{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:40:31Z","timestamp":1780468831382,"version":"3.54.1"},"reference-count":82,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Primary Sj\u00f6gren\u2019s syndrome (pSS) is an autoimmune disease, with B cell hyperactivation and autoantibody production as its immunological hallmarks. Although the distinction between immunoglobulin G4-related disease (IgG4-RD) and pSS, based on the presence or absence of certain autoantibodies, seems easy to make, possibility of elevated serum IgG4 concentration and often similar organ involvement may lead to a misdiagnosis. The increased serum concentration of IgG4 in IgG4-RD is not clearly linked to the pathogenesis of IgG-RD and it has been suggested that it may constitute just an epiphenomenon. The aim of this article is to discuss the presence of IgG4 in pSS and IgG4-RD and its potential significance for these two diseases.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1376723","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T04:26:58Z","timestamp":1726720018000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Immunoglobulin G4 in primary Sj\u00f6gren\u2019s syndrome and IgG4-related disease - connections and dissimilarities"],"prefix":"10.3389","volume":"15","author":[{"given":"Maria","family":"Maslinska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga","family":"Kostyra-Grabczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.imlet.2011.06.007","article-title":"The complexity of Sj\u00f6gren's syndrome: novel aspects on pathogenesis","volume":"141","author":"Jonsson","year":"2011","journal-title":"Immunol Lett"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2020.146","article-title":"Clinical influences of anticentromere antibody on primary Sj\u00f6gren's syndrome in a prospective Korean cohort","volume":"36","author":"Park","year":"2021","journal-title":"Korean J Intern Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.019794","article-title":"Prevalence of anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with primary Sj\u00f6gren's syndrome","volume":"64","author":"Gottenberg","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-020-04782-3","article-title":"IgA immunoglobulin isotype of rheumatoid factor in primary Sj\u00f6gren's syndrome","volume":"41","author":"Ma\u015bli\u0144ska","year":"2021","journal-title":"Rheumatol Int"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-018-4090-5","article-title":"Rheumatoid factor isotype and Ro epitope distribution in primary Sj\u00f6gren syndrome and rheumatoid arthritis with keratoconjunctivitis sicca","volume":"38","author":"Meek","year":"2018","journal-title":"RheumatolInt"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2022.100746","article-title":"Prevalence and impact of Sj\u00f6gren's syndrome in primary biliary cholangitis: a systematic review and meta-analysis","volume":"27","author":"Deng","year":"2022","journal-title":"Ann Hepatol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00121","article-title":"The association of Sj\u00f6gren syndrome and autoimmune thyroid disorders","volume":"9","author":"Baldini","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2020.98437","article-title":"Mikulicz's disease and K\u00fcttner's tumor as manifestations of IgG4-related diseases: a review of the literature","volume":"58","author":"Kami\u0144ski","year":"2020","journal-title":"Reumatologia"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh447","article-title":"Clinical and pathological differences between Mikulicz's disease and Sj\u00f6gren's syndrome","volume":"44","author":"Yamamoto","year":"2005","journal-title":"Rheumatology"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00520","article-title":"IgG subclasses and allotypes: From structure to effector functions","volume":"5","author":"Vidarsson","year":"2014","journal-title":"Front Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.022350","article-title":"IgG. 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