cell.2017.05.003","article-title":"The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention","volume":"169","author":"Pendleton","year":"2017","journal-title":"Cell"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2014.3","article-title":"MamMalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase","volume":"24","author":"Ping","year":"2014","journal-title":"Cell Res"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.05.048","article-title":"Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5\u2019 sites","volume":"8","author":"Schwartz","year":"2014","journal-title":"Cell Rep"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nature19342","article-title":"m(6)A RNA methylation promotes XIST-mediated transcriptional repression","volume":"537","author":"Patil","year":"2016","journal-title":"Nature"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.molcel.2018.02.015","article-title":"Zc3h13 regulates nuclear RNA m6A methylation and mouse embryonic stem cell self-renewal","volume":"69","author":"Wen","year":"2018","journal-title":"Mol Cell"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.687","article-title":"N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nat Chem Biol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","article-title":"ALKBH5 is a mamMalian RNA demethylase that impacts RNA metabolism and mouse fertility","volume":"49","author":"Zheng","year":"2013","journal-title":"Mol Cell"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.01.012","article-title":"Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing","volume":"61","author":"Xiao","year":"2016","journal-title":"Mol Cell"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.99","article-title":"Ythdc2 is an N6-methyladenosine binding protein that regulates mamMalian spermatogenesis","volume":"27","author":"Hsu","year":"2017","journal-title":"Cell Res"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nature12730","article-title":"N6-methyladenosine-dependent regulation of messenger RNA stability","volume":"505","author":"Wang","year":"2014","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N(6)-methyladenosine modulates messenger RNA translation efficiency","volume":"161","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"B30","unstructured":"YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA - PubMed"},{"key":"B31","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/s41467-017-02770-z","article-title":"Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2\/B1","volume":"9","author":"Wu","year":"2018","journal-title":"Nat Commun"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/nature14234","article-title":"N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions","volume":"518","author":"Liu","year":"2015","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"Huang","year":"2018","journal-title":"Nat Cell Biol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.045","article-title":"Dynamic RNA modifications in gene expression regulation","volume":"169","author":"Roundtree","year":"2017","journal-title":"Cell"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nature18298","article-title":"Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex","volume":"534","author":"Wang","year":"2016","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1261\/rna.064063.117","article-title":"Interactions, localization, and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex","volume":"24","author":"Sch\u00f6ller","year":"2018","journal-title":"RNA N Y N"},{"key":"B37","article-title":"METTL3 plays multiple functions in biological processes","volume":"10","author":"Liu","year":"2020","journal-title":"Am J Cancer Res"},{"key":"B38","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.immuni.2014.06.013","article-title":"Origin and functions of tissue macrophages","volume":"41","author":"Epelman","year":"2014","journal-title":"Immunity"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1100\/2011\/213962","article-title":"Macrophage polarization in health and disease","volume":"11","author":"Cassetta","year":"2011","journal-title":"Sci World J"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00011-015-0874-1","article-title":"Macrophage polarization: the link between inflammation and related diseases","volume":"65","author":"Bashir","year":"2016","journal-title":"Inflammation Res"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-013-9381-6","article-title":"Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo","volume":"17","author":"Jetten","year":"2014","journal-title":"Angiogenesis"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012418-012718","article-title":"Diversity, mechanisms, and significance of macrophage plasticity","volume":"15","author":"Locati","year":"2020","journal-title":"Annu Rev Pathol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24019","article-title":"Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling","volume":"36","author":"Li","year":"2022","journal-title":"J Clin Lab Anal"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2022.109176","article-title":"Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis","volume":"245","author":"Sun","year":"2022","journal-title":"Clin Immunol Orlando Fla"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101058","article-title":"The m(6)A methyltransferase METTL3 modifies PGC-1\u03b1 mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes","volume":"297","author":"Zhang","year":"2021","journal-title":"J Biol Chem"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106800","article-title":"IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome","volume":"86","author":"Guo","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110283","article-title":"METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway","volume":"93","author":"Cai","year":"2022","journal-title":"Cell Signal"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd4742","article-title":"Pooled CRISPR screening identifies m6A as a positive regulator of macrophage activation","volume":"7","author":"Tong","year":"2021","journal-title":"Sci Adv"},{"key":"B50","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1146\/annurev-immunol-032713-120240","article-title":"Microglia development and function","volume":"32","author":"Nayak","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001550","article-title":"The m6A methyltransferase METTL3 promotes LPS-induced microglia inflammation through TRAF6\/NF-\u03baB pathway","volume":"33","author":"Wen","year":"2022","journal-title":"Neuroreport"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00212.2019","article-title":"The N6-methyladenosine (m6A)-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of STAT1 mRNA","volume":"317","author":"Liu","year":"2019","journal-title":"Am J Physiol Cell Physiol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.10.032","article-title":"RNA-m6A modification of HDGF mediated by Mettl3 aggravates the progression of atherosclerosis by regulating macrophages polarization via energy metabolism reprogramming","volume":"635","author":"Zheng","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-017-0656-7","article-title":"Monocyte and macrophage immunometabolism in atherosclerosis","volume":"40","author":"Groh","year":"2018","journal-title":"Semin Immunopathol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2018","article-title":"The neutrophil\u2019s role during health and disease","volume":"99","author":"Liew","year":"2019","journal-title":"Physiol Rev"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112259","article-title":"METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling","volume":"42","author":"Luo","year":"2023","journal-title":"Cell Rep"},{"key":"B57","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1038\/s41423-021-00726-4","article-title":"Dendritic cell migration in inflammation and immunity","volume":"18","author":"Liu","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1038\/s41467-019-09903-6","article-title":"Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation","volume":"10","author":"Wang","year":"2019","journal-title":"Nat Commun"},{"key":"B59","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41435-020-0099-3","article-title":"Dendritic cells with METTL3 gene knockdown exhibit immature properties and prolong allograft survival","volume":"21","author":"Wu","year":"2020","journal-title":"Genes Immun"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat Immunol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-019-00733-8","article-title":"The pathogenicity of Th17 cells in autoimmune diseases","volume":"41","author":"Yasuda","year":"2019","journal-title":"Semin Immunopathol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/ni1261","article-title":"A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17","volume":"6","author":"Park","year":"2005","journal-title":"Nat Immunol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202201548R","article-title":"METTL3 inhibits autoreactive Th17 cell responses in experimental autoimmune uveitis via stabilizing ASH1L mRNA","volume":"37","author":"Zhao","year":"2023","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12082863","article-title":"Alteration of m6A-tagged RNA profiles in bone originated from periprosthetic joint infection","volume":"12","author":"Cai","year":"2023","journal-title":"J Clin Med"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00558-3","article-title":"Natural killer cells in antiviral immunity","volume":"22","author":"Bj\u00f6rkstr\u00f6m","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat Immunol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.07.033","article-title":"Impact of FASL-induced apoptosis in the elimination of tumor cells by NK cells","volume":"42","author":"Screpanti","year":"2005","journal-title":"Mol Immunol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"5522","DOI":"10.1038\/s41467-021-25803-0","article-title":"METTL3-mediated m(6)A RNA methylation promotes the anti-tumour immunity of natural killer cells","volume":"12","author":"Song","year":"2021","journal-title":"Nat Commun"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.731810","article-title":"N6-Methyladenosine Methyltransferase METTL3 Promotes Angiogenesis and Atherosclerosis by Upregulating the JAK2\/STAT3 Pathway via m6A Reader IGF2BP1","volume":"9","author":"Dong","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69906","article-title":"RNA N(6)-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice","volume":"11","author":"Li","year":"2022","journal-title":"eLife"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2025070118","article-title":"METTL3-dependent N6-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium","volume":"118","author":"Chien","year":"2021","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17183","article-title":"New insights into the central sympathetic hyperactivity post-myocardial infarction: Roles of METTL3-mediated m(6) A methylation","volume":"26","author":"Qi","year":"2022","journal-title":"J Cell Mol Med"},{"key":"B73","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.yjmcc.2022.06.004","article-title":"m(6)A methyltransferase METTL3 participated in sympathetic neural remodeling post-MI via the TRAF6\/NF-\u03baB pathway and ROS production","volume":"170","author":"Qi","year":"2022","journal-title":"J Mol Cell Cardiol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109968","article-title":"m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity","volume":"37","author":"Qin","year":"2021","journal-title":"Cell Rep"},{"key":"B75","doi-asserted-by":"publisher","first-page":"7213","DOI":"10.1038\/s41467-021-27539-3","article-title":"The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression","volume":"12","author":"Li","year":"2021","journal-title":"Nat Commun"},{"key":"B76","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/s41420-021-00756-x","article-title":"The METTL3\/MALAT1\/PTBP1\/USP8\/TAK1 axis promotes pyroptosis and M1 polarization of macrophages and contributes to liver fibrosis","volume":"7","author":"Shu","year":"2021","journal-title":"Cell Death Discovery"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109375","article-title":"m(6)A methyltransferase METTL3 relieves cognitive impairment of hyPeruricemia mice via inactivating MyD88\/NF-\u03baB pathway mediated NLRP3-ASC-Caspase1 inflammasome","volume":"113","author":"Chen","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abk2709","article-title":"Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms","volume":"14","author":"Wang","year":"2022","journal-title":"Sci Transl Med"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.01.002","article-title":"METTL3-mediated m(6)A modification of TIMP2 mRNA promotes podocyte injury in diabetic nephropathy","volume":"30","author":"Jiang","year":"2022","journal-title":"Mol Ther J Am Soc Gene Ther"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.667644","article-title":"Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m(6)A Modification-Mediated NLRP3-Inflammasome Activation and PTEN\/PI3K\/Akt Signaling","volume":"12","author":"Liu","year":"2021","journal-title":"Front Pharmacol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16603","article-title":"METTL3\/N6-methyladenosine\/ miR-21-5p promotes obstructive renal fibrosis by regulating inflammation through SPRY1\/ERK\/NF-\u03baB pathway activation","volume":"25","author":"Liu","year":"2021","journal-title":"J Cell Mol Med"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.05.168","article-title":"METTL3 promotes experimental osteoarthritis development by regulating inflammatory response and apoptosis in chondrocyte","volume":"516","author":"Liu","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119528","article-title":"METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response","volume":"278","author":"Sang","year":"2021","journal-title":"Life Sci"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.116182","article-title":"Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m(6)A modification","volume":"154","author":"He","year":"2022","journal-title":"Bone"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-022-01579-x","article-title":"RPL38 knockdown inhibits the inflammation and apoptosis in chondrocytes through regulating METTL3-mediated SOCS2 m6A modification in osteoarthritis","volume":"71","author":"Shi","year":"2022","journal-title":"Inflammation Res Off J Eur Histamine Res Soc Al"},{"key":"B86","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1136\/annrheumdis-2021-221091","article-title":"METTL3-mediated m(6)A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression","volume":"81","author":"Chen","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2022.101820","article-title":"SIAH1 promotes senescence and apoptosis of nucleus pulposus cells to exacerbate disc degeneration through ubiquitinating XIAP","volume":"76","author":"Fang","year":"2022","journal-title":"Tissue Cell"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3120391","article-title":"METTL3 attenuates LPS-induced inflammatory response in macrophages via NF-\u03baB signaling pathway","volume":"2019","author":"Wang","year":"2019","journal-title":"Mediators Inflammation"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.607585","article-title":"METTL3 promotes activation and inflammation of FLSs through the NF-\u03baB signaling pathway in rheumatoid arthritis","volume":"8","author":"Shi","year":"2021","journal-title":"Front Med"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012672","article-title":"Reduction of methyltransferase-like 3-mediated RNA N6-methyladenosine exacerbates the development of psoriasis vulgaris in imiquimod-induced psoriasis-like mouse model","volume":"23","author":"Wang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B91","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s41420-022-00849-1","article-title":"METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice","volume":"8","author":"Yang","year":"2022","journal-title":"Cell Death Discovery"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203506","article-title":"Genome-wide identification of altered RNA m(6)A profiles in vascular tissue of septic rats","volume":"13","author":"Shen","year":"2021","journal-title":"Aging"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.69141","article-title":"Neutrophil extracellular traps mediate m(6)A modification and regulates sepsis-associated acute lung injury by activating ferroptosis in alveolar epithelial cells","volume":"18","author":"Zhang","year":"2022","journal-title":"Int J Biol Sci"},{"key":"B94","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/s41420-022-01166-3","article-title":"Neutrophil extracellular traps-triggered impaired autophagic flux via METTL3 underlies sepsis-associated acute lung injury","volume":"8","author":"Qu","year":"2022","journal-title":"Cell Death Discovery"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.897487","article-title":"METTL3-mediated N6-methyladenosine modification of trim59 mRNA protects against sepsis-induced acute respiratory distress syndrome","volume":"13","author":"Chen","year":"2022","journal-title":"Front Immunol"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7858746","article-title":"CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress Syndrome through Mediating Macrophage Polarization via the miR-138-5p\/EZH2 Axis","volume":"2021","author":"Zhao","year":"2021","journal-title":"Mediators Inflammation"},{"key":"B97","doi-asserted-by":"publisher","first-page":"49","DOI":"10.15586\/aei.v49i5.445","article-title":"METTL3 promotes inflammation and cell apoptosis in a pediatric pneumonia model by regulating EZH2","volume":"49","author":"Yang","year":"2021","journal-title":"Allergol Immunopathol (Madr)"},{"key":"B98","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.molimm.2021.08.008","article-title":"Long noncoding RNA SNHG4 remits lipopolysaccharide-engendered inflammatory lung damage by inhibiting METTL3 - Mediated m(6)A level of STAT2 mRNA","volume":"139","author":"Li","year":"2021","journal-title":"Mol Immunol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109091","article-title":"METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection","volume":"35","author":"Li","year":"2021","journal-title":"Cell Rep"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.63.10.20","article-title":"METTL3 Attenuates Inflammation in Fusarium solani-Induced Keratitis via the PI3K\/AKT Signaling Pathway","volume":"63","author":"Huang","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.63.11.2","article-title":"Inhibition of the m6A Methyltransferase METTL3 Attenuates the Inflammatory Response in Fusarium solani-Induced Keratitis via the NF-\u03baB Signaling Pathway","volume":"63","author":"Tang","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.905211","article-title":"METTL3 inhibits inflammation of retinal pigment epithelium cells by regulating NR2F1 in an m(6)A-dependent manner","volume":"13","author":"Meng","year":"2022","journal-title":"Front Immunol"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13491","article-title":"METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells","volume":"22","author":"Feng","year":"2018","journal-title":"J Cell Mol Med"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1038\/s41467-021-21514-8","article-title":"RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming","volume":"12","author":"Yin","year":"2021","journal-title":"Nat Commun"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.01.019","article-title":"METTL3 restrains papillary thyroid cancer progression via m(6)A\/c-Rel\/IL-8-mediated neutrophil infiltration","volume":"29","author":"He","year":"2021","journal-title":"Mol Ther J Am Soc Gene Ther"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108586","article-title":"LXA4 enhances prostate cancer progression by facilitating M2 macrophage polarization via inhibition of METTL3","volume":"107","author":"Jia","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.21037\/atm-22-6104","article-title":"M2-TAMs promote immunoresistance in lung adenocarcinoma by enhancing METTL3-mediated m6A methylation","volume":"10","author":"Wu","year":"2022","journal-title":"Ann Transl Med"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.0c00961","article-title":"Tumor-Associated Macrophages Promote Oxaliplatin Resistance via METTL3-Mediated m(6)A of TRAF5 and Necroptosis in Colorectal Cancer","volume":"18","author":"Lan","year":"2021","journal-title":"Mol Pharm"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.73628","article-title":"m6A modifications regulate intestinal immunity and rotavirus infection","volume":"11","author":"Wang","year":"2022","journal-title":"eLife"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.424","article-title":"Histone demethylase JMJD1C promotes the polarization of M1 macrophages to prevent glioma by upregulating miR-302a","volume":"11","author":"Zhong","year":"2021","journal-title":"Clin Transl Med"},{"key":"B111","doi-asserted-by":"publisher","first-page":"C7","DOI":"10.1016\/j.jacc.2005.09.068","article-title":"Pathogenesis of atherosclerosis","volume":"47","author":"Falk","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet Lond Engl"},{"key":"B113","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ajpath.2021.09.005","article-title":"METTL3 regulates liver homeostasis, hepatocyte ploidy, and circadian rhythm-controlled gene expression in mice","volume":"192","author":"Barajas","year":"2022","journal-title":"Am J Pathol"},{"key":"B114","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ijcard.2015.08.109","article-title":"Regulation of uric acid metabolism and excretion","volume":"213","author":"Maiuolo","year":"2016","journal-title":"Int J Cardiol"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190408122557","article-title":"HyPeruricemia and cardiovascular disease","volume":"25","author":"Zhang","year":"2019","journal-title":"Curr Pharm Des"},{"key":"B116","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1159\/000329097","article-title":"Relationship between uric acid and subtle cognitive dysfunction in chronic kidney disease","volume":"34","author":"Afsar","year":"2011","journal-title":"Am J Nephrol"},{"key":"B117","doi-asserted-by":"publisher","first-page":"6732","DOI":"10.1038\/s41598-021-86279-y","article-title":"Detrimental effects of long-term elevated serum uric acid on cognitive function in rats","volume":"11","author":"Tian","year":"2021","journal-title":"Sci Rep"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013108","article-title":"Relationship between oxidative stress and inflammation in hyPeruricemia: Analysis based on asymptomatic young patients with primary hyPeruricemia","volume":"97","author":"Zhou","year":"2018","journal-title":"Med (Baltimore)"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176275","article-title":"Pathophysiology of type 2 diabetes mellitus","volume":"21","author":"Galicia-Garcia","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0135-6","article-title":"Epigenetics and epigenomics in diabetic kidney disease and metabolic memory","volume":"15","author":"Kato","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"B121","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.matbio.2018.05.008","article-title":"Osteoarthritis as a disease of the cartilage pericellular matrix","author":"Guilak","year":"2018","journal-title":"Matrix Biol J Int Soc Matrix Biol"},{"key":"B122","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nrrheum.2013.160","article-title":"Role of cytokines in intervertebral disc degeneration: pain and disc content","volume":"10","author":"Risbud","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"B123","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41584-021-00713-z","article-title":"A new immunometabolic perspective of intervertebral disc degeneration","volume":"18","author":"Francisco","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"B124","doi-asserted-by":"publisher","first-page":"18002","DOI":"10.1038\/nrdp.2018.2","article-title":"Rheumatoid arthritis","volume":"4","author":"Lieben","year":"2018","journal-title":"Nat Rev Dis Primer"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N Engl J Med"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2011.114","article-title":"Novel regulatory mechanisms in inflammatory arthritis: a role for microRNA","volume":"90","author":"Baxter","year":"2012","journal-title":"Immunol Cell Biol"},{"key":"B127","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1097\/BOR.0000000000000128","article-title":"Epigenetics in rheumatoid arthritis","volume":"27","author":"Klein","year":"2015","journal-title":"Curr Opin Rheumatol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet Lond Engl"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet Lond Engl"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.399","article-title":"Circulating th17, th22, and th1 cells are increased in psoriasis","volume":"130","author":"Kagami","year":"2010","journal-title":"J Invest Dermatol"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31720","article-title":"APC-derived cytokines and T cell polarization in autoimmune inflammation","volume":"117","author":"Gutcher","year":"2007","journal-title":"J Clin Invest"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2101562","article-title":"Pathophysiology of inflammatory bowel diseases","volume":"384","author":"Chen","year":"2021","journal-title":"N Engl J Med"},{"key":"B133","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3390\/epigenomes4030016","article-title":"Implication of m6A mRNA Methylation in Susceptibility to Inflammatory Bowel Disease","volume":"4","author":"Sebastian-delaCruz","year":"2020","journal-title":"Epigenomes"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000194725.48928.3a","article-title":"Sepsis in European intensive care units: Results of the SOAP study*","volume":"34","author":"Vincent","year":"2006","journal-title":"Crit Care Med"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-006-0504-z","article-title":"Incidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: the Finnsepsis study","volume":"33","author":"Karlsson","year":"2007","journal-title":"Intensive Care Med"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021333","article-title":"The pathophysiology and treatment of sepsis","volume":"348","author":"Hotchkiss","year":"2003","journal-title":"N Engl J Med"},{"key":"B138","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00259-0","article-title":"Pneumonia","volume":"7","author":"Torres","year":"2021","journal-title":"Nat Rev Dis Primer"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-020-0776-7","article-title":"Innate immune responses in RNA viral infection","volume":"15","author":"Xu","year":"2021","journal-title":"Front Med"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.396","article-title":"RNA m(6) A methylation regulates virus-host interaction and EBNA2 expression during Epstein-Barr virus infection","volume":"9","author":"Zheng","year":"2021","journal-title":"Immun Inflammation Dis"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30448-5","article-title":"The global incidence and diagnosis of fungal keratitis","volume":"21","author":"Brown","year":"2021","journal-title":"Lancet Infect Dis"},{"key":"B143","first-page":"217","article-title":"Chronic inflammation and cancer","volume":"16","author":"Shacter","year":"2002","journal-title":"Oncol Williston Park N"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2045836","article-title":"Emodin relieves the inflammation and pyroptosis of lipopolysaccharide-treated 1321N1 cells by regulating methyltransferase-like 3 -mediated NLR family pyrin domain containing 3 expression","volume":"13","author":"Wang","year":"2022","journal-title":"Bioengineered"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113367","article-title":"The methyltransferase METTL3-mediated fatty acid metabolism revealed the mechanism of cinnamaldehyde on alleviating steatosis","volume":"153","author":"Xu","year":"2022","journal-title":"BioMed Pharmacother Biomed Pharmacother"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031453","article-title":"Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations","volume":"22","author":"Izquierdo","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.568006","article-title":"Resveratrol attenuates high-fat diet induced hepatic lipid homeostasis disorder and decreases m6A RNA methylation","volume":"11","author":"Wu","year":"2020","journal-title":"Front Pharmacol"},{"key":"B148","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1186\/s13287-022-03005-9","article-title":"Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage","volume":"13","author":"Zhou","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5631","article-title":"Emodin: A review of its pharmacology, toxicity and pharmacokinetics","volume":"30","author":"Dong","year":"2016","journal-title":"Phytother Res PTR"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2019.108321","article-title":"Treatment with cinnamaldehyde reduces the visceral adiposity and regulates lipid metabolism, autophagy and endoplasmic reticulum stress in the liver of a rat model of early obesity","volume":"77","author":"Neto","year":"2020","journal-title":"J Nutr Biochem"},{"key":"B151","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1002\/ptr.6818","article-title":"Chemical constituents, clinical efficacy and molecular mechanisms of the ethanol extract of Abelmoschus manihot flowers in treatment of kidney diseases","volume":"35","author":"Li","year":"2021","journal-title":"Phytother Res"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20084","article-title":"A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"B153","doi-asserted-by":"publisher","first-page":"31","DOI":"10.5283\/mnhd.11","article-title":"Red wine, resveratrol, and Alzheimer\u2019s disease","volume":"2","author":"Lange","year":"2018","journal-title":"Mov Nutr Health Dis"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1221609\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T13:37:03Z","timestamp":1692625023000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1221609\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,21]]},"references-count":153,"alternative-id":["10.3389\/fimmu.2023.1221609"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2023.1221609","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,21]]},"article-number":"1221609"}}