{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:59:14Z","timestamp":1753891154034,"version":"3.41.2"},"reference-count":107,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This review analyzed the magnitude of the COVID-19 pandemic globally and in India and the measures to counter its effect using natural and innate immune booster molecules. The study focuses on two phases: the first focuses on the magnitude, and the second on the effect of antioxidants (natural compounds) on SARS-CoV-2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The magnitude of the prevalence, mortality, and comorbidities was acquired from the World Health Organization (WHO) report, media, a report from the Ministry of Health and Family Welfare (MoHFW), newspapers, and the National Centre of Disease Control (NCDC). Research articles from PubMed as well as other sites\/journals and databases were accessed to gather literature on the effect of antioxidants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the elderly and any chronic diseases, the declined level of antioxidant molecules enhanced the reactive oxygen species, which in turn deprived the immune system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Innate antioxidant proteins like sirtuin and sestrin play a vital role in enhancing immunity. Herbal products and holistic approaches can also be alternative solutions for everyday life to boost the immune system by improving the redox balance in COVID-19 attack. This review analyzed the counteractive effect of alternative therapy to boost the immune system against the magnitude of the COVID-19 pandemic.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2023.1241313","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T04:33:00Z","timestamp":1704256380000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel antioxidant protein target therapy to counter the prevalence and severity of SARS-CoV-2"],"prefix":"10.3389","volume":"14","author":[{"given":"Priyajit","family":"Kaur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akash","family":"Dey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kartik","family":"Rawat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharmistha","family":"Dey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3173281","article-title":"Natural antioxidants: A review of studies on human and animal coronavirus","volume":"2020","author":"Diniz","year":"2020","journal-title":"Oxid Med Cell Longevity"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.11.003","article-title":"Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis","volume":"14","author":"Nogueira","year":"2008","journal-title":"Cancer Cell"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4683","article-title":"Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy","volume":"323","author":"Onder","year":"2020","journal-title":"J Am Med Assoc"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13611","article-title":"Why the immune system fails to mount an adaptive immune response to a COVID-19 infection","volume":"33","author":"Ahmadpoor","year":"2020","journal-title":"Transplant Int"},{"key":"B5","unstructured":"The effects of virus variants on COVID-19 vaccines"},{"key":"B6","unstructured":"COVID-19 (coronavirus) variants: What are they and will vaccines work?"},{"key":"B7","unstructured":"Quanta MagazineHow to Understand COVID-19 Variants and Their Effects on Vaccines"},{"key":"B8","unstructured":"Variants of the Virus"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27588","article-title":"Omicron variant of SARS-CoV-2: Genomics, transmissibility, and responses to current COVID-19 vaccines","volume":"94","author":"Araf","year":"2022","journal-title":"J Med Virology."},{"key":"B10","unstructured":""},{"key":"B11","unstructured":""},{"key":"B12","unstructured":"The HinduThe Hindu Explains | Will the \u2018double mutant\u2019 novel coronavirus strain found in India lead to a further rise in infections?"},{"key":"B13","unstructured":"SCIENCE NewsWhat is the new \u201ctriple mutant variant\u201d of Covid-19 virus found in Bengal?"},{"key":"B14","unstructured":"SARS-CoV-2 Variant Classifications and Definitions"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-022-03157-x","article-title":"Will there be a COVID winter wave? 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