{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:33:00Z","timestamp":1791387180080,"version":"4.3.3"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/01361, DTS22\/00151"],"award-info":[{"award-number":["PI15\/01361, DTS22\/00151"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["P18-RT-4930, A-BIO-470-UGR20"],"award-info":[{"award-number":["P18-RT-4930, A-BIO-470-UGR20"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2021-128970OA-I00"],"award-info":[{"award-number":["PID2021-128970OA-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","award":["PEJ2018-003016-A"],"award-info":[{"award-number":["PEJ2018-003016-A"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023561","name":"Ministerio de Universidades","doi-asserted-by":"publisher","award":["FPU19\/00576"],"award-info":[{"award-number":["FPU19\/00576"]}],"id":[{"id":"10.13039\/501100023561","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cytomegalovirus (CMV) is a common herpesvirus with a high prevalence worldwide. After the acute infection phase, CMV can remain latent in several tissues. CD8 T cells in the lungs and salivary glands mainly control its reactivation control. White adipose tissue (WAT) contains a significant population of memory T cells reactive to viral antigens, but CMV specificity has mainly been studied in mouse WAT. Therefore, we obtained blood, omental WAT (oWAT), subcutaneous WAT (sWAT), and liver samples from 11 obese donors to characterize the human WAT adaptive immune landscape from a phenotypic and immune receptor specificity perspective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed high-throughput sequencing of the T cell receptor (TCR) locus to analyze tissue and blood TCR repertoires of the 11 donors. The presence of TCRs specific to CMV epitopes was tested through ELISpot assays. Moreover, phenotypic characterization of T cells was carried out through flow cytometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>High-throughput sequencing analyses revealed that tissue TCR repertoires in oWAT, sWAT, and liver samples were less diverse and dominated by hyperexpanded clones when compared to blood samples. Additionally, we predicted the presence of TCRs specific to viral epitopes, particularly from CMV, which was confirmed by ELISpot assays. Remarkably, we found that oWAT has a higher proportion of CMV-reactive T cells than blood or sWAT. Finally, flow cytometry analyses indicated that most WAT-infiltrated lymphocytes were tissue-resident effector memory CD8 T cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Overall, these findings postulate human oWAT as a major reservoir of CMV-specific T cells, presumably for latent viral reactivation control. This study enhances our understanding of the adaptive immune response in human WAT and highlights its potential role in antiviral defense.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2023.1303724","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T03:18:08Z","timestamp":1700450288000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Human adipose tissue as a major reservoir of cytomegalovirus-reactive T cells"],"prefix":"10.3389","volume":"14","author":[{"given":"Ana\u00efs","family":"Redruello-Romero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria S.","family":"Benitez-Cantos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lopez-Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Garc\u00eda-Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Tamayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"P\u00e9rez-Bartivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Moreno-SanJuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Ruiz-Palmero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose D.","family":"Puentes-Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose R.","family":"Vilchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1.","family":"L\u00f3pez-Nevot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefa","family":"Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Carazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1186\/s12889-022-13971-7","article-title":"A systematic literature review of the global seroprevalence of cytomegalovirus: possible implications for treatment, screening, and vaccine development","volume":"22","author":"Fowler","year":"2022","journal-title":"BMC Public Health"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.24.11495-11503.2000","article-title":"Enrichment of immediate-early 1 (m123\/pp89) peptide-specific CD8 T cells in a pulmonary CD62L(lo) memory-effector cell pool during latent murine cytomegalovirus infection of the lungs","volume":"74","author":"Holtappels","year":"2000","journal-title":"J Virol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.2.84","article-title":"Investigation of CMV disease in immunocompromised patients","volume":"54","author":"Emery","year":"2001","journal-title":"J Clin Pathol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007890","article-title":"Life-long control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemia","volume":"15","author":"Contreras","year":"2019","journal-title":"PLoS Pathogens"},{"key":"B5","doi-asserted-by":"publisher","first-page":"100205","DOI":"10.1016\/j.xcrm.2021.100205","article-title":"Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells","volume":"2","author":"Wanjalla","year":"2021","journal-title":"Cell Rep Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0230-6","article-title":"The endocrine function of adipose tissues in health and cardiometabolic disease","volume":"15","author":"Scheja","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1101\/gad.211649.112","article-title":"Adaptive thermogenesis in adipocytes: Is beige the new brown","volume":"27","author":"Wu","year":"2013","journal-title":"Genes Dev"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00635-7","article-title":"Immune and non-immune functions of adipose tissue leukocytes","volume":"22","author":"Trim","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"15203","DOI":"10.1038\/s41598-018-33488-7","article-title":"Cytometric analysis of adipose tissue reveals increments of adipocyte progenitor cells after weight loss induced by bariatric surgery","volume":"8","author":"Garc\u00eda-Rubio","year":"2018","journal-title":"Sci Rep"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.664576","article-title":"In patients with obesity, the number of adipose tissue mast cells is significantly lower in subjects with type 2 diabetes","volume":"12","author":"Lopez-Perez","year":"2021","journal-title":"Front Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.818388","article-title":"In obese patients with type 2 diabetes, mast cells in Omental adipose tissue decrease the surface expression of CD45, CD117, CD203c, and fc\u03f5RI","volume":"13","author":"Lopez-Perez","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12997","article-title":"Adipokine dysregulation and adipose tissue inflammation in human obesity","volume":"48","author":"Unamuno","year":"2018","journal-title":"Eur J Clin Invest"},{"key":"B13","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1126\/science.1260972","article-title":"Dermal adipocytes protect against invasive Staphylococcus aureus skin infection","volume":"347","author":"Zhang","year":"2015","journal-title":"Science"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3215","article-title":"Inflammation-induced formation of fat-associated lymphoid clusters","volume":"16","author":"B\u00e9n\u00e9zech","year":"2015","journal-title":"Nat Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nature08636","article-title":"Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.03.002","article-title":"Immunological functions of the omentum","volume":"38","author":"Meza-Perez","year":"2017","journal-title":"Trends Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.11.009","article-title":"The white adipose tissue is a reservoir for memory T cells that promotes protective memory responses to infection","volume":"47","author":"Han","year":"2017","journal-title":"Immunity"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005153","article-title":"Adipose tissue is a neglected viral reservoir and an inflammatory site during chronic HIV and SIV infection","volume":"11","author":"Damouche","year":"2015","journal-title":"PLoS Pathogens"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160758","article-title":"Tissue reservoirs of antiviral T cell immunity in persistent human CMV infection","volume":"214","author":"Gordon","year":"2017","journal-title":"J Exp Med"},{"key":"B20","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00251-017-1017-3","article-title":"A genomic perspective on HLA evolution","volume":"70","author":"Meyer D","year":"2018","journal-title":"Immunogenetics"},{"key":"B21","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s00251-011-0552-6","article-title":"HLA class I allele promiscuity revisited","volume":"63","author":"Rao","year":"2011","journal-title":"Immunogenetics"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12413.x","article-title":"Cytotoxic T lymphocyte reactivity to gp100, melanA\/MART-1, and tyrosinase, in HLA-A2-positive vitiligo patients","volume":"121","author":"Mandelcorn-Monson","year":"2003","journal-title":"J Invest Dermatol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nri3567","article-title":"Human memory T cells: generation, compartmentalization and homeostasis","volume":"14","author":"Farber","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00316","article-title":"The effect of age on thymic function","volume":"4","author":"Palmer","year":"2013","journal-title":"Front Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1742-4933-5-6","article-title":"Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people","volume":"5","author":"Koch","year":"2008","journal-title":"Immun Ageing"},{"key":"B26","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/biology8020023","article-title":"Deciphering white adipose tissue heterogeneity","volume":"8","author":"Luong","year":"2019","journal-title":"Biol (Basel)"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3791\/59499","article-title":"Identification and dissection of diverse mouse adipose depots","author":"Bagchi","year":"2019","journal-title":"J Vis Exp"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060237","article-title":"It\u2019s not how fat you are, it\u2019s what you do with it that counts","volume":"6","author":"Virtue","year":"2008","journal-title":"PLoS Biol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0872","article-title":"Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes","volume":"57","author":"Lumeng","year":"2008","journal-title":"Diabetes"},{"key":"B30","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/s41577-023-00835-3","article-title":"Can we predict T cell specificity with digital biology and machine learning","volume":"8","author":"Hudson","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-018-1095-x","article-title":"Class II MHC antigen processing in immune tolerance and inflammation","volume":"71","author":"Jurewicz","year":"2019","journal-title":"Immunogenetics"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502045","article-title":"Presentation of cryptic peptides by MHC I is enhanced by inflammatory stimuli","volume":"197","author":"Prasad","year":"2016","journal-title":"J Immunol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304859110","article-title":"Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system","volume":"110","author":"Sinclair","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.09.020","article-title":"Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets","volume":"38","author":"Sathaliyawala","year":"2013","journal-title":"Immunity"},{"key":"B35","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40425-017-0235-4","article-title":"Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy","volume":"5","author":"Sckisel","year":"2017","journal-title":"J Immunother Cancer"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646837","article-title":"CD69: from activation marker to metabolic gatekeeper","volume":"47","author":"Cibri\u00e1n","year":"2017","journal-title":"Eur J Immunol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.078","article-title":"Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites","volume":"20","author":"Kumar","year":"2017","journal-title":"Cell Rep"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900052","article-title":"The functional requirement for CD69 in establishment of resident memory CD8+ T cells varies with tissue location","volume":"203","author":"Walsh","year":"2019","journal-title":"J Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"108085","DOI":"10.1016\/j.celrep.2020.108085","article-title":"CD49a regulates cutaneous resident memory CD8+ T cell persistence and response","volume":"32","author":"Bromley","year":"2020","journal-title":"Cell Rep"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.8.5054","article-title":"The \u03b11\u03b21 integrin and TNF receptor II protect airway CD8+ Effector T cells from apoptosis during influenza infection1","volume":"179","author":"Richter","year":"2007","journal-title":"J Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1915681117","article-title":"TRM integrins CD103 and CD49a differentially support adherence and motility after resolution of influenza virus infection","volume":"117","author":"Reilly","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902281","article-title":"Identification of a Unique Population of Tissue-Memory CD4+ T cells in the Airways after Influenza Infection that is Dependent on the Integrin VLA-1","volume":"184","author":"Chapman","year":"2010","journal-title":"J Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.immuni.2017.01.009","article-title":"CD49a expression defines tissue-resident CD8+ T cells poised for cytotoxic function in human skin","volume":"46","author":"Cheuk","year":"2017","journal-title":"Immunity"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.728669","article-title":"CD49a identifies polyfunctional memory CD8 T cell subsets that persist in the lungs after influenza infection","volume":"12","author":"Reilly","year":"2021","journal-title":"Front Immunol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202288109","article-title":"Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation","volume":"109","author":"Mackay","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/nri3740","article-title":"T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion","volume":"14","author":"Speiser","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/nri2318","article-title":"Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections","volume":"8","author":"Nikolich-\u017dugich","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1084\/jem.2016088","article-title":"Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells","volume":"213","author":"Muschaweckh","year":"2016","journal-title":"J Exp Med"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.38","article-title":"T cell responses to cytomegalovirus","volume":"16","author":"Klenerman","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/nri1977","article-title":"Structural determinants of T-cell receptor bias in immunity","volume":"6","author":"Turner","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1126\/science.1185350","article-title":"Evasion of CD8+ T cells is critical for super-infection by cytomegalovirus","volume":"328","author":"Hansen","year":"2010","journal-title":"Science"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0225-5","article-title":"Modulation of innate and adaptive immunity by cytomegaloviruses","volume":"20","author":"Berry","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky303","article-title":"A single-molecule sequencing assay for the comprehensive profiling of T4 DNA ligase fidelity and bias during DNA end-joining","volume":"46","author":"Potapov","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw354","article-title":"MultiQC: summarize analysis results for multiple tools and samples in a single report","volume":"32","author":"Ewels","year":"2016","journal-title":"Bioinformatics"},{"key":"B55","doi-asserted-by":"publisher","first-page":"giab008","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"GigaScience"},{"key":"B56","volume-title":"Biostrings: Efficient manipulation of biological strings","author":"Pag\u00e8s","year":"2023"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw339","article-title":"RTCR: a pipeline for complete and accurate recovery of T cell repertoires from high throughput sequencing data","volume":"32","author":"Gerritsen","year":"2016","journal-title":"Bioinformatics"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02159","article-title":"A framework for annotation of antigen specificities in high-throughput T-cell repertoire sequencing studies","volume":"10","author":"Pogorelyy","year":"2019","journal-title":"Front Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01578-0","article-title":"VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2","volume":"19","author":"Goncharov","year":"2022","journal-title":"Nat Methods"},{"key":"B60","doi-asserted-by":"publisher","first-page":"4699","DOI":"10.1038\/s41467-021-25006-7","article-title":"GIANA allows computationally-efficient TCR clustering and multi-disease repertoire classification by isometric transformation","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat Commun"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1303724\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T03:18:16Z","timestamp":1700450296000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1303724\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,20]]},"references-count":60,"alternative-id":["10.3389\/fimmu.2023.1303724"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2023.1303724","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,20]]},"article-number":"1303724"}}