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Autoimmune pancreatitis (AIP) is a specific type of pancreatitis associated with autoimmune abnormalities and is divided into two clinical types: type 1 (lymphoplasmacytic sclerosing pancreatitis) and type 2 (idiopathic ductocentric pancreatitis). The current study shows an association between type 2 AIP and UC, which may be related to genetic susceptibility, inflammatory factors, and immune response. The most common manifestation of AIP in patients with type 2 AIP\u2013UC is abdominal pain with elevated pancreatic enzymes, whereas the presentation of UC in type 2 AIP\u2013UC is more severe, with an increased risk of UC-related surgery. This review focuses on diagnosis, prevalence, pathogenesis, impact, and treatment to better understand type 2 AIP\u2013UC, explore the molecular mechanisms of this condition, and encourage further research into the management of type 2 AIP\u2013UC.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1288390","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T08:18:57Z","timestamp":1701850737000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Type 2 autoimmune pancreatitis associated with ulcerative colitis"],"prefix":"10.3389","volume":"14","author":[{"given":"Nan","family":"Nan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.0031","article-title":"miR-125b and miR-223 contribute to inflammation by targeting the key molecules of NF\u03baB pathway","volume":"6","author":"Valmiki","year":"2020","journal-title":"Front Med (Lausanne)"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.207757","article-title":"Circular RNA_0001187 participates in the regulation of ulcerative colitis development via upregulating myeloid differentiation factor 88","volume":"13","author":"Ouyang","year":"2022","journal-title":"Bioengineered"},{"key":"B3","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/s12906-020-02988-","article-title":"Analysis of the pharmacological mechanism of Banxia Xiexin decoction in treating depression and ulcerative colitis based on a biological network module","volume":"20","author":"Yu","year":"2020","journal-title":"BMC Complement Med Ther"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i13.139","article-title":"Systems pharmacology approach reveals the antiinflammatory effects of Ampelopsis grossedentata on dextran sodium sulfate-induced colitis","volume":"24","author":"Chen","year":"2018","journal-title":"World J Gastroenterol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i25.274","article-title":"Current global trends in the incidence of pediatric-onset inflammatory bowel disease","volume":"24","author":"S\u00fdkora","year":"2018","journal-title":"World J Gastroenterol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/BF0228520","article-title":"Chronic pancreatitis caused by an autoimmune abnormality. 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