{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T02:17:01Z","timestamp":1791771421583,"version":"4.3.4"},"reference-count":128,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Interferon-gamma (IFN-\u03b3) is pivotal in orchestrating immune responses during healthy pregnancy. However, its dysregulation, often due to autoimmunity, infections, or chronic inflammatory conditions, is implicated in adverse reproductive outcomes such as pregnancy failure or infertility. Additionally, the underlying immunological mechanisms remain elusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we explore the impact of systemic IFN-\u03b3 elevation on cytotoxic T cell responses in female reproduction utilizing a systemic lupus-prone mouse model with impaired IFN-\u03b3 degradation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our findings reveal that heightened IFN-\u03b3 levels triggered the infiltration of CD8<jats:sup>+<\/jats:sup>T cells in the pituitary gland and female reproductive tract (FRT), resulting in prolactin deficiency and subsequent infertility. Furthermore, we demonstrate that chronic IFN-\u03b3 elevation increases effector memory CD8<jats:sup>+<\/jats:sup>T cells in the murine ovary and uterus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These insights broaden our understanding of the role of elevated IFN-\u03b3 in female reproductive dysfunction and suggest CD8<jats:sup>+<\/jats:sup>T cells as potential immunotherapeutic targets in female reproductive disorders associated with chronic systemic IFN-\u03b3 elevation.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2024.1368572","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T10:47:46Z","timestamp":1713437266000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Aberrant CD8+T cells drive reproductive dysfunction in female mice with elevated IFN-\u03b3 levels"],"prefix":"10.3389","volume":"15","author":[{"given":"Enitome E.","family":"Bafor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Erwin-Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clayton","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne E.","family":"Kimmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Duverger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Fenimore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Ramba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thea","family":"Spindel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"Hess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sanford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanja","family":"Lazarevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9r\u00e9nice A.","family":"Benayoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"Valencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1242\/jcs.175943","article-title":"Embryo-epithelium interactions during implantation at a glance","volume":"130","author":"Aplin","year":"2017","journal-title":"J Cell Sci"},{"key":"B2","doi-asserted-by":"publisher","first-page":"18159","DOI":"10.1038\/srep18159","article-title":"IFN-gamma modulates Ly-49 receptors on NK cells in IFN-gamma-induced pregnancy failure","volume":"5","author":"Li","year":"2015","journal-title":"Sci Rep"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.470","article-title":"IFN-gamma induces aberrant CD49b(+) NK cell recruitment through regulating CX3CL1: a novel mechanism by which IFN-gamma provokes pregnancy failure","volume":"5","author":"Li","year":"2014","journal-title":"Cell Death Dis"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0890447","article-title":"Control of fetal survival in CBA \u00d7 DBA\/2 mice by lymphokine therapy","volume":"89","author":"Chaouat","year":"1990","journal-title":"Reproduction"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78578","article-title":"CXCR3 blockade protects against Listeria monocytogenes infection-induced fetal wastage","volume":"125","author":"Chaturvedi","year":"2015","journal-title":"J\u00a0Clin Invest"},{"key":"B6","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.immuni.2018.07.017","article-title":"Interferons and proinflammatory cytokines in pregnancy and fetal development","volume":"49","author":"Yockey","year":"2018","journal-title":"Immunity"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq236","article-title":"Interferon gamma contributes to preimplantation embryonic development and to implantation site structure in NOD mice","volume":"25","author":"Seaward","year":"2010","journal-title":"Hum Reprod"},{"key":"B8","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1095\/biolreprod61.2.493","article-title":"Interferon-gamma contributes to the normalcy of murine pregnancy","volume":"61","author":"Ashkar","year":"1999","journal-title":"Biol Reprod"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0237-9","article-title":"Serum tumor necrosis factor-\u03b1, interleukin-6, monocyte chemotactic protein-1 and paraoxonase-1 profiles in women with endometriosis, PCOS, or unexplained infertility","volume":"31","author":"Younis","year":"2014","journal-title":"J Assist Reprod Genet"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54483-5","article-title":"Cytokine involvement in oocytes and early embryos","volume":"56","author":"Zolti","year":"1991","journal-title":"Fertil Steril"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra000763","article-title":"Implantation and the survival of early pregnancy","volume":"345","author":"Norwitz","year":"2001","journal-title":"N Engl J Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.2.259","article-title":"Interferon \u03b3 contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy","volume":"192","author":"Ashkar","year":"2000","journal-title":"J Exp Med"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.6.2937","article-title":"Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy","volume":"171","author":"Ashkar","year":"2003","journal-title":"J Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41467-017-02499-9","article-title":"Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology","volume":"9","author":"Hirsch","year":"2018","journal-title":"Nat Commun"},{"key":"B15","doi-asserted-by":"publisher","first-page":"5606","DOI":"10.1038\/s41467-022-33067-5","article-title":"Interferon gamma mediates the reduction of adipose tissue regulatory T cells in human obesity","volume":"13","author":"Bradley","year":"2022","journal-title":"Nat Commun"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000301","article-title":"PD-L1 and emerging biomarkers in immune checkpoint blockade therapy","volume":"24","author":"Cottrell","year":"2018","journal-title":"Cancer J"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-002220","article-title":"Immune checkpoint inhibitor-related hypogonadism and infertility: a neglected issue in immuno-oncology","volume":"9","author":"\u00d6zdemir","year":"2021","journal-title":"J Immunother Cancer"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319656","article-title":"Elevated interferon-gamma levels during pregnancy are associated with adverse maternofetal outcomes in IBD","volume":"69","author":"Jijon","year":"2020","journal-title":"Gut"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.01.214","article-title":"Increased risk of incident chronic medical conditions in infertile women: analysis of US claims data","volume":"220","author":"Murugappan","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2017.12.003","article-title":"Embryotoxic cytokines-Potential roles in embryo loss and fetal programming","volume":"125","author":"Robertson","year":"2018","journal-title":"J Reprod Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318637","article-title":"Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain","volume":"112","author":"Wang","year":"2003","journal-title":"J Clin Invest"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv041","article-title":"The role of infection in miscarriage","volume":"22","author":"Giakoumelou","year":"2016","journal-title":"Hum Reprod Update"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185392","article-title":"IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites","volume":"12","author":"Niikura","year":"2017","journal-title":"PloS One"},{"key":"B24","doi-asserted-by":"publisher","first-page":"8623","DOI":"10.1038\/s41598-017-08299-x","article-title":"TLR4-mediated placental pathology and pregnancy outcome in experimental malaria","volume":"7","author":"Barboza","year":"2017","journal-title":"Sci Rep"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2008.08.009","article-title":"Toxoplasma gondii-induced foetal resorption in mice involves interferon-gamma-induced apoptosis and spiral artery dilation at the maternofoetal interface","volume":"39","author":"Senegas","year":"2009","journal-title":"Int J Parasitol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"18917","DOI":"10.1038\/s41598-022-21965-z","article-title":"Increased interferon-\u03b3 levels and risk of severe malaria: a meta-analysis","volume":"12","author":"Mahittikorn","year":"2022","journal-title":"Sci Rep"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix623","article-title":"Systemic inflammatory response to malaria during pregnancy is associated with pregnancy loss and preterm delivery","volume":"65","author":"Fried","year":"2017","journal-title":"Clin Infect Dis"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat6176","article-title":"In utero priming of highly functional effector T cell responses to human malaria","volume":"10","author":"Odorizzi","year":"2018","journal-title":"Sci Transl Med"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.90","article-title":"Adapting to obesity with adipose tissue inflammation","volume":"13","author":"Reilly","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2009.05.004","article-title":"Maternal obesity and markers of inflammation in pregnancy","volume":"47","author":"Madan","year":"2009","journal-title":"Cytokine"},{"key":"B31","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jaut.2017.02.009","article-title":"Impact of systemic lupus erythematosus on maternal and fetal outcomes following pregnancy: A meta-analysis of studies published between years 2001-2016","volume":"79","author":"Bundhun","year":"2017","journal-title":"J Autoimmun"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat Med"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00265","article-title":"Autoimmune disease in women: endocrine transition and risk across the lifespan","volume":"10","author":"Desai","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.91020.2008","article-title":"Prolactin independent rescue of mouse corpus luteum life span: identification of prolactin and luteinizing hormone target genes","volume":"297","author":"Bachelot","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.23.6926","article-title":"Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene","volume":"16","author":"Horseman","year":"1997","journal-title":"EMBO J"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.7.7568","article-title":"Rescue of preimplantatory egg development and embryo implantation in prolactin receptor-deficient mice after progesterone administration","volume":"141","author":"Binart","year":"2000","journal-title":"Endocrinol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nrendo.2013.212","article-title":"Endocrine autoimmune diseases and female infertility","volume":"10","author":"Sen","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)59769-6","article-title":"Hypoprolactinemia and ovarian function","volume":"49","author":"Kauppila","year":"1988","journal-title":"Fertil Steril"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1210\/endo-96-1-219","article-title":"The control of progesterone secretion during the estrous cycle and early pseudopregnancy in the rat: prolactin, gonadotropin and steroid levels associated with rescue of the corpus luteum of pseudopregnancy","volume":"96","author":"Smith","year":"1975","journal-title":"Endocrinol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1210\/er.2004-0011","article-title":"Autoimmune hypophysitis","volume":"26","author":"Caturegli","year":"2005","journal-title":"Endocr Rev"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-016-0736-z","article-title":"Revisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspects","volume":"19","author":"Bellastella","year":"2016","journal-title":"Pituitary"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700830241","article-title":"Anterior hypophysitis and Hashimoto's disease in a young woman","volume":"83","author":"Goudie","year":"1962","journal-title":"J Pathol Bacteriol"},{"key":"B43","first-page":"78","article-title":"Lymphocytic hypophysitis in a patient with systemic lupus erythematosus","volume":"18","author":"Ji","year":"2000","journal-title":"Clin Exp Rheumatol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9654-7","article-title":"Pituitary autoimmune disease: nuances in clinical presentation","volume":"42","author":"Glezer","year":"2012","journal-title":"Endocrine"},{"key":"B45","article-title":"A case of systematic lupus erythematosus with autoimmune hypophysitis","volume":"82","author":"Hasegawa","year":"1993","journal-title":"Nihon Naika Gakkai Zasshi"},{"key":"B46","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1210\/clinem\/dgab672","article-title":"Hypophysitis, the growing spectrum of a rare pituitary disease","volume":"107","author":"Langlois","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2329048X221103051","DOI":"10.1177\/2329048X221103051","article-title":"Post COVID-19 lymphocytic hypophysitis: A rare presentation","volume":"9","author":"Joshi","year":"2022","journal-title":"Child Neurol Open"},{"key":"B48","doi-asserted-by":"publisher","first-page":"101276","DOI":"10.1016\/j.beem.2019.04.010","article-title":"New causes of hypophysitis","volume":"33","author":"Yuen","year":"2019","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2152","article-title":"Diagnosis of primary hypophysitis in Germany","volume":"100","author":"Honegger","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-73082-0_6-1","article-title":"Hypophysitis and granulomatous pituitary lesions in systemic diseases","volume-title":"Polyendocrine disorders and endocrine neoplastic syndromes","author":"Jaffrain-Rea","year":"2019"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00291","article-title":"Animal models of interferon signature positive lupus","volume":"6","author":"Zhuang","year":"2015","journal-title":"Front Immunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1177\/0961203317711772","article-title":"Autoimmune abnormality affects ovulation and oocyte-pick-up in MRL\/MpJ-Faslpr\/lpr mice","volume":"27","author":"Hosotani","year":"2018","journal-title":"Lupus"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2015.1031889","article-title":"MRL\/MpJ-Fas(lpr) mice show abnormalities in ovarian function and morphology with the progression of autoimmune disease","volume":"48","author":"Otani","year":"2015","journal-title":"Autoimmunity"},{"key":"B54","first-page":"2","article-title":"Immunodeficient rodents: A guide to their immunobiology, husbandry, and use","volume-title":"Hereditary immunodeficiencies","author":"Council","year":"1989"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2004.00165.x","article-title":"Undiagnosed systemic lupus erythematosus in a cohort of infertile women","volume":"51","author":"Geva","year":"2004","journal-title":"Am J Reprod Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00240110","article-title":"A systematic review and meta-analysis of pregnancy outcomes in patients with systemic lupus erythematosus and lupus nephritis","volume":"5","author":"Smyth","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jaut.2014.02.003","article-title":"IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice","volume":"53","author":"Hodge","year":"2014","journal-title":"J Autoimmun"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21593","article-title":"Effects of infertility, pregnancy loss, and patient concerns on family size of women with rheumatoid arthritis and systemic lupus erythematosus","volume":"64","author":"Clowse","year":"2012","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1132045","article-title":"A new insight into the impact of systemic lupus erythematosus on oocyte and embryo development as well as female fertility","volume":"14","author":"Mao","year":"2023","journal-title":"Front Immunol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00281","article-title":"Uterine glands: developmental biology and functional roles in pregnancy","volume":"40","author":"Kelleher","year":"2019","journal-title":"Endocr Rev"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1951304","article-title":"Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome","volume":"14","author":"Kahlem","year":"2004","journal-title":"Genome Res"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn389","article-title":"Positive and negative feedback regulates the transcription factor FOXL2 in response to cell stress: evidence for a regulatory imbalance induced by disease-causing mutations","volume":"18","author":"Benayoun","year":"2008","journal-title":"Hum Mol Genet"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/nature09848","article-title":"Dampening of death pathways by schnurri-2 is essential for T-cell development","volume":"472","author":"Staton","year":"2011","journal-title":"Nature"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00949-7","article-title":"Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity","volume":"22","author":"Collier","year":"2021","journal-title":"Nat Immunol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2019.01.026","article-title":"TIM-3 as a marker of exhaustion in CD8+ T cells of active chronic hepatitis B patients","volume":"128","author":"Mohammadizad","year":"2019","journal-title":"Microb Pathog"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01210-5","article-title":"Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3","volume":"23","author":"Grebinoski","year":"2022","journal-title":"Nat Immunol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo5871","article-title":"The evolving role of tissue-resident memory T cells in infections and cancer","volume":"8","author":"Yenyuwadee","year":"2022","journal-title":"Sci Adv"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.4.2396","article-title":"Rapid clonal expansion and prolonged maintenance of memory CD8+ T cells of the effector (CD44highCD62Llow) and central (CD44highCD62Lhigh) phenotype by an archaeosome adjuvant independent of TLR2","volume":"178","author":"Krishnan","year":"2007","journal-title":"J Immunol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.67","article-title":"Interferon-gamma derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity","volume":"8","author":"Bhat","year":"2017","journal-title":"Cell Death Dis"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.13.9767","article-title":"Expression of Fas ligand in activated T cells is regulated by c-Myc","volume":"275","author":"Brunner","year":"2000","journal-title":"J Biol Chem"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.03.031","article-title":"Quantifying memory CD8 T cells reveals regionalization of immunosurveillance","volume":"161","author":"Steinert","year":"2015","journal-title":"Cell"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2744","article-title":"The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin","volume":"14","author":"Mackay","year":"2013","journal-title":"Nat Immunol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042617-053214","article-title":"Tissue-resident T cells and other resident leukocytes","volume":"37","author":"Masopust","year":"2019","journal-title":"Annu Rev Immunol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nri3567","article-title":"Human memory T cells: generation, compartmentalization and homeostasis","volume":"14","author":"Farber","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/nri3442","article-title":"The integration of T cell migration, differentiation and function","volume":"13","author":"Masopust","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.11.008","article-title":"T-box transcription factors combine with the cytokines TGF-\u03b2 and IL-15 to control tissue-resident memory T cell fate","volume":"43","author":"Mackay Laura","year":"2015","journal-title":"Immunity"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002042","article-title":"Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche","volume":"185","author":"Banerjee","year":"2010","journal-title":"J Immunol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1652","article-title":"ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage","volume":"9","author":"Egawa","year":"2008","journal-title":"Nat Immunol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.3.1694","article-title":"Runx3 regulates integrin alpha E\/CD103 and CD4 expression during development of CD4-\/CD8+ T cells","volume":"175","author":"Grueter","year":"2005","journal-title":"J Immunol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01904","article-title":"The emerging role of CD8+ Tissue resident memory T (TRM) cells in antitumor immunity: A unique functional contribution of the CD103 integrin","volume":"9","author":"Corgnac","year":"2018","journal-title":"Front Immunol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"3306","DOI":"10.1038\/s41467-019-11233-6","article-title":"EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming","volume":"10","author":"Istaces","year":"2019","journal-title":"Nat Commun"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/nature24993","article-title":"Runx3 programs CD8(+) T cell residency in non-lymphoid tissues and tumours","volume":"552","author":"Milner","year":"2017","journal-title":"Nature"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.3390\/cells10082143","article-title":"Single-cell transcriptomics reveals core regulatory programs that determine the heterogeneity of circulating and tissue-resident memory CD8(+) T cells","volume":"10","author":"Chen","year":"2021","journal-title":"Cells"},{"key":"B84","doi-asserted-by":"publisher","first-page":"109118","DOI":"10.1016\/j.celrep.2021.109118","article-title":"Resident memory T cells in tumor-distant tissues fortify against metastasis formation","volume":"35","author":"Christian","year":"2021","journal-title":"Cell Rep"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128330","article-title":"Superovulation using the combined administration of inhibin antiserum and equine chorionic gonadotropin increases the number of ovulated oocytes in C57BL\/6 female mice","volume":"10","author":"Takeo","year":"2015","journal-title":"PloS One"},{"key":"B86","doi-asserted-by":"publisher","first-page":"3386","DOI":"10.1038\/s41467-021-23571-5","article-title":"Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1\/SMAD5 axis","volume":"12","author":"Monsivais","year":"2021","journal-title":"Nat Commun"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00959","article-title":"Effects of six sequential charged particle beams on behavioral and cognitive performance in B6D2F1 female and male mice","volume":"11","author":"Raber","year":"2020","journal-title":"Front Physiol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3390\/cells11060957","article-title":"New aspects of corpus luteum regulation in physiological and pathological conditions: involvement of adipokines and neuropeptides","volume":"11","author":"Mlyczynska","year":"2022","journal-title":"Cells"},{"key":"B89","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/B978-0-12-801238-3.64396-9","article-title":"Corpus luteum","volume-title":"Encyclopedia of reproduction (Second edition)","author":"Hennebold","year":"2018"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.18632\/aging.v12i10","article-title":"Ovulation and ovarian wound healing are impaired with advanced reproductive age","volume":"12","author":"Mara","year":"2020","journal-title":"Aging (Albany N Y)"},{"key":"B91","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1477-7827-1-12","article-title":"Effects of deletion of the prolactin receptor on ovarian gene expression","volume":"1","author":"Grosdemouge","year":"2003","journal-title":"Reprod Biol Endocrinol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.2.167","article-title":"Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse","volume":"11","author":"Ormandy","year":"1997","journal-title":"Genes Dev"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod52.5.1162","article-title":"Infertility in transgenic mice overexpressing the bovine growth hormone gene: luteal failure secondary to prolactin deficiency1","volume":"52","author":"Cecim","year":"1995","journal-title":"Biol Reprod"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1210\/endo-129-6-2895","article-title":"Trophoblast cell differentiation: establishment, characterization, and modulation of a rat trophoblast cell line expressing members of the placental prolactin family","volume":"129","author":"Faria","year":"1991","journal-title":"Endocrinol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0194-6","article-title":"Prolactin \u2014 a pleiotropic factor in health and disease","volume":"15","author":"Bernard","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13354","article-title":"Primary lymphocytic hypophysitis: Clinical characteristics and treatment of 50 cases in a single centre in China over 18 years","volume":"87","author":"Wang","year":"2017","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1159\/000354701","article-title":"Use of prolactin receptor antagonist to better understand prolactin regulation of pituitary homeostasis","volume":"98","author":"Ferraris","year":"2013","journal-title":"Neuroendocrinology"},{"key":"B98","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/BF00920636","article-title":"Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases","volume":"13","author":"al-Janadi","year":"1993","journal-title":"J Clin Immunol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/cei.13566","article-title":"Variety of endosomal TLRs and Interferons (IFN-\u03b1, IFN-\u03b2, IFN-\u03b3) expression profiles in patients with SLE, SSc and MCTD","volume":"204","author":"Paradowska-Gorycka","year":"2021","journal-title":"Clin Exp Immunol"},{"key":"B100","doi-asserted-by":"publisher","first-page":"41335","DOI":"10.1038\/srep41335","article-title":"An altered endometrial CD8 tissue resident memory T cell population in recurrent miscarriage","volume":"7","author":"Southcombe","year":"2017","journal-title":"Sci Rep"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-011-8294-7","article-title":"Molecular mimicry as a mechanism of autoimmune disease","volume":"42","author":"Cusick","year":"2012","journal-title":"Clin Rev Allergy Immunol"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.580636","article-title":"Molecular mimicry and uveitis","volume":"11","author":"Wildner","year":"2020","journal-title":"Front Immunol"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1071\/R96083","article-title":"Recent developments and potentialities for reducing embryo mortality in ruminants: The role of IFN-\u03c4 and other cytokines in early pregnancy","volume":"9","author":"Martal","year":"1997","journal-title":"Reprod Fertil Dev"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.10.031","article-title":"Successful implantation is associated with a transient increase in serum pro-inflammatory cytokine profile followed by a switch to anti-inflammatory cytokine profile prior to confirmation of pregnancy","volume":"115","author":"Zhao","year":"2021","journal-title":"Fertil Steril"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.22034\/IJI.2022.91464.2083","article-title":"Evaluation of CD3+ T cell percentage, function and its relationship with serum vitamin D levels in women with recurrent spontaneous abortion and recurrent implantation failure","volume":"19","author":"Mousavi Salehi","year":"2022","journal-title":"Iran J Immunol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv044","article-title":"Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome","volume":"22","author":"Vannuccini","year":"2015","journal-title":"Hum Reprod Update"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0378(95)00936-F","article-title":"Levels of interferon-gamma and tumor necrosis factor-alpha in sera and cervical mucus of fertile and infertile women: implication in infertility","volume":"29","author":"Naz","year":"1995","journal-title":"J Reprod Immunol"},{"key":"B108","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1095\/biolreprod63.1.2","article-title":"Models of luteinization","volume":"63","author":"Murphy","year":"2000","journal-title":"Biol Reprod"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091970311","article-title":"Quantitative cell changes and vascularisation in the early corpus luteum of the pregnant rat","volume":"197","author":"Meyer","year":"1980","journal-title":"Anat Rec"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1210\/endo-126-6-2919","article-title":"Interferon-gamma inhibits stimulated adrenocorticotropin, prolactin, and growth hormone secretion in normal rat anterior pituitary cell cultures","volume":"126","author":"Vankelecom","year":"1990","journal-title":"Endocrinol"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.4065\/74.2.150","article-title":"Histologically proven lymphocytic hypophysitis: spontaneous resolution and subsequent pregnancy","volume":"74","author":"Gagneja","year":"1999","journal-title":"Mayo Clin Proc"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002493","article-title":"Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors","volume":"9","author":"Kobayashi","year":"2021","journal-title":"J\u00a0Immunother Cancer"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1159\/000181926","article-title":"Effects of prolactin on fertilization and cleavage of human oocytes","author":"Oda","year":"1991","journal-title":"Horm Res"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402480116","article-title":"Infertility in transgenic female mice with human growth hormone expression: evidence for luteal failure","volume":"248","author":"Bartke","year":"1988","journal-title":"J Exp Zool"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81444-0","article-title":"Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses","volume":"93","author":"Teglund","year":"1998","journal-title":"Cell"},{"key":"B116","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/er.2007-0017","article-title":"What can we learn from rodents about prolactin in humans","volume":"29","author":"Ben-Jonathan","year":"2008","journal-title":"Endocr Rev"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1191\/096120301701549688","article-title":"Enhanced serum prolactin (PRL) in patients with systemic lupus erythematosus: PRL levels are related to the disease activity","volume":"10","author":"Jacobi","year":"2001","journal-title":"Lupus"},{"key":"B118","article-title":"Elevated serum bioactive prolactin concentrations in patients with systemic lupus erythematosus are associated with disease activity as disclosed by homologous receptor bioassays","volume":"34","author":"C\u00e1rdenas-Mondrag\u00f3n","year":"2007","journal-title":"J Rheumatol"},{"key":"B119","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1093\/rheumatology\/kei115","article-title":"Serum free prolactin concentrations in patients with systemic lupus erythematosus are associated with lupus activity","volume":"45","author":"Lea\u00f1os-Miranda","year":"2006","journal-title":"Rheumatol (Oxford)"},{"key":"B120","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1089\/clo.2006.8.295","article-title":"Zygotically activated genes are suppressed in mouse nuclear transferred embryos","volume":"8","author":"Suzuki","year":"2006","journal-title":"Cloning Stem Cells"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1997.tb00256.x","article-title":"Interferon-gamma production by the human preimplantation embryo","volume":"37","author":"Ozornek","year":"1997","journal-title":"Am J Reprod Immunol"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01127-4","article-title":"Th1-type immunity is incompatible with successful pregnancy","volume":"18","author":"Raghupathy","year":"1997","journal-title":"Immunol Today"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90030-G","article-title":"RAG-1-deficient mice have no mature B and T lymphocytes","volume":"68","author":"Mombaerts","year":"1992","journal-title":"Cell"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1126\/science.8456300","article-title":"Multiple defects of immune cell function in mice with disrupted interferon-\u03b3 Genes","volume":"259","author":"Dalton","year":"1993","journal-title":"Science"},{"key":"B125","doi-asserted-by":"publisher","first-page":"102710","DOI":"10.1016\/j.xpro.2023.102710","article-title":"Isolation of single cells from individual mouse ovaries for flow cytometry and functional analysis","volume":"4","author":"Bafor","year":"2023","journal-title":"STAR Protoc"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.3791\/4389-v","article-title":"Performing vaginal lavage, crystal violet staining, and vaginal cytological evaluation for mouse estrous cycle staging identification","volume":"67","author":"McLean","year":"2012","journal-title":"J Vis Exp"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0150131","article-title":"Oestrus-accelerating pheromone of mice: assay, androgen-dependency and presence in bladder urine","volume":"15","author":"Bronson","year":"1968","journal-title":"J Reprod Fertil"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003185","article-title":"Genetic disruption of the copulatory plug in mice leads to severely reduced fertility","volume":"9","author":"Dean","year":"2013","journal-title":"PloS Genet"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1368572\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T10:47:57Z","timestamp":1713437277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1368572\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":128,"alternative-id":["10.3389\/fimmu.2024.1368572"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1368572","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,18]]},"article-number":"1368572"}}