{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:57:44Z","timestamp":1753891064063,"version":"3.41.2"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Granulomatosis with polyangiitis (GPA) is an autoimmune inflammatory disease that affects small- and medium-sized blood vessels in the body, representing a rare entity. Cardiac involvement was identified as an independent risk factor for death in GPA patients, yet it has not been systematically elucidated in previous literature. Cardiac lesions in patients with GPA can manifest in various ways, such as pericarditis, myocarditis, coronary vasculitis, valvular abnormalities, conduction system abnormalities, and heart failure. Herein, we report a 55-year-old woman with GPA; she had a 2-year history of recurrent episodes of headache, accompanying sickness, and fatigue, which have been aggravated for the past half-month. The main manifestation is presenting as a mass in the aortic root, which was successfully diagnosed by multimodality imaging (including two-dimensional echocardiography, contrast-enhanced ultrasound, and computed tomography). After treatment with methylprednisolone and cyclophosphamide, the patient\u2019s symptoms significantly improved and she remained asymptomatic over 6 months of follow-up. This article will enrich our knowledge about cardiac involvement in GPA patients and highlights the value of imaging, especially ultrasound, in the diagnosis and post-treatment follow-up of this condition.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1373769","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T09:23:43Z","timestamp":1732785823000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: Granulomatosis with polyangiitis patient presented with a mass in the aortic root"],"prefix":"10.3389","volume":"15","author":[{"given":"Yinyan","family":"Teng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusheng","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/art.37715","article-title":"2012 revised International Chapel Hill Consensus Conference Nomenclature of vasculitides","volume":"65","author":"Jennette","year":"2013","journal-title":"Arthritis Rheum"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2021-002160","article-title":"Comparative study of granulomatosis with polyangiitis subsets according to ANCA status: data from the French Vasculitis Study Group Registry","volume":"8","author":"Pu\u00e9chal","year":"2022","journal-title":"RMD Open"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.141513","article-title":"Cardiac involvement in granulomatosis with polyangiitis","volume":"42","author":"McGeoch","year":"2015","journal-title":"J Rheumatol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.15730","article-title":"Cardiac involvement as a fatal complication of granulomatosis with polyangiitis","volume":"131","author":"Czapli\u0144ska","year":"2021","journal-title":"Pol Arch Intern Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccase.2019.11.005","article-title":"A 60-year-old with heart failure symptoms due to 1st degree AV-Block caused by granulomatosis with polyangiitis (Wegener\u2019s granulomatosis)","volume":"21","author":"Saghabalyan","year":"2019","journal-title":"J Cardiol cases"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.24875\/CIRU.20001764","article-title":"Acute myocardial infarction, as a rare manifestation in granulomatosis with polyangiitis","volume":"88","author":"Maya-Pi\u00f1a","year":"2020","journal-title":"Cir Cir"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.01.028","article-title":"Diagnosis and classification of granulomatosis with polyangiitis (aka Wegener\u2019s granulomatosis)","author":"Lutalo","year":"2014","journal-title":"J Autoimmun"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew490","article-title":"Cardiac involvement in granulomatosis with polyangiitis: a magnetic resonance imaging study of 31 consecutive patients","volume":"56","author":"Pugnet","year":"2017","journal-title":"Rheumatol (Oxford)"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/art.33361","article-title":"Risk factors for relapse of antineutrophil cytoplasmic antibody-associated vasculitis","volume":"64","author":"Walsh","year":"2012","journal-title":"Arthritis Rheum"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2019.06.004","article-title":"Update on eosinophilic granulomatosis with polyangiitis","volume":"68","author":"Furuta","year":"2019","journal-title":"Allergol Int"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s12055-021-01263-5","article-title":"Granulomatosis polyangiitis of the heart\u2014an unusual presentation: a case report and review of literature","volume":"38","author":"Karthik Raman","year":"2022","journal-title":"Indian J Thorac Cardiovasc Surgery"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.5935\/0103-507X.20170052","article-title":"Heart conduction system defects and sustained ventricular tachycardia complications in a patient with granulomatosis with polyangiitis. 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