{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:43:46Z","timestamp":1791855826307,"version":"4.3.4"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["N\u00ba22-25-00534 , 19-75-30032"],"award-info":[{"award-number":["N\u00ba22-25-00534 , 19-75-30032"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    is a gram-negative anaerobic bacterium, which represents a part of the commensal human microbiota. Decline in the abundance of\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    among other microbial species in the gut correlates with severe systemic diseases such as diabetes, obesity, intestinal inflammation and colorectal cancer. Due to its mucin-reducing and immunomodulatory properties, the use of probiotics containing\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    sp. appears as a promising approach to the treatment of metabolic and inflammatory diseases. In particular, a number of studies have focused on the role of\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    in colorectal cancer. Of note, the results of these studies in mice are contradictory: some reported a protective role of\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    in colorectal cancer, while others demonstrated that administration of\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    could aggravate the course of the disease resulting in increased tumor burden. More recent studies suggested the immunomodulatory effect of certain unique surface antigens of\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    on the intestinal immune system. In this Perspective, we attempt to explain how\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    contributes to protection against colorectal cancer in some models, while being pathogenic in others. We argue that differences in the experimental protocols of administration of\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    , as well as viability of bacteria, may significantly affect the results. In addition, we hypothesize that antigens presented by pasteurized bacteria or live\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    may exert distinct effects on the barrier functions of the gut. Finally,\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    may reduce the mucin barrier and exerts combined effects with other bacterial species in either promoting or inhibiting cancer development.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2023.1303795","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T03:33:50Z","timestamp":1701833630000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":51,"title":["Akkermansia muciniphila - friend or foe in colorectal cancer?"],"prefix":"10.3389","volume":"14","author":[{"given":"Ekaterina O.","family":"Gubernatorova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina A.","family":"Gorshkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina A.","family":"Bondareva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga A.","family":"Podosokorskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna D.","family":"Sheynova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia S.","family":"Yakovleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta A.","family":"Bonch-Osmolovskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei A.","family":"Nedospasov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey A.","family":"Kruglov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina S.","family":"Drutskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.02873-0","article-title":"Akkermansia muciniphila gen. 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