{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:40:02Z","timestamp":1793209202479,"version":"4.5.0"},"reference-count":248,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Overcoming the immunosuppressive tumor microenvironment and identifying widely used immunosuppressants with minimal side effects are two major challenges currently hampering cancer immunotherapy. Regulatory T cells (Tregs) are present in almost all cancer tissues and play an important role in preserving autoimmune tolerance and tissue homeostasis. The tumor inflammatory microenvironment causes the reprogramming of Tregs, resulting in the conversion of Tregs to immunosuppressive phenotypes. This process ultimately facilitates tumor immune escape or tumor progression. However, current systemic Treg depletion therapies may lead to severe autoimmune toxicity. Therefore, it is crucial to understand the mechanism of Treg reprogramming and develop immunotherapies that selectively target Tregs within tumors. This article provides a comprehensive review of the potential mechanisms involved in Treg cell reprogramming and explores the application of Treg cell immunotherapy. The interference with reprogramming pathways has shown promise in reducing the number of tumor-associated Tregs or impairing their function during immunotherapy, thereby improving anti-tumor immune responses. Furthermore, a deeper understanding of the mechanisms that drive Treg cell reprogramming could reveal new molecular targets for future treatments.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1345838","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T04:34:52Z","timestamp":1708490092000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Reprogramming of regulatory T cells in inflammatory tumor microenvironment: can it become immunotherapy turning point?"],"prefix":"10.3389","volume":"15","author":[{"given":"Jinming","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.09.020","article-title":"Hallmarks of response, resistance, and toxicity to immune checkpoint blockade","volume":"184","author":"Morad","year":"2021","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00600-w","article-title":"Immune-checkpoint inhibitors: Long-term implications of toxicity","volume":"19","author":"Johnson","year":"2022","journal-title":"Nat Rev Clin Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4321","article-title":"Is autoimmunity the achilles' Heel of cancer immunotherapy","volume":"23","author":"June","year":"2017","journal-title":"Nat Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/s41573-021-00155-y","article-title":"Beyond immune checkpoint blockade: Emerging immunological strategies","volume":"20","author":"Kubli","year":"2021","journal-title":"Nat Rev Drug Discovery"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1217654","article-title":"Panoptosis-related molecular subtype and prognostic model associated with the immune microenvironment and individualized therapy in pancreatic cancer","volume":"13","author":"Zhang","year":"2023","journal-title":"Front Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202212_30696","article-title":"Risk factors for the development of hepatocellular carcinoma in chengdu: A prospective cohort study","volume":"26","author":"Cao","year":"2022","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01587","article-title":"Tissue immune cells fuel obesity-associated inflammation in adipose tissue and beyond","volume":"10","author":"Liu","year":"2019","journal-title":"Front Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0324-7","article-title":"Transcriptional and epigenetic basis of treg cell development and function: Its genetic anomalies or variations in autoimmune diseases","volume":"30","author":"Ohkura","year":"2020","journal-title":"Cell Res"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.626172","article-title":"Post-translational regulations of foxp3 in treg cells and their therapeutic applications","volume":"12","author":"Dong","year":"2021","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2554","article-title":"Regulatory T cells: Recommendations to simplify the nomenclature","volume":"14","author":"Abbas","year":"2013","journal-title":"Nat Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002591","article-title":"Mechanisms of regulatory T cell infiltration in tumors: Implications for innovative immune precision therapies","volume":"9","author":"Nishikawa","year":"2021","journal-title":"J immunotherapy Cancer"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.3390\/cancers13081850","article-title":"Recruitment and expansion of tregs cells in the tumor environment-how to target them","volume":"13","author":"Cinier","year":"2021","journal-title":"Cancers"},{"key":"B13","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/imr.12160","article-title":"Ttregs, ptregs, and itregs: Similarities and differences","volume":"259","author":"Shevach","year":"2014","journal-title":"Immunol Rev"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201847659","article-title":"Targeting treg cells in cancer immunotherapy","volume":"49","author":"Tanaka","year":"2019","journal-title":"Eur J Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202049123","article-title":"Mechanisms of extreg induction","volume":"51","author":"Saxena","year":"2021","journal-title":"Eur J Immunol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2015.03.004","article-title":"Immune evasion in cancer: Mechanistic basis and therapeutic strategies","author":"Vinay","year":"2015","journal-title":"Semin Cancer Biol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12943-020-01234-1","article-title":"Regulatory T cells in tumor microenvironment: New mechanisms, potential therapeutic strategies and future prospects","volume":"19","author":"Li","year":"2020","journal-title":"Mol Cancer"},{"key":"B18","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/imm.13058","article-title":"Treg programming and therapeutic reprogramming in cancer","volume":"157","author":"Moreno Ayala","year":"2019","journal-title":"Immunology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/s12943-018-0913-y","article-title":"Effects of tumor metabolic microenvironment on regulatory T cells","volume":"17","author":"Wang","year":"2018","journal-title":"Mol Cancer"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-019-00684-7","article-title":"Regulatory T cells: The many faces of foxp3","volume":"39","author":"Georgiev","year":"2019","journal-title":"J Clin Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13045-022-01322-3","article-title":"Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: Implications for antitumor immunity","volume":"15","author":"Yan","year":"2022","journal-title":"J Hematol Oncol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02486","article-title":"Foxp3 post-translational modifications and treg suppressive activity","volume":"10","author":"Deng","year":"2019","journal-title":"Front Immunol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.75","article-title":"The regulation of immune tolerance by foxp3","volume":"17","author":"Lu","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1075813","article-title":"The emerging role of regulatory cell-based therapy in autoimmune disease","volume":"13","author":"Ghobadinezhad","year":"2022","journal-title":"Front Immunol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.611795","article-title":"Immunosuppressive mechanisms of regulatory B cells","volume":"12","author":"Catal\u00e1n","year":"2021","journal-title":"Front Immunol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01015.x","article-title":"Dendritic cell control of tolerogenic responses","volume":"241","author":"Manicassamy","year":"2011","journal-title":"Immunol Rev"},{"key":"B27","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41416-018-0333-1","article-title":"Immunosuppression mediated by myeloid-derived suppressor cells (Mdscs) during tumour progression","volume":"120","author":"Groth","year":"2019","journal-title":"Br J Cancer"},{"key":"B28","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s12943-022-01657-y","article-title":"Myeloid-derived suppressor cells: An emerging target for anticancer immunotherapy","volume":"21","author":"Wu","year":"2022","journal-title":"Mol Cancer"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01267-2","article-title":"The complex role of tumor-infiltrating macrophages","volume":"23","author":"Christofides","year":"2022","journal-title":"Nat Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12929-019-0568-z","article-title":"Tumor-associated macrophages: An accomplice in solid tumor progression","volume":"26","author":"Chen","year":"2019","journal-title":"J Biomed Sci"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nri3464","article-title":"The plasticity and stability of regulatory T cells","volume":"13","author":"Sakaguchi","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.014","article-title":"Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy","volume":"41","author":"Tay","year":"2023","journal-title":"Cancer Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1600-065X.2009.00779.x","article-title":"Dynamic regulation of T-cell costimulation through tcr-cd28 microclusters","volume":"229","author":"Yokosuka","year":"2009","journal-title":"Immunol Rev"},{"key":"B34","doi-asserted-by":"publisher","first-page":"8777","DOI":"10.1038\/ncomms9777","article-title":"The paracaspase malt1 cleaves hoil1 reducing linear ubiquitination by lubac to dampen lymphocyte nf-\u039ab signalling","volume":"6","author":"Klein","year":"2015","journal-title":"Nat Commun"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202430","article-title":"Binding of C-rel to stat5 target sequences in htlv-I-transformed T cells","volume":"18","author":"Sun","year":"1999","journal-title":"Oncogene"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.707","article-title":"Transcription factors of the nfat family: Regulation and function","volume":"15","author":"Rao","year":"1997","journal-title":"Annu Rev Immunol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.111.260729","article-title":"Interaction between nf\u03bab and nfat coordinates cardiac hypertrophy and pathological remodeling","volume":"110","author":"Liu","year":"2012","journal-title":"Circ Res"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03326-4","article-title":"Ctla-4 blockade drives loss of T(Reg) stability in glycolysis-low tumours","volume":"591","author":"Zappasodi","year":"2021","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15756","article-title":"Activated ctla-4-independent immunosuppression of treg cells disturbs ctla-4 blockade-mediated antitumor immunity","volume":"114","author":"Watanabe","year":"2023","journal-title":"Cancer Sci"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116471","article-title":"Study on the action mechanism of buyang huanwu decoction against ischemic stroke based on S1p\/S1pr1\/pi3k\/akt signaling pathway","volume":"312","author":"Liu","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.4.5454","article-title":"Interleukin-2 receptor downstream events in regulatory T cells: Implications for the choice of immunosuppressive drug therapy","volume":"7","author":"Zeiser","year":"2008","journal-title":"Cell Cycle (Georgetown Tex)"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.12.004","article-title":"Foxo1 and foxo3 help foxp3","volume":"33","author":"Ohkura","year":"2010","journal-title":"Immunity"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28546","article-title":"Overexpression of hypoxia-inducible factor 1 alpha impacts foxp3 levels in mycosis fungoides\u2013cutaneous T-cell lymphoma: Clinical implications","volume":"134","author":"Alc\u00e1ntara-Hern\u00e1ndez","year":"2014","journal-title":"Int J Cancer"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.033","article-title":"Control of T(H)17\/T(Reg) balance by hypoxia-inducible factor 1","volume":"146","author":"Dang","year":"2011","journal-title":"Cell"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1500845","article-title":"The pten pathway in tregs is a critical driver of the suppressive tumor microenvironment","volume":"1","author":"Sharma","year":"2015","journal-title":"Sci Adv"},{"key":"B46","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.coi.2015.12.009","article-title":"T(Reg) stability: To be or not to be","volume":"39","author":"Overacre","year":"2016","journal-title":"Curr Opin Immunol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2520","article-title":"Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis","volume":"14","author":"Sekiya","year":"2013","journal-title":"Nat Immunol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/943149","article-title":"Socs1 and regulation of regulatory T cells plasticity","volume":"2014","author":"Takahashi","year":"2014","journal-title":"J Immunol Res"},{"key":"B49","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/ni1549","article-title":"Smad3 and nfat cooperate to induce foxp3 expression through its enhancer","volume":"9","author":"Tone","year":"2008","journal-title":"Nat Immunol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-01036-7","article-title":"Intricacies of tgf-\u0392 Signaling in treg and th17 cell biology","volume":"20","author":"Wang","year":"2023","journal-title":"Cell Mol Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-022-02215-1","article-title":"Nf-\u039ab in control of regulatory T cell development, identity, and function","volume":"100","author":"H\u00f6velmeyer","year":"2022","journal-title":"J Mol Med (Berlin Germany)"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413223200","article-title":"Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase","volume":"280","author":"Yi","year":"2005","journal-title":"J Biol Chem"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.589192","article-title":"Constitutive activation of mek1 promotes treg cell instability in vivo","volume":"289","author":"Guo","year":"2014","journal-title":"J Biol Chem"},{"key":"B54","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41571-020-0403-1","article-title":"Tgf\u03b2 Biology in cancer progression and immunotherapy","volume":"18","author":"Derynck","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.024","article-title":"Transforming growth factor-\u0392 Signaling in immunity and cancer","volume":"50","author":"Batlle","year":"2019","journal-title":"Immunity"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0007-0","article-title":"Contextual determinants of tgf\u03b2 Action in development, immunity and cancer","volume":"19","author":"David","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41568-021-00413-6","article-title":"Overcoming tgf\u03b2-mediated immune evasion in cancer","volume":"22","author":"Tauriello","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13146","article-title":"Dual inhibition of tgf-\u0392 and pd-L1: A novel approach to cancer treatment","volume":"16","author":"Gulley","year":"2022","journal-title":"Mol Oncol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-005543","article-title":"Anti-tgf-\u0392\/pd-L1 bispecific antibody promotes T cell infiltration and exhibits enhanced antitumor activity in triple-negative breast cancer","volume":"10","author":"Yi","year":"2022","journal-title":"J Immunother Cancer"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1196970","article-title":"Bispecific antibody targeting tgf-\u0392 and pd-L1 for synergistic cancer immunotherapy","volume":"14","author":"Li","year":"2023","journal-title":"Front Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13045-021-01045-x","article-title":"The construction, expression, and enhanced anti-tumor activity of ym101: A bispecific antibody simultaneously targeting tgf-\u0392 and pd-L1","volume":"14","author":"Yi","year":"2021","journal-title":"J Hematol Oncol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/cac2.12244","article-title":"Anti-pd-L1\/tgf-\u0392r fusion protein (Shr-1701) overcomes disrupted lymphocyte recovery-induced resistance to pd-1\/pd-L1 inhibitors in lung cancer","volume":"42","author":"Cheng","year":"2022","journal-title":"Cancer Commun (London England)"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0785-3","article-title":"Interleukin-33 activates regulatory T cells to suppress innate \u0393\u03b4 T cell responses in the lung","volume":"21","author":"Faustino","year":"2020","journal-title":"Nat Immunol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.21","article-title":"Il-36\u03b3 Signaling controls the induced regulatory T cell-th9 cell balance via nf\u03bab activation and stat transcription factors","volume":"10","author":"Harusato","year":"2017","journal-title":"Mucosal Immunol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.05.027","article-title":"Stat3 transcription factor promotes instability of ntreg cells and limits generation of itreg cells during acute murine graft-versus-host disease","volume":"37","author":"Laurence","year":"2012","journal-title":"Immunity"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1004074","article-title":"Stat4 is critical for the balance between th17 cells and regulatory T cells in colitis","volume":"186","author":"Xu","year":"2011","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3233\/jpd-202417","article-title":"Expression of transcription factors in cd4\u200a+\u200aT cells as potential biomarkers of motor complications in parkinson's disease","volume":"11","author":"Contaldi","year":"2021","journal-title":"J Parkinson's Dis"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1093\/cei\/uxac105","article-title":"Il-2-based approaches to treg enhancement","volume":"211","author":"Harris","year":"2023","journal-title":"Clin Exp Immunol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042617-053352","article-title":"Signaling and function of interleukin-2 in T lymphocytes","volume":"36","author":"Ross","year":"2018","journal-title":"Annu Rev Immunol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/cei.12940","article-title":"Low-dose interleukin-2 promotes stat-5 phosphorylation, T(Reg) survival and ctla-4-dependent function in autoimmune liver diseases","volume":"188","author":"Jeffery","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"134ra62","DOI":"10.1126\/scitranslmed.3003330","article-title":"Cd25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients","volume":"4","author":"Rech","year":"2012","journal-title":"Sci Trans Med"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000612","article-title":"Dynamic roles for il-2-stat5 signaling in effector and regulatory cd4(+) T cell populations","volume":"205","author":"Jones","year":"2020","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B73","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.immuni.2023.01.010","article-title":"Tissue-Specific Abundance of Interferon-Gamma Drives Regulatory T cells to Restrain Dc1-Mediated Priming of Cytotoxic T cells against Lung Cancer","volume":"56","author":"Zagorulya","year":"2023","journal-title":"Immunity"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3540","article-title":"An essential role for the il-2 receptor in T(Reg) cell function","volume":"17","author":"Chinen","year":"2016","journal-title":"Nat Immunol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/ni1536","article-title":"Cd4+Cd25+Foxp3+ Regulatory T cells induce cytokine deprivation-mediated apoptosis of effector cd4+ T cells","volume":"8","author":"Pandiyan","year":"2007","journal-title":"Nat Immunol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.615868","article-title":"Stat6 pathway is critical for the induction and function of regulatory T cells induced by mucosal B cells","volume":"11","author":"Chu","year":"2020","journal-title":"Front Immunol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1209772","article-title":"Regulation of the T helper cell type 2 (Th2)\/T regulatory cell (Treg) balance by il-4 and stat6","volume":"87","author":"Chapoval","year":"2010","journal-title":"J Leukoc Biol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1365-2249.2007.03356.x","article-title":"The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease","volume":"148","author":"Afzali","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.03037.x","article-title":"Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells","volume":"127","author":"O'Malley","year":"2009","journal-title":"Immunology"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646710","article-title":"The il-10\/stat3 axis: Contributions to immune tolerance by thymus and peripherally derived regulatory T-cells","volume":"47","author":"Schmetterer","year":"2017","journal-title":"Eur J Immunol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901024RR","article-title":"Il-10 promotes endothelial progenitor cell infiltration and wound healing via stat3","volume":"36","author":"Short","year":"2022","journal-title":"FASEB J Off Publ Fed Am Societies Exp Biol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.12.018","article-title":"Regulation of the il-23 and il-12 balance by stat3 signaling in the tumor microenvironment","volume":"15","author":"Kortylewski","year":"2009","journal-title":"Cancer Cell"},{"key":"B83","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.dci.2017.03.001","article-title":"Chicken il-26 regulates immune responses through the jak\/stat and nf-\u039ab signaling pathways","volume":"73","author":"Truong","year":"2017","journal-title":"Dev Comp Immunol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.08.001","article-title":"Il-27-induced modulation of autoimmunity and its therapeutic potential","volume":"14","author":"Meka","year":"2015","journal-title":"Autoimmun Rev"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.309","article-title":"A novel potential target of il-35-regulated jak\/stat signaling pathway in lupus nephritis","volume":"11","author":"Cai","year":"2021","journal-title":"Clin Trans Med"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/ni759","article-title":"Stimulation of cd25(+)Cd4(+) regulatory T cells through gitr breaks immunological self-tolerance","volume":"3","author":"Shimizu","year":"2002","journal-title":"Nat Immunol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010436","article-title":"Agonist anti-gitr monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation","volume":"5","author":"Cohen","year":"2010","journal-title":"PloS One"},{"key":"B88","doi-asserted-by":"publisher","first-page":"2582","DOI":"10.1038\/s41467-021-22885-8","article-title":"Targeting treg cells with gitr activation alleviates resistance to immunotherapy in murine glioblastomas","volume":"12","author":"Amoozgar","year":"2021","journal-title":"Nat Commun"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1720447115","article-title":"Comparative transcriptome analysis reveals distinct genetic modules associated with helios expression in intratumoral regulatory T cells","volume":"115","author":"Yates","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"B90","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/eji.202149318","article-title":"Helios is a marker, not a driver, of human treg stability","volume":"52","author":"Lam","year":"2022","journal-title":"Eur J Immunol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.Cir-13-0086","article-title":"Gitr pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability","volume":"1","author":"Schaer","year":"2013","journal-title":"Cancer Immunol Res"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604765113","article-title":"Instability of helios-deficient tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity","volume":"113","author":"Nakagawa","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034547","article-title":"Phenotypic and functional properties of helios+ Regulatory T cells","volume":"7","author":"Zabransky","year":"2012","journal-title":"PloS One"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.11.7240","article-title":"Activation of nf-kappab1 by ox40 contributes to antigen-driven T cell expansion and survival","volume":"180","author":"Song","year":"2008","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B95","doi-asserted-by":"publisher","first-page":"892","DOI":"10.4049\/jimmunol.1101373","article-title":"New insights on ox40 in the control of T cell immunity and immune tolerance in vivo","volume":"188","author":"Xiao","year":"2012","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.06.052","article-title":"Ox40 costimulation inhibits foxp3 expression and treg induction via batf3-dependent and independent mechanisms","volume":"24","author":"Zhang","year":"2018","journal-title":"Cell Rep"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141700","article-title":"Intratumor ox40 stimulation inhibits irf1 expression and il-10 production by treg cells while enhancing cd40l expression by effector memory T cells","volume":"41","author":"Burocchi","year":"2011","journal-title":"Eur J Immunol"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071341","article-title":"Ox40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection","volume":"205","author":"Piconese","year":"2008","journal-title":"J Exp Med"},{"key":"B99","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1749-6632.2009.05125.x","article-title":"Dioxin and immune regulation: Emerging role of aryl hydrocarbon receptor in the generation of regulatory T cells","volume":"1183","author":"Marshall","year":"2010","journal-title":"Ann New York Acad Sci"},{"key":"B100","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/nature06880","article-title":"Control of T(Reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor","volume":"453","author":"Quintana","year":"2008","journal-title":"Nature"},{"key":"B101","doi-asserted-by":"publisher","first-page":"4011","DOI":"10.1038\/s41467-020-17750-z","article-title":"Blockade of the ahr restricts a treg-macrophage suppressive axis induced by L-kynurenine","volume":"11","author":"Campesato","year":"2020","journal-title":"Nat Commun"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-004806","article-title":"Targeting of cdc42 gtpase in regulatory T cells unleashes antitumor T-cell immunity","volume":"10","author":"Kalim","year":"2022","journal-title":"J immunotherapy Cancer"},{"key":"B103","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1158\/0008-5472.Can-06-2925","article-title":"Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses","volume":"67","author":"Hou","year":"2007","journal-title":"Cancer Res"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/nature13444","article-title":"Inactivation of pi(3)K P110\u03b4 Breaks regulatory T-cell-mediated immune tolerance to cancer","volume":"510","author":"Ali","year":"2014","journal-title":"Nature"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-035279","article-title":"Altered activation of akt is required for the suppressive function of human cd4+Cd25+ T regulatory cells","volume":"109","author":"Crellin","year":"2007","journal-title":"Blood"},{"key":"B106","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.it.2016.01.002","article-title":"Ido in the tumor microenvironment: Inflammation, counter-regulation, and tolerance","volume":"37","author":"Munn","year":"2016","journal-title":"Trends Immunol"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abi5781","article-title":"Combined tumor-directed recruitment and protection from immune suppression enable car T cell efficacy in solid tumors","volume":"7","author":"Cadilha","year":"2021","journal-title":"Sci Adv"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1621280114","article-title":"Ccr8(+)Foxp3(+) T(Reg) cells as master drivers of immune regulation","volume":"114","author":"Barsheshet","year":"2017","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-020-02583-y","article-title":"Ccr8 blockade primes anti-tumor immunity through intratumoral regulatory T cells destabilization in muscle-invasive bladder cancer","volume":"69","author":"Wang","year":"2020","journal-title":"Cancer Immunol Immunother CII"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.15586\/aei.v50i5.654","article-title":"Cinnamtannin D1 ameliorates dss-induced colitis by preventing th17\/treg imbalance through activation of the ampk\/mtor pathway","volume":"50","author":"Yang","year":"2022","journal-title":"Allergol Immunopathol"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15987","article-title":"Extracellular Vesicles produced by bone Marrow Mesenchymal Stem Cells Overexpressing Programmed Death-Ligand 1 Ameliorate Dextran Sodium Sulfate-Induced Ulcerative Colitis in Rats by Regulating Th17\/Treg Cell Balance through Pten\/Pi3k\/Akt\/Mtor Axis","volume":"37","author":"He","year":"2022","journal-title":"J Gastroenterol Hepatol"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.049","article-title":"Cd28 Signaling Controls Metabolic fitness of Pathogenic T Cells in Medium and Large vessel vasculitis","volume":"73","author":"Zhang","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"B113","doi-asserted-by":"publisher","first-page":"5005","DOI":"10.1038\/s41467-020-18731-y","article-title":"Hif-2\u03b1 Is indispensable for regulatory T cell function","volume":"11","author":"Hsu","year":"2020","journal-title":"Nat Commun"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(18)30485-9","article-title":"Sirolimus in Patients with Clinically Active Systemic Lupus Erythematosus Resistant to, or Intolerant of, Conventional Medications: A Single-Arm, Open-Label, Phase 1\/2 Trial","volume":"391","author":"Lai","year":"2018","journal-title":"Lancet (London England)"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.2174\/092986707780059599","article-title":"The janus face of cd4+Cd25+ Regulatory T cells in cancer and autoimmunity","volume":"14","author":"Danese","year":"2007","journal-title":"Curr Med Chem"},{"key":"B116","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/nm.3411","article-title":"Regulatory T cell proliferative potential is impaired in human autoimmune disease","volume":"20","author":"Carbone","year":"2014","journal-title":"Nat Med"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.11.024","article-title":"An oscillatory switch in mtor kinase activity sets regulatory T cell responsiveness","volume":"33","author":"Procaccini","year":"2010","journal-title":"Immunity"},{"key":"B118","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.critrevonc.2004.09.009","article-title":"Rapamycin: an anti-cancer immunosuppressant","volume":"56","author":"Law","year":"2005","journal-title":"Crit Rev Oncol Hematol"},{"key":"B119","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.it.2023.06.001","article-title":"Targeting the metabolism of tumor-infiltrating regulatory T cells","volume":"44","author":"Wang","year":"2023","journal-title":"Trends Immunol"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.01.001","article-title":"Rapamycin: One drug, many effects","volume":"19","author":"Li","year":"2014","journal-title":"Cell Metab"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-10-4158","article-title":"Transcriptional control of cellular metabolism by mtor signaling","volume":"71","author":"Yecies","year":"2011","journal-title":"Cancer Res"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2023.103112","article-title":"Mtor-dependent loss of pon1 secretion and antiphospholipid autoantibody production underlie autoimmunity-mediated cirrhosis in transaldolase deficiency","volume":"140","author":"Winans","year":"2023","journal-title":"J Autoimmun"},{"key":"B123","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s42255-022-00711-9","article-title":"Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis","volume":"5","author":"Oaks","year":"2023","journal-title":"Nat Metab"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3577","article-title":"Foxp3 and toll-like receptor signaling balance T(Reg) cell anabolic metabolism for suppression","volume":"17","author":"Gerriets","year":"2016","journal-title":"Nat Immunol"},{"key":"B125","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.immuni.2017.10.017","article-title":"Regulatory T cell migration is dependent on glucokinase-mediated glycolysis","volume":"47","author":"Kishore","year":"2017","journal-title":"Immunity"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00151","article-title":"Regulation of T cell homeostasis and responses by pten","volume":"3","author":"Newton","year":"2012","journal-title":"Front Immunol"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1038\/nature11581","article-title":"Novel foxo1-dependent transcriptional programs control T(Reg) cell function","volume":"491","author":"Ouyang","year":"2012","journal-title":"Nature"},{"key":"B128","doi-asserted-by":"publisher","first-page":"11877","DOI":"10.3390\/ijms231911877","article-title":"Foxo transcription factors: applicability as a novel immune cell regulators and therapeutic targets in oxidative stress-related diseases","volume":"23","author":"Kim","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.cmet.2016.12.018","article-title":"Foxp3 reprograms T cell metabolism to function in low-glucose, high-lactate environments","volume":"25","author":"Angelin","year":"2017","journal-title":"Cell Metab"},{"key":"B130","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.immuni.2019.10.001","article-title":"Amino acids license kinase mtorc1 activity and treg cell function via small G proteins rag and rheb","volume":"51","author":"Shi","year":"2019","journal-title":"Immunity"},{"key":"B131","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.cmet.2020.03.004","article-title":"Glutathione restricts serine metabolism to preserve regulatory T cell function","volume":"31","author":"Kurniawan","year":"2020","journal-title":"Cell Metab"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003613","article-title":"Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory cd4+ T cell subsets","volume":"186","author":"Michalek","year":"2011","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B133","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12964-022-00849-9","article-title":"The Activation of Ppar\u03b3 Enhances Treg Responses through up-Regulating Cd36\/Cpt1-Mediated Fatty Acid Oxidation and Subsequent N-Glycan Branching of T\u03b2rii\/Il-2r\u03b1","volume":"20","author":"Miao","year":"2022","journal-title":"Cell Commun Signal CCS"},{"key":"B134","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/s41590-019-0589-5","article-title":"Cd36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors","volume":"21","author":"Wang","year":"2020","journal-title":"Nat Immunol"},{"key":"B135","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.1016\/j.celrep.2019.05.020","article-title":"Activation of mevalonate pathway via lkb1 is essential for stability of T(Reg) cells","volume":"27","author":"Timilshina","year":"2019","journal-title":"Cell Rep"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03235-6","article-title":"Lipid signalling enforces functional specialization of T(Reg) cells in tumours","volume":"591","author":"Lim","year":"2021","journal-title":"Nature"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129786","article-title":"Methylcholanthrene-induced sarcomas develop independently from nox2-derived ros","volume":"10","author":"Ligtenberg","year":"2015","journal-title":"PloS One"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.10.020","article-title":"Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling","volume":"38","author":"Sena","year":"2013","journal-title":"Immunity"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0846-z","article-title":"Mitochondrial complex iii is essential for suppressive function of regulatory T cells","volume":"565","author":"Weinberg","year":"2019","journal-title":"Nature"},{"key":"B140","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.celrep.2019.06.024","article-title":"Requirement of mitochondrial transcription factor a in tissue-resident regulatory T cell maintenance and function","volume":"28","author":"Fu","year":"2019","journal-title":"Cell Rep"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.133","article-title":"The role of all-trans retinoic acid in the biology of foxp3+ Regulatory T cells","volume":"12","author":"Liu","year":"2015","journal-title":"Cell Mol Immunol"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-004747","article-title":"Il-2 regulates foxp3 expression in human cd4+Cd25+ Regulatory T cells through a stat-dependent mechanism and induces the expansion of these cells in vivo","volume":"108","author":"Zorn","year":"2006","journal-title":"Blood"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00869-y","article-title":"Retinoic acid signaling acts as a rheostat to balance treg function","volume":"19","author":"Thangavelu","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"B144","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/s1874-6047(06)80003-x","article-title":"1 protein methyltransferases: their distribution among the five structural classes of adomet-dependent methyltransferases","volume":"24","author":"Schubert","year":"2006","journal-title":"Enzymes"},{"key":"B145","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jaut.2018.09.011","article-title":"Arginine methylation of foxp3 is crucial for the suppressive function of regulatory T cells","volume":"97","author":"Kagoya","year":"2019","journal-title":"J Autoimmun"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00174","article-title":"Prmt5 associates with the foxp3 homomer and when disabled enhances targeted P185(Erbb2\/neu) tumor immunotherapy","volume":"10","author":"Nagai","year":"2019","journal-title":"Front Immunol"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00621","article-title":"Prmt5 is required for T cell survival and proliferation by maintaining cytokine signaling","volume":"11","author":"Tanaka","year":"2020","journal-title":"Front Immunol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1172\/jci131254","article-title":"Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated th17 responses and autoimmunity","volume":"130","author":"Webb","year":"2020","journal-title":"J Clin Invest"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2016.1216971","article-title":"Panobinostat for the treatment of acute myelogenous leukemia","volume":"25","author":"Morabito","year":"2016","journal-title":"Expert Opin investigational Drugs"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-207118","article-title":"Regulation of treg functionality by acetylation-mediated foxp3 protein stabilization","volume":"115","author":"van Loosdregt","year":"2010","journal-title":"Blood"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100903","article-title":"Three novel acetylation sites in the foxp3 transcription factor regulate the suppressive activity of regulatory T cells","volume":"188","author":"Kwon","year":"2012","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3286","article-title":"Inhibition of P300 impairs foxp3\u207a T regulatory cell function and promotes antitumor immunity","volume":"19","author":"Liu","year":"2013","journal-title":"Nat Med"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(00)80452-9","article-title":"Hats off: selective synthetic inhibitors of the histone acetyltransferases P300 and pcaf","volume":"5","author":"Lau","year":"2000","journal-title":"Mol Cell"},{"key":"B154","doi-asserted-by":"publisher","first-page":"3993","DOI":"10.1128\/mcb.00919-14","article-title":"Two histone\/protein acetyltransferases, cbp and P300, are indispensable for foxp3+ T-regulatory cell development and function","volume":"34","author":"Liu","year":"2014","journal-title":"Mol Cell Biol"},{"key":"B155","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.yexmp.2013.04.003","article-title":"Lysosome-dependent P300\/foxp3 degradation and limits treg cell functions and enhances targeted therapy against cancers","volume":"95","author":"Du","year":"2013","journal-title":"Exp Mol Pathol"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aai9297","article-title":"Suppression by human foxp3(+) regulatory T cells requires foxp3-tip60 interactions","volume":"2","author":"Bin Dhuban","year":"2017","journal-title":"Sci Immunol"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13357","article-title":"Foxp3 in T(Reg) cell biology: A molecular and structural perspective","volume":"199","author":"Deng","year":"2020","journal-title":"Clin Exp Immunol"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.313","article-title":"Chemical phylogenetics of histone deacetylases","volume":"6","author":"Bradner","year":"2010","journal-title":"Nat Chem Biol"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxm043","article-title":"Foxp3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human xlaad\/ipex autoimmune disease","volume":"19","author":"Li","year":"2007","journal-title":"Int Immunol"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1172\/jci77088","article-title":"Foxp3+ Regulatory T cell development and function require histone\/protein deacetylase 3","volume":"125","author":"Wang","year":"2015","journal-title":"J Clin Invest"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.05155-11","article-title":"Histone deacetylase 6 and heat shock protein 90 control the functions of foxp3(+) T-regulatory cells","volume":"31","author":"de Zoeten","year":"2011","journal-title":"Mol Cell Biol"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000082","article-title":"Genome-wide identification of human foxp3 target genes in natural regulatory T cells","volume":"185","author":"Sadlon","year":"2010","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700298104","article-title":"Foxp3 interactions with histone acetyltransferase and class ii histone deacetylases are required for repression","volume":"104","author":"Li","year":"2007","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1038\/nm1652","article-title":"Deacetylase inhibition promotes the generation and function of regulatory T cells","volume":"13","author":"Tao","year":"2007","journal-title":"Nat Med"},{"key":"B165","doi-asserted-by":"publisher","first-page":"ra45","DOI":"10.1126\/scisignal.2002873","article-title":"Histone deacetylases 6 and 9 and sirtuin-1 control foxp3+ Regulatory T cell function through shared and isoform-specific mechanisms","volume":"5","author":"Beier","year":"2012","journal-title":"Sci Signaling"},{"key":"B166","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41598-019-57294-x","article-title":"Hdac10 deletion promotes foxp3(+) T-regulatory cell function","volume":"10","author":"Dahiya","year":"2020","journal-title":"Sci Rep"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.087585","article-title":"Sirt1 regulates autoacetylation and histone acetyltransferase activity of tip60","volume":"285","author":"Wang","year":"2010","journal-title":"J Biol Chem"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.575266","article-title":"Regulation of histone acetyltransferase tip60 function by histone deacetylase 3","volume":"289","author":"Yi","year":"2014","journal-title":"J Biol Chem"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.668442","article-title":"Mammalian sterile 20-like kinase 1 (Mst1) enhances the stability of forkhead box P3 (Foxp3) and the function of regulatory T cells by modulating foxp3 acetylation","volume":"290","author":"Li","year":"2015","journal-title":"J Biol Chem"},{"key":"B170","doi-asserted-by":"publisher","first-page":"8626","DOI":"10.1038\/s41598-017-09211-3","article-title":"Histone\/protein deacetylase 11 targeting promotes foxp3+ Treg function","volume":"7","author":"Huang","year":"2017","journal-title":"Sci Rep"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.467704","article-title":"Foxp3 protein stability is regulated by cyclin-dependent kinase 2","volume":"288","author":"Morawski","year":"2013","journal-title":"J Biol Chem"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202313","article-title":"Cyclin-dependent kinase 2 controls peripheral immune tolerance","volume":"189","author":"Chunder","year":"2012","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.586651","article-title":"Pim1 Kinase Phosphorylates the Human Transcription Factor Foxp3 at Serine 422 to Negatively Regulate Its Activity under Inflammation","volume":"289","author":"Li","year":"2014","journal-title":"J Biol Chem"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.638221","article-title":"Pim-2 kinase influences regulatory T cell function and stability by mediating foxp3 protein N-terminal phosphorylation","volume":"290","author":"Deng","year":"2015","journal-title":"J Biol Chem"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.9.5794","article-title":"Cutting edge: foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in rapamycin","volume":"180","author":"Basu","year":"2008","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077099","article-title":"Phosphorylation of foxp3 by lck downregulates mmp9 expression and represses cell invasion","volume":"8","author":"Nakahira","year":"2013","journal-title":"PloS One"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1280741","article-title":"Targeting post-translational modifications of foxp3: A new paradigm for regulatory T cell-specific therapy","volume":"14","author":"Riaz","year":"2023","journal-title":"Front Immunol"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3085","article-title":"Phosphorylation of foxp3 controls regulatory T cell function and is inhibited by tnf-\u0391 in rheumatoid arthritis","volume":"19","author":"Nie","year":"2013","journal-title":"Nat Med"},{"key":"B179","doi-asserted-by":"publisher","first-page":"3600","DOI":"10.1016\/j.celrep.2019.02.087","article-title":"Nemo-like kinase drives foxp3 stability and is critical for maintenance of immune tolerance by regulatory T cells","volume":"26","author":"Fleskens","year":"2019","journal-title":"Cell Rep"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.08.006","article-title":"The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor foxp3","volume":"39","author":"Chen","year":"2013","journal-title":"Immunity"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12250","article-title":"Protein monoubiquitylation: Targets and diverse functions","volume":"20","author":"Nakagawa","year":"2015","journal-title":"Genes to Cells devoted to Mol Cell Mech"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1002\/iub.589","article-title":"Protein monoubiquitination and polyubiquitination generate structural diversity to control distinct biological processes","volume":"64","author":"Sadowski","year":"2012","journal-title":"IUBMB Life"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-09-1225","article-title":"Lysine 63 polyubiquitination in immunotherapy and in cancer-promoting inflammation","volume":"15","author":"Martinez-Forero","year":"2009","journal-title":"Clin Cancer Res an Off J Am Assoc Cancer Res"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2012.105","article-title":"Lubac synthesizes linear ubiquitin chains via a thioester intermediate","volume":"13","author":"Stieglitz","year":"2012","journal-title":"EMBO Rep"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1038\/nature09816","article-title":"Linear ubiquitination prevents inflammation and regulates immune signalling","volume":"471","author":"Gerlach","year":"2011","journal-title":"Nature"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160041","article-title":"\u2013lubac Deficiency Perturbs Tlr3 Signaling to Cause Immunodeficiency and Autoinflammation","volume":"213","author":"Zinngrebe","year":"2016","journal-title":"J Exp Med"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.04.014","article-title":"The ubiquitin ligase xiap recruits lubac for nod2 signaling in inflammation and innate immunity","volume":"46","author":"Damgaard","year":"2012","journal-title":"Mol Cell"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132486","article-title":"The linear ubiquitin assembly complex (Lubac) is essential for nlrp3 inflammasome activation","volume":"211","author":"Rodgers","year":"2014","journal-title":"J Exp Med"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.005802","article-title":"Ring finger protein 31-mediated atypical ubiquitination stabilizes forkhead box P3 and thereby stimulates regulatory T-cell function","volume":"293","author":"Zhu","year":"2018","journal-title":"J Biol Chem"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242554","article-title":"Stub1 is essential for T-cell activation by ubiquitinating carma1","volume":"43","author":"Wang","year":"2013","journal-title":"Eur J Immunol"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(03)00230-9","article-title":"Traf6 is a critical factor for dendritic cell maturation and development","volume":"19","author":"Kobayashi","year":"2003","journal-title":"Immunity"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201899766","article-title":"Traf6 directs foxp3 localization and facilitates regulatory T-cell function through K63-linked ubiquitination","volume":"38","author":"Ni","year":"2019","journal-title":"EMBO J"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.11.007","article-title":"A genomic and functional inventory of deubiquitinating enzymes","volume":"123","author":"Nijman","year":"2005","journal-title":"Cell"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.05.018","article-title":"Stabilization of the transcription factor foxp3 by the deubiquitinase usp7 increases treg-cell-suppressive capacity","volume":"39","author":"van Loosdregt","year":"2013","journal-title":"Immunity"},{"key":"B195","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ebiom.2016.10.018","article-title":"Ubiquitin-specific protease-7 inhibition impairs tip60-dependent foxp3+ T-regulatory cell function and promotes antitumor immunity","volume":"13","author":"Wang","year":"2016","journal-title":"EBioMedicine"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13559","article-title":"Usp21 prevents the generation of T-helper-1-like treg cells","volume":"7","author":"Li","year":"2016","journal-title":"Nat Commun"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.374744","article-title":"Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (Usp21) as a positive regulator of the transcription factor gata3","volume":"288","author":"Zhang","year":"2013","journal-title":"J Biol Chem"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2246-4","article-title":"Crispr screen in regulatory T cells reveals modulators of foxp3","volume":"582","author":"Cortez","year":"2020","journal-title":"Nature"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202050308","article-title":"The deubiquitinase usp44 promotes treg function during inflammation by preventing foxp3 degradation","volume":"21","author":"Yang","year":"2020","journal-title":"EMBO Rep"},{"key":"B200","doi-asserted-by":"publisher","first-page":"3157","DOI":"10.1038\/s41467-018-05676-6","article-title":"Senp3 maintains the stability and function of regulatory T cells via bach2 desumoylation","volume":"9","author":"Yu","year":"2018","journal-title":"Nat Commun"},{"key":"B201","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12929-020-00648-9","article-title":"O-glcnacylation and its role in the immune system","volume":"27","author":"Chang","year":"2020","journal-title":"J Biomed Sci"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00987","article-title":"Distinctive surface glycosylation patterns associated with mouse and human cd4(+) regulatory T cells and their suppressive function","volume":"8","author":"Cabral","year":"2017","journal-title":"Front Immunol"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1038\/nature05815","article-title":"Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins","volume":"446","author":"Hart","year":"2007","journal-title":"Nature"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwab001","article-title":"Negative regulation of foxp3 expression by C-rel O-glcnacylation","volume":"31","author":"de Jesus","year":"2021","journal-title":"Glycobiology"},{"key":"B205","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/s41467-019-08300-3","article-title":"The lineage stability and suppressive program of regulatory T cells require protein O-glcnacylation","volume":"10","author":"Liu","year":"2019","journal-title":"Nat Commun"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2022.06.008","article-title":"Therapeutic targeting of regulatory T cells in cancer","volume":"8","author":"Shan","year":"2022","journal-title":"Trends Cancer"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1215-2","article-title":"Targeting the cbm complex causes T(Reg) cells to prime tumours for immune checkpoint therapy","volume":"570","author":"Di Pilato","year":"2019","journal-title":"Nature"},{"key":"B208","doi-asserted-by":"publisher","first-page":"61","DOI":"10.36401\/jipo-22-18","article-title":"Translational studies using the malt1 inhibitor (S)-mepazine to induce treg fragility and potentiate immune checkpoint therapy in cancer","volume":"6","author":"Di Pilato","year":"2023","journal-title":"J immunotherapy Precis Oncol"},{"key":"B209","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/s41419-021-03999-9","article-title":"Srebp1 site 1 protease inhibitor pf-429242 suppresses renal cell carcinoma cell growth","volume":"12","author":"Wang","year":"2021","journal-title":"Cell Death Dis"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0603-2","article-title":"Sphingosine-1-phosphate (S1p) and S1p signaling pathway: Therapeutic targets in autoimmunity and inflammation","volume":"76","author":"Tsai","year":"2016","journal-title":"Drugs"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1939","article-title":"The S1p(1)-mtor axis directs the reciprocal differentiation of T(H)1 and T(Reg) cells","volume":"11","author":"Liu","year":"2010","journal-title":"Nat Immunol"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2016.1138183","article-title":"A pten inhibitor displays preclinical activity against hepatocarcinoma cells","volume":"15","author":"Augello","year":"2016","journal-title":"Cell Cycle (Georgetown Tex)"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29713","article-title":"Synergistic antitumor responses by combined gitr activation and sunitinib in metastatic renal cell carcinoma","volume":"138","author":"Yu","year":"2016","journal-title":"Int J Cancer"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2850-3","article-title":"Cancer immunotherapy via targeted tgf-\u0392 Signalling blockade in T(H) cells","volume":"587","author":"Li","year":"2020","journal-title":"Nature"},{"key":"B215","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s13045-021-01155-6","article-title":"Combine and conquer: Manganese synergizing anti-tgf-\u0392\/pd-L1 bispecific antibody ym101 to overcome immunotherapy resistance in non-inflamed cancers","volume":"14","author":"Yi","year":"2021","journal-title":"J Hematol Oncol"},{"key":"B216","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.3390\/pharmaceutics14122753","article-title":"Ox40-ox40l inhibition for the treatment of atopic dermatitis-focus on rocatinlimab and amlitelimab","volume":"14","author":"L\u00e9","year":"2022","journal-title":"Pharmaceutics"},{"key":"B217","doi-asserted-by":"publisher","first-page":"3744","DOI":"10.3390\/molecules26123744","article-title":"Combined ox40 agonist and pd-1 inhibitor immunotherapy improves the efficacy of vascular targeted photodynamic therapy in a urothelial tumor model","volume":"26","author":"Alvim","year":"2021","journal-title":"Molecules (Basel Switzerland)"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.2174\/1871520619666190415165212","article-title":"The opposite effect of L-kynurenine and ahr inhibitor ch223191 on apoptotic protein expression in pancreatic carcinoma cells (Panc-1)","volume":"19","author":"Leja-Szpak","year":"2019","journal-title":"Anti-cancer Agents medicinal Chem"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10816","article-title":"Ido inhibitor synergized with radiotherapy to delay tumor growth by reversing T cell exhaustion","volume":"21","author":"Liu","year":"2020","journal-title":"Mol Med Rep"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001749","article-title":"Therapeutic depletion of ccr8(+) tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-pd-1 therapy","volume":"9","author":"Van Damme","year":"2021","journal-title":"J immunotherapy Cancer"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-203012","article-title":"Antagonism of chemokine receptor ccr8 is ineffective in a primate model of asthma","volume":"68","author":"Wang","year":"2013","journal-title":"Thorax"},{"key":"B222","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.molcel.2018.07.030","article-title":"Metformin promotes antitumor immunity via endoplasmic-reticulum-associated degradation of pd-L1","volume":"71","author":"Cha","year":"2018","journal-title":"Mol Cell"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.10.009","article-title":"Attenuation of cd4(+)Cd25(+) regulatory T cells in the tumor microenvironment by metformin, a type 2 diabetes drug","volume":"25","author":"Kunisada","year":"2017","journal-title":"EBioMedicine"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.11817\/j.issn.1672-7347.2021.200063","article-title":"Oligomycin a promotes radioresistance in ht29 colorectal cancer cells and its mechanisms","volume":"46","author":"Li","year":"2021","journal-title":"Zhong nan da xue xue bao Yi xue ban = J Cent South Univ Med Sci"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-07-0389","article-title":"Chemical inhibition of acetyl-coa carboxylase induces growth arrest and cytotoxicity selectively in cancer cells","volume":"67","author":"Beckers","year":"2007","journal-title":"Cancer Res"},{"key":"B226","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s00125-014-3456-9","article-title":"Pioglitazone and bladder cancer risk: A multipopulation pooled, cumulative exposure analysis","volume":"58","author":"Levin","year":"2015","journal-title":"Diabetologia"},{"key":"B227","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1186\/s12951-021-01058-1","article-title":"Simvastatin induced ferroptosis for triple-negative breast cancer therapy","volume":"19","author":"Yao","year":"2021","journal-title":"J nanobiotechnology"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111858","article-title":"The potential use of simvastatin for cancer treatment: A review","volume":"141","author":"Duarte","year":"2021","journal-title":"Biomedicine pharmacotherapy = Biomedecine pharmacotherapie"},{"key":"B229","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.celrep.2019.03.029","article-title":"Hif-1\u03b1 Is a metabolic switch between glycolytic-driven migration and oxidative phosphorylation-driven immunosuppression of tregs in glioblastoma","volume":"27","author":"Miska","year":"2019","journal-title":"Cell Rep"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2020-0307","article-title":"Novel hif-1\u03b1 Inhibitor cdmp-tqz for cancer therapy","volume":"13","author":"Chu","year":"2021","journal-title":"Future medicinal Chem"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106400","article-title":"Advances in antitumor research of hif-1\u03b1 Inhibitor yc-1 and its derivatives","volume":"133","author":"Ouyang","year":"2023","journal-title":"Bioorganic Chem"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-011-1021-3","article-title":"A novel approach to cancer therapy using px-478 as a hif-1\u03b1 Inhibitor","volume":"34","author":"Lee","year":"2011","journal-title":"Arch pharmacal Res"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2020.102278","article-title":"Liposomal formulation of hif-1\u03b1 Inhibitor echinomycin eliminates established metastases of triple-negative breast cancer","volume":"29","author":"Bailey","year":"2020","journal-title":"Nanomedicine nanotechnology biology Med"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2021.105129","article-title":"Impact of a cd36 inhibitor on porphyromonas gingivalis mediated atherosclerosis","volume":"126","author":"Rekhi","year":"2021","journal-title":"Arch Oral Biol"},{"key":"B235","doi-asserted-by":"publisher","first-page":"2806","DOI":"10.1038\/s41467-023-38443-3","article-title":"Prmt1 mediated methylation of cgas suppresses anti-tumor immunity","volume":"14","author":"Liu","year":"2023","journal-title":"Nat Commun"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-1270-z","article-title":"P300\/cbp inhibition enhances the efficacy of programmed death-ligand 1 blockade treatment in prostate cancer","volume":"39","author":"Liu","year":"2020","journal-title":"Oncogene"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.2a0618-228r","article-title":"Phosphatase inhibitor ppp1r11 modulates resistance of human T cells toward treg-mediated suppression of cytokine expression","volume":"106","author":"Joshi","year":"2019","journal-title":"J leukocyte Biol"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100655","article-title":"Rnf31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells","volume":"3","author":"Zhang","year":"2022","journal-title":"Cell Rep Med"},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105965","article-title":"Traf6 inhibitor boosts antitumor immunity by impeding regulatory T cell migration in hepa1-6 tumor model","volume":"77","author":"Wu","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-01093-y","article-title":"The ox40-traf6 axis promotes ctla-4 degradation to augment antitumor cd8(+) T-cell immunity","volume":"20","author":"Yu","year":"2023","journal-title":"Cell Mol Immunol"},{"key":"B241","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.canlet.2020.05.021","article-title":"Combined administration of a small-molecule inhibitor of traf6 and docetaxel reduces breast cancer skeletal metastasis and osteolysis","volume":"488","author":"Bishop","year":"2020","journal-title":"Cancer Lett"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2016.151","article-title":"Regulatory T cells in cancer immunotherapy","volume":"27","author":"Tanaka","year":"2017","journal-title":"Cell Res"},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205044","article-title":"Integrated single-cell and bulk rna sequencing revealed the molecular characteristics and prognostic roles of neutrophils in pancreatic cancer","volume":"15","author":"Zhang","year":"2023","journal-title":"Aging"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1244752","article-title":"Integrated multi-omics identified the novel intratumor microbiome-derived subtypes and signature to predict the outcome, tumor microenvironment heterogeneity, and immunotherapy response for pancreatic cancer patients","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Pharmacol"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1039786","article-title":"Metabolomics study identified bile acids as potential biomarkers for gastric cancer: A case control study","volume":"13","author":"Pan","year":"2022","journal-title":"Front Endocrinol"},{"key":"B246","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s41573-021-00371-6","article-title":"Protac targeted protein degraders: The past is prologue","volume":"21","author":"B\u00e9k\u00e9s","year":"2022","journal-title":"Nat Rev Drug Discovery"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.T300009-MCP200","article-title":"Development of protacs to target cancer-promoting proteins for ubiquitination and degradation","volume":"2","author":"Sakamoto","year":"2003","journal-title":"Mol Cell Proteomics MCP"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.141230798","article-title":"Protacs: chimeric molecules that target proteins to the skp1-cullin-F box complex for ubiquitination and degradation","volume":"98","author":"Sakamoto","year":"2001","journal-title":"Proc Natl Acad Sci United States America"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1345838\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T04:35:01Z","timestamp":1708490101000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1345838\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,21]]},"references-count":248,"alternative-id":["10.3389\/fimmu.2024.1345838"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1345838","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,21]]},"article-number":"1345838"}}