{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:14:32Z","timestamp":1791231272143,"version":"4.1.0"},"reference-count":226,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["24NSFSC1590, 24NSFSC0244"],"award-info":[{"award-number":["24NSFSC1590, 24NSFSC0244"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Interleukin-27 (IL-27) is a member of the IL-12 family. The gene encoding IL-27 is located at chromosome 16p11. IL-27 is considered as a heterodimeric cytokine, which consists of Epstein\u2013Barr virus (EBV)-induced gene 3 (Ebi3) and IL-27p28. Based on the function of IL-27, it binds to receptor IL-27r\u03b1 or gp130 and then regulates downstream cascade. To date, findings show that the expression of IL-27 is abnormal in different inflammatory autoimmune diseases (including systemic lupus erythematosus, rheumatoid arthritis, Sjogren syndrome, Behcet\u2019s disease, inflammatory bowel disease, multiple sclerosis, systemic sclerosis, type 1 diabetes, Vogt\u2013Koyanagi\u2013Harada, and ankylosing spondylitis). Moreover,\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies demonstrated that IL-27 is significantly in3volved in the development of these diseases by regulating innate and adaptive immune responses, playing either an anti-inflammatory or a pro-inflammatory role. In this review, we comprehensively summarized information about IL-27 and autoimmunity based on available evidence. It is hoped that targeting IL-27 will hold great promise in the treatment of inflammatory autoimmune disorders in the future.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2024.1366377","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:16:56Z","timestamp":1710807416000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["An updated advancement of bifunctional IL-27 in inflammatory autoimmune diseases"],"prefix":"10.3389","volume":"15","author":[{"given":"Wang-Dong","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Fang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1159\/000503923","article-title":"Interleukin-27 ameliorates renal ischemia-reperfusion injury through signal transducers and activators of transcription 3 signaling pathway","volume":"44","author":"Zhou","year":"2019","journal-title":"Kidney Blood Press Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.06.009","article-title":"Interleukin-27 induces the endothelial differentiation in Sca-1+ cardiac resident stem cells","volume":"75","author":"Tanaka","year":"2015","journal-title":"Cytokine"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910260208","article-title":"Establishment and characterization of a human acute monocytic leukemia cell line (THP-1)","volume":"26","author":"Tsuchiya","year":"1980","journal-title":"Int J Cancer"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.12.154","article-title":"Regulation of the class ii and class I mhc pathways in human thp-1 monocytic cells by interleukin-27","volume":"367","author":"Feng","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.003501","article-title":"The effects of cd14 and il-27 on induction of endotoxin tolerance in human monocytes and macrophages","volume":"293","author":"Petes","year":"2018","journal-title":"J Biol Chem"},{"key":"B6","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1189\/jlb.3A0316-098R","article-title":"Il-27 enhances lps-induced il-1beta in human monocytes and murine macrophages","volume":"102","author":"Petes","year":"2017","journal-title":"J Leukoc Biol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00256","article-title":"Interleukin\u2002(IL)-6 inhibits\u2002IL-27- and\u2002IL-30-mediated inflammatory responses in human\u2002Monocytes","volume":"9","author":"Petes","year":"2018","journal-title":"Front Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cyto.2017.12.001","article-title":"Interleukin-27 and interleukin-37 are elevated in sickle cell anemia patients and inhibit in vitro secretion of interleukin-8 in neutrophils and monocytes","volume":"107","author":"Alagbe","year":"2018","journal-title":"Cytokine"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.9.6325","article-title":"Il-27 activates human monocytes via stat1 and suppresses il-10 production but the inflammatory functions of il-27 are abrogated by tlrs and P38","volume":"180","author":"Kalliolias","year":"2008","journal-title":"J Immunol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101912","article-title":"Il-27 enhances lps-induced proinflammatory cytokine production via upregulation of tlr4 expression and signaling in human monocytes","volume":"188","author":"Guzzo","year":"2012","journal-title":"J Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108498","article-title":"Il-27: an endogenous constitutive repressor of human monocytes","volume":"217","author":"Frangieh","year":"2020","journal-title":"Clin Immunol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/938561","article-title":"Il-27 driven upregulation of surface hla-E expression on monocytes inhibits ifn-gamma release by autologous nk cells","volume":"2014","author":"Morandi","year":"2014","journal-title":"J Immunol Res"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-003539","article-title":"Intermediate monocytes induced by ifn-gamma inhibit cancer metastasis by promoting nk cell activation through foxo1 and interleukin-27","volume":"10","author":"Wang","year":"2022","journal-title":"J Immunother Cancer"},{"key":"B14","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.cyto.2015.12.003","article-title":"Interleukin-27 inhibits Malignant behaviors of pancreatic cancer cells by targeting M2 polarized tumor associated macrophages","volume":"89","author":"Yao","year":"2017","journal-title":"Cytokine"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.08.120","article-title":"Interleukin-27 inhibits foam cell formation by promoting macrophage abca1 expression through jak2\/stat3 pathway","volume":"452","author":"Fu","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2021.104411","article-title":"Interleukin 27 as an inducer of antiviral response against chikungunya virus infection in human macrophages","volume":"367","author":"Valdes-Lopez","year":"2021","journal-title":"Cell Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.07.096","article-title":"Il-27 affects helper T cell responses via regulation of pge(2) production by macrophages","volume":"451","author":"Sato","year":"2014","journal-title":"Biochem Bioph Res Co"},{"key":"B18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1097\/QAD.0b013e3282f3356c","article-title":"Il-27, a novel anti-hiv cytokine, activates multiple interferon-inducible genes in macrophages","volume":"22","author":"Imamichi","year":"2008","journal-title":"Aids"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001290","article-title":"Suppression of tnf-alpha and il-1 signaling identifies a mechanism of homeostatic regulation of macrophages by il-27","volume":"185","author":"Kalliolias","year":"2010","journal-title":"J Immunol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.07.011","article-title":"Il-27 regulates hif-1alpha-mediated vegfa response in macrophages of diabetic retinopathy patients and healthy individuals","volume":"113","author":"Zhang","year":"2019","journal-title":"Cytokine"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/srep43441","article-title":"Interleukin-27 enhances the potential of reactive oxygen species generation from monocyte-derived macrophages and dendritic cells by induction of P47(Phox)","volume":"7","author":"Sowrirajan","year":"2017","journal-title":"Sci Rep"},{"key":"B22","doi-asserted-by":"publisher","first-page":"14898","DOI":"10.1038\/s41598-021-94061-3","article-title":"Interleukin-27 promotes autophagy in human serum-induced primary macrophages via an mtor- and lc3-independent pathway","volume":"11","author":"Laverdure","year":"2021","journal-title":"Sci Rep"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120572","article-title":"Il-27 inhibits hiv-1 infection in human macrophages by down-regulating host factor sptbn1 during monocyte to macrophage differentiation","volume":"210","author":"Dai","year":"2013","journal-title":"J Exp Med"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.08.022","article-title":"Il-27 inhibits ifn-gamma induced autophagy by concomitant induction of jak\/pi3 K\/akt\/mtor cascade and up-regulation of mcl-1 in mycobacterium tuberculosis H37rv infected macrophages","volume":"55","author":"Sharma","year":"2014","journal-title":"Int J Biochem Cell Biol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-12-16","article-title":"Il-12 and il-27 regulate the phagolysosomal pathway in mycobacteria-infected human macrophages","volume":"12","author":"Jung","year":"2014","journal-title":"Cell Commun Signal"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00198.2013","article-title":"Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice","volume":"305","author":"Hirase","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2014.02.004","article-title":"Il-27 improves migrational and antiviral potential of cb dendritic cells","volume":"75","author":"Birkholz","year":"2014","journal-title":"Hum Immunol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302656","article-title":"Il-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs hla class I-restricted antigen presentation","volume":"192","author":"Morandi","year":"2014","journal-title":"J Immunol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0112045","article-title":"Viral dsrna-activated human dendritic cells produce il-27, which selectively promotes cytotoxicity in naive cd8(+) T cells","volume":"92","author":"de Groot","year":"2012","journal-title":"J Leukocyte Biol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12417","article-title":"The presence of interleukin-27 during monocyte-derived dendritic cell differentiation promotes improved antigen processing and stimulation of T cells","volume":"144","author":"Jung","year":"2015","journal-title":"Immunology"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142093","article-title":"Apoptotic tumor cells induce il-27 release from human dcs to activate treg cells that express cd69 and attenuate cytotoxicity","volume":"42","author":"Sekar","year":"2012","journal-title":"Eur J Immunol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1209788","article-title":"Il-27 renders dc immunosuppressive by induction of B7-H1","volume":"89","author":"Karakhanova","year":"2011","journal-title":"J Leukocyte Biol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03385-20","article-title":"Il-27 negatively regulates tip-dc development during infection","volume":"12","author":"Liu","year":"2021","journal-title":"Mbio"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103382","article-title":"Il-27 production and stat3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells","volume":"188","author":"Matta","year":"2012","journal-title":"J Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/ni.1772","article-title":"Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10","volume":"10","author":"Ilarregui","year":"2009","journal-title":"Nat Immunol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.10.6421","article-title":"Augmentation of antigen-presenting and th1-promoting functions of dendritic cells by wsx-1(Il-27r) deficiency","volume":"179","author":"Wang","year":"2007","journal-title":"J Immunol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200808","article-title":"Ifn-gamma limits th9-mediated autoimmune inflammation through dendritic cell modulation of il-27","volume":"189","author":"Murugaiyan","year":"2012","journal-title":"J Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"628","DOI":"10.21037\/atm.2019.11.02","article-title":"Gal-1 regulates dendritic cells-induced treg\/th17 balance though nf-kappab\/relb-il-27 pathway","volume":"7","author":"Lu","year":"2019","journal-title":"Ann Transl Med"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2010.02422.x","article-title":"Interleukin-27 as a negative regulator of human neutrophil function","volume":"72","author":"Li","year":"2010","journal-title":"Scand J Immunol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242526","article-title":"Production of interleukin-27 by human neutrophils regulates their function during bacterial infection","volume":"42","author":"Rinchai","year":"2012","journal-title":"Eur J Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00770-7","article-title":"Neutrophil polarization by il-27 as a therapeutic target for intracerebral hemorrhage","volume":"8","author":"Zhao","year":"2017","journal-title":"Nat Commun"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137651","article-title":"Anti-inflammatory effects of il-27 in zymosan-induced peritonitis: inhibition of neutrophil recruitment partially explained by impaired mobilization from bone marrow and reduced chemokine levels","volume":"10","author":"Watzlawick","year":"2015","journal-title":"PloS One"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1128\/Iai.00283-16","article-title":"Interleukin-27 (Il-27) mediates susceptibility to visceral leishmaniasis by suppressing the il-17-neutrophil response","volume":"84","author":"Quirino","year":"2016","journal-title":"Infect Immun"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000957","article-title":"Il-27\/il-27r mediates protective immunity against chlamydial infection by suppressing excessive th17 responses and reducing neutrophil inflammation","volume":"206","author":"Zha","year":"2021","journal-title":"J Immunol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2010.10.002","article-title":"Interleukin-27 and interleukin-12 augment activation of distinct cord blood natural killer cells responses via stat3 pathways","volume":"111","author":"Chen","year":"2012","journal-title":"J Formosan Med Assoc"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0652-7","article-title":"Il-27 enhances il-15\/il-18-mediated activation of human natural killer cells","volume":"7","author":"Choi","year":"2019","journal-title":"J Immunother Cancer"},{"key":"B47","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1002\/eji.201444699","article-title":"Il-27 stimulates human nk-cell effector functions and primes nk cells for il-18 responsiveness","volume":"45","author":"Ziblat","year":"2015","journal-title":"Eur J Immunol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17070","article-title":"Nk cells and multiple myeloma-associated endothelial cells: molecular interactions and influence of il-27","volume":"8","author":"Dondero","year":"2017","journal-title":"Oncotarget"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026173","article-title":"Il-27 imparts immunoregulatory function to human nk cell subsets","volume":"6","author":"Laroni","year":"2011","journal-title":"PloS One"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901464","article-title":"The il-27 P28 subunit binds cytokine-like factor 1 to form a cytokine regulating nk and T cell activities requiring il-6r for signaling","volume":"183","author":"Crabe","year":"2009","journal-title":"J Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106350","article-title":"Il-27 impact on nk cells activity: implication for a robust anti-tumor response in chronic lymphocytic leukemia","volume":"82","author":"Hemati","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-08-2793","article-title":"Interleukin-27 activates natural killer cells and suppresses nk-resistant head and neck squamous cell carcinoma through inducing antibody-dependent cellular cytotoxicity","volume":"69","author":"Matsui","year":"2009","journal-title":"Cancer Res"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2008.02111.x","article-title":"Il-27-mediated activation of natural killer cells and inflammation produced antitumour effects for human oesophageal carcinoma cells","volume":"68","author":"Liu","year":"2008","journal-title":"Scand J Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41478-6","article-title":"Il-27 promotes nk cell effector functions via maf-nrf2 pathway during influenza infection","volume":"9","author":"Kumar","year":"2019","journal-title":"Sci Rep-Uk"},{"key":"B55","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.imbio.2010.03.004","article-title":"Activation of eosinophils by il-12 family cytokine il-27: implications of the pleiotropic roles of il-27 in allergic responses","volume":"216","author":"Hu","year":"2011","journal-title":"Immunobiology"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1159\/000493398","article-title":"Intranasal administration of il-27 ameliorates nasal allergic responses and symptoms","volume":"178","author":"Suzuki","year":"2019","journal-title":"Int Arch Allergy Imm"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006173","article-title":"Il-27 limits type 2 immunopathology following parainfluenza virus infection","volume":"13","author":"Muallem","year":"2017","journal-title":"PloS Pathog"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.2MA1221-637R","article-title":"Il-27 signaling negatively regulates fceri-mediated mast cell activation and allergic response","volume":"112","author":"Wan","year":"2022","journal-title":"J Leukocyte Biol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/srep00974","article-title":"Il-27 increases bst-2 expression in human monocytes and T cells independently of type I ifn","volume":"2","author":"Guzzo","year":"2012","journal-title":"Sci Rep-Uk"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.221010","article-title":"Signaling events involved in interleukin 27 (Il-27)-induced proliferation of human naive cd4(+) T cells and B cells","volume":"286","author":"Charlot-Rabiega","year":"2011","journal-title":"J Biol Chem"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900568","article-title":"Il-27 is a key regulator of il-10 and il-17 production by human cd4(+) T cells","volume":"183","author":"Murugaiyan","year":"2009","journal-title":"J Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.imlet.2013.05.001","article-title":"Il-27 suppresses the production of il-22 in human cd4(+) T cells by inducing the expression of socs1","volume":"152","author":"Wang","year":"2013","journal-title":"Immunol Lett"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2010.11.007","article-title":"Il-27 induces the differentiation of tr1-like cells from human naive cd4(+) T cells via the phosphorylation of stat1 and stat3","volume":"136","author":"Wang","year":"2011","journal-title":"Immunol Lett"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2010.0115","article-title":"Interleukin-27-mediated suppression of human th17 cells is associated with activation of stat1 and suppressor of cytokine signaling protein 1","volume":"31","author":"Liu","year":"2011","journal-title":"J Interf Cytok Res"},{"key":"B65","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/eji.201040804","article-title":"Il-27 increases the proliferation and effector functions of human naive cd8(+) T lymphocytes and promotes their development into tc1 cells","volume":"41","author":"Schneider","year":"2011","journal-title":"Eur J Immunol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2012.14","article-title":"Il-27 induction of il-21 from human cd8(+) T cells induces granzyme B in an autocrine manner","volume":"90","author":"Mittal","year":"2012","journal-title":"Immunol Cell Biol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142241","article-title":"Human tcrgammadelta+ T cells represent a novel target for il-27 activity","volume":"42","author":"Morandi","year":"2012","journal-title":"Eur J Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100064","article-title":"Il-27 supports germinal center function by enhancing il-21 production and the function of T follicular helper cells","volume":"207","author":"Batten","year":"2010","journal-title":"J Exp Med"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103588","article-title":"Il-27 induces ifn\/stat1-dependent genes and enhances function of tigit(+) hivgag-specific T cells","volume":"25","author":"Cheng","year":"2022","journal-title":"iScience"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.599648","article-title":"Il-21-deficient T follicular helper cells support B cell responses through il-27 in patients with chronic hepatitis B","volume":"11","author":"Khanam","year":"2021","journal-title":"Front Immunol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/ni1537","article-title":"Interleukins 27 and 6 induce stat3-mediated T cell production of interleukin 10","volume":"8","author":"Stumhofer","year":"2007","journal-title":"Nat Immunol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7072","article-title":"An il-27\/nfil3 signalling axis drives tim-3 and il-10 expression and T-cell dysfunction","volume":"6","author":"Zhu","year":"2015","journal-title":"Nat Commun"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242942","article-title":"Egr-2 transcription factor is required for blimp-1-mediated il-10 production in il-27-stimulated cd4(+) T cells","volume":"43","author":"Iwasaki","year":"2013","journal-title":"Eur J Immunol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200131","article-title":"Cutting edge: suppression of gm-csf expression in murine and human T cells by il-27","volume":"189","author":"Young","year":"2012","journal-title":"J Immunol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"797","DOI":"10.4049\/jimmunol.0901233","article-title":"Cutting edge: il-27 induces the transcription factor C-maf, cytokine il-21, and the costimulatory receptor icos that coordinately act together to promote differentiation of il-10-producing tr1 cells","volume":"183","author":"Pot","year":"2009","journal-title":"J Immunol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.5.2752","article-title":"Cutting edge: il-27 is a potent inducer of il-10 but not foxp3 in murine T cells","volume":"180","author":"Batten","year":"2008","journal-title":"J Immunol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12805","article-title":"Interleukin-27 signalling induces stem cell antigen-1 expression in T lymphocytes invivo","volume":"152","author":"Liu","year":"2017","journal-title":"Immunology"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12789","article-title":"Pi3k-akt pathway enhances the differentiation of interleukin-27-induced type 1 regulatory T cells","volume":"152","author":"Nadya","year":"2017","journal-title":"Immunology"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201017","article-title":"A novel role for il-27 in mediating the survival of activated mouse cd4 T lymphocytes","volume":"190","author":"Kim","year":"2013","journal-title":"J Immunol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.5.2903","article-title":"Stat3 is indispensable to il-27-mediated cell proliferation but not to il-27-induced th1 differentiation and suppression of proinflammatory cytokine production","volume":"180","author":"Owaki","year":"2008","journal-title":"J Immunol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.imlet.2011.02.022","article-title":"Il-27 suppresses rankl expression in cd4(+) T cells in part through stat3","volume":"138","author":"Kamiya","year":"2011","journal-title":"Immunol Lett"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.4.2191","article-title":"A role for il-27 in early regulation of th1 differentiation","volume":"175","author":"Owaki","year":"2005","journal-title":"J Immunol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.03.024","article-title":"Interleukin-27 priming of T cells controls il-17 production in trans via induction of the ligand pd-L1","volume":"36","author":"Hirahara","year":"2012","journal-title":"Immunity"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801162","article-title":"Il-27 blocks rorc expression to inhibit lineage commitment of th17 cells","volume":"182","author":"Diveu","year":"2009","journal-title":"J Immunol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636896","article-title":"Il-27 controls the development of inducible regulatory T cells and th17 cells via differential effects on stat1","volume":"37","author":"Neufert","year":"2007","journal-title":"Eur J Immunol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-019-0174-0","article-title":"Mucosal T follicular helper cells in siv-infected rhesus macaques: contributing role of il-27","volume":"12","author":"Moukambi","year":"2019","journal-title":"Mucosal Immunol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.3.1686","article-title":"Augmentation of effector cd8+ T cell generation with enhanced granzyme B expression by il-27","volume":"175","author":"Morishima","year":"2005","journal-title":"J Immunol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.4049\/jimmunol.2100362","article-title":"Self-renewing islet tcf1(+) cd8 T cells undergo il-27-controlled differentiation to become tcf1(-) terminal effectors during the progression of type 1 diabetes","volume":"207","author":"Ciecko","year":"2021","journal-title":"J Immunol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"13","DOI":"10.4049\/immunohorizons.1800083","article-title":"Il-27 and tcr stimulation promote T cell expression of multiple inhibitory receptors","volume":"3","author":"DeLong","year":"2019","journal-title":"Immunohorizons"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1004182","article-title":"A role for il-27 in limiting T regulatory cell populations","volume":"187","author":"Wojno","year":"2011","journal-title":"J Immunol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2536517100","article-title":"Il-27 regulates il-12 responsiveness of naive cd4+ T cells through stat1-dependent and -independent mechanisms","volume":"100","author":"Lucas","year":"2003","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190173","article-title":"Il-27 promotes the expansion of self-renewing cd8(+) T cells in persistent viral infection","volume":"216","author":"Huang","year":"2019","journal-title":"J Exp Med"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1780_18","article-title":"Blockade of il-27 signaling ameliorates herpes stromal keratitis with upregulated cd4(+) foxp3(+) regulatory T cells influx in mice","volume":"67","author":"Xia","year":"2019","journal-title":"Indian J Ophthalmol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006640","article-title":"Early il-6 signalling promotes il-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology","volume":"13","author":"Pyle","year":"2017","journal-title":"PloS Pathog"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00500-17","article-title":"Modulation of cd4(+) and cd8(+) T cell function and cytokine responses in strongyloides stercoralis infection by interleukin-27 (Il-27) and il-37","volume":"85","author":"Anuradha","year":"2017","journal-title":"Infect Immun"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00455-19","article-title":"Impact of interleukin-27p28 on T and B cell responses during toxoplasmosis","volume":"87","author":"Park","year":"2019","journal-title":"Infect Immun"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008994","article-title":"Il-27 signalling regulates glycolysis in th1 cells to limit immunopathology during infection","volume":"16","author":"Montes de Oca","year":"2020","journal-title":"PloS Pathog"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.8.5377","article-title":"Two-sided roles of il-27: induction of th1 differentiation on naive cd4+ T cells versus suppression of proinflammatory cytokine production including il-23-induced il-17 on activated cd4+ T cells partially through stat3-dependent mechanism","volume":"177","author":"Yoshimura","year":"2006","journal-title":"J Immunol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202049076","article-title":"Il-27 mediates anti-inflammatory effect in cigarette smoke induced emphysema by negatively regulating ifn-gamma producing cytotoxic cd8(+) T cells in mice","volume":"52","author":"Qiu","year":"2022","journal-title":"Eur J Immunol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27422","article-title":"Preventative tracheal administration of interleukin-27 attenuates allergic asthma by improving the lung th1 microenvironment","volume":"234","author":"Liu","year":"2019","journal-title":"J Cell Physiol"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1111\/all.13691","article-title":"Il-27 signaling deficiency develops th17-enhanced th2-dominant inflammation in murine allergic conjunctivitis model","volume":"74","author":"Chen","year":"2019","journal-title":"Allergy"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.2.1041","article-title":"Regulation of the foxp3 gene by the th1 cytokines: the role of il-27-induced stat1","volume":"182","author":"Ouaked","year":"2009","journal-title":"J Immunol"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxm139","article-title":"Il-27 inhibits the development of regulatory T cells via stat3","volume":"20","author":"Huber","year":"2008","journal-title":"Int Immunol"},{"key":"B104","doi-asserted-by":"publisher","first-page":"e123216","DOI":"10.1172\/jci.insight.123216","article-title":"IL-27 targets Foxp3+ Tregs to mediate antiinflammatory functions during experimental allergic airway inflammation","volume":"4","author":"Nguyen","year":"2019","journal-title":"JCI Insight"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800898","article-title":"Cutting Edge: IL-27 Attenuates Autoimmune Neuroinflammation via Regulatory T Cell\/Lag3-Dependent but IL-10-Independent Mechanisms In Vivo","volume":"202","author":"Kim","year":"2019","journal-title":"J Immunol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1703100114","article-title":"Treg-specific IL-27Ralpha deletion uncovers a key role for IL-27 in Treg function to control autoimmunity","volume":"114","author":"Do","year":"2017","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.45","article-title":"An IL-27\/Lag3 axis enhances Foxp3+ regulatory T cell-suppressive function and therapeutic efficacy","volume":"9","author":"Do","year":"2016","journal-title":"Mucosal Immunol"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00181","article-title":"Interleukin-27 enforces regulatory T cell functions to prevent graft-versus-host disease","volume":"11","author":"Le","year":"2020","journal-title":"Front Immunol"},{"key":"B109","doi-asserted-by":"publisher","first-page":"e20230063","DOI":"10.1084\/jem.20230063","article-title":"Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice","volume":"221","author":"Vasquez Ayala","year":"2024","journal-title":"J Exp Med"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.014","article-title":"The cytokines interleukin 27 and interferon-gamma promote distinct Treg cell populations required to limit infection-induced pathology","volume":"37","author":"Hall","year":"2012","journal-title":"Immunity"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29747","article-title":"Evaluating the mechanism underlying antitumor effect of interleukin 27 on B cells of chronic lymphocytic leukemia patients","volume":"235","author":"Manouchehri-Doulabi","year":"2020","journal-title":"J Cell Physiol"},{"key":"B112","article-title":"Il-27 induces the production of igg1 by human B cells","volume":"17","author":"Boumendjel","year":"2006","journal-title":"Eur Cytokine Netw"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.10.5890","article-title":"Differential effects of il-27 on human B cell subsets","volume":"176","author":"Larousserie","year":"2006","journal-title":"J Immunol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600652","article-title":"Il-27 directly enhances germinal center B cell activity and potentiates lupus in sanroque mice","volume":"197","author":"Vijayan","year":"2016","journal-title":"J Immunol"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.4.2479","article-title":"Induction of igg2a class switching in B cells by il-27","volume":"173","author":"Yoshimoto","year":"2004","journal-title":"J Immunol"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2109548118","article-title":"Il-27-producing B-1a cells suppress neuroinflammation and cns autoimmune diseases","volume":"118","author":"Choi","year":"2021","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2116741119","article-title":"B cell-derived il-27 promotes control of persistent lcmv infection","volume":"119","author":"Pratumchai","year":"2022","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10204788","article-title":"Lack of association between serum interleukin-23 and interleukin-27 levels and disease activity in patients with active systemic lupus erythematosus","volume":"10","author":"Pawlak-Bus","year":"2021","journal-title":"J Clin Med"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-013-2588-1","article-title":"Decreased serum interleukin 27 in Brazilian systemic lupus erythematosus patients","volume":"40","author":"Duarte","year":"2013","journal-title":"Mol Biol Rep"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e3181d88f7b","article-title":"Low level of serum interleukin 27 in patients with systemic lupus erythematosus","volume":"58","author":"Li","year":"2010","journal-title":"J Invest Med"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2014.962080","article-title":"Interleukin-27 and interleukin-23 in patients with systemic lupus erythematosus: possible role in lupus nephritis","volume":"44","author":"Xia","year":"2015","journal-title":"Scand J Rheumatol"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3AB0518-180RR","article-title":"The cytokine network type I ifn-il-27-il-10 is augmented in murine and human lupus","volume":"106","author":"Lee","year":"2019","journal-title":"J Leukocyte Biol"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13663","article-title":"Altered peripheral B lymphocyte homeostasis and functions mediated by il-27 via activating the mammalian target of rapamycin signaling pathway in patients with rheumatoid arthritis","volume":"206","author":"Tang","year":"2021","journal-title":"Clin Exp Immunol"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21111565","article-title":"Circulating il-27 is elevated in rheumatoid arthritis patients","volume":"21","author":"Lai","year":"2016","journal-title":"Molecules"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1002\/art.30180","article-title":"Increased levels of interleukin-27 in patients with rheumatoid arthritis","volume":"63","author":"Shen","year":"2011","journal-title":"Arthritis Rheum-Us"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1186\/ar3067","article-title":"Effects of inflammatory cytokine il-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis","volume":"12","author":"Wong","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.04.020","article-title":"Il-27-producing cd14(+) cells infiltrate inflamed joints of rheumatoid arthritis and regulate inflammation and chemotactic migration","volume":"55","author":"Tanida","year":"2011","journal-title":"Cytokine"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132307","article-title":"Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis","volume":"212","author":"Jones","year":"2015","journal-title":"J Exp Med"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2011.620574","article-title":"Elevated levels of interleukin-27 in patients with sjogren's syndrome","volume":"41","author":"Xia","year":"2012","journal-title":"Scand J Rheumatol"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1002\/art.41289","article-title":"Impaired interleukin-27-mediated control of cd4+ T cell function impact on ectopic lymphoid structure formation in patients with sjogren's syndrome","volume":"72","author":"Lucchesi","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.7150\/thno.37351","article-title":"Mesenchymal stem cell transplantation alleviates experimental sjogren's syndrome through ifn-beta\/il-27 signaling axis","volume":"9","author":"Yao","year":"2019","journal-title":"Theranostics"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01699","article-title":"Il-27 regulated cd4(+)Il-10(+) T cells in experimental sjogren syndrome","volume":"11","author":"Qi","year":"2020","journal-title":"Front Immunol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-020-01530-1","article-title":"Serum il-4, il-12, il-13, il-27, and il-33 levels in active and inactive ocular behcet's disease","volume":"40","author":"Cingu","year":"2020","journal-title":"Int Ophthalmol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1186\/ar4570","article-title":"Decreased interleukin 27 expression is associated with active uveitis in behcet's disease","volume":"16","author":"Wang","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"B135","article-title":"Serum levels of th17-related cytokines in behcet disease patients after cataract surgery","volume":"17","author":"Jiang","year":"2011","journal-title":"Mol Vis"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2020.0458","article-title":"Interleukin-27 gene variant rs153109 is associated with enhanced cytokine serum levels and susceptibility to behcet's disease in the Iranian population","volume":"31","author":"Gholijani","year":"2020","journal-title":"Eur Cytokine Network"},{"key":"B137","article-title":"Evaluation of il-12a, il-12b, il-23a and il-27 mrna expression level genes in peripheral mononuclear cells of inflammatory bowel disease patients in an Iranian population","volume":"11","author":"Norouzinia","year":"2018","journal-title":"Gastroenterol Hepatol Bed Bench"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-016-8804-z","article-title":"Interleukin 27 is up-regulated in patients with active inflammatory bowel disease","volume":"64","author":"Carballeda","year":"2016","journal-title":"Immunol Res"},{"key":"B139","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/00054725-200501000-00003","article-title":"Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in crohn's disease but not in ulcerative colitis","volume":"11","author":"Schmidt","year":"2005","journal-title":"Inflammation Bowel Dis"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.294355","article-title":"A novel role for interleukin-27 (Il-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (Stat) protein signaling and induction of antibacterial and anti-inflammatory proteins","volume":"287","author":"Diegelmann","year":"2012","journal-title":"J Biol Chem"},{"key":"B141","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1093\/infdis\/jix581","article-title":"Il-27\/il-27 receptor signaling provides protection in clostridium difficile-induced colitis","volume":"217","author":"Wang","year":"2018","journal-title":"J Infect Dis"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12572","article-title":"Il27 T4730c polymorphism and serology in multiple sclerosis: A pilot study","volume":"35","author":"Barac","year":"2021","journal-title":"In Vivo"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.11.035","article-title":"Decreased expression of il-27 and its correlation with th1 and th17 cells in progressive multiple sclerosis","volume":"348","author":"Tang","year":"2015","journal-title":"J Neurol Sci"},{"key":"B144","first-page":"47","article-title":"Increased il-17a but decreased il-27 serum levels in patients with multiple sclerosis","volume":"10","author":"Babaloo","year":"2013","journal-title":"Iran J Immunol"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0919-1","article-title":"Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients","volume":"14","author":"Lalive","year":"2017","journal-title":"J Neuroinflamm"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1080\/15321819.2016.1195746","article-title":"Il-27 plasma level in relapsing remitting multiple sclerosis subjects: the double-faced cytokine","volume":"37","author":"Naderi","year":"2016","journal-title":"J Immunoassay Immunochem"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1262","article-title":"The il-27\/il-27r axis is altered in cd4(+) and cd8(+) T lymphocytes from multiple sclerosis patients","volume":"10","author":"Clenet","year":"2021","journal-title":"Clin Transl Immunol"},{"key":"B148","doi-asserted-by":"publisher","first-page":"491","DOI":"10.22092\/ari.2019.126151.1333","article-title":"Anti-inflammatory activity of caspian cobra (Naja naja oxiana) snake venom on the serum level of interleukin-27 and histopathological changes in myelin oligodendrocyte glycoprotein-experimental autoimmune encephalomyelitisinduced mice","volume":"75","author":"Mohammadnejad","year":"2021","journal-title":"Arch Razi Inst"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22948","article-title":"Production of il-27 in multiple sclerosis lesions by astrocytes and myeloid cells: modulation of local immune responses","volume":"64","author":"Senecal","year":"2016","journal-title":"Glia"},{"key":"B150","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1684\/ecn.2016.0371","article-title":"Clinical and cytokine profile evaluation in northeast Brazilian psoriasis plaque-type patients","volume":"27","author":"Cardoso","year":"2016","journal-title":"Eur Cytokine Network"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.349","article-title":"Possible roles of il-27 in the pathogenesis of psoriasis","volume":"130","author":"Shibata","year":"2010","journal-title":"J Invest Dermatol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.11.011","article-title":"Decreased expression of il-27 in moderate-to-severe psoriasis and its anti-inflammation role in imiquimod-induced psoriasis-like mouse model","volume":"85","author":"Chen","year":"2017","journal-title":"J Dermatol Sci"},{"key":"B153","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1136\/ard.2009.121053","article-title":"Elevated serum interleukin-27 levels in patients with systemic sclerosis: association with T cell, B cell and fibroblast activation","volume":"70","author":"Yoshizaki","year":"2011","journal-title":"Ann Rheumatic Dis"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081110","article-title":"Sirtuin 1, visfatin and il-27 serum levels of type 1 diabetic females in relation to cardiovascular parameters and autoimmune thyroid disease","volume":"11","author":"Lukawska-Tatarczuk","year":"2021","journal-title":"Biomolecules"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2016.1197243","article-title":"Elevated levels of T-helper 17-associated cytokines in diabetes type I patients: indicators for following the course of disease","volume":"45","author":"Baharlou","year":"2016","journal-title":"Immunol Invest"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142976","article-title":"Increased blood levels of growth factors, proinflammatory cytokines, and th17 cytokines in patients with newly diagnosed type 1 diabetes","volume":"10","author":"Alnek","year":"2015","journal-title":"PloS One"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2009_2469","article-title":"Diminished expression of icos, gitr and ctla-4 at the mrna level in T regulatory cells of children with newly diagnosed type 1 diabetes","volume":"56","author":"Luczynski","year":"2009","journal-title":"Acta Biochim Pol"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9863","article-title":"Decreased il-27 expression in association with an increased th17 response in vogt-koyanagi-harada disease","volume":"53","author":"Wang","year":"2012","journal-title":"Invest Ophth Vis Sci"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.169052","article-title":"Elevated serum il-23 correlates with intraocular inflammation after cataract surgery in patients with vogt-koyanagi-harada disease","volume":"94","author":"Jiang","year":"2010","journal-title":"Brit J Ophthalmol"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-014-0281-x","article-title":"Elevated serum level of il-27 and vegf in patients with ankylosing spondylitis and associate with disease activity","volume":"15","author":"Lin","year":"2015","journal-title":"Clin Exp Med"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-021-05858-6","article-title":"Genetic polymorphisms of il-27 and risk of systemic lupus erythematosus disease in the Egyptian population","volume":"40","author":"Ali","year":"2021","journal-title":"Clin Rheumatol"},{"key":"B162","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/sji.12439","article-title":"Genetic variants in il-12b and il-27 in the polish patients with systemic lupus erythematosus","volume":"84","author":"Paradowska-Gorycka","year":"2016","journal-title":"Scand J Immunol"},{"key":"B163","article-title":"Relationship between il-27 gene polymorphism and susceptibility of rheumatoid arthritis in chinese han population","volume":"8","author":"Yan","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"B164","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1111\/sji.12209","article-title":"Association of single nucleotide polymorphisms in the il27 gene with rheumatoid arthritis","volume":"80","author":"Paradowska-Gorycka","year":"2014","journal-title":"Scand J Immunol"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2015.150843","article-title":"Il-27 gene polymorphisms in Iranian patients with behcet's disease","volume":"62","author":"Dehghanzadeh","year":"2016","journal-title":"Clin Lab"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2017.01.002","article-title":"Functional variant in the promoter region of il-27 alters gene transcription and confers a risk for ulcerative colitis in northern chinese han","volume":"78","author":"Yu","year":"2017","journal-title":"Hum Immunol"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05901.x","article-title":"Interleukin-27 polymorphisms are associated with inflammatory bowel diseases in a korean population","volume":"24","author":"Li","year":"2009","journal-title":"J Gastroen Hepatol"},{"key":"B168","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.imlet.2016.02.010","article-title":"Protective role of interleukin 27 (Il-27) gene polymorphisms in patients with ulcerative colitis","volume":"172","author":"Yamamoto-Furusho","year":"2016","journal-title":"Immunol Lett"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11010037","article-title":"Potential contribution of il-27 and il-23 gene polymorphisms to multiple sclerosis susceptibility: an association analysis at genotype and haplotype level","volume":"11","author":"Barac","year":"2022","journal-title":"J Clin Med"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.12.003","article-title":"Lack of association between il27 gene variants and type 1 diabetes susceptibility","volume":"61","author":"Santos","year":"2013","journal-title":"Cytokine"},{"key":"B171","article-title":"Cfh 184g as a genetic risk marker for anterior uveitis in chinese females","volume":"17","author":"Yang","year":"2011","journal-title":"Mol Vis"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0102-6","article-title":"Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via il-27","volume":"19","author":"Ryu","year":"2018","journal-title":"Nat Immunol"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10244.x","article-title":"T cell-specific overexpression of interleukin-27 receptor alpha subunit (Wsx-1) prevents spontaneous skin inflammation in mrl\/lpr mice","volume":"164","author":"Kido","year":"2011","journal-title":"Br J Dermatol"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.11.7185","article-title":"Membranous glomerulonephritis development with th2-type immune deviations in mrl\/lpr mice deficient for il-27 receptor (Wsx-1)","volume":"175","author":"Shimizu","year":"2005","journal-title":"J Immunol"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.077537","article-title":"Amelioration of human lupus-like phenotypes in mrl\/lpr mice by overexpression of interleukin 27 receptor alpha (Wsx-1)","volume":"67","author":"Sugiyama","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"B176","first-page":"14","article-title":"Expression of igf-1, il-27 and il-35 receptors in adjuvant induced rheumatoid arthritis model","volume":"15","author":"Abdi","year":"2018","journal-title":"Iran J Immunol"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.03.010","article-title":"The effect of interleukins 27 and 35 and their role on mediating the action of insulin like growth factor-1 on the inflammation and blood flow of chronically inflamed rat knee joint","volume":"81","author":"Houshmandi","year":"2016","journal-title":"Cytokine"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.2.922","article-title":"Il-27 induces a th1 immune response and susceptibility to experimental arthritis","volume":"180","author":"Cao","year":"2008","journal-title":"J Immunol"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.1171","article-title":"Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the P28 subunit of il-27","volume":"173","author":"Goldberg","year":"2004","journal-title":"J Immunol"},{"key":"B180","doi-asserted-by":"publisher","first-page":"7590","DOI":"10.1038\/s41598-018-25988-3","article-title":"Gammadeltatcr regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis","volume":"8","author":"Bouchareychas","year":"2018","journal-title":"Sci Rep"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.083360","article-title":"Interleukin 27 attenuates collagen-induced arthritis","volume":"67","author":"Niedbala","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"B182","doi-asserted-by":"publisher","first-page":"e46","DOI":"10.1038\/emm.2013.89","article-title":"In vivo action of il-27: reciprocal regulation of th17 and treg cells in collagen-induced arthritis","volume":"45","author":"Moon","year":"2013","journal-title":"Exp Mol Med"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2012.03622.x","article-title":"Interleukin-27 suppresses osteoclastogenesis via induction of interferon-gamma","volume":"137","author":"Park","year":"2012","journal-title":"Immunology"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1002\/art.27200","article-title":"Interleukin-27 inhibits human osteoclastogenesis by abrogating rankl-mediated induction of nuclear factor of activated T cells C1 and suppressing proximal rank signaling","volume":"62","author":"Kalliolias","year":"2010","journal-title":"Arthritis Rheum"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1002\/art.30324","article-title":"Local expression of interleukin-27 ameliorates collagen-induced arthritis","volume":"63","author":"Pickens","year":"2011","journal-title":"Arthritis Rheum"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-166843","article-title":"Naive and activated T cells display differential responsiveness to tl1a that affects th17 generation, maintenance, and proliferation","volume":"25","author":"Jones","year":"2011","journal-title":"FASEB J"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.187013","article-title":"Interleukin-27 and interferon-gamma are involved in regulation of autoimmune arthritis","volume":"286","author":"Rajaiah","year":"2011","journal-title":"J Biol Chem"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.10.6465","article-title":"Suppression of ongoing experimental autoimmune encephalomyelitis by neutralizing the function of the P28 subunit of il-27","volume":"173","author":"Goldberg","year":"2004","journal-title":"J Immunol"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032414-112134","article-title":"The immunobiology of interleukin-27","volume":"33","author":"Yoshida","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"B190","doi-asserted-by":"publisher","first-page":"R172","DOI":"10.1186\/ar3925","article-title":"Gene therapy using il-27 ameliorates sjogren's syndrome-like autoimmune exocrinopathy","volume":"14","author":"Lee","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.11.010","article-title":"Interleukin-27 is essential for type 1 diabetes development and sjogren syndrome-like inflammation","volume":"29","author":"Ciecko","year":"2019","journal-title":"Cell Rep"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.3390\/biology11030427","article-title":"Interleukin-27 regulates the function of the gastrointestinal epithelial barrier in a human tissue-derived organoid model","volume":"11","author":"Brice","year":"2022","journal-title":"Biology-Basel"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1968258","article-title":"Il-27 induces ll-37\/cramp expression from intestinal epithelial cells: implications for immunotherapy of clostridioides difficile infection","volume":"13","author":"Xu","year":"2021","journal-title":"Gut Microbes"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00329.2010","article-title":"Treatment with il-27 attenuates experimental colitis through the suppression of the development of il-17-producing T helper cells","volume":"300","author":"Sasaoka","year":"2011","journal-title":"Am J Physiol-Gastr L"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802918","article-title":"Il-27 regulates homeostasis of the intestinal cd4(+) effector T cell pool and limits intestinal inflammation in a murine model of colitis","volume":"183","author":"Troy","year":"2009","journal-title":"J Immunol"},{"key":"B196","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.jcmgh.2015.01.002","article-title":"Resident bacteria-stimulated il-10-secreting B cells ameliorate T cell-mediated colitis by inducing tr-1 cells that require il-27-signaling","volume":"1","author":"Mishima","year":"2015","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1268309","article-title":"Protective function of interleukin 27 in colitis-associated cancer via suppression of inflammatory cytokines in intestinal epithelial cells","volume":"6","author":"Cui","year":"2017","journal-title":"Oncoimmunology"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1097\/Mib.0000000000001274","article-title":"Interleukin-27 is a potential rescue therapy for acute severe colitis through interleukin-10-dependent, T-cell-independent attenuation of colonic mucosal innate immune responses","volume":"23","author":"McLean","year":"2017","journal-title":"Inflammatory Bowel Dis"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.09.060","article-title":"Oral delivery of il-27 recombinant bacteria attenuates immune colitis in mice","volume":"146","author":"Hanson","year":"2014","journal-title":"Gastroenterology"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3A1215-540R","article-title":"Systemic delivery of il-27 by an adeno-associated viral vector inhibits T cell-mediated colitis and induces multiple inhibitory pathways in T cells","volume":"100","author":"Zhu","year":"2016","journal-title":"J Leukocyte Biol"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1128\/Iai.00066-14","article-title":"Attenuation of intestinal inflammation in interleukin-10-deficient mice infected with citrobacter rodentium","volume":"82","author":"Dann","year":"2014","journal-title":"Infect Immun"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000191611.05466.1f","article-title":"T helper 1-inducing property of il-27\/wsx-1 signaling is required for the induction of experimental colitis","volume":"11","author":"Honda","year":"2005","journal-title":"Inflammation Bowel Dis"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100410","article-title":"Il-27 promotes T cell-dependent colitis through multiple mechanisms","volume":"208","author":"Cox","year":"2011","journal-title":"J Exp Med"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.82","article-title":"Il-27, targeting antigen-presenting cells, promotes th17 differentiation and colitis in mice","volume":"7","author":"Visperas","year":"2014","journal-title":"Mucosal Immunol"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxn032","article-title":"Il-27r deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic ibd","volume":"20","author":"Villarino","year":"2008","journal-title":"Int Immunol"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2013.0154","article-title":"Interleukin-27 mediates inflammation during chronic disease","volume":"34","author":"Wynick","year":"2014","journal-title":"J Interf Cytok Res"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20753","article-title":"Distinct cytokine patterns identified from multiplex profiles of murine dss and tnbs-induced colitis","volume":"15","author":"Alex","year":"2009","journal-title":"Inflammatory Bowel Dis"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.03.007","article-title":"Il-27 mediates the response to ifn-beta therapy in multiple sclerosis patients by inhibiting th17 cells","volume":"25","author":"Sweeney","year":"2011","journal-title":"Brain Behav Immun"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.5.3268","article-title":"Suppressive effect of il-27 on encephalitogenic th17 cells and the effector phase of experimental autoimmune encephalomyelitis","volume":"179","author":"Fitzgerald","year":"2007","journal-title":"J Immunol"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00873","article-title":"Interleukin-27 gene therapy prevents the development of autoimmune encephalomyelitis but fails to attenuate established inflammation due to the expansion of cd11b(+)Gr-1(+) myeloid cells","volume":"9","author":"Zhu","year":"2018","journal-title":"Front Immunol"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038751","article-title":"Il-27 regulates il-18 binding protein in skin resident cells","volume":"7","author":"Wittmann","year":"2012","journal-title":"PloS One"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.313","article-title":"Il-27 activates th1-mediated responses in imiquimod-induced psoriasis-like skin lesions","volume":"133","author":"Shibata","year":"2013","journal-title":"J Invest Dermatol"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-015-0012-4","article-title":"Il-27 alleviates the bleomycin-induced pulmonary fibrosis by regulating the th17 cell differentiation","volume":"15","author":"Dong","year":"2015","journal-title":"BMC Pulm Med"},{"key":"B214","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.lfs.2016.01.004","article-title":"Il-27 attenuates the tgf-beta1-induced proliferation, differentiation and collagen synthesis in lung fibroblasts","volume":"146","author":"Dong","year":"2016","journal-title":"Life Sci"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1375.024","article-title":"New members of the interleukin-12 family of cytokines: il-23 and il-27 modulate autoimmune diabetes","volume":"1079","author":"Mensah-Brown","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.08.001","article-title":"Il-27 inhibits hyperglycemia and pancreatic islet inflammation induced by streptozotocin in mice","volume":"179","author":"Fujimoto","year":"2011","journal-title":"Am J Pathol"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8540-1","article-title":"The pathogenic role of interleukin-27 in autoimmune diabetes","volume":"65","author":"Wang","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"B218","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/imm.2011.132.issue-4","article-title":"Retinal cells suppress intraocular inflammation (Uveitis) through production of interleukin-27 and interleukin-10","volume":"132","author":"Lee","year":"2011","journal-title":"Immunology"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.390625","article-title":"Novel il27p28\/il12p40 cytokine suppressed experimental autoimmune uveitis by inhibiting autoreactive th1\/th17 cells and promoting expansion of regulatory T cells","volume":"287","author":"Wang","year":"2012","journal-title":"J Biol Chem"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1038\/nm1585","article-title":"Th17 cells contribute to uveitis and scleritis and are expanded by il-2 and inhibited by il-27\/stat1","volume":"13","author":"Amadi-Obi","year":"2007","journal-title":"Nat Med"},{"key":"B221","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jaut.2013.08.003","article-title":"Il-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing th1 and th17 responses","volume":"50","author":"Chong","year":"2014","journal-title":"J Autoimmun"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147517","article-title":"Deficiency of il-27 signaling exacerbates experimental autoimmune uveitis with elevated uveitogenic th1 and th17 responses","volume":"22","author":"Wu","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxl125","article-title":"Wsx-1 plays a significant role for the initiation of experimental autoimmune uveitis","volume":"19","author":"Sonoda","year":"2007","journal-title":"Int Immunol"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2020.04.014","article-title":"Interleukin 27 protects from gastric atrophy and metaplasia during chronic autoimmune gastritis","volume":"10","author":"Bockerstett","year":"2020","journal-title":"Cell Mol Gastroenter"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14761","article-title":"Relationship between SHP2 gene polymorphisms and systemic lupus erythematosus risk","volume":"26","author":"Li","year":"2023","journal-title":"Int J Rheum Dis"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14257","article-title":"Gene polymorphisms of SIRT1 in patients with rheumatoid arthritis","volume":"25","author":"Zhou","year":"2022","journal-title":"Int J Rheum Dis"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1366377\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:17:06Z","timestamp":1710807426000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1366377\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,19]]},"references-count":226,"alternative-id":["10.3389\/fimmu.2024.1366377"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1366377","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,19]]},"article-number":"1366377"}}