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Furthermore, keratinocytes play a role in the development of psoriasis as immune cells by secreting antibacterial peptides, chemokines, tumor necrosis factor-\u03b1, interleukin (IL)-36, and IL-23. These immune cells and skin cells interact and drive the aberrant differentiation and proliferation of keratinocytes. This crosstalk between keratinocytes and immune cells critical in the pathogenesis of psoriasis forms an inflammatory loop, resulting in the persistence or exacerbation of psoriasis plaques.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1286344","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T03:43:49Z","timestamp":1699847029000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":112,"title":["Crosstalk: keratinocytes and immune cells in 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