{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:21:26Z","timestamp":1773102086432,"version":"3.50.1"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The involvement of palms and soles is variable among disease entities belonging to autoimmune bullous diseases (AIBD). We present our own clinical-laboratory experience concerning presentations of skin lesions on palms and soles in the pemphigus diseases group, pemphigoid diseases group, epidermolysis bullosa acquisita (EBA), and lichen planus pemphigoides (LPP) and discuss the pertinent literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lesions on palms and soles were assessed retrospectively on the basis of just photographic archives from the beginning of 2014 to March 2023. We comparatively evaluated 462 Slavic patients with AIBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Palmoplantar involvement was observed in only 21 patients with AIBD (12 females and 9 males). There was no statistically significant difference between palmoplantar involvement in the pemphigus diseases group compared to the pemphigoid diseases group and no statistically significant difference between the pemphigus diseases group compared to the subepithelial AIBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Nevertheless, particularly in LPP and EBA, and occasionally in pemphigus diseases and pemphigoid diseases groups of AIBD, localization on palms and soles may be diagnostically important at the clinical level.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2023.1227855","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T07:28:41Z","timestamp":1696922921000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Involvement of palms and soles in patients with autoimmune bullous diseases: a comparative analysis of a diagnostically relevant localization"],"prefix":"10.3389","volume":"14","author":[{"given":"Magdalena","family":"Ja\u0142owska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Spa\u0142ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Bowszyc-Dmochowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Gornowicz- Porowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Dmochowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1103375","article-title":"Issues occupying our minds: Nomenclature of autoimmune blistering diseases requires updating, pemphigus vulgaris propensity to affect areas adjacent to natural body orifices unifies seemingly diverse clinical features of this disease","volume":"19","author":"Dmochowski","year":"2022","journal-title":"Front Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm111028557","article-title":"Sacral dimple, conjunctiva, and nipple as less obvious pemphigus vulgaris locations around natural body orifices: A report of three cases","volume":"11","author":"Ja\u0142owska","year":"2022","journal-title":"J Clin Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18220","article-title":"Updated S2 K guidelines for the management of bullous pemphigoid initiated by the European Academy of Dermatology and Venereology (EADV)","volume":"36","author":"Borradori","year":"2022","journal-title":"J Eur Acad Dermatol Venerol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01389","article-title":"Lichen planus pemphigoides: From lichenoid inflammation to autoantibody-mediated blistering","volume":"10","author":"H\u00fcbner","year":"2019","journal-title":"Front Immunol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2019.06.007","article-title":"Epidermolysis bullosa acquisita: A comprehensive review","volume":"18","author":"Kridin","year":"2019","journal-title":"Autoimmun Rev"},{"key":"B6","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/bjd.16138","article-title":"International Bullous Diseases Group: consensus on diagnostic criteria for epidermolysis bullosa acquisita","volume":"179","author":"Prost-Squarcioni","year":"2018","journal-title":"Br J Dermatol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57040398","article-title":"Dyshidrosiform bullous pemphigoid","volume":"57","author":"Cohen","year":"2021","journal-title":"Medicina (Kaunas)"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.3236","article-title":"Factors associated with complete remission after rituximab therapy for pemphigus","volume":"155","author":"Kushner","year":"2019","journal-title":"JAMA Dermatol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2021.102857","article-title":"Clinical significance of umbilical region involvement in pemphigus vulgaris in a series of 81 ethnic Poles: a comparative analysis of the distribution of lesions in two infrequent locations","volume":"39","author":"Ja\u0142owska","year":"2022","journal-title":"Adv Dermatol Allergol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e20647","DOI":"10.7759\/cureus.20647","article-title":"A Case of drug-induced bullous pemphigoid with an isomorphic response and updated review of koebnerization in bullous diseases","volume":"13","author":"Ambur","year":"2021","journal-title":"Cureus"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12582","article-title":"Radiotherapy-induced pemphigus vulgaris","volume":"41","author":"Jang","year":"2014","journal-title":"J Dermatol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"299","DOI":"10.4103\/0378-6323.155566","article-title":"Pemphigus vulgaris associated with surgery: A rare association","volume":"81","author":"Rashid","year":"2015","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2001.00247.x","article-title":"Mohs micrographic surgery-induced pemphigus","volume":"27","author":"Duick","year":"2001","journal-title":"Dermatol Surg"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2020.07.018","article-title":"Pemphigus vegetans developing after Mohs micrographic surgery and cryotherapy","volume":"96","author":"Jetter","year":"2021","journal-title":"Bras Dermatol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.09.014","article-title":"The koebner phenomenon","volume":"29","author":"Sagi","year":"2011","journal-title":"Clin Dermatol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.1273814:166\u2013171","article-title":"Trauma-induced pemphigus: a case series of 36 patients","volume":"14","author":"Daneshpazhooh","year":"2016","journal-title":"J Dtsch Dermatol Ges"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2697","article-title":"Localized bullous pemphigoid: Four clinical cases and a literature review","volume":"8","author":"Algoet","year":"2020","journal-title":"Clin Case Rep"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2017.09.032","article-title":"Unilateral, localized bullous pemphigoid in a patient with chronic venous stasis","volume":"4","author":"Shi","year":"2018","journal-title":"JAAD Case Rep"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2340\/0001555577187190","article-title":"Immunoblot analysis of autoantigens in localized pemphigoid and pemphigoid nodularis","volume":"77","author":"Kawahara","year":"1997","journal-title":"Acta Derm Venereol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31047","article-title":"Pemphigus foliaceus masquerading as postoperative wound infection: report of a case and review of the Koebner and related phenomenon following surgical procedures","volume":"31","author":"Rotunda","year":"2005","journal-title":"Dermatol Surg"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.31","article-title":"Erythrodermic epidermolysis bullosa acquisita","volume":"151","author":"H\u00e4fliger","year":"2015","journal-title":"JAMA Dermatol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2851","article-title":"Epidermolysis bullosa (EB) acquisita in an adult patient with previously unrecognized mild dystrophic EB and biallelic COL7A1 Mutations","volume":"98","author":"Guerra","year":"2018","journal-title":"Acta Derm Venereol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.2.227","article-title":"Inflammatory variant of epidermolysis bullosa acquisita with IgG autoantibodies against type VII collagen and laminin alpha3","volume":"136","author":"Jonkman","year":"2000","journal-title":"Arch Dermatol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05693.x","article-title":"Lichen planus pemphigoides: four new cases and a review of the literature","volume":"52","author":"Zaraa","year":"2013","journal-title":"Int J Dermatol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"AB142","DOI":"10.1016\/j.jaad.2016.02.560","article-title":"Atypical presentation of lichen planus pemphigoides","volume":"74","author":"Tan","year":"2016","journal-title":"J Am Acad Dermatol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1713184","article-title":"Unilateral dyshidrosiform pemphigus vulgaris","volume":"56","author":"Daroach","year":"2020","journal-title":"Ann Natl Acad Med Sci (India)"},{"key":"B27","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.yexcr.2015.01.014","article-title":"Matrigel basement membrane matrix induces eccrine sweat gland cells to reconstitute sweat gland-like structures in nude mice","volume":"332","author":"Li","year":"2015","journal-title":"Exp Cell Res"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.53173","article-title":"Pemphigus: active or inactive","volume":"54","author":"Vaishnani","year":"2009","journal-title":"Indian J Dermatol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1994.tb00790.x","article-title":"Podopompholyx due to pemphigus vulgaris and Trichophyton rubrum infection. Report of an unusual case","volume":"37","author":"Borradori","year":"1994","journal-title":"Mycoses"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07920.x","article-title":"Acquired palmoplantar keratoderma and immunobullous disease associated with antibodies to desmocollin 3","volume":"157","author":"Bolling","year":"2007","journal-title":"Br J Dermatol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"703","DOI":"10.3390\/biom13040703","article-title":"Classification and antigen molecules of autoimmune bullous diseases","volume":"13","author":"Hashimoto","year":"2023","journal-title":"Biomolecules"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1227855\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T07:28:43Z","timestamp":1696922923000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1227855\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,10]]},"references-count":31,"alternative-id":["10.3389\/fimmu.2023.1227855"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2023.1227855","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,10]]},"article-number":"1227855"}}