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The complexity and safety of the process can be addressed with various emerging technologies (artificial intelligence, wearable sensors, point-of-care analytical devices, drones, virtual assistants) that allow continuous patient monitoring and improved decision-making processes. Patients, caregivers, and staff can also benefit from improved training with simulation or virtual reality. However, many technical, operational, and above all, ethical concerns need to be addressed. Finally, outpatient or at-home hematopoietic transplantation or CAR-T therapy creates a different, integrated operative system that must be planned, designed, and carefully adapted to the patient\u2019s characteristics and distance from the hospital. Patients, clinicians, and their clinical environments can benefit from technically improved at-home transplantation.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1366962","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T04:28:51Z","timestamp":1714105731000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Brave new world: expanding home care in stem cell transplantation and advanced therapies with new technologies"],"prefix":"10.3389","volume":"15","author":[{"given":"I\u00f1igo","family":"Romon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Gonzalez-Barrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Coello de Portugal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Ocio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Sampedro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"B1","unstructured":"Gonzalez-HuelgasR\n            BarbaR\n            CorbellaX\n            Garc\u00eda-Alegr\u00edaJ\n            HerranzMT\n            VallejoI\n          El hospital del FUTURO2021"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-0828-2","article-title":"Is there no place like home for an allogeneic stem cell transplant","volume":"55","author":"Szer","year":"2020","journal-title":"Bone Marrow Transplant"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.04.012","article-title":"Worldwide network for blood and marrow transplantation recommendations for establishing a hematopoietic stem cell transplantation program in countries with limited resources, part II: clinical, technical, and socioeconomic considerations. 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