{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:38:27Z","timestamp":1792708707256,"version":"4.5.0"},"reference-count":91,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174185, 82074267, 82104639, 82204872, 82204871"],"award-info":[{"award-number":["82174185, 82074267, 82104639, 82204872, 82204871"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Rheumatoid arthritis (RA) is a self-immune inflammatory disease characterized by joint damage. A series of cytokines are involved in the development of RA. Oncostatin M (OSM) is a pleiotropic cytokine that primarily activates the Janus kinase (JAK)\/signal transducer and activator of transcription (STAT) signaling pathway, the mitogen-activated protein kinase (MAPK) signaling pathway, and other physiological processes such as cell proliferation, inflammatory response, immune response, and hematopoiesis through its receptor complex. In this review, we first describe the characteristics of OSM and its receptor, and the biological functions of OSM signaling. Subsequently, we discuss the possible roles of OSM in the development of RA from clinical and basic research perspectives. Finally, we summarize the progress of clinical studies targeting OSM for the treatment of RA. This review provides researchers with a systematic understanding of the role of OSM signaling in RA, which can guide the development of drugs targeting OSM for the treatment of RA.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1258765","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T17:34:07Z","timestamp":1698860047000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Multifaceted oncostatin M: novel roles and therapeutic potential of the oncostatin M signaling in rheumatoid arthritis"],"prefix":"10.3389","volume":"14","author":[{"given":"Liang","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiji","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinhong","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifeng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghao","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102400","article-title":"The etiology of rheumatoid arthritis","volume":"110","author":"Scherer","year":"2020","journal-title":"J Autoimmun"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and management of rheumatoid arthritis: A review","volume":"320","author":"Aletaha","year":"2018","journal-title":"Jama"},{"key":"B3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41584-018-0109-2","article-title":"Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis","volume":"15","author":"Chen","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/bor.0000000000000470","article-title":"What are the dominant cytokines in early rheumatoid arthritis","volume":"30","author":"Ridgley","year":"2018","journal-title":"Curr Opin Rheumatol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2013.04.001","article-title":"Fibroblasts and synovial immunity","volume":"13","author":"Leech","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102758","article-title":"Novel insights into macrophage diversity in rheumatoid arthritis synovium","volume":"20","author":"Boutet","year":"2021","journal-title":"Autoimmun Rev"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0413-5","article-title":"Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes","volume":"16","author":"Nygaard","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12694","article-title":"The oncostatin M-stromal cell axis in health and disease","volume":"88","author":"West","year":"2018","journal-title":"Scand J Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/512103","article-title":"The enigmatic cytokine oncostatin m and roles in disease","volume":"2013","author":"Richards","year":"2013","journal-title":"ISRN Inflammation"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2018.1500558","article-title":"Oncostatin M and its role in fibrosis","volume":"60","author":"Stawski","year":"2019","journal-title":"Connect Tissue Res"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1922729117","article-title":"Engineering a potent receptor superagonist or antagonist from a novel IL-6 family cytokine ligand","volume":"117","author":"Kim","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.24.9739","article-title":"Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells","volume":"83","author":"Zarling","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.11.2399","article-title":"Receptor recognition by gp130 cytokines","volume":"19","author":"Bravo","year":"2000","journal-title":"EMBO J"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/s0969-2126(00)00176-3","article-title":"Crystal structure and functional dissection of the cytostatic cytokine oncostatin M","volume":"8","author":"Deller","year":"2000","journal-title":"Structure"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303168200","article-title":"Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor","volume":"278","author":"Plun-Favreau","year":"2003","journal-title":"J Biol Chem"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1016\/j.jaci.2016.10.039","article-title":"Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease","volume":"139","author":"Pothoven","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13221","article-title":"Oncostatin M induces RIG-I and MDA5 expression and enhances the double-stranded RNA response in fibroblasts","volume":"21","author":"Hergovits","year":"2017","journal-title":"J Cell Mol Med"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/art.20166","article-title":"Secretion of oncostatin M by neutrophils in rheumatoid arthritis","volume":"50","author":"Cross","year":"2004","journal-title":"Arthritis Rheum"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.96034","article-title":"Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications","volume":"2","author":"Torossian","year":"2017","journal-title":"JCI Insight"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028415","article-title":"Interleukin-6 family cytokines","volume":"10","author":"Rose-John","year":"2018","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.25.15760","article-title":"Signaling of type II oncostatin M receptor","volume":"272","author":"Auguste","year":"1997","journal-title":"J Biol Chem"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.3.804","article-title":"Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit","volume":"93","author":"Tanaka","year":"1999","journal-title":"Blood"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.00029","article-title":"Molecular simulation of oncostatin M and receptor (OSM-OSMR) interaction as a potential therapeutic target for inflammatory bowel disease","volume":"7","author":"Du","year":"2020","journal-title":"Front Mol Biosci"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2021.129907","article-title":"Cross-reactivity of two human IL-6 family cytokines OSM and LIF explored by protein-protein docking and molecular dynamics simulation","volume":"1865","author":"Du","year":"2021","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.001920","article-title":"The AB loop and D-helix in binding site III of human Oncostatin M (OSM) are required for OSM receptor activation","volume":"293","author":"Adrian-Segarra","year":"2018","journal-title":"J Biol Chem"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1172\/jci40568","article-title":"Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice","volume":"120","author":"Walker","year":"2010","journal-title":"J Clin Invest"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043155","article-title":"Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor","volume":"7","author":"Drechsler","year":"2012","journal-title":"PloS One"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.fob.2015.04.001","article-title":"Expression of nephronectin is inhibited by oncostatin M via both JAK\/STAT and MAPK pathways","volume":"5","author":"Kurosawa","year":"2015","journal-title":"FEBS Open Bio"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01165","article-title":"an underestimated player in the central nervous system","volume":"10","author":"Houben","year":"2019","journal-title":"Front Immunol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2015.07.006","article-title":"Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology","volume":"26","author":"Hermanns","year":"2015","journal-title":"Cytokine Growth Factor Rev"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1016\/j.cell.2016.11.034","article-title":"CDK substrate phosphorylation and ordering the cell cycle","volume":"167","author":"Swaffer","year":"2016","journal-title":"Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/(sici)1097-0215(19980105)75:1<64::aid-ijc11>3.0.co;2-d","article-title":"Oncostatin M induces the differentiation of breast cancer cells","volume":"75","author":"Douglas","year":"1998","journal-title":"Int J Cancer"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202708","article-title":"Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27\/Kip1","volume":"18","author":"Kortylewski","year":"1999","journal-title":"Oncogene"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203707","article-title":"Oncostatin M and interleukin 6 inhibit cell cycle progression by prevention of p27kip1 degradation in HepG2 cells","volume":"19","author":"Klausen","year":"2000","journal-title":"Oncogene"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20086","article-title":"Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice","volume":"39","author":"Nakamura","year":"2004","journal-title":"Hepatology"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.85.12.1124","article-title":"Oncostatin M induces interleukin-6 and cyclooxygenase-2 expression in human vascular smooth muscle cells : synergy with interleukin-1beta","volume":"85","author":"Bernard","year":"1999","journal-title":"Circ Res"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.12.8740","article-title":"Oncostatin M-induced IL-6 expression in murine fibroblasts requires the activation of protein kinase Cdelta","volume":"177","author":"Smyth","year":"2006","journal-title":"J Immunol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.02167-08","article-title":"Oncostatin M enhances the antiviral effects of type I interferon and activates immunostimulatory functions in liver epithelial cells","volume":"83","author":"Larrea","year":"2009","journal-title":"J Virol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502314","article-title":"Oncostatin M suppresses activation of IL-17\/Th17 via SOCS3 regulation in CD4+ T cells","volume":"198","author":"Son","year":"2017","journal-title":"J Immunol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-02-0367","article-title":"Targeted disruption of oncostatin M receptor results in altered hematopoiesis","volume":"102","author":"Tanaka","year":"2003","journal-title":"Blood"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/s1359-6101(00)00003-4","article-title":"Role of Oncostatin M in hematopoiesis and liver development","volume":"11","author":"Miyajima","year":"2000","journal-title":"Cytokine Growth Factor Rev"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc6261","article-title":"Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans","volume":"369","author":"Arunachalam","year":"2020","journal-title":"Science"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab032","article-title":"Oncostatin M is a biomarker of diagnosis, worse disease prognosis, and therapeutic nonresponse in inflammatory bowel disease","volume":"27","author":"Verstockt","year":"2021","journal-title":"Inflammation Bowel Dis"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abf8188","article-title":"Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma","volume":"14","author":"Headland","year":"2022","journal-title":"Sci Transl Med"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/317503","article-title":"Oncostatin M and TLR-4 ligand synergize to induce MCP-1, IL-6, and VEGF in human aortic adventitial fibroblasts and smooth muscle cells","volume":"2013","author":"Schnittker","year":"2013","journal-title":"Mediators Inflammation"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.90003.iii75","article-title":"Oncostatin M in the anti-inflammatory response","author":"Wahl","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s12565-017-0421-y","article-title":"Oncostatin M in the development of metabolic syndrome and its potential as a novel therapeutic target","volume":"93","author":"Komori","year":"2018","journal-title":"Anat Sci Int"},{"key":"B48","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1002\/hep.29421","article-title":"Oncostatin M causes liver fibrosis by regulating cooperation between hepatic stellate cells and macrophages in mice","volume":"67","author":"Matsuda","year":"2018","journal-title":"Hepatology"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2005.03.015","article-title":"The gp130 ligand oncostatin M regulates tissue inhibitor of metalloproteinases-1 through ERK1\/2 and p38 in human adult cardiac myocytes and in human adult cardiac fibroblasts: a possible role for the gp130\/gp130 ligand system in the modulation of extracellular matrix degradation in the human hea rt","volume":"39","author":"Weiss","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.cyto.2014.11.007","article-title":"Oncostatin M binds to extracellular matrix in a bioactive conformation: implications for inflammation and metastasis","volume":"72","author":"Ryan","year":"2015","journal-title":"Cytokine"},{"key":"B51","article-title":"Effect of oncostatin M on wound healing activity of diabetic fibroblasts","volume":"35","author":"Lim","year":"2008","journal-title":"vitro. J Korean Soc Plast Reconstr Surg"},{"key":"B52","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/j.1742-481X.2012.01107.x","article-title":"Potential of oncostatin M to accelerate diabetic wound healing","volume":"11","author":"Shin","year":"2014","journal-title":"Int Wound J"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abe3037","article-title":"Oncostatin M can sensitize sensory neurons in inflammatory pruritus","volume":"13","author":"Tseng","year":"2021","journal-title":"Sci Transl Med"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2013.849701","article-title":"Association of OSMR gene polymorphisms with rheumatoid arthritis and systemic lupus erythematosus patients","volume":"47","author":"Lin","year":"2014","journal-title":"Autoimmunity"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2019.05.004","article-title":"Investigation of systemic lupus erythematosus (SLE) with integrating transcriptomics and genome wide association information","volume":"706","author":"Gorji","year":"2019","journal-title":"Gene"},{"key":"B56","article-title":"Oncostatin M as a potential molecular target in systemic sclerosis [abstract]","volume":"67","author":"Feeney","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1136\/ard.56.3.184","article-title":"Detection of oncostatin M in synovial fluid from patients with rheumatoid arthritis","volume":"56","author":"Hui","year":"1997","journal-title":"Ann Rheum Dis"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199810)41:10<1760::Aid-art8>3.0.Co;2-m","article-title":"The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint","volume":"41","author":"Cawston","year":"1998","journal-title":"Arthritis Rheum"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200002)43:2<281::Aid-anr7>3.0.Co;2-7","article-title":"Synovial fluid levels of tumor necrosis factor alpha and oncostatin M correlate with levels of markers of the degradation of crosslinked collagen and cartilage aggrecan in rheumatoid arthritis but not in osteoarthritis","volume":"43","author":"Manicourt","year":"2000","journal-title":"Arthritis Rheum"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.02.012","article-title":"The role of synovitis in osteoarthritis pathogenesis","volume":"51","author":"Scanzello","year":"2012","journal-title":"Bone"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-017-9753-1","article-title":"Mesenchymal stem\/progenitor cells derived from articular cartilage, synovial membrane and synovial fluid for cartilage regeneration: current status and future perspectives","volume":"13","author":"Huang","year":"2017","journal-title":"Stem Cell Rev Rep"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214783","article-title":"TNF-induced inflammatory genes escape repression in fibroblast-like synoviocytes: transcriptomic and epigenomic analysis","volume":"78","author":"Loh","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"B63","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s13075-017-1303-3","article-title":"Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis","volume":"19","author":"Bustamante","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"B64","doi-asserted-by":"publisher","first-page":"R72","DOI":"10.1186\/ar3333","article-title":"CP690,550 inhibits oncostatin M-induced JAK\/STAT signaling pathway in rheumatoid synoviocytes","volume":"13","author":"Migita","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02056","article-title":"STAT3 mediates the differential effects of oncostatin M and TNF\u03b1 on RA synovial fibroblast and endothelial cell function","volume":"10","author":"Hanlon","year":"2019","journal-title":"Front Immunol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155828","article-title":"Interleukin-8: An evolving chemokine","volume":"153","author":"Matsushima","year":"2022","journal-title":"Cytokine"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.04.001","article-title":"Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts","volume":"68","author":"Le Goff","year":"2014","journal-title":"Cytokine"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104511","article-title":"Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy","volume":"150","author":"Abdel-Wahab","year":"2019","journal-title":"Pharmacol Res"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01483","article-title":"How autoantibodies regulate osteoclast induced bone loss in rheumatoid arthritis","volume":"10","author":"Steffen","year":"2019","journal-title":"Front Immunol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21245","article-title":"Oncostatin M promotes osteogenesis and suppresses adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells","volume":"101","author":"Song","year":"2007","journal-title":"J Cell Biochem"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-014-2099-y","article-title":"Oncostatin M regulates osteogenic differentiation of murine adipose-derived mesenchymal progenitor cells through a PKCdelta-dependent mechanism","volume":"360","author":"Smyth","year":"2015","journal-title":"Cell Tissue Res"},{"key":"B72","article-title":"Effects of oncostatin M on cell proliferation and osteogenic differentiation in C3H10T1\/2","volume":"16","author":"Zou","year":"2016","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34293","article-title":"Toward zonally tailored scaffolds for osteochondral differentiation of synovial mesenchymal stem cells","volume":"107","author":"Diaz-Rodriguez","year":"2019","journal-title":"J BioMed Mater Res B Appl Biomater"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9261","article-title":"Oncostatin M promotes the osteogenic differentiation of mouse MC3T3\u2212E1osteoblasts through the regulation of monocyte chemotactic protein\u22121","volume":"18","author":"Zheng","year":"2018","journal-title":"Mol Med Rep"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1186\/ar1460","article-title":"A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK\/RANKL","volume":"7","author":"Hui","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.11.008","article-title":"Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury","volume":"185","author":"Guihard","year":"2015","journal-title":"Am J Pathol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.12.1357","article-title":"Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not","volume":"39","author":"Ribbens","year":"2000","journal-title":"Rheumatol (Oxford)"},{"key":"B78","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1006\/cyto.1996.0067","article-title":"(OSM) stimulates resorption and inhibits synthesis of proteoglycan in porcine articular cartilage explants","volume":"8","author":"Hui","year":"1996","journal-title":"Cytokine"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1002\/art.22161","article-title":"Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures","volume":"54","author":"Fearon","year":"2006","journal-title":"Arthritis Rheum"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab133","article-title":"TSP1 is the essential domain of SEMA5A involved in pannus formation in rheumatoid arthritis","volume":"60","author":"Xiao","year":"2021","journal-title":"Rheumatol (Oxford)"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1002\/art.22401","article-title":"Amelioration of collagen-induced arthritis in rats by nanogold","volume":"56","author":"Tsai","year":"2007","journal-title":"Arthritis Rheum"},{"key":"B82","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.3390\/ijms19072012","article-title":"Implications of angiogenesis involvement in arthritis","volume":"19","author":"MacDonald","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1134\/s1607672919010198","article-title":"Regulation of recombinase rag-1 expression by female sex steroids in treg and th17 lymphocytes: role of oncostatin M","volume":"484","author":"Shirshev","year":"2019","journal-title":"Dokl Biochem Biophys"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200111)44:11<2697::aid-art450>3.0.co;2-#","article-title":"Amelioration of arthritis in two murine models using antibodies to oncostatin M","volume":"44","author":"Plater-Zyberk","year":"2001","journal-title":"Arthritis Rheum"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)64634-2","article-title":"Murine oncostatin M stimulates mouse synovial fibroblasts in vitro and induces inflammation and destruction in mouse joints in vivo","volume":"157","author":"Langdon","year":"2000","journal-title":"Am J Pathol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"508","DOI":"10.3390\/cells10030508","article-title":"Association between oncostatin M expression and inflammatory phenotype in experimental arthritis models and osteoarthritis patients","volume":"10","author":"Garcia","year":"2021","journal-title":"Cells"},{"key":"B87","doi-asserted-by":"publisher","first-page":"R132","DOI":"10.1186\/ar4312","article-title":"Safety, tolerability, pharmacokinetics and pharmacodynamics of an anti- oncostatin M monoclonal antibody in rheumatoid arthritis: results from phase II randomized, placebo-controlled trials","volume":"15","author":"Choy","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13669","article-title":"In vivo affinity and target engagement in skin and blood in a first-time-in-human study of an anti-oncostatin M monoclonal antibody","volume":"84","author":"Reid","year":"2018","journal-title":"Br J Clin Pharmacol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101826","article-title":"Efficacy and safety of vixarelimab, a human monoclonal oncostatin M receptor \u03b2 antibody, in moderate-to-severe prurigo nodularis: a randomised, double-blind, placebo-controlled, phase 2a study","volume":"57","author":"Sofen","year":"2023","journal-title":"EClinicalMedicine"},{"key":"B90","doi-asserted-by":"publisher","first-page":"16174","DOI":"10.1038\/s41598-021-95424-6","article-title":"Bioactive recombinant human oncostatin M for NMR-based screening in drug discovery","volume":"11","author":"Mass","year":"2021","journal-title":"Sci Rep"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.106709","article-title":"Unbiased molecular dynamics simulation of a first-in-class small molecule inhibitor binds to oncostatin M","volume":"155","author":"Du","year":"2023","journal-title":"Comput Biol Med"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1258765\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T17:35:01Z","timestamp":1698860101000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1258765\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":91,"alternative-id":["10.3389\/fimmu.2023.1258765"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2023.1258765","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,1]]},"article-number":"1258765"}}