{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:02:48Z","timestamp":1792638168529,"version":"4.5.0"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Innate immune training is a metabolic, functional, and epigenetic long-term reprogramming of innate cells triggered by different stimuli. This imprinting also reaches hematopoietic precursors in the bone marrow to sustain a memory-like phenotype. Dendritic cells (DCs) can exhibit memory-like responses, enhanced upon subsequent exposure to a pathogen; however, whether this imprinting is lineage and stimulus-restricted is still being determined. Nevertheless, the functional consequences of DCs training on the adaptive and protective immune response against non-infectious diseases remain unresolved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated the effect of the nontoxic cholera B subunit (CTB), LPS and LTA in the induction of trained immunity in murine DCs revealed by TNFa and LDH expression, through confocal microscopy. Additionally, we obtained bone marrow DCs (BMDCs) from mice treated with CTB, LPS, and LTA and evaluated training features in DCs and their antigen-presenting cell capability using multiparametric cytometry. Finally, we design an experimental melanoma mouse model to demonstrate protection induced by CTB-trained DCs in vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CTB-trained DCs exhibit increased expression of TNFa, and metabolic reprogramming indicated by LDH expression. Moreover, CTB training has an imprint on DC precursors, increasing the number and antigen-presenting function in BMDCs. We found that training by CTB stimulates the recruitment of DC precursors and DCs infiltration at the skin and lymph nodes. Interestingly, training-induced by CTB promotes a highly co-stimulatory phenotype in tumor-infiltrating DCs (CD86+) and a heightened functionality of exhausted CD8 T cells (Ki67+, GZMB+), which were associated with a protective response against melanoma challenge in vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our work indicates that CTB can induce innate immune training on DCs, which turns into an efficient adaptive immune response in the melanoma model and might be a potential immunotherapeutic approach for tumor growth control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2024.1362289","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:37:57Z","timestamp":1715733477000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["The cholera toxin B subunit induces trained immunity in dendritic cells and promotes CD8 T cell antitumor immunity"],"prefix":"10.3389","volume":"15","author":[{"given":"Araceli","family":"Tepale-Segura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n A.","family":"Gaj\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Mu\u00f1oz-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio","family":"Castro-Escamilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Bonifaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.612747","article-title":"Optimize prime\/boost vaccine strategies: Trained immunity as a new player in the game","volume":"12","author":"Palgen","year":"2021","journal-title":"Front Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3178","article-title":"Innate immune memory: A paradigm shift in understanding host defense","volume":"16","author":"Netea","year":"2015","journal-title":"Nat Immunol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.09.013","article-title":"Natural killer cell memory","volume":"43","author":"O\u2019Sullivan","year":"2015","journal-title":"Immunity"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2010.03260.x","article-title":"Memory CD4 T cells: Generation, reactivation and re-assignment","volume":"130","author":"MacLeod","year":"2010","journal-title":"Immunology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/76907","article-title":"Response of na.ve and 521 memory CD8+ T cells to antigen stimulation in vivo","author":"Veiga-Fernandes","year":"2000","journal-title":"Nat Immunol"},{"key":"B6","volume-title":"Trained immunity: A Yin-Yang balance","author":"Hu","year":"2022"},{"key":"B7","doi-asserted-by":"publisher","first-page":"12305","DOI":"10.1038\/s41598-017-12110-2","article-title":"Anti-mycobacterial activity correlates with altered DNA methylation pattern in immune cells from BCG-vaccinated subjects","volume":"7","author":"Verma","year":"2017","journal-title":"Sci Rep"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2014.101","article-title":"Beyond receptors and signaling: Epigenetic factors in the regulation of innate immunity","volume":"93","author":"Mehta","year":"2015","journal-title":"Immunol Cell Biol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.06.006","article-title":"Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes","volume":"12","author":"Quintin","year":"2012","journal-title":"Cell Host Microbe"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251086","article-title":"Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity","volume":"345","author":"Saeed","year":"2014","journal-title":"Sci (1979)"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2021","article-title":"Trained immunity: Adaptation within innate immune mechanisms","volume":"103","author":"Dom\u00ednguez-Andr\u00e9es","year":"2023","journal-title":"Physiol Rev"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202870109","article-title":"Bacille Calmette-Gu\u00e9rin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes","volume":"109","author":"Kleinnijenhuis","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-102119-073855","article-title":"Trained immunity: Reprogramming innate immunity in health and disease","volume":"39","author":"Bekkering","year":"2021","journal-title":"Annu Rev Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2020.100897","article-title":"Immunometabolic control of trained immunity","volume":"77","author":"Riksen","year":"2021","journal-title":"Mol Aspects Med"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1250684","article-title":"MTOR- and HIF-1\u03b1-mediated aerobic glycolysis as metabolic basis for trained immunity","volume":"345","author":"Cheng","year":"2014","journal-title":"Sci (1979)"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.11.011","article-title":"Immunometabolic pathways in BCG-induced trained immunity","volume":"17","author":"Arts","year":"2016","journal-title":"Cell Rep"},{"key":"B18","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.cell.2017.12.031.","article-title":"BCG educates hematopoietic stem cells to generate protective innate immunity against tuberculosis","volume":"172","author":"Kaufmann","year":"2018","journal-title":"Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","article-title":"Modulation of myelopoiesis progenitors is an integral component of trained immunity","volume":"172","author":"Mitroulis","year":"2018","journal-title":"Cell"},{"key":"B20","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/trstmh\/tru168","article-title":"Trained immunity: Consequences for the heterologous effects of BCG vaccination","volume":"109","author":"Kleinnijenhuis","year":"2014","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"B21","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.chom.2020.05.014","article-title":"BCG vaccination in humans elicits trained immunity via the hematopoietic progenitor compartment","volume":"28","author":"Cirovic","year":"2020","journal-title":"Cell Host Microbe"},{"key":"B22","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.stem.2020.01.017","article-title":"C\/EBP\u03b2-dependent epigenetic memory induces trained immunity in hematopoietic stem cells","volume":"26","author":"de Laval","year":"2020","journal-title":"Cell Stem Cell"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2017.13","article-title":"Evaluation of trained immunity by \u03b2-1, 3 (d)-glucan on murine monocytes in vitro and duration of response in vivo","volume":"95","author":"Garcia-Valtanen","year":"2017","journal-title":"Immunol Cell Biol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.699645","article-title":"Fungal chitin induces trained immunity in human monocytes during cross-talk of the host with Saccharomyces cerevisiae","volume":"291","author":"Rizzetto","year":"2016","journal-title":"J Biol Chem"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-019-10486-5","article-title":"Induction of memory-like dendritic cell responses in vivo","volume":"10","author":"Hole","year":"2019","journal-title":"Nat Commun"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.6861","article-title":"CD103\u2013 and CD103+ Bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells","volume":"178","author":"del Rio","year":"2007","journal-title":"J Immunol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.06.003","article-title":"Critical role for CD103+\/CD141+ Dendritic cells bearing CCR7 for tumor antigen trafficking and priming of T cell immunity in melanoma","volume":"30","author":"Roberts","year":"2016","journal-title":"Cancer Cell"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1126\/science.1136080","article-title":"Differential antigen processing by dendritic cell subsets in vivo","volume":"315","author":"Dudziak","year":"2007","journal-title":"Sci (1979)"},{"key":"B29","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.0105-2896.2009.00888.x","article-title":"Features of the dendritic cell lineage","volume":"234","author":"Steinman","year":"2010","journal-title":"Immunol Rev"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.12.001","article-title":"The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells","volume":"45","author":"Menezes","year":"2016","journal-title":"Immunity"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903793","article-title":"Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways","volume":"185","author":"Zhan","year":"2010","journal-title":"J Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.immuni.2017.12.014","article-title":"Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors","volume":"48","author":"Sharma","year":"2018","journal-title":"Immunity"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02212","article-title":"The nontoxic cholera B subunit is a potent adjuvant for intradermal DC-targeted vaccination","volume":"9","author":"Antonio-Herrera","year":"2018","journal-title":"Front Immunol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.583382","article-title":"Induction of progenitor exhausted tissue-resident memory CD8+ T cells upon salmonella typhi porins adjuvant immunization correlates with melanoma control and anti-PD-1 immunotherapy cooperation","volume":"11","author":"Le\u00f3n-Letelier","year":"2020","journal-title":"Front Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.immuni.2022.03.006","article-title":"Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches","volume":"55","author":"D\u00e4hling","year":"2022","journal-title":"Immunity"},{"key":"B36","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1146\/annurev-immunol-020711-074950","article-title":"The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting","volume":"31","author":"Merad","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1146\/annurev-immunol-061020-053707","article-title":"Dendritic cells revisited","volume":"26","author":"Cabeza-Cabrerizo","year":"2021","journal-title":"Annu Rev Immunol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701514","article-title":"Tumor dendritic cells (DCs) derived from precursors of conventional DCs are dispensable for intratumor CTL responses","volume":"201","author":"Diao","year":"2018","journal-title":"J Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1016\/j.immuni.2023.05.011","article-title":"Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses","volume":"56","author":"Bayerl","year":"2023","journal-title":"Immunity"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/sciimmunol.aaw1941","article-title":"Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors","volume":"4","author":"Cabeza-Cabrerizo","year":"2019","journal-title":"Sci Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"3882","DOI":"10.1016\/j.cell.2023.07.019","article-title":"Epigenetic memory of coronavirus infection in innate immune cells and their progenitors","volume":"186","author":"Cheong","year":"2023","journal-title":"Cell"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108325","article-title":"Macrophage immune memory controls endometriosis in mice and humans","volume":"33","author":"Jeljeli","year":"2020","journal-title":"Cell Rep"},{"key":"B43","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.cell.2020.09.058","article-title":"Innate immune training of granulopoiesis promotes anti-tumor activity","volume":"183","author":"Kalafati","year":"2020","journal-title":"Cell"},{"key":"B44","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.chom.2017.12.010","article-title":"BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity","volume":"23","author":"Arts","year":"2018","journal-title":"Cell Host Microbe"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008404","article-title":"New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia","volume":"16","author":"Taranc\u00f3n","year":"2020","journal-title":"PLoS Pathog"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1172\/JCI145157","article-title":"BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers","volume":"131","author":"Rivas","year":"2021","journal-title":"J Clin Invest"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040997","article-title":"Intradermal immunization in the ear with cholera toxin and its non-toxic ?? subunit promotes efficient Th1 and Th17 differentiation dependent on migrating DCs","volume":"41","author":"Meza-S\u00e1nchez","year":"2011","journal-title":"Eur J Immunol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-100610","article-title":"Monocyte migration to inflamed skin and lymph nodes is differentially controlled by L-selectin and PSGL-1","volume":"111","author":"Le\u00f3n","year":"2008","journal-title":"Blood"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.01.017","article-title":"Monocyte-Derived Dendritic Cells Formed at the Infection Site Control the Induction of Protective T Helper 1 Responses against Leishmania","volume":"26","author":"Le\u00f3n","year":"2007","journal-title":"Immunity"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.621039","article-title":"A novel inflammatory dendritic cell that is abundant and contiguous to T cells in the kidneys of patients with lupus nephritis","volume":"12","author":"Parikh","year":"2021","journal-title":"Front Immunol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.coi.2017.06.003","article-title":"Turbocharging vaccines: emerging adjuvants for dendritic cell based therapeutic cancer vaccines","volume":"47","author":"Saxena","year":"2017","journal-title":"Curr Opin Immunol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(93)90039-Z","article-title":"Cholera toxin and cholera B subunit as oral\u2014mucosal adjuvant and antigen vector systems","volume":"11","author":"Holmgren","year":"1993","journal-title":"Vaccine"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3390\/toxins7030974","article-title":"Cholera toxin B: One subunit with many pharmaceutical applications","volume":"7","author":"Baldauf","year":"2015","journal-title":"Toxins. MDPI AG"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2100107","article-title":"\u03b2-glucan induces distinct and protective innate immune memory in differentiated macrophages","volume":"207","author":"Stothers","year":"2021","journal-title":"J Immunol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.20944\/preprints202308.1764.v1","article-title":"Prolonged inhibition of the MEK1\/2-ERK signaling axis primes interleukin-1 beta expression through histone 3 lysine 9 demethylation in murine macrophages","volume":"24","author":"Low","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00349-16","article-title":"In Vitro experimental model of trained innate immunity in human primary monocytes","volume":"23","author":"Bekkering","year":"2016","journal-title":"Clin Vaccine Immunol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90169-4","article-title":"Carbone FR. T cell receptor antagonist peptides induce positive selection","volume":"76","author":"Hogquist","year":"1994","journal-title":"Cell"},{"key":"B58","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.cell.2020.09.059.","article-title":"Trained immunity-promoting nanobiologic therapy suppresses tumor growth and potentiates checkpoint inhibition","volume":"183","author":"Priem","year":"2020","journal-title":"Cell"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2015.05.008","article-title":"Evidence for TLR4 and FcRg \u2013 CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors","volume":"66","author":"Phongsisay","year":"2015","journal-title":"Mol Immunol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.790309","article-title":"GM-CSF programs hematopoietic stem and progenitor cells during candida albicans vaccination for protection against reinfection","volume":"12","author":"Bono","year":"2021","journal-title":"Front Immunol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00680","article-title":"GM-CSF and IL-3 modulate human monocyte TNF-\u03b1 production and renewal in in vitro models of trained immunity","volume":"7","author":"Borriello","year":"2017","journal-title":"Front Immunol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/nri3405","article-title":"Molecular mechanisms of T cell co-stimulation and co-inhibition","volume":"13","author":"Chen","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.9.5936","article-title":"CD86 has sustained costimulatory effects on CD8 T cells","volume":"179","author":"Thomas","year":"2007","journal-title":"J Immunol"},{"key":"B64","article-title":"From Innate Immunity to Immunological Memory","volume":"311","author":"Compans","year":"2006","journal-title":"Current Topics Microbiol Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1016\/j.ccell.2021.10.008","article-title":"Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation","volume":"39","author":"Duraiswamy","year":"2021","journal-title":"Cancer Cell"},{"key":"B66","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3892\/or","article-title":"Ciprofloxacin promotes polarization of CD86+CD206- macrophages to suppress liver cancer","volume":"44","author":"Fan","year":"2020","journal-title":"Oncol Rep"},{"key":"B67","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/cmi.2013.7","article-title":"The liver works as a school to educate regulatory immune cells","volume":"10","author":"Li","year":"2013","journal-title":"Cell Mol Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/ni928","article-title":"Dynamics of CD8 + T cell priming by dendritic cells in intact lymph nodes","volume":"4","author":"Bousso","year":"2003","journal-title":"Nat Immunol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070051","article-title":"Two-photon imaging of lymphocyte motility and antigen response in intact lymph node","volume":"296","author":"Miller","year":"2002","journal-title":"Science (1979)"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.09.040191.001415","article-title":"The Dendritic Cell System and its role in immunogenicity","volume":"9","author":"Steinman","year":"1991","journal-title":"Annu Rev Immunol."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-020-00652-x","article-title":"Lactate exposure promotes immunosuppressive phenotypes in innate immune cells","volume":"13","author":"Sangsuwan","year":"2020","journal-title":"Cell Mol Bioeng"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms21218363","article-title":"Lactic acid and an acidic tumor microenvironment suppress anticancer immunity","volume":"21","author":"Wang","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1016\/j.ccell.2023.06.008","article-title":"A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity","volume":"41","author":"Meiser","year":"2023","journal-title":"Cancer Cell"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02990","article-title":"CD8+XCR1neg dendritic cells express high levels of toll-like receptor 5 and a unique complement of endocytic receptors","volume":"10","author":"Wylie","year":"2019","journal-title":"Front Immunol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2370","article-title":"Deciphering the transcriptional network of the dendritic cell lineage","volume":"13","author":"Miller","year":"2012","journal-title":"Nat Immunol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1016\/j.immuni.2021.08.026","article-title":"Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes","volume":"54","author":"Schenkel","year":"2021","journal-title":"Immunity"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1097\/01.cji.0000211316.15278.6e","article-title":"Polarized type-1 dendritic cells (DC1) producing high levels of IL-12 family members rescue patient T H 1-type antimelanoma CD4 + T cell responses in vitro","volume":"30","author":"Wesa","year":"2006","journal-title":"J Immunotherapy"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-012-0144-7","article-title":"Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-\u03baB signaling improves the efficacy of immunotherapy in a brain cancer model","volume":"9","author":"Mineharu","year":"2012","journal-title":"Neurotherapeutics"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adg0878","article-title":"Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1 + PD-1 + CD8 T cells","volume":"8","author":"Humblin","year":"2023","journal-title":"Sci Immunol."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05257-0","article-title":"PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program","volume":"610","author":"Hashimoto","year":"2022","journal-title":"Nature"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2022.04.051","article-title":"Oral MucoRice-CTB vaccine is safe and immunogenic in healthy US adults","volume":"40","author":"Yuki","year":"2022","journal-title":"Vaccine"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1362289\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:38:01Z","timestamp":1715733481000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1362289\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,15]]},"references-count":81,"alternative-id":["10.3389\/fimmu.2024.1362289"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1362289","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,15]]},"article-number":"1362289"}}