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Our paper presents the tumor-suppressing effect of <jats:italic>Taenia crassiceps<\/jats:italic> and <jats:italic>Mesocestoides corti<\/jats:italic> on B16F10 melanoma, the intraperitoneal application of which followed the experimental infection with these tapeworms, resulting in varying degrees of effectiveness in two strains of mice. In the case of <jats:italic>M. corti<\/jats:italic>-infected ICR mice, a strong tumor growth suppression occurred, which was accompanied by a significant reduction in the formation of distant metastases in the liver and lung. Tapeworm-infected C57BL\/6J mice also showed a suppression of tumor growth and, in addition, the overall survival of infected C57BL\/6J mice was significantly improved. Experiments with potential cross-reaction of melanoma and tapeworm antigens with respective specific antibodies, restimulation of spleen T cells, or the direct effect of tapeworm excretory-secretory products on melanoma cells <jats:italic>in vitro<\/jats:italic> could not explain the phenomenon. However, infections with <jats:italic>T. crassiceps<\/jats:italic> and <jats:italic>M. corti<\/jats:italic> increased the number of leukocytes possibly involved in anti-tumor immunity in the peritoneal cavity of both ICR and C57BL\/6J mice. This study unveils the complex interplay between tapeworm infections, immune responses, and melanoma progression, emphasizing the need for further exploration of the mechanisms driving observed tumor-suppressive effects.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1376907","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T04:30:02Z","timestamp":1710909002000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Suppression of the growth and metastasis of mouse melanoma by Taenia crassiceps and Mesocestoides corti 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