{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:30:35Z","timestamp":1792801835817,"version":"4.5.0"},"reference-count":119,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>NETosis, a regulated form of neutrophil death, is crucial for host defense against pathogens. However, the release of neutrophil extracellular traps (NETs) during NETosis can have detrimental effects on surrounding tissues and contribute to the pro-inflammatory response, in addition to their role in controlling microbes. Although it is well-established that the IL-23-Th17 axis plays a key role in the pathogenesis of psoriasis, emerging evidence suggests that psoriasis, as an autoinflammatory disease, is also associated with NETosis. The purpose of this review is to provide a comprehensive understanding of the mechanisms underlying NETosis in psoriasis. It will cover topics such as the formation of NETs, immune cells involved in NETosis, and potential biomarkers as prognostic\/predicting factors in psoriasis. By analyzing the intricate relationship between NETosis and psoriasis, this review also aims to identify novel possibilities targeting NETosis for the treatment of psoriasis.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1374934","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T01:18:42Z","timestamp":1722475122000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["NETosis of psoriasis: a critical step in amplifying the inflammatory response"],"prefix":"10.3389","volume":"15","author":[{"given":"Jinke","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120225","article-title":"Immunology of psoriasis","volume":"32","author":"Lowes","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1159\/000210811","article-title":"Migration of polymorphonuclear leukocytes in psoriasis","volume":"2","author":"van de Kerkhof.","year":"1989","journal-title":"Skin Pharmacol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1034\/j.1600-0625.2000.009001001.x","article-title":"Role of neutrophils in induction of acute inflammation in T cell mediated immune dermatosis psoriasis a neutrophil-associated inflammation boosting loop","volume":"9","author":"Terui","year":"2000","journal-title":"Exp Dermatol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12500035","article-title":"On the mechanism of enhanced monocyte and neutrophil cytotoxicity in severe psoriasis","volume":"79","author":"Herlin","year":"1982","journal-title":"J Invest Dermatol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12710","article-title":"Evidence that a neutrophil\u2013keratinocyte crosstalk is an early target of IL-17A inhibition in psoriasis","volume":"24","author":"Reich","year":"2015","journal-title":"Exp Dermatol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12560","article-title":"Biologic therapy improves psoriasis by decreasing the activity of monocytes and neutrophils","volume":"41","author":"Yamanaka","year":"2014","journal-title":"J Dermatol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.04.029","article-title":"IL-17A inhibition by secukinumab induces early clinical, histopathologic, and molecular resolution of psoriasis","volume":"144","author":"Krueger","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41423-018-0024-0","article-title":"NETosis, complement, and coagulation: a triangular relationship","volume":"16","author":"de Bont","year":"2018","journal-title":"Cell Mol Immunol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1959","article-title":"Netting neutrophils in autoimmune small-vessel vasculitis","volume":"15","author":"Kessenbrock","year":"2009","journal-title":"Nat Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"73ra20","DOI":"10.1126\/scitranslmed.3001201","article-title":"Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus","volume":"3","author":"Garcia-Romo","year":"2011","journal-title":"Sci Transl Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"178ra40","DOI":"10.1126\/scitranslmed.3005580","article-title":"NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis","volume":"5","author":"Khandpur","year":"2013","journal-title":"Sci Transl Me"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1039\/C6NR03416K","article-title":"The architecture of neutrophil extracellular traps investigated by atomic force microscopy","volume":"8","author":"Pires","year":"2016","journal-title":"Nanoscale"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00423","article-title":"Caught in a trap? 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