{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:07:36Z","timestamp":1773119256032,"version":"3.50.1"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Chronic obstructive lung diseases, such as asthma and COPD, appear to have a more extensive impact on overall functioning than previously believed. The latest data from clinical trials suggests a potential link between cognitive deterioration and chronic obstructive inflammatory lung disease. This raises the question of whether these diseases affect cognitive functions and whether any relevant biomarker may be identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective observational study included 78 patients divided equally into asthma, COPD, and control groups (n=26, 27 and 25 respectively). The participants underwent identical examinations at the beginning of the study and after at least 12 months. The test battery comprised 16 questionnaires (11 self-rated, 5 observer-rated, assessing cognition and mental state), spirometry, and blood samples taken for PKA and CREB mRNA evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 2.3-fold increase in CREB mRNA was observed between examinations (p=0.014) for all participants; no distinctions were observed between the asthma, COPD, and control groups. Pooled, adjusted data revealed a borderline interaction between diagnosis and CREB expression in predicting MMSE (p=0.055) in COPD, CREB expression is also associated with MMSE (\u03b2=0.273, p=0.034) like with the other conducted tests (\u03b2=0.327, p=0.024) from COPD patients. No correlations were generally found for PKA, although one significant negative correlation was found between the first and second time points in the COPD group (\u03b2=-0.4157, p=0.049),.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Chronic obstructive lung diseases, such as asthma and COPD, may have some linkage to impairment of cognitive functions. However, the noted rise in CREB mRNA expression might suggest a potential avenue for assessing possible changes in cognition, especially in COPD; such findings may reveal additional transcription factors linked to cognitive decline.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2024.1363373","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T04:39:55Z","timestamp":1721623195000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Potential association between obstructive lung diseases and cognitive decline"],"prefix":"10.3389","volume":"15","author":[{"given":"Magdalena","family":"Figat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Wi\u015bniewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Plichta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Mi\u0142kowska-Dymanowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Majewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142 S.","family":"Karbownik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Kuna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142 G.","family":"Panek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160487","article-title":"Cellular and molecular mechanisms of asthma and COPD","volume":"131","author":"Barnes","year":"2017","journal-title":"Clin Sci"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.8.577","article-title":"New insights into the role of cytokines in asthma","volume":"54","author":"Renauld","year":"2001","journal-title":"J Clin Pathol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.07.066","article-title":"The participation of oxidative stress in the pathogenesis of bronchial asthma","volume":"94","author":"Kleniewska","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.018","article-title":"The cytokines of asthma","volume":"50","author":"Lambrecht","year":"2019","journal-title":"Immunity"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.2_suppl.10S","article-title":"Mechanisms in COPD: differences from asthma","volume":"117","author":"Barnes","year":"2000","journal-title":"Chest"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12010221","article-title":"Transcription factors and asthma","volume":"12","author":"Barnes","year":"1998","journal-title":"Eur Respir J"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/all.13760","article-title":"Inflammatory endotypes in COPD","volume":"74","author":"Barnes","year":"2019","journal-title":"Allergy"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00651-2019","article-title":"Airway inflammation in COPD: progress to precision medicine","volume":"54","author":"Brightling","year":"2019","journal-title":"Eur Respir J"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.06.024","article-title":"Inflammation in COPD: implications for management","volume":"125","author":"Sethi","year":"2012","journal-title":"Am J Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01417.x","article-title":"Variable p-CREB expression depicts different asthma phenotypes","volume":"62","author":"Chiappara","year":"2007","journal-title":"Allergy"},{"key":"B11","article-title":"Cytoplasm-nuclear trafficking of CREB and CREB phosphorylation at Ser133 during therapy of chronic obstructive pulmonary disease","author":"Ho\u0142ownia","year":"2007","journal-title":"J Physiol Pharmacol: an Off J Polish Physiol Soc"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.20.2.3160","article-title":"Forskolin inhibits cyclin D1 expression in cultured airway smooth-muscle cells","volume":"20","author":"Musa","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"16326","DOI":"10.18632\/aging.v12i16","article-title":"PTEN participates in airway remodeling of asthma by regulating CD38\/Ca2+\/CREB signaling","volume":"12","author":"Wu","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0398-3","article-title":"Differentiating effects of the glucagon-like peptide-1 analogue exendin-4 in a human neuronal cell model","volume":"67","author":"Luciani","year":"2010","journal-title":"Cell Mol Life Sci"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1414","article-title":"Increasing GLP-1-induced \u03b2-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-\u03b1 and DUSP14","volume":"57","author":"Klinger","year":"2008","journal-title":"Diabetes"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.3390\/brainsci12081090","article-title":"Beneficial influence of exendin-4 on specific organs and mechanisms favourable for the elderly with concomitant obstructive lung diseases","volume":"12","author":"Figat","year":"2022","journal-title":"Brain Sci. from MDPI"},{"key":"B17","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1210\/jc.2011-1508","article-title":"Exenatide exerts a potent antiinflammatory effect","volume":"97","author":"Chaudhuri","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160920195","article-title":"Glucagon like peptide-1 (GLP-1) modulates OVA-induced airway inflammation and mucus secretion involving a protein kinase A (PKA)-dependent nuclear factor-\u03baB (NF-\u03baB) signaling pathway in mice","volume":"16","author":"Zhu","year":"2015","journal-title":"Int J Mol Sci"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031574","article-title":"Anti-inflammatory role of the cAMP effectors epac and PKA: implications in chronic obstructive pulmonary disease","volume":"7","author":"Oldenburger","year":"2012","journal-title":"PloS One"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1096\/FJ.10-164798","article-title":"Anti-mitogenic effects of \u03b2-agonists and PGE2 on airway smooth muscle are PKA dependent","volume":"25","author":"Yan","year":"2011","journal-title":"FASEB J"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12860","article-title":"Glucagon-like peptide-1 receptor expression on human eosinophils and its regulation of eosinophil activation","volume":"47","author":"Mitchell","year":"2017","journal-title":"Clin Exp Allergy"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3892\/MMR.2017.6618\/HTML","article-title":"Overexpression of GLP-1 receptors suppresses proliferation and cytokine release by airway smooth muscle cells of patients with chronic obstructive pulmonary disease via activation of ABCA1","volume":"16","author":"Sun","year":"2017","journal-title":"Mol Med Rep"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20051105","article-title":"Endothelial progenitor cells as pathogenetic and diagnostic factors, and potential targets for GLP-1 in combination with metabolic syndrome and chronic obstructive pulmonary disease","volume":"20","author":"Skurikhin","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B24","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1183\/13993003.01132-2016","article-title":"Metabolic consequences of obesity as an \u201coutside in\u201d mechanism of disease severity in asthma","volume":"48","author":"Peters","year":"2016","journal-title":"Eur Respir J"},{"key":"B25","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/S2213-2600(16)30048-0","article-title":"Plasma IL6 levels, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts","volume":"4","author":"Peters","year":"2016","journal-title":"Lancet Respir Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/FNINT.2013.00059\/BIBTEX","article-title":"Inflammatory process in alzheimer\u2019s disease","author":"Meraz-R\u00edos","year":"2013","journal-title":"Front Integr Neurosci"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2008-13402","article-title":"Inflammatory aspects of alzheimer disease and other neurodegenerative disorders","volume":"13","author":"Schwab","year":"2008","journal-title":"J Alzheimer\u2019s Dis"},{"key":"B28","article-title":"Neuroinflammatory cytokines-the common thread in alzheimer\u2019s pathogenesis","volume":"6","author":"Sue","year":"2010","journal-title":"US Neurol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1111\/j.1600-0404.2009.01230.x","article-title":"The combinations of TNFalpha-308 and IL-6 -174 or IL-10 -1082 genes polymorphisms suggest an association with susceptibility to sporadic late-onset Alzheimer\u2019s disease","volume":"120","author":"Vural","year":"2009","journal-title":"Acta Neurol Scand"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2021.09.010","article-title":"Neuroimaging and biomarker evidence of neurodegeneration in asthma","volume":"149","author":"Rosenkranz","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2014-204445","article-title":"Adult asthma increases dementia risk: a nationwide cohort study","volume":"69","author":"Peng","year":"2015","journal-title":"J Epidemiol Community Health (1978)"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2014.06.003","article-title":"Risk of dementia among patients with asthma: a nationwide longitudinal study","volume":"15","author":"Chen","year":"2014","journal-title":"J Am Med Dir Assoc"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.2174\/1567205011310050011","article-title":"Chronic obstructive pulmonary disease and asthma and the risk of mild cognitive impairment and dementia: a population based CAIDE study","volume":"10","author":"Rusanen","year":"2013","journal-title":"Curr Alzheimer Res"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2011.32.3459","article-title":"Improved activity and mental function related to proper antiasthmatic treatment in elderly patients with Alzheimer\u2019s disease","volume":"32","author":"Bozek","year":"2011","journal-title":"Allergy Asthma Proc"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2016.62842","article-title":"Allergic rhinitis, bronchial asthma and other allergies in patients with Alzheimer\u2019s disease: unnoticed issue","volume":"5","author":"Bo\u017cek","year":"2016","journal-title":"Adv Dermatol Allergol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190850","article-title":"Asthma and chronic obstructive pulmonary disease as a comorbidity and association with the choice of antidementia medication among persons with alzheimer\u2019s disease","volume":"73","author":"Lampela","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(23)00461-7","article-title":"GOLD COPD report: 2024 update","volume":"12","author":"Venkatesan","year":"2024","journal-title":"Lancet Respir Med"},{"key":"B38","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/S2213-2600(23)00230-8","article-title":"2023 GINA report for asthma","volume":"11","author":"Venkatesan","year":"2023","journal-title":"Lancet Respir Med"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1164\/RCCM.202301-0106PP\/SUPPL_FILE\/DISCLOSURES.PDF","article-title":"Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary","volume":"207","author":"Agust\u00ed","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01499-2021","article-title":"Early View Task force report ERS\/ATS technical standard on interpretive strategies for routine lung function tests ERS\/ATS Technical Standard on Interpretive Strategies for Routine Lung Function Tests","volume":"60","author":"Stanojevic","year":"2022","journal-title":"Eur Respir J"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012588218728\/METRICS","article-title":"Interpreting SF-36 summary health measures: A response","volume":"10","author":"Ware","year":"2001","journal-title":"Qual Life Res"},{"key":"B42","unstructured":"Turska, WiolettaFBCMetodyka oceny jako\u015bci \u017cycia"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2296-9-29\/TABLES\/2","article-title":"The accuracy of the MMSE in detecting cognitive impairment when administered by general practitioners: A prospective observational study","volume":"9","author":"Pezzotti","year":"2008","journal-title":"BMC Fam Pract"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-mental state\u201d: A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"B45","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1136\/jnnp.2006.095414","article-title":"A review of screening tests for cognitive impairment","volume":"78","author":"Cullen","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/S40520-018-1009-7\/TABLES\/2","article-title":"The comparison of the 1972 Hodkinson\u2019s Abbreviated Mental Test Score (AMTS) and its variants in screening for cognitive impairment","volume":"31","author":"Piotrowicz","year":"2019","journal-title":"Aging Clin Exp Res"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/BF02339212","article-title":"Hachinski\u2019s ischemic score and the diagnosis of vascular dementia: A review","volume":"14","author":"Pantoni","year":"1993","journal-title":"Ital J Neurological Sci"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410070516","article-title":"Pathological verification of ischemic score in differentiation of dementias","volume":"7","author":"Rosen","year":"1980","journal-title":"Ann Neurol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.4.1096","article-title":"Meta-analysis of the Hachinski Ischemic Score in pathologically verified dementias","volume":"49","author":"Moroney","year":"1997","journal-title":"Neurology"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/gps.930010209","article-title":"The challenge of time: Clock-drawing and cognitive function in the elderly","volume":"1","author":"Shulman","year":"1986","journal-title":"Int J Geriatr Psychiatry"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2001.49185.x","article-title":"Clock drawing: analysis in a retirement community","volume":"49","author":"Paganini-Hill","year":"2001","journal-title":"J Am Geriatr Soc"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.02.346","article-title":"Depression and dementia","volume":"283","author":"Korczyn","year":"2009","journal-title":"J Neurol Sci"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1007\/S11064-007-9385-Y\/TABLES\/1","article-title":"Inflammation, depression and dementia: Are they connected","volume":"32","author":"Leonard","year":"2007","journal-title":"Neurochem Res"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e32834bb9d4","article-title":"Depression in dementia: Epidemiology, mechanisms, and treatment","volume":"24","author":"Enache","year":"2011","journal-title":"Curr Opin Psychiatry"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1002\/(ISSN)1099-1166","article-title":"Short versions of the geriatric depression scale: a study of their validity for the diagnosis of a major depressive episode according to ICD-10 and DSM-IV","volume":"14","author":"Almeida","year":"1999","journal-title":"Int J OF GERIATRIC Psychiatry Int J Geriat Psychiatry"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/11.3.260","article-title":"Screening, detection and management of depression in elderly primary care attenders. I: The acceptability and performance of the 15 item Geriatric Depression Scale (GDS15) and the development of short versions","volume":"11","author":"D\u2019Ath","year":"1994","journal-title":"Fam Pract"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1002\/(ISSN)1099-1166","article-title":"Development of initial validation of a 15-item informant version of the Geriatric Depression Scale","volume":"20","author":"Brown","year":"2005","journal-title":"Int J Geriatr Psychiatry"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241370","article-title":"The bi-factor structure of the 17-item Hamilton Depression Rating Scale in persistent major depression; dimensional measurement of outcome","volume":"15","author":"Nixon","year":"2020","journal-title":"PloS One"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1023\/B:JOBA.0000045340.38371.04","article-title":"Structural validation of the hamilton depression rating scale","volume":"26","author":"Cole","year":"2004","journal-title":"J Psychopathol Behav Assess"},{"key":"B60","doi-asserted-by":"publisher","first-page":"pdb.top101709","DOI":"10.1101\/pdb.top101709","article-title":"Quantifying and storing RNA","volume":"2020","author":"Green","year":"2020","journal-title":"Cold Spring Harb Protoc"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.3726","article-title":"Identification of reference genes in blood before and after entering the plateau for SYBR green RT-qPCR studies","volume":"5","author":"Xiao","year":"2017","journal-title":"PeerJ"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61377-4","article-title":"International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study","volume":"370","author":"Buist","year":"2007","journal-title":"Lancet"},{"key":"B63","doi-asserted-by":"publisher","first-page":"945","DOI":"10.2147\/COPD.S46761","article-title":"Distinguishing adult-onset asthma from COPD: a review and a new approach","volume":"9","author":"Abramson","year":"2014","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"B64","unstructured":"Covariate selectionNCBI BookshelfDeveloping a Protocol for Observational Comparative Effectiveness Research: A User\u2019s Guide"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1159\/000112729","article-title":"Asthma, eczema, rhinitis and the risk for dementia","volume":"25","author":"Eriksson","year":"2008","journal-title":"Dement Geriatr Cognit Disord"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-030227","article-title":"Risk of neurodegenerative dementia in asthma patients: a nested case-control study using a national sample cohort","volume":"9","author":"Kim","year":"2019","journal-title":"BMJ Open"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.04.008","article-title":"Chronic asthma results in cognitive dysfunction in immature mice","volume":"247","author":"Guo","year":"2013","journal-title":"Exp Neurol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1983","article-title":"Exendin-4 protects hypoxic islets from oxidative stress and improves islet transplantation outcome","volume":"154","author":"Padmasekar","year":"2013","journal-title":"Endocrinology"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3682","article-title":"Protective effects of extendin-4 on hypoxia\/reoxygenation-induced injury in H9c2 cells","volume":"12","author":"Lu","year":"2015","journal-title":"Mol Med Rep"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.01.013","article-title":"The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson\u2019s disease: mechanisms of action","volume":"21","author":"Athauda","year":"2016","journal-title":"Drug Discov. Today"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1363373\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T04:39:59Z","timestamp":1721623199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1363373\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,22]]},"references-count":70,"alternative-id":["10.3389\/fimmu.2024.1363373"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1363373","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,22]]},"article-number":"1363373"}}