{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:15:33Z","timestamp":1787026533669,"version":"build-2736575974"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Excessive fibrous capsule formation around silicone mammary implants (SMI) involves immune reactions to silicone. Capsular fibrosis, a common SMI complication linked to host responses, worsens with specific implant topographies. Our study with 10 patients investigated intra- and inter-individually, reduced surface roughness effects on disease progression, wound responses, chronic inflammation, and capsular composition. The results illuminate the significant impact of surface roughness on acute inflammatory responses, fibrinogen accumulation, and the subsequent fibrotic cascade. The reduction of surface roughness to an average roughness of 4 \u03bcm emerges as a promising approach for mitigating detrimental immune reactions, promoting healthy wound healing, and curbing excessive fibrosis. The identified proteins adhering to rougher surfaces shed light on potential mediators of pro-inflammatory and pro-fibrotic processes, further emphasizing the need for meticulous consideration of surface design. The composition of the implant capsule and the discovery of intracapsular HSP60 expression highlight the intricate web of stress responses and immune activation that can impact long-term tissue outcomes.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1342895","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:54:33Z","timestamp":1710809673000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Silicone implant surface microtopography modulates inflammation and tissue repair in capsular fibrosis"],"prefix":"10.3389","volume":"15","author":[{"given":"Ines","family":"Schoberleitner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Faserl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph H.","family":"Tripp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth Judith","family":"Pechriggl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Sigl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Zelger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natascha","family":"Hermann-Kleiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leoni","family":"Baier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresia","family":"Steinkellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Sarg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Egle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Wolfram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1055\/s-0041-1731793","article-title":"Healing, inflammation, and fibrosis: current concepts in capsular contracture: pathophysiology, prevention, and management","volume":"35","author":"Safran","year":"2021","journal-title":"Semin Plast Surg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3233\/CH-170365","article-title":"Capsular fibrosis in aesthetic and reconstructive-cancer patients: A retrospective analysis of 319 cases","volume":"70","author":"Kuehlmann","year":"2018","journal-title":"Clin Hemorheol Microcirc"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e318066f0bd","article-title":"The safety of silicone gel-filled breast implants: A review of the epidemiologic evidence","volume":"59","author":"McLaughlin","year":"2007","journal-title":"Ann Plast Surg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1097\/01.sap.0000128087.51384.f9","article-title":"Silicone breast implants and connective tissue disease: an updated review of the epidemiologic evidence","volume":"52","author":"Lipworth","year":"2004","journal-title":"Ann Plast Surg"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-095937","article-title":"The immunology of fibrosis","author":"Wick","year":"2013","journal-title":"Annu Rev Immunol Mar"},{"key":"B6","article-title":"Women with silicone breast implants and unexplained systemic symptoms: A descriptive cohort study","volume":"71","author":"Maijers","year":"2014","journal-title":"Netherlands J Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.anplas.2017.02.001","article-title":"Breast-implant texturing associated with delamination of capsular layers: A histological analysis of the double capsule phenomenon","volume":"62","author":"Efanov","year":"2017","journal-title":"Ann Chir Plast Esthet"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2015.06.007","article-title":"Understanding the etiology and prevention of capsular contracture: translating science into practice","volume":"42","author":"Chong","year":"2015","journal-title":"Clin Plast Surg"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1021\/pr0603755","article-title":"Identification and dynamics of proteins adhering to the surface of medical silicones in vivo and in vitro","volume":"6","author":"Backovic","year":"2007","journal-title":"J Proteome Res"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.12.001","article-title":"The immunology of fibrosis: innate and adaptive responses","author":"Wick","year":"2010","journal-title":"Trends Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.imlet.2008.03.007","article-title":"Altered systemic serologic parameters in patients with silicone mammary implants","volume":"118","author":"Wolfram","year":"2008","journal-title":"Immunol Lett"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2007.08.016","article-title":"Simultaneous analysis of multiple serum proteins adhering to the surface of medical grade polydimethylsiloxane elastomers","volume":"328","author":"Backovic","year":"2007","journal-title":"J Immunol Methods"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/biom13020305","article-title":"Quantitative proteomic characterization of foreign body response towards silicone breast implants identifies chronological disease-relevant biomarker dynamics","volume":"13","author":"Schoberleitner","year":"2023","journal-title":"Biomolecules"},{"key":"B14","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jaut.2004.03.005","article-title":"Cellular and molecular composition of fibrous capsules formed around silicone breast implants with special focus on local immune reactions *","volume":"23","author":"Wolfram","year":"2004","journal-title":"J Autoimmun"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31823aeacf","article-title":"T regulatory cells and TH17 cells in peri-silicone implant capsular fibrosis","author":"Wolfram","year":"2012","journal-title":"Plast Reconstr Surg"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199708000-00065","article-title":"Anaplastic T-cell lymphoma in proximity to a saline-filled breast implant","volume":"100","author":"Keech","year":"1997","journal-title":"Plast Reconstr Surg"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2011.03.020","article-title":"ALK-1-negative anaplastic large cell lymphoma associated with breast implants: a new clinical entity","volume":"11","author":"Lazzeri","year":"2011","journal-title":"Clin Breast Cancer"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192108","article-title":"Immunophenotypic characterization of human T cells after in vitro exposure to different silicone breast implant surfaces","author":"Cappellano","year":"2018","journal-title":"PloS One"},{"key":"B19","article-title":"Non-active surgical implants \u2014 Mammary implants \u2014 Particular requirements","year":"2018"},{"key":"B20","doi-asserted-by":"publisher","first-page":"30S","DOI":"10.1097\/PRS.0000000000005567","article-title":"Current risk estimate of breast implant-associated anaplastic large cell lymphoma in textured breast implants","volume":"143","author":"Collett","year":"2019","journal-title":"Plast Reconstr Surg"},{"key":"B21","doi-asserted-by":"crossref","DOI":"10.1097\/01.prs.0000435317.76381.68","article-title":"Risk factor analysis for capsular contracture: A 5-year sientra study analysis using round, smooth, and textured implants for breast augmentation","author":"Stevens","year":"2013","journal-title":"Plast Reconstr Surg"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1177\/2292550317716127","article-title":"Textured breast implants: A closer look at the surface debris under the microscope","volume":"25","author":"Webb","year":"2017","journal-title":"Plast Surgery"},{"key":"B23","article-title":"An extended 7-year review of textured breast implants for primary breast augmentation: Allergan\u00ae versus Mentor\u00ae","volume":"3","author":"Martin erena","year":"2019","journal-title":"Ann Breast Surg"},{"key":"B24","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1126\/sciadv.aay0076","article-title":"The surface stress of biomedical silicones is a stimulant of cellular response","volume":"6","author":"Cheng","year":"2020","journal-title":"Sci Adv"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00739-4","article-title":"The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans","volume":"5","author":"Doloff","year":"2021","journal-title":"Nat Biomed Eng"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12041315","article-title":"Is it all about surface topography? An intra-individual clinical outcome analysis of two different implant surfaces in breast reconstruction","volume":"12","author":"Schoberleitner","year":"2023","journal-title":"J Clin Med"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000003449","article-title":"Breast implant utilization trends in USA versus Europe and the impact of BIA-ALCL publications","author":"Jalalabadi","year":"2021","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/ma11122393","article-title":"The A, B and C\u2019s of silicone breast implants: Anaplastic large cell lymphoma, biofilm and capsular contracture","volume":"11","author":"Mempin","year":"2018","journal-title":"MDPI AG"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2020.151474","article-title":"Reconsideration of the first recognition of breast implant-associated anaplastic large cell lymphoma: A critical review of the literature","volume":"45","author":"Lyapichev","year":"2020","journal-title":"Ann Diagn Pathol"},{"key":"B30","volume-title":"Plastic Surgery Statistics. American Society of Plastic Surgery Statistics: Report 2022","year":"2022"},{"key":"B31","doi-asserted-by":"publisher","first-page":"43","DOI":"10.21037\/gs","article-title":"Two-stage prepectoral breast reconstruction","volume":"8","author":"Nahabedian","year":"2019","journal-title":"Gland Surg"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2015.07.015","article-title":"Comparison of one-stage vs two-stage prosthesis-based breast reconstruction: a systematic review and meta-analysis","volume":"212","author":"Lee","year":"2016","journal-title":"Am J Surg"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182589ba6","article-title":"A prospective randomized study comparing two different expander approaches in implant-based breast reconstruction: one stage versus two stages","volume":"130","author":"Eriksen","year":"2012","journal-title":"Plast Reconstr Surg"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12859-015-0611-3","article-title":"InteractiVenn: A web-based tool for the analysis of sets through Venn diagrams","volume":"16","author":"Heberle","year":"2015","journal-title":"BMC Bioinf"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: a graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinformatics"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv468","article-title":"ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap","volume":"43","author":"Metsalu","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/jsp2.1017","article-title":"Isolation of high-quality RNA from intervertebral disc tissue via pronase predigestion and tissue pulverization","author":"Caprez","year":"2018"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174317","article-title":"Validation of qPCR reference genes in lymphocytes from patients with amyotrophic lateral sclerosis","author":"Usarek","year":"2017"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.20944\/preprints202212.0004.v1","article-title":"Quantitative proteomic characterization of foreign body response towards silicone breast implants identifies chronological disease-relevant biomarker dynamics","author":"Schoberleitner","year":"2022"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.08.013","article-title":"Anti-angiogenic collagen fragment arresten is increased from 16 weeks\u2019 gestation in pre-eclamptic plasma","author":"Yong","year":"2015"},{"key":"B41","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jphs.2018.12.001","article-title":"A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain","volume":"139","author":"Okada","year":"2019","journal-title":"J Pharmacol Sci"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202153509","article-title":"Myeloid-derived growth factor (MYDGF) protects bone mass through inhibiting osteoclastogenesis and promoting osteoblast differentiation","volume":"23","author":"Xu","year":"2022","journal-title":"EMBO Rep"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe6903","article-title":"Myeloid-derived growth factor inhibits inflammation and alleviates endothelial injury and atherosclerosis in mice","volume":"7","author":"Meng","year":"2021","journal-title":"Sci Adv"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190103","article-title":"Transforming growth factor\u2013\u00df in tissue fibrosis","volume":"217","author":"Frangogiannis","year":"2020","journal-title":"J Exp Med"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22604","article-title":"TGFBR3, a potential negative regulator of TGF-\u03b2 signaling, protects cardiac fibroblasts from hypoxia-induced apoptosis","volume":"226","author":"Chu","year":"2011","journal-title":"J Cell Physiol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00352","article-title":"The effects of biomaterial implant wear debris on osteoblasts","volume":"8","author":"Zhang","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/bs.acc.2020.02.006","article-title":"S100 family proteins in inflammation and beyond","volume":"98","author":"Sreejit","year":"2020","journal-title":"Adv Clin Chem"},{"key":"B48","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.3390\/cells11152274","article-title":"Multifunctional role of S100 protein family in the immune system: an update","volume":"11","author":"Singh","year":"2022","journal-title":"Cells 2022"},{"key":"B49","doi-asserted-by":"publisher","first-page":"118677","DOI":"10.1016\/j.bbamcr.2020.118677","article-title":"Role of S100 proteins in health and disease","volume":"1867","author":"Gonzalez","year":"2020","journal-title":"Biochim Biophys Acta (BBA) - Mol Cell Res"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5488591","article-title":"The S100 protein family as players and therapeutic targets in pulmonary diseases","volume":"2021","author":"Sattar","year":"2021","journal-title":"Pulm Med"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2023.02.022","article-title":"Interaction between platelet and fibrinogen on clot strength in healthy patients","volume":"37","author":"Maslow","year":"2023","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.791860","article-title":"FGA controls VEGFA secretion to promote angiogenesis by activating the VEGFR2-FAK signalling pathway","volume":"13","author":"Li","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212537","article-title":"Fibrinogen and antifibrinolytic proteins: interactions and future therapeutics","volume":"22","author":"Pechlivani","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioaa126","article-title":"Fibrinogen alpha chain promotes the migration and invasion of human endometrial stromal cells in endometriosis through focal adhesion kinase\/protein kinase B\/matrix metallopeptidase 2 pathway","volume":"103","author":"Li","year":"2020","journal-title":"Biol Reprod"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8327945","article-title":"Expression of matrix metalloproteinases and their tissue inhibitors in peripheral blood leukocytes and plasma of children with nonalcoholic fatty liver disease","volume":"2020","author":"Trojanek","year":"2020","journal-title":"Mediators Inflammation"},{"key":"B56","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.matbio.2015.01.004","article-title":"Matrix metalloproteinases in liver injury, repair and fibrosis","author":"Duarte","year":"2015","journal-title":"Matrix Biol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"5","DOI":"10.26502\/fccm","article-title":"Regulation of collagen I and collagen III in tissue injury and regeneration","volume":"7","author":"Singh","year":"2023","journal-title":"Cardiol Cardiovasc Med"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduction Targeted Ther"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00869-6","article-title":"Inflammasomes and adaptive immune responses","volume":"22","author":"Deets","year":"2021","journal-title":"Nat Immunol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.167042","article-title":"Type I interferon-dependent IFIT3 signaling is critical for viral clearance in airway neutrophils","author":"Margaroli","year":"2023","journal-title":"Res Sq"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s42003-021-01829-4","article-title":"IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection","volume":"4","author":"Rosa","year":"2021","journal-title":"Commun Biol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"3932","DOI":"10.1111\/febs.15803","article-title":"Roles of neutrophil granule proteins in orchestrating inflammation and immunity","volume":"289","author":"Othman","year":"2022","journal-title":"FEBS J"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.633486","article-title":"The outcome of neutrophil-T cell contact differs depending on activation status of both cell types","volume":"12","author":"Minns","year":"2021","journal-title":"Front Immunol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/imr.13162","article-title":"Neutrophil-T cell crosstalk and the control of the host inflammatory response","volume":"314","author":"Bert","year":"2023","journal-title":"Immunol Rev"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00898","article-title":"The Role of Neutrophils in the Induction of Specific Th1 and Th17 during Vaccination against Tuberculosis","volume":"7","author":"Trentini","year":"2016","journal-title":"Front Microbiol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1172\/JCI118549","article-title":"Molecular determinants of acute inflammatory responses to biomaterials","volume":"97","author":"Tang","year":"1996","journal-title":"J Clin Invest"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1007\/BF03402124","article-title":"Molecular medicine natural responses to unnatural materials: A molecular mechanism for foreign body reactions","volume":"5","author":"Tang","year":"1999","journal-title":"Mol Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005159","article-title":"Skin-derived C-terminal filaggrin-2 fragments are pseudomonas aeruginosa-directed antimicrobials targeting bacterial replication","volume":"11","author":"Hansmann","year":"2015","journal-title":"PloS Pathog"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12749","article-title":"Filaggrin-2 barrier protein inversely varies with skin inflammation","volume":"24","author":"Seykora","year":"2015","journal-title":"Exp Dermatol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1080\/09553002.2016.1222094","article-title":"Effects of IL-4 on pulmonary fibrosis and the accumulation and phenotype of macrophage subpopulations following thoracic irradiation","volume":"92","author":"Groves","year":"2016","journal-title":"Int J Radiat Biol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/13.9.1121","article-title":"Eukaryotic heat shock proteins as molecular links in innate and adaptive immune responses: Hsp60-mediated activation of cytotoxic T cells","volume":"13","author":"Mor\u00e9","year":"2001","journal-title":"Int Immunol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830230107","article-title":"Inflammation activates self hsp60-specific T cells","volume":"23","author":"Anderton","year":"1993","journal-title":"Eur J Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"102634","DOI":"10.1016\/j.jaut.2021.102634","article-title":"Autoreactive T cells and their role in atopic dermatitis","volume":"120","author":"De Bruyn Carlier","year":"2021","journal-title":"J Autoimmun"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.217877","article-title":"Heat shock protein 60 and immune inflammatory responses in atherosclerosis","volume":"31","author":"Grundtman","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.91","article-title":"The role of heat shock proteins in atherosclerosis","volume":"11","author":"Wick","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199710000-00039","article-title":"On the safety of breast implants","volume":"100","author":"Brody","year":"1997","journal-title":"Plast Reconstructive Surg"},{"key":"B77","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1097\/PRS.0b013e3181fad34d","article-title":"Breast implant complication review: double capsules and late seromas","volume":"127","author":"Hall-Findlay","year":"2011","journal-title":"Plast Reconstr Surg"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1342895\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:54:39Z","timestamp":1710809679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1342895\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,19]]},"references-count":77,"alternative-id":["10.3389\/fimmu.2024.1342895"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1342895","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,19]]},"article-number":"1342895"}}