{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:58:46Z","timestamp":1772794726074,"version":"3.50.1"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Sepsis is one of the major complications of surgery resulting in high morbidity and mortality, but there are no specific therapies for sepsis-induced organ dysfunction. Data obtained under Gene Expression Omnibus accession GSE131761 were re-analyzed and showed an increased gene expression of Janus Kinase 2 (JAK2) and Signal Transducer and Activator of Transcription 3 (STAT3) in the whole blood of post-operative septic patients. Based on these results, we hypothesized that JAK\/STAT activation may contribute to the pathophysiology of septic shock and, hence, investigated the effects of baricitinib (JAK1\/JAK2 inhibitor) on sepsis-induced cardiac dysfunction and multiple-organ failure (MOF). In a mouse model of post-trauma sepsis induced by midline laparotomy and cecal ligation and puncture (CLP), 10-week-old male (n=32) and female (n=32) C57BL\/6 mice received baricitinib (1mg\/kg; i.p.) or vehicle at 1h or 3h post-surgery. Cardiac function was assessed at 24h post-CLP by echocardiography <jats:italic>in vivo<\/jats:italic>, and the degree of MOF was analyzed by determination of biomarkers in the serum. The potential mechanism underlying both the cardiac dysfunction and the effect of baricitinib was analyzed by western blot analysis in the heart. Trauma and subsequent sepsis significantly depressed the cardiac function and induced multiple-organ failure, associated with an increase in the activation of JAK2\/STAT3, NLRP3 inflammasome and NF- \u03ba\u03b2 pathways in the heart of both male and female animals. These pathways were inhibited by the administration of baricitinib post the onset of sepsis. Moreover, treatment with baricitinib at 1h or 3h post-CLP protected mice from sepsis-induced cardiac injury and multiple-organ failure. Thus, baricitinib may be repurposed for trauma-associated sepsis.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1223014","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T04:32:31Z","timestamp":1694579551000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["RETRACTED: Baricitinib protects mice from sepsis-induced cardiac dysfunction and multiple-organ failure"],"prefix":"10.3389","volume":"14","author":[{"given":"Chiara","family":"Verra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shireen","family":"Mohammad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Ferreira","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Porchietto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina Maren","family":"Coldewey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Collino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Thiemermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA - J Am Med Assoc"},{"key":"B2","doi-asserted-by":"publisher","first-page":"ofy313","DOI":"10.1093\/ofid\/ofy313","article-title":"Sepsis in intensive care unit patients: worldwide data from the intensive care over nations audit","volume":"5","author":"Sakr","year":"2018","journal-title":"Open Forum Infect Dis"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/S00281-017-0639-8","article-title":"Cytokine storm and sepsis disease pathogenesis","volume":"39","author":"Chousterman","year":"2017","journal-title":"Semin Immunopathol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet (London England)"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/J.ARCMED.2021.10.007","article-title":"Sepsis in trauma: A deadly complication","volume":"52","author":"Mas-Celis","year":"2021","journal-title":"Arch Med Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.1016\/J.BBADIS.2017.08.008","article-title":"Immune and metabolic alterations following trauma and sepsis \u2013 An overview","volume":"1863","author":"Raju","year":"2017","journal-title":"Biochim Biophys Acta"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.4161\/VIRU.27372","article-title":"Epidemiology of severe sepsis","volume":"5","author":"Mayr","year":"2014","journal-title":"Virulence"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHSURG.137.1.74","article-title":"Estradiol administration improves splanchnic perfusion following trauma-hemorrhage and sepsis","volume":"137","author":"Kuebler","year":"2002","journal-title":"Arch Surg"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1001\/JAMASURG.2013.2514","article-title":"Independent predictors of enteric fistula and abdominal sepsis after damage control laparotomy: results from the prospective AAST open abdomen registry","volume":"148","author":"Bradley","year":"2013","journal-title":"JAMA Surg"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.003865","article-title":"Left ventricular systolic longitudinal function as predictor of outcome in patients with sepsis","volume":"8","author":"Palmieri","year":"2015","journal-title":"Circ Cardiovasc Imaging"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.08.1037","article-title":"The septic heart: current understanding of molecular mechanisms and clinical implications","author":"Martin","year":"2019","journal-title":"Chest"},{"key":"B12","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1161\/CIRCULATIONAHA.106.678359","article-title":"Sepsis and the heart","volume":"116","author":"Merx","year":"2007","journal-title":"Circulation"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196710000-00004","article-title":"Patterns of septic shock in man\u2013a detailed study of 56 patients","volume":"166","author":"MacLean","year":"1967","journal-title":"Ann Surg"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196606000-00008","article-title":"Circulatory and metabolic alterations associated with survival or death in peritonitis: clinical analysis of 25 cases","volume":"163","author":"Clowes","year":"1966","journal-title":"Ann Surg"},{"key":"B15","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40779-016-0099-9","article-title":"Pathophysiology of sepsis-induced myocardial dysfunction","volume":"3","author":"Lv","year":"2016","journal-title":"Military Med Res"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2014.03.028","article-title":"Myocardial depression in sepsis: From pathogenesis to clinical manifestations and treatment","volume":"29","author":"Antonucci","year":"2014","journal-title":"J Crit Care"},{"key":"B17","doi-asserted-by":"publisher","first-page":"57","DOI":"10.4266\/ACC.2020.00248","article-title":"Sepsis-induced cardiac dysfunction: a review of pathophysiology","volume":"35","author":"Habimana","year":"2020","journal-title":"Acute Crit Care"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.3.949","article-title":"Tumor necrosis factor \u03b1 and interleukin 1\u03b2 are responsible for in vitro myocardial cell depression induced by human septic shock serum","volume":"183","author":"Kumar","year":"1996","journal-title":"J Exp Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/S40560-016-0148-1","article-title":"Sepsis-induced myocardial dysfunction: pathophysiology and management","volume":"4","author":"Kakihana","year":"2016","journal-title":"J Intensive Care"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000398","article-title":"Role of cardiac- and myeloid-MyD88 signaling in endotoxin shock: a study with tissue-specific deletion models","volume":"121","author":"Feng","year":"2014","journal-title":"Anesthesiology"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.21037\/JTD.2018.11.74","article-title":"Improving clinical outcomes in sepsis and multiple organ dysfunction through precision medicine","volume":"11","author":"Mehta","year":"2019","journal-title":"J Thorac Dis"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA2001017\/SUPPL_FILE\/NEJMOA2001017_DISCLOSURES.PDF","article-title":"A novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N Engl J Med"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2020.01446\/BIBTEX","article-title":"The COVID-19 cytokine storm; what we know so far","volume":"11","author":"Ragab","year":"2020","journal-title":"Front Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12985-022-01814-1","article-title":"COVID-19 infection: an overview on cytokine storm and related interventions","volume":"19","author":"Montazersaheb","year":"2022","journal-title":"Virol J 2022 191"},{"key":"B25","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1186\/S13063-020-04641-3","article-title":"Corticosteroid therapy for critically ill patients with COVID-19: A structured summary of a study protocol for a prospective meta-analysis of randomized trials","volume":"21","author":"Sterne","year":"2020","journal-title":"Trials"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00676-0","article-title":"Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial","volume":"397","author":"Abani","year":"2021","journal-title":"Lancet (London England)"},{"key":"B27","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1056\/NEJMOA2021436","article-title":"Dexamethasone in hospitalized patients with Covid-19","volume":"384","author":"Horby","year":"2021","journal-title":"N Engl J Med"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00006-6","article-title":"Efficacy and safety of baricitinib plus standard of care for the treatment of critically ill hospitalised adults with COVID-19 on invasive mechanical ventilation or extracorporeal membrane oxygenation: an exploratory, randomised, placebo-controlled trial","volume":"10","author":"Ely","year":"2022","journal-title":"Lancet Respir Med"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01109-6","article-title":"Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis","volume":"400","author":"Abani","year":"2022","journal-title":"Lancet"},{"key":"B30","volume-title":"Overview | Baricitinib for treating moderate to severe atopic dermatitis | Guidance | NICE","year":"2021"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00331-3","article-title":"Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial","volume":"9","author":"Marconi","year":"2021","journal-title":"Lancet Respir Med"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/S40265-017-0701-9","article-title":"JAK-STAT signaling as a target for inflammatory and autoimmune diseases: current and future prospects","volume":"77","author":"Banerjee","year":"2017","journal-title":"Drugs"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005571","article-title":"Inhibition of the JAK\/STAT pathway with baricitinib reduces the multiple organ dysfunction caused by hemorrhagic shock in rats","author":"Patel","year":"2022","journal-title":"Ann Surg"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/S00134-021-06506-Y","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/J.JINF.2021.05.039","article-title":"Distinguishing septic shock from non-septic shock in postsurgical patients using gene expression","volume":"83","author":"Mart\u00ednez-Paz","year":"2021","journal-title":"J Infect"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2022.900906\/BIBTEX","article-title":"RG100204, A novel aquaporin-9 inhibitor, reduces septic cardiomyopathy and multiple organ failure in murine sepsis","volume":"13","author":"Mohammad","year":"2022","journal-title":"Front Immunol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.02.010","article-title":"Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research","volume":"20","author":"Kilkenny","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.3791\/2860","article-title":"Cecal ligation puncture procedure","author":"Toscano","year":"2011","journal-title":"J Vis Exp"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-233","article-title":"A robust scoring system to evaluate sepsis severity in an animal model","volume":"7","author":"Shrum","year":"2014","journal-title":"BMC Res Notes"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02129","article-title":"Bruton\u2019s tyrosine kinase inhibition attenuates the cardiac dysfunction caused by cecal ligation and puncture in mice","volume":"10","author":"O\u2019Riordan","year":"2019","journal-title":"Front Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2020.581758","article-title":"X-linked immunodeficient mice with no functional Bruton\u2019s tyrosine kinase are protected from sepsis-induced multiple organ failure","volume":"11","author":"O\u2019Riordan","year":"2020","journal-title":"Front Immunol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1242\/DMM.011353","article-title":"Pharmacological preconditioning with erythropoietin attenuates the organ injury and dysfunction induced in a rat model of hemorrhagic shock","volume":"6","author":"Nandra","year":"2013","journal-title":"Dis Model Mech"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005357","article-title":"Inhibition of Bruton\u2019s tyrosine kinase activity attenuates hemorrhagic shock-induced multiple organ dysfunction in rats","volume":"277","author":"Patel","year":"2023","journal-title":"Ann Surg"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003407","article-title":"Resolvin D1 attenuates the organ injury associated with experimental hemorrhagic shock","volume":"273","author":"Sordi","year":"2021","journal-title":"Ann Surg"},{"key":"B45","unstructured":"Baricitinib | Drugs | BNF | NICE"},{"key":"B46","unstructured":"Olumiant | European medicines agency"},{"key":"B47","unstructured":"FDA approves first systemic treatment for alopecia areata | FDA"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/J.AMSU.2022.104157","article-title":"Olumniant (Baricitinib) oral tablets: An insight into FDA-approved systemic treatment for Alopecia Areata","volume":"80","author":"Ali","year":"2022","journal-title":"Ann Med Surg"},{"key":"B49","volume-title":"HIGHLIGHTS OF PRESCRIBING INFORMATION","year":"2022"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1001\/JAMA.2022.9846","article-title":"Baricitinib is first approved COVID-19 immunomodulatory treatment","volume":"327","author":"Rubin","year":"2022","journal-title":"JAMA"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12964-020-00603-Z\/FIGURES\/7","article-title":"Phospho-Tyr705 of STAT3 is a therapeutic target for sepsis through regulating inflammation and coagulation","volume":"18","author":"Xu","year":"2020","journal-title":"Cell Commun Signal"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.4049\/JIMMUNOL.1002971","article-title":"IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3","volume":"186","author":"Greenhill","year":"2011","journal-title":"J Immunol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/J.CCR.2009.02.015","article-title":"Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors","volume":"15","author":"Lee","year":"2009","journal-title":"Cancer Cell"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200014020-00007","article-title":"Activation of NF-kappaB varies in different regions of the gastrointestinal tract during endotoxemia","volume":"14","author":"Pritts","year":"2000","journal-title":"Shock"},{"key":"B55","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1681\/ASN.2015060670","article-title":"I\u03baB kinase inhibitor attenuates sepsis-induced cardiac dysfunction in CKD","volume":"28","author":"Chen","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"B56","unstructured":"Role of cytokines as a double-edged sword in sepsis"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/J.EXPNEUROL.2018.01.011","article-title":"Upregulation of NLRP3 via STAT3-dependent histone acetylation contributes to painful neuropathy induced by bortezomib","volume":"302","author":"Liu","year":"2018","journal-title":"Exp Neurol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13046-022-02376-4\/FIGURES\/11","article-title":"Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2\/STAT3\/Sox4\/NLRP3 signaling pathway","volume":"41","author":"Xiao","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2021.714943\/BIBTEX","article-title":"Janus kinase inhibition ameliorates ischemic stroke injury and neuroinflammation through reducing NLRP3 inflammasome activation via JAK2\/STAT3 pathway inhibition","volume":"12","author":"Zhu","year":"2021","journal-title":"Front Immunol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/FPHAR.2020.00306","article-title":"Suppression of NLRP3 inflammasome by erythropoietin via the EPOR\/JAK2\/STAT3 pathway contributes to attenuation of acute lung injury in mice","volume":"11","author":"Cao","year":"2020","journal-title":"Front Pharmacol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1186\/S13075-018-1685-X","article-title":"Tofacitinib inhibits granulocyte-macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils","volume":"20","author":"Furuya","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"B62","doi-asserted-by":"publisher","first-page":"477","DOI":"10.2147\/JIR.S178084","article-title":"Inflammasomes: Pandora\u2019s box for sepsis","volume":"11","author":"Kumar","year":"2018","journal-title":"J Inflamm Res"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1002\/JCSM.12763","article-title":"Inhibition of the NLRP3\/IL-1\u03b2 axis protects against sepsis-induced cardiomyopathy","volume":"12","author":"Busch","year":"2021","journal-title":"J Cachexia. Sarcopenia Muscle"},{"key":"B64","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/J.NIOX.2018.09.005","article-title":"Sulfur dioxide attenuates sepsis-induced cardiac dysfunction via inhibition of NLRP3 inflammasome activation in rats","author":"Yang","year":"2018","journal-title":"Nitric Oxide Biol Chem"},{"key":"B65","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/S00395-017-0603-8","article-title":"Carbon monoxide releasing molecule-3 improves myocardial function in mice with sepsis by inhibiting NLRP3 inflammasome activation in cardiac fibroblasts","volume":"112","author":"Zhang","year":"2017","journal-title":"Basic Res Cardiol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1164\/RCCM.201604-0892OC","article-title":"NLRP3 Inflammasome Deficiency Protects against Microbial Sepsis via Increased Lipoxin B4 Synthesis","volume":"196","author":"Lee","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"B67","doi-asserted-by":"publisher","first-page":"H1025","DOI":"10.1152\/AJPHEART.00795.2013","article-title":"Interleukin-18 mediates interleukin-1-induced cardiac dysfunction","volume":"306","author":"Toldo","year":"2014","journal-title":"Am J Physiol - Hear. Circ Physiol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"R158","DOI":"10.1186\/CC7157","article-title":"Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study","volume":"12","author":"Blanco","year":"2008","journal-title":"Crit Care"},{"key":"B69","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1053\/J.ACKD.2006.04.004","article-title":"Infectious complications in chronic kidney disease","volume":"13","author":"Naqvi","year":"2006","journal-title":"Adv Chronic Kidney Dis"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHINTE.168.21.2333","article-title":"Risk of bloodstream infection in patients with chronic kidney disease not treated with dialysis","volume":"168","author":"James","year":"2008","journal-title":"Arch Intern Med"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit Care Med"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1378\/CHEST.127.3.942","article-title":"Incidence and impact of organ dysfunctions associated with sepsis","volume":"127","author":"Guidet","year":"2005","journal-title":"Chest"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/S41390-023-02541-1","article-title":"Organ dysfunction and mortality in preterm neonates with late-onset bloodstream infection","volume":"94","author":"Kharrat","year":"2023","journal-title":"Pediatr Res"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2023.1124140","article-title":"Interleukin-27-dependent transcriptome signatures during neonatal sepsis","volume":"14","author":"Povroznik","year":"2023","journal-title":"Front Immunol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/NRI1394","article-title":"Neonatal adaptive immunity comes of age","volume":"4","author":"Adkins","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.5492\/WJCCM.V1.I1.23","article-title":"Severe sepsis and septic shock in the elderly: An overview","volume":"1","author":"Nasa","year":"2012","journal-title":"World J Crit Care Med"},{"key":"B77","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/01.CCM.0000194535.82812.BA","article-title":"The effect of age on the development and outcome of adult sepsis","volume":"34","author":"Martin","year":"2006","journal-title":"Crit Care Med"}],"updated-by":[{"DOI":"10.3389\/fimmu.2024.1521254","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"record-id":"62580"},{"DOI":"10.3389\/fimmu.2024.1521254","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000}}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1223014\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T10:27:30Z","timestamp":1731061650000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1223014\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,12]]},"references-count":77,"alternative-id":["10.3389\/fimmu.2023.1223014"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2023.1223014","relation":{"retraction":[{"id-type":"doi","id":"10.3389\/fimmu.2024.1521254","asserted-by":"object"}]},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,12]]},"article-number":"1223014"}}