{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:50:07Z","timestamp":1793731807468,"version":"4.6.1"},"reference-count":376,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Gliomas are one of the most common primary malignant tumours of the central nervous system (CNS), of which glioblastomas (GBMs) are the most common and destructive type. The glioma tumour microenvironment (TME) has unique characteristics, such as hypoxia, the blood-brain barrier (BBB), reactive oxygen species (ROS) and tumour neovascularization. Therefore, the traditional treatment effect is limited. As cellular oxidative metabolites, ROS not only promote the occurrence and development of gliomas but also affect immune cells in the immune microenvironment. In contrast, either too high or too low ROS levels are detrimental to the survival of glioma cells, which indicates the threshold of ROS. Therefore, an in-depth understanding of the mechanisms of ROS production and scavenging, the threshold of ROS, and the role of ROS in the glioma TME can provide new methods and strategies for glioma treatment. Current methods to increase ROS include photodynamic therapy (PDT), sonodynamic therapy (SDT), and chemodynamic therapy (CDT), etc., and methods to eliminate ROS include the ingestion of antioxidants. Increasing\/scavenging ROS is potentially applicable treatment, and further studies will help to provide more effective strategies for glioma treatment.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1259797","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T07:08:24Z","timestamp":1701932904000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":56,"title":["ROS regulation in gliomas: implications for treatment strategies"],"prefix":"10.3389","volume":"14","author":[{"given":"Yu-Chen","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Jia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can-Jun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Tian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.05.125","article-title":"Current status and future therapeutic perspectives of glioblastoma multiforme (Gbm) therapy: A review","volume":"92","author":"Anjum","year":"2017","journal-title":"Biomed Pharmacother = Biomed Pharmacotherapie"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2015.03.015","article-title":"Mechanisms regulating glioma invasion","volume":"362","author":"Paw","year":"2015","journal-title":"Cancer Lett"},{"key":"B3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s10555-021-09997-9","article-title":"Glioma: molecular signature and crossroads with tumor microenvironment","volume":"41","author":"Barthel","year":"2022","journal-title":"Cancer metastasis Rev"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3720","DOI":"10.1038\/s41467-021-24108-6","article-title":"Suppression of mitochondrial ros by prohibitin drives glioblastoma progression and therapeutic resistance","volume":"12","author":"Huang","year":"2021","journal-title":"Nat Commun"},{"key":"B5","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3390\/ijms22010351","article-title":"Molecular mechanisms of treatment resistance in glioblastoma","volume":"22","author":"Ou","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"New Engl J Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-017-2477-x","article-title":"The role of bevacizumab in the treatment of glioblastoma","volume":"133","author":"Diaz","year":"2017","journal-title":"J neuro-oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-021-00717-7","article-title":"Dissecting the mechanism of temozolomide resistance and its association with the regulatory roles of intracellular reactive oxygen species in glioblastoma","volume":"28","author":"Chien","year":"2021","journal-title":"J Biomed Sci"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-16-2983","article-title":"Temozolomide in the era of precision medicine","volume":"77","author":"Thomas","year":"2017","journal-title":"Cancer Res"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2021.188616","article-title":"Elucidating the mechanisms of temozolomide resistance in gliomas and the strategies to overcome the resistance","volume":"1876","author":"Tomar","year":"2021","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B11","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.gendis.2016.04.007","article-title":"Temozolomide resistance in glioblastoma multiforme","volume":"3","author":"Lee","year":"2016","journal-title":"Genes Dis"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717x-6-2","article-title":"Antiangiogenic agents in the treatment of recurrent or newly diagnosed glioblastoma: analysis of single-agent and combined modality approaches","volume":"6","author":"Beal","year":"2011","journal-title":"Radiat Oncol (London England)"},{"key":"B13","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1186\/s12885-023-11043-6","article-title":"Use of bevacizumab in recurrent glioblastoma: A scoping review and evidence map","volume":"23","author":"Fu","year":"2023","journal-title":"BMC Cancer"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2174\/092986712799320646","article-title":"Efficacy and safety of bevacizumab in glioblastomas","volume":"19","author":"De Fazio","year":"2012","journal-title":"Curr medicinal Chem"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (Ros) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1177\/1177271918755391","article-title":"Reactive oxygen species: A key constituent in cancer survival","volume":"13","author":"Kumari","year":"2018","journal-title":"biomark Insights"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2020.04.001","article-title":"Exercise-induced oxidative stress: friend or foe","volume":"9","author":"Powers","year":"2020","journal-title":"J sport Health Sci"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/cells11010072","article-title":"Ros- and radiation source-dependent modulation of leukocyte adhesion to primary microvascular endothelial cells","volume":"11","author":"Eckert","year":"2021","journal-title":"Cells"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700170R","article-title":"Physiological role of reactive oxygen species as promoters of natural defenses","volume":"31","author":"Roy","year":"2017","journal-title":"FASEB J"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-0602-4_9","article-title":"Oxidative stress and autophagy","volume":"1206","author":"Gao","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.tips.2017.04.005","article-title":"Targeting free radicals in oxidative stress-related human diseases","volume":"38","author":"Poprac","year":"2017","journal-title":"Trends Pharmacol Sci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/cells8091065","article-title":"Total DNA methylation changes reflect random oxidative DNA damage in gliomas","volume":"8","author":"Barciszewska","year":"2019","journal-title":"Cells"},{"key":"B23","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1186\/s12885-023-11025-8","article-title":"Aqp8 promotes glioma proliferation and growth, possibly through the ros\/pten\/akt signaling pathway","volume":"23","author":"Hao","year":"2023","journal-title":"BMC Cancer"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.09.015","article-title":"Contribution of reactive oxygen species to migration\/invasion of human glioblastoma cells U87 via erk-dependent cox-2\/pge(2) activation","volume":"37","author":"Chiu","year":"2010","journal-title":"Neurobiol Dis"},{"key":"B25","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13046-015-0174-1","article-title":"Ros-P53-cyclophilin-D signaling mediates salinomycin-induced glioma cell necrosis","volume":"34","author":"Qin","year":"2015","journal-title":"J Exp Clin Cancer Res: CR"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114359","article-title":"Isoaaptamine increases ros levels causing autophagy and mitochondria-mediated apoptosis in glioblastoma multiforme cells","volume":"160","author":"Wen","year":"2023","journal-title":"Biomed Pharmacother = Biomed Pharmacotherapie"},{"key":"B27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cbi.2010.09.028","article-title":"Naringenin, a flavanone inhibits the proliferation of cerebrally implanted C6 glioma cells in rats","volume":"189","author":"Sabarinathan","year":"2011","journal-title":"Chemico-biological Interact"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3061607","article-title":"Modulation of antioxidant potential with coenzyme Q10 suppressed invasion of temozolomide-resistant rat glioma in vitro and in vivo","volume":"2019","author":"Buri\u0107","year":"2019","journal-title":"Oxid Med Cell Longevity"},{"key":"B29","doi-asserted-by":"publisher","first-page":"3918","DOI":"10.3390\/cancers15153918","article-title":"Systematic review of photodynamic therapy in gliomas","volume":"15","author":"Hsia","year":"2023","journal-title":"Cancers"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2017.02.020","article-title":"Current status and future perspectives of sonodynamic therapy in glioma treatment","volume":"37","author":"Wang","year":"2017","journal-title":"Ultrasonics sonochemistry"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1838","article-title":"Nanotechnology meets glioblastoma multiforme: emerging therapeutic strategies","volume":"15","author":"Liu","year":"2023","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.03.011","article-title":"Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing P21waf1\/cip1 expression: involvement of P38 mitogen-activated protein kinase","volume":"69","author":"Weng","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.07.028","article-title":"Roles of dioxins and heavy metals in cancer and neurological diseases using ros-mediated mechanisms","volume":"49","author":"Mat\u00e9s","year":"2010","journal-title":"Free Radical Biol Med"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8135985","article-title":"Autophagy: multiple mechanisms to protect skin from ultraviolet radiation-driven photoaging","volume":"2019","author":"Wang","year":"2019","journal-title":"Oxid Med Cell Longevity"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/671539","article-title":"The protective role of antioxidants in the defence against ros\/rns-mediated environmental pollution","volume":"2014","author":"Polj\u0161ak","year":"2014","journal-title":"Oxid Med Cell Longevity"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1039\/d0cc00470g","article-title":"Gsh-triggered release of sulfur dioxide gas to regulate redox balance for enhanced photodynamic therapy","volume":"56","author":"Zhang","year":"2020","journal-title":"Chem Commun (Cambridge England)"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3618806","article-title":"Pm2.5 exposure and asthma development: the key role of oxidative stress","volume":"2022","author":"Liu","year":"2022","journal-title":"Oxid Med Cell Longevity"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101674","article-title":"Mitochondrial electron transport chain: oxidative phosphorylation, oxidant production, and methods of measurement","volume":"37","author":"Nolfi-Donegan","year":"2020","journal-title":"Redox Biol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7915","article-title":"The nadph oxidase family and its inhibitors","volume":"33","author":"Chocry","year":"2020","journal-title":"Antioxid Redox Signaling"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2021.02.005","article-title":"Peroxisomes as cellular adaptors to metabolic and environmental stress","volume":"31","author":"He","year":"2021","journal-title":"Trends Cell Biol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.7150\/thno.56747","article-title":"The double-edged roles of ros in cancer prevention and therapy","volume":"11","author":"Wang","year":"2021","journal-title":"Theranostics"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2021.105189","article-title":"Brg1 mutation alters oxidative stress responses in glioblastoma","volume":"150","author":"Gowda","year":"2021","journal-title":"Neurochemistry Int"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4081380","article-title":"Ccaat\/enhancer-binding protein delta regulates glioblastoma survival through catalase-mediated hydrogen peroxide clearance","volume":"2022","author":"Lin","year":"2022","journal-title":"Oxid Med Cell Longevity"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101413","article-title":"Ar ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting gpx4-mediated redox homeostasis","volume":"30","author":"Chen","year":"2020","journal-title":"Redox Biol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/jnc.14250","article-title":"Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis","volume":"144","author":"Zhu","year":"2018","journal-title":"J neurochemistry"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-010-0513-1","article-title":"Inhibition of heme oxygenase-1 enhances anti-cancer effects of arsenic trioxide on glioma cells","volume":"104","author":"Liu","year":"2011","journal-title":"J neuro-oncol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23431","article-title":"Detoxification of oxidative stress in glioma stem cells: mechanism, clinical relevance, and therapeutic development","volume":"92","author":"Kim","year":"2014","journal-title":"J Neurosci Res"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.889971","article-title":"Thioredoxin reductase inhibitors as potential antitumors: mercury compounds efficacy in glioma cells","volume":"9","author":"Pires","year":"2022","journal-title":"Front Mol Biosci"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101578","article-title":"C\/ebp\u03b2 Mediates nqo1 and gstp1 anti-oxidative reductases expression in glioblastoma, promoting brain tumor proliferation","volume":"34","author":"Lei","year":"2020","journal-title":"Redox Biol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.60","article-title":"Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system xc-, leading to glutathione depletion","volume":"34","author":"Sleire","year":"2015","journal-title":"Oncogene"},{"key":"B51","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.biopha.2018.12.077","article-title":"Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of trpa1 channel in human glioblastoma cell line","volume":"111","author":"Deveci","year":"2019","journal-title":"Biomed Pharmacother = Biomed Pharmacotherapie"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.04.033","article-title":"Regulation of the oxidative balance with coenzyme Q10 sensitizes human glioblastoma cells to radiation and temozolomide","volume":"128","author":"Fronti\u00f1\u00e1n-Rubio","year":"2018","journal-title":"Radiother Oncol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/med.21396","article-title":"The keap1-nrf2-are pathway as a potential preventive and therapeutic target: an update","volume":"36","author":"Lu","year":"2016","journal-title":"Medicinal Res Rev"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-015-9588-7","article-title":"Tumor cell survival pathways activated by photodynamic therapy: A molecular basis for pharmacological inhibition strategies","volume":"34","author":"Broekgaarden","year":"2015","journal-title":"Cancer metastasis Rev"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.08.037","article-title":"Variants in oxidative stress-related genes affect the chemosensitivity through nrf2-mediated signaling pathway in biliary tract cancer","volume":"48","author":"Zhan","year":"2019","journal-title":"EBioMedicine"},{"key":"B57","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1089\/ars.2012.4634","article-title":"Keratinocyte growth factor and glucocorticoid induction of human peroxiredoxin 6 gene expression occur by independent mechanisms that are synergistic","volume":"20","author":"Chowdhury","year":"2014","journal-title":"Antioxid Redox Signaling"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153241","article-title":"Enhanced keap1-nrf2\/trx-1 axis by daphnetin protects against oxidative stress-driven hepatotoxicity via inhibiting ask1\/jnk and txnip\/nlrp3 inflammasome activation","volume":"71","author":"Lv","year":"2020","journal-title":"Phytomed: Int J Phytother Phytopharmacol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02397-5","article-title":"Gbp3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair","volume":"41","author":"Xu","year":"2022","journal-title":"Oncogene"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.100","article-title":"Mgmt testing\u2013the challenges for biomarker-based glioma treatment","volume":"10","author":"Wick","year":"2014","journal-title":"Nat Rev Neurol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.celrep.2018.03.076","article-title":"Genomic and molecular landscape of DNA damage repair deficiency across the cancer genome atlas","volume":"23","author":"Knijnenburg","year":"2018","journal-title":"Cell Rep"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010767","article-title":"Targeting egfr induced oxidative stress by parp1 inhibition in glioblastoma therapy","volume":"5","author":"Nitta","year":"2010","journal-title":"PloS One"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-22-2036","article-title":"Mex3a impairs DNA mismatch repair signaling and mediates acquired temozolomide resistance in glioblastoma","volume":"82","author":"Gan","year":"2022","journal-title":"Cancer Res"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.7150\/thno.29987","article-title":"Oncogenic msh6-cxcr4-tgfb1 feedback loop: A novel therapeutic target of photothermal therapy in glioblastoma multiforme","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2013.01.003","article-title":"Ner initiation factors, ddb2 and xpc, regulate uv radiation response by recruiting atr and atm kinases to DNA damage sites","volume":"12","author":"Ray","year":"2013","journal-title":"DNA Repair"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz202","article-title":"Acquired temozolomide resistance in mgmt-deficient glioblastoma cells is associated with regulation of DNA repair by dhc2","volume":"142","author":"Yi","year":"2019","journal-title":"Brain: J Neurol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-275404","article-title":"Mitochondria-targeted antioxidants","volume":"29","author":"Oyewole","year":"2015","journal-title":"FASEB J"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232213915","article-title":"Gsk343, an inhibitor of enhancer of zeste homolog 2, reduces glioblastoma progression through inflammatory process modulation: focus on canonical and non-canonical nf-Kb\/I\u03bab\u03b1 Pathways","volume":"23","author":"Scuderi","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5413035","article-title":"Expression of eif4e gene in glioma and its sensitivity to oxidative stress","volume":"2022","author":"Liang","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.08.005","article-title":"Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O(6)-methylguanine-DNA methyltransferase","volume":"13","author":"Chang","year":"2017","journal-title":"Redox Biol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10121988","article-title":"Catalase overexpression drives an aggressive phenotype in glioblastoma","volume":"10","author":"Flor","year":"2021","journal-title":"Antioxid (Basel Switzerland)"},{"key":"B72","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ejmech.2015.04.040","article-title":"The role of antioxidants in the chemistry of oxidative stress: A review","volume":"97","author":"Pisoschi","year":"2015","journal-title":"Eur J Med Chem"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-01800-y","article-title":"Targeting nqo1\/gpx4-mediated ferroptosis by plumbagin suppresses in vitro and in vivo glioma growth","volume":"127","author":"Zhan","year":"2022","journal-title":"Br J Cancer"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3150145","article-title":"Unraveling the potential role of glutathione in multiple forms of cell death in cancer therapy","volume":"2019","author":"Lv","year":"2019","journal-title":"Oxid Med Cell Longevity"},{"key":"B75","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/s41419-019-2107-y","article-title":"The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma","volume":"10","author":"Ozyerli-Goknar","year":"2019","journal-title":"Cell Death Dis"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5674","article-title":"Signaling function of heme oxygenase proteins","volume":"20","author":"Dennery","year":"2014","journal-title":"Antioxid Redox Signaling"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1134-z","article-title":"Overexpression of nrf2 attenuates carmustine-induced cytotoxicity in U87mg human glioma cells","volume":"15","author":"Sukumari-Ramesh","year":"2015","journal-title":"BMC Cancer"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3390\/antiox7120177","article-title":"Piecing together how peroxiredoxins maintain genomic stability","volume":"7","author":"West","year":"2018","journal-title":"Antioxidants"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201601453","article-title":"Au nanoclusters and photosensitizer dual loaded spatiotemporal controllable liposomal nanocomposites enhance tumor photodynamic therapy effect by inhibiting thioredoxin reductase","volume":"6","author":"Gao","year":"2017","journal-title":"Advanced Healthc Mater"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.09.031","article-title":"Antiglioma activity of 2,2\u2019:6\u2019,2\u201d-terpyridineplatinum(Ii) complexes in a rat model\u2013effects on cellular redox metabolism","volume":"40","author":"Ahmadi","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"B81","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s13045-020-00979-y","article-title":"Discovery of a dual inhibitor of nqo1 and gstp1 for treating glioblastoma","volume":"13","author":"Lei","year":"2020","journal-title":"J Hematol Oncol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101950","article-title":"The diverse functionality of nqo1 and its roles in redox control","volume":"41","author":"Ross","year":"2021","journal-title":"Redox Biol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.02.014","article-title":"A novel strategy for glioblastoma treatment by induction of noptosis, an nqo1-dependent necrosis","volume":"166","author":"Zhong","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.813","article-title":"Redox pathways of the mitochondrion","volume":"8","author":"Koehler","year":"2006","journal-title":"Antioxid Redox Signaling"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308518200","article-title":"Glitazones differentially regulate primary astrocyte and glioma cell survival. Involvement of reactive oxygen species and peroxisome proliferator-activated receptor-gamma","volume":"279","author":"P\u00e9rez-Ortiz","year":"2004","journal-title":"J Biol Chem"},{"key":"B86","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/s41419-020-02866-3","article-title":"Autophagy activated by silibinin contributes to glioma cell death via induction of oxidative stress-mediated bnip3-dependent nuclear translocation of aif","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.2174\/0929867329666221006115329","article-title":"Potential for novel therapeutic uses of alpha lipoic acid","volume":"30","author":"Fasipe","year":"2023","journal-title":"Curr medicinal Chem"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112891","article-title":"Oxidative stress mitigation by antioxidants - an overview on their chemistry and influences on health status","volume":"209","author":"Pisoschi","year":"2021","journal-title":"Eur J medicinal Chem"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1048","article-title":"Targeting ogg1 arrests cancer cell proliferation by inducing replication stress","volume":"48","author":"Visnes","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.Mcr-16-0053","article-title":"Oxidative stress-induced protein damage inhibits DNA repair and determines mutation risk and therapeutic efficacy","volume":"14","author":"McAdam","year":"2016","journal-title":"Mol Cancer Res: MCR"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2492063","article-title":"Epigenetic versus genetic deregulation of the keap1\/nrf2 axis in solid tumors: focus on methylation and noncoding rnas","volume":"2018","author":"Fabrizio","year":"2018","journal-title":"Oxid Med Cell Longevity"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-022-00917-3","article-title":"Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing keap1\/nrf2 and cbs-regulated ferroptosis","volume":"43","author":"Zheng","year":"2022","journal-title":"Acta Pharmacologica Sin"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-013-1260-x","article-title":"Temozolomide and irradiation combined treatment-induced nrf2 activation increases chemoradiation sensitivity in human glioblastoma cells","volume":"116","author":"Cong","year":"2014","journal-title":"J Neurooncol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.145441","article-title":"The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic gmp, in the antioxidant adaptive response","volume":"285","author":"Fujii","year":"2010","journal-title":"J Biol Chem"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3390\/cells10092257","article-title":"The interplay between glioblastoma and its microenvironment","volume":"10","author":"Dapash","year":"2021","journal-title":"Cells"},{"key":"B96","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/labinvest.2017.19","article-title":"Immune microenvironment of gliomas","volume":"97","author":"Gieryng","year":"2017","journal-title":"Lab Invest"},{"key":"B97","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12929-022-00859-2","article-title":"Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend","volume":"29","author":"Kuo","year":"2022","journal-title":"J Biomed Sci"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12071748","article-title":"Reactive oxygen species and antitumor immunity-from surveillance to evasion","volume":"12","author":"Kotsafti","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noz212","article-title":"Immune biology of glioma-associated macrophages and microglia: functional and therapeutic implications","volume":"22","author":"Wei","year":"2020","journal-title":"Neuro-oncology"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.10.026","article-title":"Signal transduction and epigenetic mechanisms in the control of microglia activation during neuroinflammation","volume":"1862","author":"Kaminska","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2019.0353","article-title":"Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the hmgb1\/rage\/il-8 axis","volume":"17","author":"Zha","year":"2020","journal-title":"Cancer Biol Med"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nor042","article-title":"Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma","volume":"13","author":"Raychaudhuri","year":"2011","journal-title":"Neuro-oncology"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802740","article-title":"Myeloid-derived suppressor cells: linking inflammation and cancer","volume":"182","author":"Ostrand-Rosenberg","year":"2009","journal-title":"J Immunol (Baltimore Md: 1950)"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-031856","article-title":"L-arginine availability regulates T-lymphocyte cell-cycle progression","volume":"109","author":"Rodriguez","year":"2007","journal-title":"Blood"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov280","article-title":"Cd4+ T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients","volume":"18","author":"Dubinski","year":"2016","journal-title":"Neuro-oncology"},{"key":"B107","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1186\/s12967-021-02987-z","article-title":"Cyb561d2 up-regulation activates stat3 to induce immunosuppression and aggression in gliomas","volume":"19","author":"Tao","year":"2021","journal-title":"J Trans Med"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13050986","article-title":"Oxidative stress in the tumor microenvironment and its relevance to cancer immunotherapy","volume":"13","author":"Aboelella","year":"2021","journal-title":"Cancers"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00304","article-title":"Extracellular adenosine-mediated modulation of regulatory T cells","volume":"5","author":"Ohta","year":"2014","journal-title":"Front Immunol"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.3390\/cells11020310","article-title":"Myeloid-derived suppressor cells in solid tumors","volume":"11","author":"Ma","year":"2022","journal-title":"Cells"},{"key":"B111","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/s41419-022-05041-y","article-title":"Natural killer cell awakening: unleash cancer-immunity cycle against glioblastoma","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Death Dis"},{"key":"B112","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.jaci.2009.12.980","article-title":"Overview of the immune response","volume":"125","author":"Chaplin","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1038\/nri1733","article-title":"Monocyte and macrophage heterogeneity","volume":"5","author":"Gordon","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.577571","article-title":"Targeting macrophages as a therapeutic option in coronavirus disease 2019","volume":"11","author":"Gracia-Hernandez","year":"2020","journal-title":"Front Pharmacol"},{"key":"B115","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.coi.2007.10.010","article-title":"Antigen presentation by monocytes and monocyte-derived cells","volume":"20","author":"Randolph","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.09.014","article-title":"Microglia: immune and non-immune functions","volume":"54","author":"Borst","year":"2021","journal-title":"Immunity"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3710","article-title":"Microglial phagocytosis of live neurons","volume":"15","author":"Brown","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"B118","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.cell.2020.05.050","article-title":"Microglial remodeling of the extracellular matrix promotes synapse plasticity","volume":"182","author":"Nguyen","year":"2020","journal-title":"Cell"},{"key":"B119","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1146\/annurev-immunol-032713-120240","article-title":"Microglia development and function","volume":"32","author":"Nayak","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.566511","article-title":"Tumor-associated macrophages in human breast, colorectal, lung, ovarian and prostate cancers","volume":"10","author":"Larionova","year":"2020","journal-title":"Front Oncol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13750","article-title":"Plasminogen activator urokinase receptor implies immunosuppressive features and acts as an unfavorable prognostic biomarker in glioma","volume":"26","author":"Zeng","year":"2021","journal-title":"Oncologist"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15436","article-title":"Resolvin D1 and D2 inhibit tumour growth and inflammation via modulating macrophage polarization","volume":"24","author":"Shan","year":"2020","journal-title":"J Cell Mol Med"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636910","article-title":"New vistas on macrophage differentiation and activation","volume":"37","author":"Mantovani","year":"2007","journal-title":"Eur J Immunol"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-013-0645-9","article-title":"Immune system: A double-edged sword in cancer","volume":"62","author":"Lakshmi Narendra","year":"2013","journal-title":"Inflammation Res"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01004","article-title":"Immune microenvironment in glioblastoma subtypes","volume":"9","author":"Chen","year":"2018","journal-title":"Front Immunol"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/264124","article-title":"Microglia and macrophages in malignant gliomas: recent discoveries and implications for promising therapies","volume":"2013","author":"da Fonseca","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3390\/cancers6031670","article-title":"Tumor-associated macrophages as major players in the tumor microenvironment","volume":"6","author":"Chanmee","year":"2014","journal-title":"Cancers"},{"key":"B128","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.immuni.2014.06.010","article-title":"Tumor-associated macrophages: from mechanisms to therapy","volume":"41","author":"Noy","year":"2014","journal-title":"Immunity"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109369","article-title":"Increased expression of mmp-2 and mmp-9 indicates poor prognosis in glioma recurrence","volume":"118","author":"Zhou","year":"2019","journal-title":"Biomed Pharmacother = Biomed Pharmacotherapie"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1529-6","article-title":"Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors","volume":"131","author":"Brandenburg","year":"2016","journal-title":"Acta Neuropathologica"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x16666180302120925","article-title":"The delicate equilibrium between oxidants and antioxidants in brain glioma","volume":"17","author":"Ram\u00edrez-Exp\u00f3sito","year":"2019","journal-title":"Curr Neuropharmacol"},{"key":"B132","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s11060-014-1608-x","article-title":"Romo1 is associated with ros production and cellular growth in human gliomas","volume":"121","author":"Yu","year":"2015","journal-title":"J neuro-oncol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102648","article-title":"Romo1 is involved in the immune response of glioblastoma by regulating the function of macrophages","volume":"12","author":"Sun","year":"2020","journal-title":"Aging"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-022-08719-w","article-title":"Prognosis and immune landscapes in glioblastoma based on gene-signature related to reactive-oxygen-species","volume":"25","author":"Kaushal","year":"2023","journal-title":"Neuromolecular Med"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22397","article-title":"Glutathione peroxidase 1 activity dictates the sensitivity of glioblastoma cells to oxidative stress","volume":"60","author":"Dokic","year":"2012","journal-title":"Glia"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1161\/01.Res.0000164401.21929.Cf","article-title":"Adenosine-dependent induction of glutathione peroxidase 1 in human primary endothelial cells and protection against oxidative stress","volume":"96","author":"Zhang","year":"2005","journal-title":"Circ Res"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030561","article-title":"Myeloid-derived suppressor cells as a therapeutic target for cancer","volume":"9","author":"Law","year":"2020","journal-title":"Cells"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00576","article-title":"Apolipoprotein a-I mimetic peptide L-4f suppresses granulocytic-myeloid-derived suppressor cells in mouse pancreatic cancer","volume":"11","author":"Peng","year":"2020","journal-title":"Front Pharmacol"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-017-0022-x","article-title":"Myeloid-derived suppressor cells coming of age","volume":"19","author":"Veglia","year":"2018","journal-title":"Nat Immunol"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701069","article-title":"Myeloid-derived suppressor cells impair B cell responses in lung cancer through il-7 and stat5","volume":"201","author":"Wang","year":"2018","journal-title":"J Immunol (Baltimore Md: 1950)"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-05-1299","article-title":"Gr-1+Cd115+ Immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host","volume":"66","author":"Huang","year":"2006","journal-title":"Cancer Res"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3A0414-210R","article-title":"Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors","volume":"96","author":"Beury","year":"2014","journal-title":"J Leukoc Biol"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00676-9","article-title":"Myeloid-derived itaconate suppresses cytotoxic cd8(+) T cells and promotes tumour growth","volume":"4","author":"Zhao","year":"2022","journal-title":"Nat Metab"},{"key":"B144","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1002\/hep.23054","article-title":"Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the nkp30 receptor","volume":"50","author":"Hoechst","year":"2009","journal-title":"Hepatol (Baltimore Md)"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2012.01.011","article-title":"Cross-talk between myeloid-derived suppressor cells (Mdsc), macrophages, and dendritic cells enhances tumor-induced immune suppression","volume":"22","author":"Ostrand-Rosenberg","year":"2012","journal-title":"Semin Cancer Biol"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.4161\/auto.21315","article-title":"Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes","volume":"8","author":"Garc\u00eda-Navas","year":"2012","journal-title":"Autophagy"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2012.11.018","article-title":"Altered functions of natural killer cells in response to L-arginine availability","volume":"280","author":"Lamas","year":"2012","journal-title":"Cell Immunol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines4040036","article-title":"The role of myeloid-derived suppressor cells (Mdsc) in cancer progression","volume":"4","author":"Umansky","year":"2016","journal-title":"Vaccines"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1080\/2162402x.2022.2060907","article-title":"Lilrb4 promotes tumor metastasis by regulating mdscs and inhibiting mir-1 family mirnas","volume":"11","author":"Su","year":"2022","journal-title":"Oncoimmunology"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03048-x","article-title":"Immunosenescence: the potential role of myeloid-derived suppressor cells (Mdsc) in age-related immune deficiency","volume":"76","author":"Salminen","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4683607","article-title":"Immune checkpoint modulators: an emerging antiglioma armamentarium","volume":"2016","author":"Kim","year":"2016","journal-title":"J Immunol Res"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-021-00878-9","article-title":"Myeloid-derived suppressor cells (Mdscs) in brain cancer: challenges and therapeutic strategies","volume":"29","author":"Salemizadeh Parizi","year":"2021","journal-title":"Inflammopharmacology"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2016.10.003","article-title":"Immunosuppressive myeloid cells\u2019 Blockade in the glioma microenvironment enhances the efficacy of immune-stimulatory gene therapy","volume":"25","author":"Kamran","year":"2017","journal-title":"Mol Ther"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010018","article-title":"Myeloid cells in glioblastoma microenvironment","volume":"10","author":"De Leo","year":"2020","journal-title":"Cells"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-21-3840","article-title":"Distinct cell adhesion signature defines glioblastoma myeloid-derived suppressor cell subsets","volume":"82","author":"Bayik","year":"2022","journal-title":"Cancer Res"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12150","article-title":"Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards","volume":"7","author":"Bronte","year":"2016","journal-title":"Nat Commun"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131916","article-title":"Pd-L1 is a novel direct target of hif-1\u03b1, and its blockade under hypoxia enhanced mdsc-mediated T cell activation","volume":"211","author":"Noman","year":"2014","journal-title":"J Exp Med"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501785","article-title":"Myeloid-derived suppressor cell survival and function are regulated by the transcription factor nrf2","volume":"196","author":"Beury","year":"2016","journal-title":"J Immunol (Baltimore Md: 1950)"},{"key":"B159","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s11060-020-03483-y","article-title":"Immune suppression in gliomas","volume":"151","author":"Grabowski","year":"2021","journal-title":"J neuro-oncol"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02499","article-title":"Reactive oxygen species as regulators of mdsc-mediated immune suppression","volume":"9","author":"Ohl","year":"2018","journal-title":"Front Immunol"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0103010","article-title":"Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species","volume":"74","author":"Kusmartsev","year":"2003","journal-title":"J Leukoc Biol"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900092","article-title":"Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells","volume":"182","author":"Corzo","year":"2009","journal-title":"J Immunol (Baltimore Md: 1950)"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.813888","article-title":"Upregulation of atypical cadherin fat1 promotes an immunosuppressive tumor microenvironment via tgf-B","volume":"13","author":"Irshad","year":"2022","journal-title":"Front Immunol"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21809","article-title":"Increased pd-L1 expression and pd-L1\/cd86 ratio on dendritic cells were associated with impaired dendritic cells function in hcv infection","volume":"82","author":"Shen","year":"2010","journal-title":"J Med Virol"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.682708","article-title":"Interleukin 10 (Il-10)-mediated immunosuppression: march-I induction regulates antigen presentation by macrophages but not dendritic cells","volume":"290","author":"Mittal","year":"2015","journal-title":"J Biol Chem"},{"key":"B166","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev.immunol.24.021605.090737","article-title":"Transforming growth factor-beta regulation of immune responses","volume":"24","author":"Li","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"B167","doi-asserted-by":"publisher","first-page":"111ra20","DOI":"10.1126\/scitranslmed.3003130","article-title":"The pdl1-pd1 axis converts human th1 cells into regulatory T cells","volume":"3","author":"Amarnath","year":"2011","journal-title":"Sci Trans Med"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01276","article-title":"Antigen cross-presentation by macrophages","volume":"11","author":"Muntjewerff","year":"2020","journal-title":"Front Immunol"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.04.015","article-title":"Antibodies to interleukin-2 elicit selective T cell subset potentiation through distinct conformational mechanisms","volume":"42","author":"Spangler","year":"2015","journal-title":"Immunity"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0306-5","article-title":"A guide to cancer immunotherapy: from T cell basic science to clinical practice","volume":"20","author":"Waldman","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-100219-020937","article-title":"Regulatory T cell development","volume":"38","author":"Savage","year":"2020","journal-title":"Annu Rev Immunol"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0044-0","article-title":"Cd4(+) T cell help in cancer immunology and immunotherapy","volume":"18","author":"Borst","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.873293","article-title":"Glucose-restricted diet regulates the tumor immune microenvironment and prevents tumor growth in lung adenocarcinoma","volume":"12","author":"G\u00e4hler","year":"2022","journal-title":"Front Oncol"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15365","article-title":"Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment","volume":"8","author":"Kim","year":"2017","journal-title":"Nat Commun"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00014","article-title":"Recent advances in targeting cd8 T-cell immunity for more effective cancer immunotherapy","volume":"9","author":"Durgeau","year":"2018","journal-title":"Front Immunol"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.678201","article-title":"Canonical secretomes, innate immune caspase-1-, 4\/11-gasdermin D non-canonical secretomes and exosomes may contribute to maintain treg-ness for treg immunosuppression, tissue repair and modulate anti-tumor immunity via ros pathways","volume":"12","author":"Ni","year":"2021","journal-title":"Front Immunol"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165838","article-title":"Caix Regulates Gbm Motility and Tam Adhesion and Polarization through Egfr\/Stat3 under Hypoxic Conditions","volume":"21","author":"Huang","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B178","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev-immunol-032713-120257","article-title":"Tgf-B Activation and function in immunity","volume":"32","author":"Travis","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.967159","article-title":"Development and validation of cuproptosis-associated prognostic signatures in who 2\/3 glioma","volume":"12","author":"Ye","year":"2022","journal-title":"Front Oncol"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.941556","article-title":"Novel macrophage-related gene prognostic index for glioblastoma associated with M2 macrophages and T cell dysfunction","volume":"13","author":"Ji","year":"2022","journal-title":"Front Immunol"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1080\/2162402x.2018.1448329","article-title":"The immune checkpoint protein pd-L1 induces and maintains regulatory T cells in glioblastoma","volume":"7","author":"DiDomenico","year":"2018","journal-title":"Oncoimmunology"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2022.109178","article-title":"Expression and clinical significance of vista, B7-H3, and pd-L1 in glioma","volume":"245","author":"Wang","year":"2022","journal-title":"Clin Immunol (Orlando Fla)"},{"key":"B183","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.it.2018.01.005","article-title":"Reactive oxygen species: involvement in T cell signaling and metabolism","volume":"39","author":"FranChina","year":"2018","journal-title":"Trends Immunol"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.5.2595","article-title":"Inhibition of activated\/memory (Cd45ro(+)) T cells by oxidative stress associated with block of nf-kappab activation","volume":"167","author":"Malmberg","year":"2001","journal-title":"J Immunol (Baltimore Md: 1950)"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111451200","article-title":"Reactive oxygen species differentially affect T cell receptor-signaling pathways","volume":"277","author":"Cemerski","year":"2002","journal-title":"J Biol Chem"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1177\/0300060518767796","article-title":"Hyperbaric oxygen inhibits production of cd3+ T cells in the thymus and facilitates malignant glioma cell growth","volume":"46","author":"Wang","year":"2018","journal-title":"J Int Med Res"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01028","article-title":"Bam32\/dapp1-dependent neutrophil reactive oxygen species in wkymvm-induced microvascular hyperpermeability","volume":"11","author":"Hao","year":"2020","journal-title":"Front Immunol"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2010.05.006","article-title":"Neutrophil kinetics in health and disease","volume":"31","author":"Summers","year":"2010","journal-title":"Trends Immunol"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176347","article-title":"Characterization of the impact of oncolytic vesicular stomatitis virus on the trafficking, phenotype, and antigen presentation potential of neutrophils and their ability to acquire a non-structural viral protein","volume":"21","author":"Stegelmeier","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B190","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13054-021-03481-0","article-title":"Identification and characterization of neutrophil heterogeneity in sepsis","volume":"25","author":"Qi","year":"2021","journal-title":"Crit Care (London England)"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111128","article-title":"Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy","volume":"40","author":"Chang","year":"2022","journal-title":"Cell Rep"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1080\/2162402x.2019.1624129","article-title":"Neutrophil cathepsin G and tumor cell rage facilitate neutrophil anti-tumor cytotoxicity","volume":"8","author":"Sionov","year":"2019","journal-title":"Oncoimmunology"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01146","article-title":"Tumor associated neutrophils. Their role in tumorigenesis, metastasis, prognosis and therapy","volume":"9","author":"Masucci","year":"2019","journal-title":"Front Oncol"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0915-y","article-title":"Neutrophils escort circulating tumour cells to enable cell cycle progression","volume":"566","author":"Szczerba","year":"2019","journal-title":"Nature"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1172\/jci67484","article-title":"Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis","volume":"123","author":"Cools-Lartigue","year":"2013","journal-title":"J Clin Invest"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Sci (New York NY)"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1080\/2162402x.2015.1075693","article-title":"Enhanced neutrophil activity is associated with shorter time to tumor progression in glioblastoma patients","volume":"5","author":"Rahbar","year":"2016","journal-title":"Oncoimmunology"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2000.11740701","article-title":"Elastase expression by infiltrating neutrophils in gliomas","volume":"22","author":"Iwatsuki","year":"2000","journal-title":"Neurological Res"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-13-1279","article-title":"Neutrophils promote the Malignant glioma phenotype through S100a4","volume":"20","author":"Liang","year":"2014","journal-title":"Clin Cancer Res"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-17-1294","article-title":"S100a4 is a biomarker and regulator of glioma stem cells that is critical for mesenchymal transition in glioblastoma","volume":"77","author":"Chow","year":"2017","journal-title":"Cancer Res"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200606027","article-title":"Novel cell death program leads to neutrophil extracellular traps","volume":"176","author":"Fuchs","year":"2007","journal-title":"J Cell Biol"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.115921","article-title":"Tetrachlorobenzoquinone exhibits immunotoxicity by inducing neutrophil extracellular traps through a mechanism involving ros-jnk-nox2 positive feedback loop","volume":"268","author":"Lv","year":"2021","journal-title":"Environ pollut (Barking Essex: 1987)"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24391","article-title":"Reactive oxygen species-induced activation of erk and P38 mapk mediates pma-induced nets release from human neutrophils","volume":"114","author":"Keshari","year":"2013","journal-title":"J Cell Biochem"},{"key":"B205","doi-asserted-by":"publisher","first-page":"5424","DOI":"10.1038\/s41467-020-19193-y","article-title":"Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression","volume":"11","author":"Yee","year":"2020","journal-title":"Nat Commun"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-06-857789","article-title":"Epigenetic control of early dendritic cell lineage specification by the transcription factor irf8 in mice","volume":"133","author":"Kurotaki","year":"2019","journal-title":"Blood"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00438","article-title":"Immature, semi-mature, and fully mature dendritic cells: toward a dc-cancer cells interface that augments anticancer immunity","volume":"4","author":"Dudek","year":"2013","journal-title":"Front Immunol"},{"key":"B208","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41586-019-1593-5","article-title":"Harnessing innate immunity in cancer therapy","volume":"574","author":"Demaria","year":"2019","journal-title":"Nature"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103519","article-title":"Prognostic landscape of tumor-infiltrating immune cells and immune-related genes in the tumor microenvironment of gastric cancer","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2013.11.003","article-title":"Ferritin protein cage nanoparticles as versatile antigen delivery nanoplatforms for dendritic cell (Dc)-based vaccine development","volume":"10","author":"Han","year":"2014","journal-title":"Nanomed: Nanotechnol Biol Med"},{"key":"B211","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.it.2003.10.012","article-title":"Nk cell and dc interactions","volume":"25","author":"Cooper","year":"2004","journal-title":"Trends Immunol"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0650-3","article-title":"A dendritic cell-targeted adenoviral vector facilitates adaptive immune response against human glioma antigen (Cmv-ie) and prolongs survival in a human glioma tumor model","volume":"15","author":"Kim","year":"2018","journal-title":"Neurotherapeutics: J Am Soc Exp Neurother"},{"key":"B213","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s12951-022-01360-6","article-title":"Biomimetic gbm-targeted drug delivery system boosting ferroptosis for immunotherapy of orthotopic drug-resistant gbm","volume":"20","author":"Liu","year":"2022","journal-title":"J Nanobiotechnol"},{"key":"B214","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/cei.13476","article-title":"Suppressor of cytokine signaling 1 inhibits the maturation of dendritic cells involving the nuclear factor kappa B signaling pathway in the glioma microenvironment","volume":"202","author":"He","year":"2020","journal-title":"Clin Exp Immunol"},{"key":"B215","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s12967-015-0586-x","article-title":"Microglia and astrocytes attenuate the replication of the oncolytic vaccinia virus livp 1.1.1 in murine gl261 gliomas by acting as vaccinia virus traps","volume":"13","author":"Kober","year":"2015","journal-title":"J Trans Med"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030742","article-title":"D-2-hydroxyglutarate and L-2-hydroxyglutarate inhibit il-12 secretion by human monocyte-derived dendritic cells","volume":"20","author":"Ugele","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B217","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.yexcr.2017.07.031","article-title":"Nrf2 suppresses the function of dendritic cells to facilitate the immune escape of glioma cells","volume":"360","author":"Wang","year":"2017","journal-title":"Exp Cell Res"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-022-00491-0","article-title":"Natural killer cells in antitumour adoptive cell immunotherapy","volume":"22","author":"Laskowski","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1586\/eci.10.102","article-title":"Stimulating natural killer cells to protect against cancer: recent developments","volume":"7","author":"Gillgrass","year":"2011","journal-title":"Expert Rev Clin Immunol"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.07.006","article-title":"Natural killer cell biology: an update and future directions","volume":"132","author":"Campbell","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00741-17","article-title":"Dengue Virus-Infected Dendritic Cells, but Not Monocytes, Activate Natural Killer Cells through a Contact-Dependent Mechanism Involving Adhesion Molecules","volume":"8","author":"Costa","year":"2017","journal-title":"mBio"},{"key":"B222","doi-asserted-by":"publisher","first-page":"231ra49","DOI":"10.1126\/scitranslmed.3007579","article-title":"Immunological visibility: posttranscriptional regulation of human nkg2d ligands by the egf receptor pathway","volume":"6","author":"Vantourout","year":"2014","journal-title":"Sci Trans Med"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.07.033","article-title":"Impact of fasl-induced apoptosis in the elimination of tumor cells by nk cells","volume":"42","author":"Screpanti","year":"2005","journal-title":"Mol Immunol"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.989895","article-title":"Sot101 induces nk cell cytotoxicity and potentiates antibody-dependent cell cytotoxicity and anti-tumor activity","volume":"13","author":"Antosova","year":"2022","journal-title":"Front Immunol"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11060874","article-title":"Tumor-derived extracellular vesicles inhibit natural killer cell function in pancreatic cancer","volume":"11","author":"Zhao","year":"2019","journal-title":"Cancers"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0789","article-title":"Ifn-gamma-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha-galactosylceramide","volume":"100","author":"Hayakawa","year":"2002","journal-title":"Blood"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1080\/2162402x.2021.1939601","article-title":"A novel mir1983-tlr7-ifn\u03b2 Circuit licenses nk cells to kill glioma cells, and is under the control of galectin-1","volume":"10","author":"Shah","year":"2021","journal-title":"Oncoimmunology"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.212","article-title":"Wash has a critical role in nk cell cytotoxicity through lck-mediated phosphorylation","volume":"7","author":"Huang","year":"2016","journal-title":"Cell Death Dis"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22189975","article-title":"Ex vivo expanded and activated natural killer cells prolong the overall survival of mice with glioblastoma-like cell-derived tumors","volume":"22","author":"Shida","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B230","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/neuonc\/nop009","article-title":"Tgf-beta downregulates the activating receptor nkg2d on nk cells and cd8+ T cells in glioma patients","volume":"12","author":"Crane","year":"2010","journal-title":"Neuro-oncology"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.5.7.1621","article-title":"Cetuximab: an igg(1) monoclonal antibody for the treatment of epidermal growth factor receptor-expressing tumours","volume":"5","author":"Humblet","year":"2004","journal-title":"Expert Opin Pharmacother"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2011.00515.x","article-title":"Human glioblastoma stem-like cells are more sensitive to allogeneic nk and T cell-mediated killing compared with serum-cultured glioblastoma cells","volume":"22","author":"Avril","year":"2012","journal-title":"Brain Pathol (Zurich Switzerland)"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1172\/jci141460","article-title":"Nk cells in the tumor microenvironment and thioredoxin activity","volume":"130","author":"Whiteside","year":"2020","journal-title":"J Clin Invest"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.1998.13.275","article-title":"Susceptibility of natural killer (Nk) cells to reactive oxygen species (Ros) and their restoration by the mimics of superoxide dismutase (Sod)","volume":"13","author":"Nakamura","year":"1998","journal-title":"Cancer Biother Radiopharmaceuticals"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8769","article-title":"Reactive oxygen species induced by therapeutic cd20 antibodies inhibit natural killer cell-mediated antibody-dependent cellular cytotoxicity against primary cll cells","volume":"7","author":"Werlenius","year":"2016","journal-title":"Oncotarget"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.7.12.7067","article-title":"Cancer cell killing via ros: to increase or decrease, that is the question","volume":"7","author":"Wang","year":"2008","journal-title":"Cancer Biol Ther"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2012.10.004","article-title":"Oxidative stress and cancer: an overview","volume":"12","author":"Sosa","year":"2013","journal-title":"Ageing Res Rev"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215752","article-title":"Trpml1-induced autophagy inhibition triggers mitochondrial mediated apoptosis","volume":"541","author":"Liu","year":"2022","journal-title":"Cancer Lett"},{"key":"B239","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/s41419-022-04997-1","article-title":"Hsp90 induces acsl4-dependent glioma ferroptosis via dephosphorylating ser637 at drp1","volume":"13","author":"Miao","year":"2022","journal-title":"Cell Death Dis"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2019.4942","article-title":"A ketogenic diet attenuates proliferation and stemness of glioma stem\u2212Like cells by altering metabolism resulting in increased ros production","volume":"56","author":"Ji","year":"2020","journal-title":"Int J Oncol"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13200","article-title":"Nox4 regulates tgf\u03b2-induced proliferation and self-renewal in glioblastoma stem cells","volume":"16","author":"Garc\u00eda-G\u00f3mez","year":"2022","journal-title":"Mol Oncol"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.582694","article-title":"Mitochondria\u2019s role in the maintenance of cancer stem cells in glioblastoma","volume":"11","author":"Iranmanesh","year":"2021","journal-title":"Front Oncol"},{"key":"B243","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s13287-015-0174-2","article-title":"Metabolic activation of mitochondria in glioma stem cells promotes cancer development through a reactive oxygen species-mediated mechanism","volume":"6","author":"Yuan","year":"2015","journal-title":"Stem Cell Res Ther"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.067843","article-title":"Peroxiredoxin iv protects cells from oxidative stress by removing H2o2 produced during disulphide formation","volume":"123","author":"Tavender","year":"2010","journal-title":"J Cell Sci"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.640720","article-title":"Ucp2 as a potential biomarker for adjunctive metabolic therapies in tumor management","volume":"11","author":"Vallejo","year":"2021","journal-title":"Front Oncol"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.04.001","article-title":"The warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism","volume":"356","author":"Lu","year":"2015","journal-title":"Cancer Lett"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12071822","article-title":"Insights into the New Cancer Therapy through Redox Homeostasis and Metabolic Shifts","volume":"12","author":"Hyun","year":"2020","journal-title":"Cancers"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.12.001","article-title":"Nac selectively inhibit cancer telomerase activity: A higher redox homeostasis threshold exists in cancer cells","volume":"8","author":"Li","year":"2016","journal-title":"Redox Biol"},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.01.033","article-title":"Nrf2 amplifies oxidative stress via induction of klf9","volume":"53","author":"Zucker","year":"2014","journal-title":"Mol Cell"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175537","article-title":"Natural and synthetic compounds for glioma treatment based on ros-mediated strategy","volume":"953","author":"Wang","year":"2023","journal-title":"Eur J Pharmacol"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15133427","article-title":"Photodynamic therapy for glioblastoma: illuminating the path toward clinical applicability","volume":"15","author":"Bhanja","year":"2023","journal-title":"Cancers"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.1039\/c9bm00292h","article-title":"Imaging-guided focused ultrasound-induced thermal and sonodynamic effects of nanosonosensitizers for synergistic enhancement of glioblastoma therapy","volume":"7","author":"Wan","year":"2019","journal-title":"Biomater Sci"},{"key":"B253","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s40820-020-00490-6","article-title":"Self-assembly protein superstructures as a powerful chemodynamic therapy nanoagent for glioblastoma treatment","volume":"12","author":"Zheng","year":"2020","journal-title":"Nano-micro Lett"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.07.049","article-title":"Photodynamic therapy - mechanisms, photosensitizers and combinations","volume":"106","author":"Kwiatkowski","year":"2018","journal-title":"Biomed Pharmacother = Biomed Pharmacotherapie"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28010332","article-title":"Recent progress in type I aggregation-induced emission photosensitizers for photodynamic therapy","volume":"28","author":"Yu","year":"2022","journal-title":"Mol (Basel Switzerland)"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.1364\/boe.8.005040","article-title":"Photodynamic opening of blood-brain barrier","volume":"8","author":"Semyachkina-Glushkovskaya","year":"2017","journal-title":"Biomed Optics Express"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120763","article-title":"From molecules to nanovectors: current state of the art and applications of photosensitizers in photodynamic therapy","volume":"604","author":"Verger","year":"2021","journal-title":"Int J Pharmaceutics"},{"key":"B258","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s11060-019-03103-4","article-title":"5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas","volume":"141","author":"Mahmoudi","year":"2019","journal-title":"J neuro-oncol"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2001.19.2.519","article-title":"Phase I and pharmacokinetic study of photodynamic therapy for high-grade gliomas using a novel boronated porphyrin","volume":"19","author":"Rosenthal","year":"2001","journal-title":"J Clin Oncol"},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00024","article-title":"Intraoperative photodynamic diagnosis using talaporfin sodium simultaneously applied for photodynamic therapy against Malignant glioma: A prospective clinical study","volume":"9","author":"Shimizu","year":"2018","journal-title":"Front Neurol"},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.1177\/039463200802100126","article-title":"Intratumoral vs systemic administration of meta-tetrahydroxyphenylchlorin for photodynamic therapy of malignant gliomas: assessment of uptake and spatial distribution in C6 rat glioma model","volume":"21","author":"Mannino","year":"2008","journal-title":"Int J Immunopathol Pharmacol"},{"key":"B262","doi-asserted-by":"publisher","first-page":"188308","DOI":"10.1016\/j.bbcan.2019.07.003","article-title":"Cell death in photodynamic therapy: from oxidative stress to anti-tumor immunity","volume":"1872","author":"Donohoe","year":"2019","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B263","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1002\/tcr.201600121","article-title":"Photodynamic therapy: past, present and future","volume":"17","author":"Chilakamarthi","year":"2017","journal-title":"Chem Rec (New York NY)"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001926","article-title":"Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future","volume":"9","author":"Alzeibak","year":"2021","journal-title":"J Immunother Cancer"},{"key":"B265","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2013.03.001","article-title":"Parameter-finding studies of photodynamic therapy for approval in Japan and the USA","volume":"10","author":"Kawase","year":"2013","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8101581","article-title":"Photodynamic therapy: A brief history","volume":"8","author":"Kessel","year":"2019","journal-title":"J Clin Med"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2019.111544","article-title":"Photodynamic therapy for skin cancer: how to enhance drug penetration","volume":"197","author":"Champeau","year":"2019","journal-title":"J Photochem Photobiol B Biol"},{"key":"B268","doi-asserted-by":"publisher","DOI":"10.1007\/bf02327395","article-title":"Photodynamic therapy is potentiated by co60 and intratumoral injection of hematoporphyrin derivative","volume":"6","author":"Kostron","year":"1988","journal-title":"J neuro-oncol"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/31\/2\/002","article-title":"Instrumentation and light dosimetry for intra-operative photodynamic therapy (Pdt) of Malignant brain tumours","volume":"31","author":"Wilson","year":"1986","journal-title":"Phys Med Biol"},{"key":"B270","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1186\/s40425-019-0826-3","article-title":"Immunogenic cell death induced by a new photodynamic therapy based on photosens and photodithazine","volume":"7","author":"Turubanova","year":"2019","journal-title":"J Immunother Cancer"},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2022.103119","article-title":"Ablation efficacy of 5-aminolevulinic acid-mediated photodynamic therapy on human glioma stem cells","volume":"41","author":"Omura","year":"2023","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2014.10.007","article-title":"Combination of photodynamic therapy and temozolomide on glioma in a rat C6 glioma model","volume":"11","author":"Zhang","year":"2014","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.927219","article-title":"Bibliometric analysis of global research on cancer photodynamic therapy: focus on nano-related research","volume":"13","author":"Cheng","year":"2022","journal-title":"Front Pharmacol"},{"key":"B274","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2015.05.007","article-title":"Photodynamic therapy in the treatment of brain tumours. A feasibility study","volume":"12","author":"Vanaclocha","year":"2015","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"B275","doi-asserted-by":"publisher","first-page":"e2104125","DOI":"10.1002\/advs.202104125","article-title":"Enhancing penetration ability of semiconducting polymer nanoparticles for sonodynamic therapy of large solid tumor","volume":"9","author":"Wang","year":"2022","journal-title":"Advanced Sci (Weinheim Baden-Wurttemberg Germany)"},{"key":"B276","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-021-03718-6","article-title":"Standardized intraoperative 5-ala photodynamic therapy for newly diagnosed glioblastoma patients: A preliminary analysis of the indygo clinical trial","volume":"152","author":"Vermandel","year":"2021","journal-title":"J neuro-oncol"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.7150\/thno.73566","article-title":"Progress in advanced nanotherapeutics for enhanced photodynamic immunotherapy of tumor","volume":"12","author":"Wei","year":"2022","journal-title":"Theranostics"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.3390\/cancers8100091","article-title":"Boosting tumor-specific immunity using pdt","volume":"8","author":"Maeding","year":"2016","journal-title":"Cancers"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S344679","article-title":"Biodegradable materials with disulfide-bridged-framework confine photosensitizers for enhanced photo-immunotherapy","volume":"16","author":"Li","year":"2021","journal-title":"Int J Nanomed"},{"key":"B280","doi-asserted-by":"publisher","first-page":"2994","DOI":"10.1002\/1878-0261.12851","article-title":"Targeting immunogenic cell death in cancer","volume":"14","author":"Ahmed","year":"2020","journal-title":"Mol Oncol"},{"key":"B281","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/s41419-022-04851-4","article-title":"Which cell death modality wins the contest for photodynamic therapy of cancer","volume":"13","author":"Mishchenko","year":"2022","journal-title":"Cell Death Dis"},{"key":"B282","doi-asserted-by":"publisher","first-page":"e1900132","DOI":"10.1002\/adhm.201900132","article-title":"Photosensitizers for photodynamic therapy","volume":"8","author":"Lan","year":"2019","journal-title":"Advanced Healthc Mater"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.7150\/thno.54227","article-title":"Recent advances in innovative strategies for enhanced cancer photodynamic therapy","volume":"11","author":"Hu","year":"2021","journal-title":"Theranostics"},{"key":"B284","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2013.06.001","article-title":"Low-dose arsenic trioxide enhances 5-aminolevulinic acid-induced ppix accumulation and efficacy of photodynamic therapy in human glioma","volume":"127","author":"Wang","year":"2013","journal-title":"J Photochem Photobiol B Biol"},{"key":"B285","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.12.015","article-title":"Nf-kappab inhibition improves the sensitivity of human glioblastoma cells to 5-aminolevulinic acid-based photodynamic therapy","volume":"81","author":"Coupienne","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2015.07.169","article-title":"Interstitial 5-ala photodynamic therapy and glioblastoma: preclinical model development and preliminary results","volume":"13","author":"Tetard","year":"2016","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1783-9","article-title":"Photodynamic therapy using talaporfin sodium induces concentration-dependent programmed necroptosis in human glioblastoma T98g cells","volume":"30","author":"Miki","year":"2015","journal-title":"Lasers Med Sci"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13091332","article-title":"Photodynamic therapy review: principles, photosensitizers, applications, and future directions","volume":"13","author":"Correia","year":"2021","journal-title":"Pharmaceutics"},{"key":"B289","doi-asserted-by":"publisher","first-page":"194","DOI":"10.2307\/3579157","article-title":"Effect of gallium-porphyrin analogue atx-70 on nitroxide formation from a cyclic secondary amine by ultrasound: on the mechanism of sonodynamic activation","volume":"143","author":"Miyoshi","year":"1995","journal-title":"Radiat Res"},{"key":"B290","doi-asserted-by":"publisher","DOI":"10.2307\/3579537","article-title":"Sonodynamic toxicity of gallium-porphyrin analogue atx-70 in human leukemia cells","volume":"148","author":"Miyoshi","year":"1997","journal-title":"Radiat Res"},{"key":"B291","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1048211","article-title":"Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study","volume":"13","author":"Wu","year":"2022","journal-title":"Front Pharmacol"},{"key":"B292","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201906823","article-title":"Ultrasound-activated sensitizers and applications","volume":"59","author":"Lin","year":"2020","journal-title":"Angewandte Chemie (International ed English)"},{"key":"B293","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.216033","article-title":"Ultrasound-excited temozolomide sonosensitization induces necroptosis in glioblastoma","volume":"554","author":"Wang","year":"2023","journal-title":"Cancer Lett"},{"key":"B294","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1186\/s12951-021-01094-x","article-title":"Gene augmented nuclear-targeting sonodynamic therapy via nrf2 pathway-based redox balance adjustment boosts peptide-based anti-pd-L1 therapy on colorectal cancer","volume":"19","author":"Wan","year":"2021","journal-title":"J Nanobiotechnol"},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2022.105972","article-title":"Oxygen-carrying biomimetic nanoplatform for sonodynamic killing of bacteria and treatment of infection diseases","volume":"84","author":"Geng","year":"2022","journal-title":"Ultrasonics sonochemistry"},{"key":"B296","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jconrel.2017.05.009","article-title":"Tumor ablation using low-intensity ultrasound and sound excitable drug","volume":"258","author":"Tung","year":"2017","journal-title":"J Controlled Release: Off J Controlled Release Soc"},{"key":"B297","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40779-022-00386-z","article-title":"Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives","volume":"9","author":"Guo","year":"2022","journal-title":"Military Med Res"},{"key":"B298","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11060-021-03807-6","article-title":"Sonodynamic therapy for gliomas","volume":"156","author":"Bunevicius","year":"2022","journal-title":"J neuro-oncol"},{"key":"B299","doi-asserted-by":"publisher","DOI":"10.2147\/ott.S52426","article-title":"Study of the mechanism of sonodynamic therapy in a rat glioma model","volume":"7","author":"Song","year":"2014","journal-title":"OncoTargets Ther"},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201510031","article-title":"Synthesis of iron nanometallic glasses and their application in cancer therapy by a localized fenton reaction","volume":"55","author":"Zhang","year":"2016","journal-title":"Angewandte Chemie (International ed English)"},{"key":"B301","doi-asserted-by":"publisher","first-page":"e2103868","DOI":"10.1002\/smll.202103868","article-title":"Chemodynamic therapy via fenton and fenton-like nanomaterials: strategies and recent advances","volume":"18","author":"Jia","year":"2022","journal-title":"Small (Weinheim an der Bergstrasse Germany)"},{"key":"B302","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2019.04.023","article-title":"Nanocatalysts-augmented fenton chemical reaction for nanocatalytic tumor therapy","volume":"211","author":"Qian","year":"2019","journal-title":"Biomaterials"},{"key":"B303","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.1c01605","article-title":"A multifunctional nanoplatform based on fenton-like and russell reactions of cu, mn bimetallic ions synergistically enhanced ros stress for improved chemodynamic therapy","volume":"8","author":"Ma","year":"2022","journal-title":"ACS Biomater Sci Eng"},{"key":"B304","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jhazmat.2016.04.003","article-title":"Mn(2+)-mediated homogeneous fenton-like reaction of fe(Iii)-nta complex for efficient degradation of organic contaminants under neutral conditions","volume":"313","author":"Li","year":"2016","journal-title":"J Hazard Mater"},{"key":"B305","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.1c00856","article-title":"Research progress on nanoplatforms and nanotherapeutic strategies in treating glioma","volume":"19","author":"Qiao","year":"2022","journal-title":"Mol Pharmaceutics"},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c05147","article-title":"Multifunctional hybrid hydrogel system enhanced the therapeutic efficacy of treatments for postoperative glioma","volume":"14","author":"Cao","year":"2022","journal-title":"ACS Appl Mater Interfaces"},{"key":"B307","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2022.106319","article-title":"Blood-brain barrier permeable and multi-stimuli responsive nanoplatform for orthotopic glioma inhibition by synergistic enhanced chemo-\/chemodynamic\/photothermal\/starvation therapy","volume":"180","author":"Cao","year":"2023","journal-title":"Eur J Pharm Sci"},{"key":"B308","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"B309","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1146\/annurev-cellbio-100617-062608","article-title":"Development and cell biology of the blood-brain barrier","volume":"35","author":"Langen","year":"2019","journal-title":"Annu Rev Cell Dev Biol"},{"key":"B310","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020412","article-title":"The blood-brain barrier","volume":"7","author":"Daneman","year":"2015","journal-title":"Cold Spring Harbor Perspect Biol"},{"key":"B311","doi-asserted-by":"publisher","first-page":"4196","DOI":"10.1038\/ncomms5196","article-title":"Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells","volume":"5","author":"Watkins","year":"2014","journal-title":"Nat Commun"},{"key":"B312","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12010018","article-title":"Brain invasion along perivascular spaces by glioma cells: relationship with blood-brain barrier","volume":"12","author":"Pacioni","year":"2019","journal-title":"Cancers"},{"key":"B313","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c10219","article-title":"Immune exosomes loading self-assembled nanomicelles traverse the blood-brain barrier for chemo-immunotherapy against glioblastoma","volume":"17","author":"Cui","year":"2023","journal-title":"ACS Nano"},{"key":"B314","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.09.096","article-title":"Concurrent blood-brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment","volume":"33","author":"Ting","year":"2012","journal-title":"Biomaterials"},{"key":"B315","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2018.01.021","article-title":"Enhancing glioblastoma treatment using cisplatin-gold-nanoparticle conjugates and targeted delivery with magnetic resonance-guided focused ultrasound","volume":"14","author":"Coluccia","year":"2018","journal-title":"Nanomed: Nanotechnol Biol Med"},{"key":"B316","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.07.102","article-title":"Polysaccharide based bionanocomposites, properties and applications: A review","volume":"92","author":"Zafar","year":"2016","journal-title":"Int J Biol Macromol"},{"key":"B317","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.ejpb.2015.03.018","article-title":"Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy","volume":"93","author":"P\u00e9rez-Herrero","year":"2015","journal-title":"Eur J Pharmaceutics Biopharmaceutics"},{"key":"B318","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25092193","article-title":"Therapeutic nanoparticles and their targeted delivery applications","volume":"25","author":"Yetisgin","year":"2020","journal-title":"Mol (Basel Switzerland)"},{"key":"B319","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121287","article-title":"Inhibiting autophagy flux and DNA repair of tumor cells to boost radiotherapy of orthotopic glioblastoma","volume":"280","author":"Xu","year":"2022","journal-title":"Biomaterials"},{"key":"B320","doi-asserted-by":"publisher","DOI":"10.1039\/d0nh00077a","article-title":"A brain tumor-homing tetra-peptide delivers a nano-therapeutic for more effective treatment of a mouse model of glioblastoma","volume":"5","author":"Kang","year":"2020","journal-title":"Nanoscale Horizons"},{"key":"B321","doi-asserted-by":"publisher","DOI":"10.1039\/c4tb00954a","article-title":"Inhibition of glioma proliferation and migration by magnetic nanoparticle mediated jam-2 silencing","volume":"2","author":"Qi","year":"2014","journal-title":"J Mater Chem B"},{"key":"B322","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11050201","article-title":"Exploring light-sensitive nanocarriers for simultaneous triggered antibiotic release and disruption of biofilms upon generation of laser-induced vapor nanobubbles","volume":"11","author":"Teirlinck","year":"2019","journal-title":"Pharmaceutics"},{"key":"B323","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s40824-019-0166-x","article-title":"Therapeutic efficacy of nanoparticles and routes of administration","volume":"23","author":"Chenthamara","year":"2019","journal-title":"Biomater Res"},{"key":"B324","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.pdpdt.2018.06.026","article-title":"Evaluation of targeted curcumin (Cur) loaded plga nanoparticles for in vitro photodynamic therapy on human glioblastoma cell line","volume":"23","author":"Jamali","year":"2018","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"B325","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.1c00321","article-title":"Dual blood-brain barrier-glioma targeting peptide-poly(Levodopamine) hybrid nanoplatforms as potential near infrared phototheranostic agents in glioblastoma","volume":"32","author":"Dube","year":"2021","journal-title":"Bioconjugate Chem"},{"key":"B326","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2015.08.005","article-title":"Real-time vascular imaging and photodynamic therapy efficacy with micelle-nanocarrier delivery of chlorin E6 to the microenvironment of melanoma","volume":"80","author":"Lee","year":"2015","journal-title":"J Dermatol Sci"},{"key":"B327","doi-asserted-by":"publisher","DOI":"10.1016\/j.omto.2021.12.006","article-title":"A pd1 targeted nano-delivery system based on epigenetic alterations of T cell responses in the treatment of gastric cancer","volume":"24","author":"Hu","year":"2022","journal-title":"Mol Ther Oncolytics"},{"key":"B328","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.08.018","article-title":"Preparation of a multifunctional verapamil-loaded nano-carrier based on a self-assembling pegylated prodrug","volume":"135","author":"Zhao","year":"2015","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"B329","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S97223","article-title":"Pigment epithelial-derived factor gene loaded novel cooh-peg-plga-cooh nanoparticles promoted tumor suppression by systemic administration","volume":"11","author":"Yu","year":"2016","journal-title":"Int J Nanomed"},{"key":"B330","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10010096","article-title":"Nanomedicine in clinical photodynamic therapy for the treatment of brain tumors","volume":"10","author":"Kim","year":"2022","journal-title":"Biomedicines"},{"key":"B331","doi-asserted-by":"publisher","DOI":"10.1039\/c8bm01187g","article-title":"Tumor targeting dvdms-nanoliposomes for an enhanced sonodynamic therapy of gliomas","volume":"7","author":"Sun","year":"2019","journal-title":"Biomater Sci"},{"key":"B332","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c05604","article-title":"Endogenous labile iron pool-mediated free radical generation for cancer chemodynamic therapy","volume":"142","author":"Lin","year":"2020","journal-title":"J Am Chem Soc"},{"key":"B333","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.07.075","article-title":"Transferrin-conjugated magnetic silica plga nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment","volume":"34","author":"Cui","year":"2013","journal-title":"Biomaterials"},{"key":"B334","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.10.012","article-title":"Transferrin\/aptamer conjugated mesoporous ruthenium nanosystem for redox-controlled and targeted chemo-photodynamic therapy of glioma","volume":"82","author":"Zhu","year":"2018","journal-title":"Acta biomaterialia"},{"key":"B335","doi-asserted-by":"publisher","DOI":"10.34133\/2021\/9861384","article-title":"Sequence-defined nanotubes assembled from ir780-conjugated peptoids for chemophototherapy of malignant glioma","volume":"2021","author":"Cai","year":"2021","journal-title":"Res (Washington DC)"},{"key":"B336","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2022.112407","article-title":"Near infrared triggered chemo-ptt-pdt effect mediated by glioma directed twin functional-chimeric peptide-decorated gold nanoroses","volume":"228","author":"Dube","year":"2022","journal-title":"J Photochem Photobiol B Biol"},{"key":"B337","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S261352","article-title":"Multiscale selectivity and in vivo biodistribution of nrp-1-targeted theranostic aguix nanoparticles for pdt of glioblastoma","volume":"15","author":"Gries","year":"2020","journal-title":"Int J Nanomed"},{"key":"B338","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13040500","article-title":"Plga nanoparticle-based formulations to cross the blood-brain barrier for drug delivery: from R&D to cgmp","volume":"13","author":"Zhi","year":"2021","journal-title":"Pharmaceutics"},{"key":"B339","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119666","article-title":"An irgd-conjugated prodrug micelle with blood-brain-barrier penetrability for anti-glioma therapy","volume":"230","author":"Lu","year":"2020","journal-title":"Biomaterials"},{"key":"B340","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2017.04.017","article-title":"Light source is critical to induce glioblastoma cell death by photodynamic therapy using chloro-aluminiumphtalocyanine albumin-based nanoparticles","volume":"19","author":"Davanzo","year":"2017","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"B341","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b15293","article-title":"Lipid-polymer bilaminar oxygen nanobubbles for enhanced photodynamic therapy of cancer","volume":"10","author":"Song","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"key":"B342","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121833","article-title":"Targeted photodynamic therapy of glioblastoma mediated by platelets with photo-controlled release property","volume":"290","author":"Xu","year":"2022","journal-title":"Biomaterials"},{"key":"B343","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1687210","article-title":"Manipulation of mitophagy by \u201cAll-in-one\u201d Nanosensitizer augments sonodynamic glioma therapy","volume":"16","author":"Qu","year":"2020","journal-title":"Autophagy"},{"key":"B344","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202110364","article-title":"Engineering macrophage exosome disguised biodegradable nanoplatform for enhanced sonodynamic therapy of glioblastoma","volume":"34","author":"Wu","year":"2022","journal-title":"Advanced Mater (Deerfield Beach Fla)"},{"key":"B345","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201906985","article-title":"Intelligent nanocomposites with intrinsic blood-brain-barrier crossing ability designed for highly specific mr imaging and sonodynamic therapy of glioblastoma","volume":"16","author":"Liang","year":"2020","journal-title":"Small (Weinheim an der Bergstrasse Germany)"},{"key":"B346","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202003036","article-title":"Theranostic nanomedicine for synergistic chemodynamic therapy and chemotherapy of orthotopic glioma","volume":"7","author":"Tan","year":"2020","journal-title":"Advanced Sci (Weinheim Baden-Wurttemberg Germany)"},{"key":"B347","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.08.035","article-title":"Hypoxia-activated ros burst liposomes boosted by local mild hyperthermia for photo\/chemodynamic therapy","volume":"328","author":"Tang","year":"2020","journal-title":"J Controlled Release: Off J Controlled Release Soc"},{"key":"B348","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2022.03.003","article-title":"Neuroinflammation associated with ultrasound-mediated permeabilization of the blood-brain barrier","volume":"45","author":"Jung","year":"2022","journal-title":"Trends Neurosci"},{"key":"B349","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.addr.2019.11.009","article-title":"The blood-brain barrier: physiology and strategies for drug delivery","author":"Pandit","year":"2020","journal-title":"Advanced Drug Delivery Rev"},{"key":"B350","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.646626","article-title":"Bibliometric analysis of global research trends on ultrasound microbubble: A quickly developing field","volume":"12","author":"Wu","year":"2021","journal-title":"Front Pharmacol"},{"key":"B351","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s13534-017-0016-5","article-title":"Microbubbles used for contrast enhanced ultrasound and theragnosis: A review of principles to applications","volume":"7","author":"Lee","year":"2017","journal-title":"Biomed Eng Lett"},{"key":"B352","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c04990","article-title":"An advanced in situ magnetic resonance imaging and ultrasonic theranostics nanocomposite platform: crossing the blood-brain barrier and improving the suppression of glioblastoma using iron-platinum nanoparticles in nanobubbles","volume":"13","author":"Chan","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"key":"B353","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.706105","article-title":"Mapping knowledge structure and research frontiers of ultrasound-induced blood-brain barrier opening: A scientometric study","volume":"15","author":"Wu","year":"2021","journal-title":"Front Neurosci"},{"key":"B354","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S286221","article-title":"Gene therapy for drug-resistant glioblastoma via lipid-polymer hybrid nanoparticles combined with focused ultrasound","volume":"16","author":"Yang","year":"2021","journal-title":"Int J Nanomed"},{"key":"B355","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.12.019","article-title":"Focused ultrasound-mediated blood-brain barrier opening increases delivery and efficacy of etoposide for glioblastoma treatment","volume":"110","author":"Wei","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"B356","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2022.10.025","article-title":"Nir-ii fluorescence visualization of ultrasound-induced blood-brain barrier opening for enhanced photothermal therapy against glioblastoma using indocyanine green microbubbles","volume":"67","author":"Liang","year":"2022","journal-title":"Sci Bull"},{"key":"B357","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2022.12.006","article-title":"Refining the delivery and therapeutic efficacy of cetuximab using focused ultrasound in a mouse model of glioblastoma: an (89)Zr-cetuximab immunopet study","volume":"182","author":"Porret","year":"2023","journal-title":"Eur J Pharmaceutics Biopharmaceutics"},{"key":"B358","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.03.010","article-title":"Ultrasound for drug and gene delivery to the brain","volume":"60","author":"Hynynen","year":"2008","journal-title":"Advanced Drug Delivery Rev"},{"key":"B359","doi-asserted-by":"publisher","first-page":"343re2","DOI":"10.1126\/scitranslmed.aaf6086","article-title":"Clinical trial of blood-brain barrier disruption by pulsed ultrasound","volume":"8","author":"Carpentier","year":"2016","journal-title":"Sci Trans Med"},{"key":"B360","doi-asserted-by":"publisher","DOI":"10.1080\/10408690490464960","article-title":"Comprehensive study on vitamin C equivalent antioxidant capacity (Vceac) of various polyphenolics in scavenging a free radical and its structural relationship","volume":"44","author":"Kim","year":"2004","journal-title":"Crit Rev Food Sci Nutr"},{"key":"B361","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-016-0264-5","article-title":"The antioxidant activity of some curcuminoids and chalcones","volume":"24","author":"S\u00f6kmen","year":"2016","journal-title":"Inflammopharmacology"},{"key":"B362","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab148","article-title":"Antioxidants associated with oncogenic human papillomavirus infection in women","volume":"224","author":"Lin","year":"2021","journal-title":"J Infect Dis"},{"key":"B363","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/s12943-022-01668-9","article-title":"Antioxidants in brain tumors: current therapeutic significance and future prospects","volume":"21","author":"Qi","year":"2022","journal-title":"Mol Cancer"},{"key":"B364","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2021.105168","article-title":"Safety and efficacy assessments to take antioxidants in glioblastoma therapy: from in vitro experiences to animal and clinical studies","volume":"150","author":"Turkez","year":"2021","journal-title":"Neurochemistry Int"},{"key":"B365","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2005.05.010","article-title":"Coenzyme Q distribution in hl-60 human cells depends on the endomembrane system","volume":"1713","author":"Fern\u00e1ndez-Ayala","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"B366","doi-asserted-by":"publisher","DOI":"10.5650\/jos.62.181","article-title":"Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin","volume":"62","author":"Maoka","year":"2013","journal-title":"J Oleo Sci"},{"key":"B367","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2017.01.024","article-title":"Preventive Treatment of Astaxanthin Provides Neuroprotection through Suppression of Reactive Oxygen Species and Activation of Antioxidant Defense Pathway after Stroke in Rats","volume":"130","author":"Pan","year":"2017","journal-title":"Brain Res Bull"},{"key":"B368","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.66.488","article-title":"Central nervous system migration of astaxanthin and adonixanthin following their oral administration in cynomolgus monkeys","volume":"66","author":"Nakamura","year":"2020","journal-title":"J Nutr Sci Vitaminol"},{"key":"B369","doi-asserted-by":"publisher","DOI":"10.3390\/md18090474","article-title":"Antitumour effects of astaxanthin and adonixanthin on glioblastoma","volume":"18","author":"Tsuji","year":"2020","journal-title":"Mar Drugs"},{"key":"B370","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12052","article-title":"Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of hif-1\u03b1","volume":"55","author":"Zhang","year":"2013","journal-title":"J Pineal Res"},{"key":"B371","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.3.877","article-title":"Prospective study of intake of fruit, vegetables, and carotenoids and the risk of adult glioma","volume":"85","author":"Holick","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"B372","doi-asserted-by":"publisher","DOI":"10.1159\/000369345","article-title":"Vitamin E intake is not associated with glioma risk: evidence from a meta-analysis","volume":"43","author":"Qin","year":"2014","journal-title":"Neuroepidemiology"},{"key":"B373","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32574","article-title":"A prospective study of tea and coffee intake and risk of glioma","volume":"146","author":"Cote","year":"2020","journal-title":"Int J Cancer"},{"key":"B374","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1002\/jcp.26899","article-title":"Biomedical applications of carbon nanomaterials: drug and gene delivery potentials","volume":"234","author":"Mohajeri","year":"2018","journal-title":"J Cell Physiol"},{"key":"B375","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S212907","article-title":"The toxicity of metallic nanoparticles on liver: the subcellular damages, mechanisms, and outcomes","volume":"14","author":"Yao","year":"2019","journal-title":"Int J Nanomed"},{"key":"B376","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2020.1739170","article-title":"Ultrasound-responsive highly biocompatible nanodroplets loaded with doxorubicin for tumor imaging and treatment in vivo","volume":"27","author":"Zhou","year":"2020","journal-title":"Drug Delivery"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1259797\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T07:08:30Z","timestamp":1701932910000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1259797\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,7]]},"references-count":376,"alternative-id":["10.3389\/fimmu.2023.1259797"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2023.1259797","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,7]]},"article-number":"1259797"}}