{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:41:32Z","timestamp":1790638892841,"version":"4.1.0"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004201","name":"Oncosuisse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004201","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    The transforming growth factor-\u03b2 (TGF-\u03b2) family member activin A (hereafter Activin-A) is overexpressed in many cancer types, often correlating with cancer-associated cachexia and poor prognosis. Activin-A secretion by melanoma cells indirectly impedes CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell-mediated anti-tumor immunity and promotes resistance to immunotherapies, even though Activin-A can be proinflammatory in other contexts. To identify underlying mechanisms, we here analyzed the effect of Activin-A on syngeneic grafts of\n                    <jats:italic>Braf<\/jats:italic>\n                    mutant YUMM3.3 mouse melanoma cells and on their microenvironment using single-cell RNA sequencing. We found that the Activin-A-induced immune evasion was accompanied by a proinflammatory interferon signature across multiple cell types, and that the associated increase in tumor growth depended at least in part on pernicious STING activity within the melanoma cells. Besides corroborating a role for proinflammatory signals in facilitating immune evasion, our results suggest that STING holds considerable potential as a therapeutic target to mitigate tumor-promoting Activin-A signaling at least in melanoma.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2023.1335207","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T23:22:21Z","timestamp":1705533741000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING"],"prefix":"10.3389","volume":"14","author":[{"given":"Katarina","family":"Pinjusic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Ambrosini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao","family":"Lourenco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Iseli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Guex","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Egorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Nassiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Constam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0306-5","article-title":"A guide to cancer immunotherapy: from T cell basic science to clinical practice","volume":"20","author":"Waldman","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9103323","article-title":"Challenges and opportunities in the clinical development of STING agonists for cancer immunotherapy","volume":"9","author":"Motedayen Aval","year":"2020","journal-title":"J Clin Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.017","article-title":"Primary, adaptive, and acquired resistance to cancer immunotherapy","volume":"168","author":"Sharma","year":"2017","journal-title":"Cell"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-2267","article-title":"Primary and acquired resistance to immune checkpoint inhibitors in metastatic melanoma","volume":"24","author":"Gide","year":"2018","journal-title":"Clin Cancer Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"5166","DOI":"10.1038\/ncomms6166","article-title":"Inflammation-driven carcinogenesis is mediated through STING","volume":"5","author":"Ahn","year":"2014","journal-title":"Nat Commun"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1242\/JCS.02554","article-title":"Non-smad TGF-beta signals","volume":"118","author":"Moustakas","year":"2005","journal-title":"J Cell Sci"},{"key":"B7","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12943-015-0456-4","article-title":"Activin and TGF\u03b2 use diverging mitogenic signaling in advanced colon cancer","volume":"14","author":"Bauer","year":"2015","journal-title":"Mol Cancer"},{"key":"B8","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/cancers7010070","article-title":"Intertwining of Activin A and TGF\u03b2 Signaling: Dual roles in cancer progression and cancer cell invasion","volume":"7","author":"Loomans","year":"2014","journal-title":"Cancers"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAUT.2019.102314","article-title":"Activin-A in the regulation of immunity in health and disease","volume":"104","author":"Morianos","year":"2019","journal-title":"J Autoimmun"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-1103-0","article-title":"A NF-\u0138B-Activin A signaling axis enhances prostate cancer metastasis","volume":"39","author":"Chen","year":"2020","journal-title":"Oncogene"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1904714116","article-title":"CRISPR-Cas9-mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes","volume":"116","author":"Takeda","year":"2019","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020527","article-title":"Overexpression of wild-type activin receptor Alk4-1 restores activin antiproliferative effects in human pituitary tumor cells","volume":"87","author":"Danila","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4318","article-title":"Role of activin A and myostatin in human cancer cachexia","volume":"100","author":"Loumaye","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12209","article-title":"Circulating Activin A predicts survival in cancer patients","volume":"8","author":"Loumaye","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"B15","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1080\/14728222.2020.1799350","article-title":"Activin A: an emerging target for improving cancer treatment","volume":"20","author":"Ries","year":"2020","journal-title":"Expert Opin Ther Targets"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.07.845","article-title":"Paracrine Activin-A signaling promotes melanoma growth and metastasis through immune evasion","volume":"137","author":"Donovan","year":"2017","journal-title":"J Invest Dermatol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e004533","DOI":"10.1136\/JITC-2022-004533","article-title":"Activin-A impairs CD8 T cell-mediated immunity and immune checkpoint therapy response in melanoma","volume":"10","author":"Pinjusic","year":"2022","journal-title":"J Immunother Cancer"},{"key":"B18","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/ncomms1585","article-title":"Activin enhances skin tumourigenesis and Malignant progression by inducing a pro-tumourigenic immune cell response","volume":"2","author":"Antsiferova","year":"2011","journal-title":"Nat Commun"},{"key":"B19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.15252\/emmm.201606493","article-title":"Activin promotes skin carcinogenesis by attraction and reprogramming of macrophages","volume":"9","author":"Antsiferova","year":"2017","journal-title":"EMBO Mol Med"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-0219","article-title":"Activin A\u2013mediated polarization of cancer-associated fibroblasts and macrophages confers resistance to checkpoint immunotherapy in skin cancer","volume":"29","author":"Pich-Bavastro","year":"2023","journal-title":"Clin Cancer Res"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-022-32670-w","article-title":"Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma","volume":"13","author":"Yerly","year":"2022","journal-title":"Nat Commun"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00331","article-title":"Novel murine dendritic cell lines: A powerful auxiliary tool for dendritic cell research","volume":"3","author":"Fuertes Marraco","year":"2012","journal-title":"Front Immunol"},{"key":"B23","article-title":"A mathematical model for tumor volume evaluation using two-dimensions","volume":"4","author":"Feldman","year":"2009","journal-title":"J Appl Quant Methods"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baz046","article-title":"PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data","volume":"2019","author":"Franz\u00e9n","year":"2019","journal-title":"Database"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-021-23324-4","article-title":"Interpretation of T cell states from single-cell transcriptomics data using reference atlases","volume":"12","author":"Andreatta","year":"2021","journal-title":"Nat Commun"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinf"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0667-5","article-title":"NicheNet: modeling intercellular communication by linking ligands to target genes","volume":"17","author":"Browaeys","year":"2020","journal-title":"Nat Methods"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innov Camb Mass"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I- and type-II-interferon-mediated signalling","volume":"5","author":"Platanias","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.638395","article-title":"Cysteine cathepsins activate ELR chemokines and inactivate non-ELR chemokines","volume":"290","author":"Repnik","year":"2015","journal-title":"J Biol Chem"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-019-09807-3","article-title":"Proteolytic chemokine cleavage as a regulator of lymphocytic infiltration in solid tumors","volume":"38","author":"Bronger","year":"2019","journal-title":"Cancer Metastasis Rev"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13059-019-1671-x","article-title":"BRB-seq: Ultra-affordable high-throughput transcriptomics enabled by bulk RNA barcoding and sequencing","volume":"20","author":"Alpern","year":"2019","journal-title":"Genome Biol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.189","article-title":"FUCCI sensors: powerful new tools for analysis of cell proliferation","volume":"4","author":"Zielke","year":"2015","journal-title":"WIREs Dev Biol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3691","article-title":"Mechanisms and consequences of Jak\u2013STAT signaling in the immune system","volume":"18","author":"Villarino","year":"2017","journal-title":"Nat Immunol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00331","article-title":"RNA interference-induced innate immunity, off-target effect, or immune adjuvant","volume":"8","author":"Meng","year":"2017","journal-title":"Front Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"102080","DOI":"10.1016\/j.isci.2021.102080","article-title":"Activin A impairs ActRIIA+ neutrophil recruitment into infected skin of mice","volume":"24","author":"Qi","year":"2021","journal-title":"iScience"},{"key":"B42","article-title":"The N-myc oncogene in human neuroblastoma cells: Down-regulation of an angiogenesis inhibitor\u00a0identified as activin A","volume":"60","author":"Breit","year":"2000","journal-title":"Cancer Res"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.348","article-title":"Activin A inhibits vascular endothelial cell growth and suppresses tumour angiogenesis in gastric cancer","volume":"105","author":"Kaneda","year":"2011","journal-title":"Br J Cancer"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2828","article-title":"Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms","volume":"65","author":"Panopoulou","year":"2005","journal-title":"Cancer Res"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0213","article-title":"Crucial role of activin A in tubulogenesis of endothelial cells induced by vascular endothelial growth factor","volume":"145","author":"Maeshima","year":"2004","journal-title":"Endocrinology"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63216-6","article-title":"Activin a in the regulation of corneal neovascularization and vascular endothelial growth factor expression","volume":"164","author":"Poulaki","year":"2004","journal-title":"Am J Pathol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2020.07.009","article-title":"Wound repair, scar formation, and cancer: converging on Activin","volume":"26","author":"Cangkrama","year":"2020","journal-title":"Trends Mol Med"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00480-X","article-title":"Activin receptors are expressed on human lung fibroblast and activin a facilitates fibroblast-mediated collagen gel contraction","volume":"66","author":"Ohga","year":"2000","journal-title":"Life Sci"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-020-16409-z","article-title":"Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds","volume":"11","author":"Wietecha","year":"2020","journal-title":"Nat Commun"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2008.0121","article-title":"Production and function of activin A in human dendritic cells","volume":"19","author":"Scutera","year":"2008","journal-title":"Eur Cytokine Netw"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1477-7827-6-17","article-title":"The glycoprotein-hormones activin A and inhibin A interfere with dendritic cell maturation","volume":"6","author":"Segerer","year":"2008","journal-title":"Reprod Biol Endocrinol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-080994","article-title":"Activin-A: A novel dendritic cell derived cytokine that potently attenuates CD40 ligand specific cytokine and chemokine production","volume":"111","author":"Robson","year":"2008","journal-title":"Blood"},{"key":"B53","doi-asserted-by":"publisher","first-page":"e0167813","DOI":"10.1371\/journal.pone.0167813","article-title":"A key role for inhibins in dendritic cell maturation and function","volume":"11","author":"Olgu\u00edn-Alor","year":"2016","journal-title":"PloS One"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.03.047","article-title":"Dendritic cells conditioned by activin A\u2013induced regulatory T cells exhibit enhanced tolerogenic properties and protect against experimental asthma","volume":"141","author":"Semitekolou","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2015.09.054","article-title":"TGF-\u03b2-induced transcription sustains amoeboid melanoma migration and dissemination","volume":"25","author":"Cantelli","year":"2015","journal-title":"Curr Biol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1172\/JCI94295","article-title":"SMAD signaling promotes melanoma metastasis independently of phenotype switching","volume":"129","author":"Tuncer","year":"2019","journal-title":"J Clin Invest"},{"key":"B57","doi-asserted-by":"publisher","first-page":"111471","DOI":"10.1016\/j.yexcr.2019.06.016","article-title":"Activin A promotes ovarian cancer cell migration by suppressing E-cadherin expression","volume":"382","author":"Yi","year":"2019","journal-title":"Exp Cell Res"},{"key":"B58","doi-asserted-by":"publisher","first-page":"15007","DOI":"10.1038\/npjbcancer.2015.7","article-title":"Activin-A signaling promotes epithelial\u2013mesenchymal transition, invasion, and metastatic growth of breast cancer","volume":"1","author":"Bashir","year":"2015","journal-title":"NPJ Breast Cancer"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/nature09666","article-title":"Interferon-\u03b3 3 links ultraviolet radiation to melanomagenesis in mice","volume":"469","author":"Zaidi","year":"2011","journal-title":"Nature"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-166926","article-title":"Activin-A attenuates several human natural killer cell functions","volume":"113","author":"Robson","year":"2009","journal-title":"Blood"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aat7527","article-title":"Therapeutic blockade of activin-A improves NK cell function and antitumor immunity","volume":"12","author":"Rautela","year":"2019","journal-title":"Sci Signal"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1016\/j.cell.2016.11.022","article-title":"Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade","volume":"167","author":"Benci","year":"2016","journal-title":"Cell"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2018.0087","article-title":"The interferon-gamma paradox in cancer","volume":"39","author":"Zaidi","year":"2019","journal-title":"J Interferon Cytokine Res"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn0478","article-title":"Lineage plasticity in prostate cancer depends on JAK\/STAT inflammatory signaling","volume":"377","author":"Chan","year":"2022","journal-title":"Science"},{"key":"B65","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12943-023-01868-x","article-title":"ERK mediates interferon gamma-induced melanoma cell death","volume":"22","author":"Champhekar","year":"2023","journal-title":"Mol Cancer"},{"key":"B66","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s10585-018-9906-x","article-title":"The Kraken Wakes: induced EMT as a driver of tumour aggression and poor outcome","volume":"35","author":"Redfern","year":"2018","journal-title":"Clin Exp Metastasis"},{"key":"B67","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.cell.2016.08.069","article-title":"Loss of IFN-\u03b3 pathway genes in tumor cells as a mechanism of resistance to anti-CTLA-4 therapy","volume":"167","author":"Gao","year":"2016","journal-title":"Cell"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-018-0471-9","article-title":"Strategies for predicting response to checkpoint inhibitors","volume":"13","author":"Zappasodi","year":"2018","journal-title":"Curr Hematol Malig Rep"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2020-0967","article-title":"Addressing resistance to immune checkpoint inhibitor therapy: An urgent unmet need","volume":"17","author":"Hu-Lieskovan","year":"2021","journal-title":"Future Oncol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1172\/JCI91190","article-title":"IFN-\u03b3-related mRNA profile predicts clinical response to PD-1 blockade","volume":"127","author":"Ayers","year":"2017","journal-title":"J Clin Invest"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.019","article-title":"Opposing functions of interferon coordinate adaptive and innate immune responses to cancer immune checkpoint blockade","volume":"178","author":"Benci","year":"2019","journal-title":"Cell"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41525-021-00169-w","article-title":"Ratio of the interferon-\u03b3 signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma","volume":"6","author":"Cui","year":"2021","journal-title":"NPJ Genomic Med"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-4191","article-title":"Activation of the IFN signaling pathway is associated with resistance to CDK4\/6 inhibitors and immune checkpoint activation in ER-positive breast cancer","volume":"27","author":"De Angelis","year":"2021","journal-title":"Clin Cancer Res"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809242105","article-title":"An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer","volume":"105","author":"Weichselbaum","year":"2008","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00524-z","article-title":"The cGAS\u2013STING pathway as a therapeutic target in inflammatory diseases","volume":"21","author":"Decout","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.immuni.2018.09.016","article-title":"Tumor-derived cGAMP triggers a STING-mediated interferon response in non-tumor cells to activate the NK cell response","volume":"49","author":"Marcus","year":"2018","journal-title":"Immunity"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/nature25432","article-title":"Chromosomal instability drives metastasis through a cytosolic DNA response","volume":"553","author":"Bakhoum","year":"2018","journal-title":"Nature"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109412","article-title":"Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING","volume":"36","author":"Bruand","year":"2021","journal-title":"Cell Rep"},{"key":"B79","doi-asserted-by":"publisher","first-page":"e2013598118","DOI":"10.1073\/pnas.2013598118","article-title":"Epigenetic reprogramming of tumor cell\u2013intrinsic STING function sculpts antigenicity and T cell recognition of melanoma","volume":"118","author":"Falahat","year":"2021","journal-title":"Proc Natl Acad Sci"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1038\/s41467-023-37217-1","article-title":"Epigenetic state determines the in vivo efficacy of STING agonist therapy","volume":"14","author":"Falahat","year":"2023","journal-title":"Nat Commun"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1335207\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T23:22:26Z","timestamp":1705533746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1335207\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,18]]},"references-count":80,"alternative-id":["10.3389\/fimmu.2023.1335207"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2023.1335207","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,18]]},"article-number":"1335207"}}