{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:20:46Z","timestamp":1791537646443,"version":"4.3.4"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Germany's Excellence Strategy \u2013 EXC 2151 \u2013 390873048 and DFG Project number 411345524 and 432325352."],"award-info":[{"award-number":["Germany's Excellence Strategy \u2013 EXC 2151 \u2013 390873048 and DFG Project number 411345524 and 432325352."]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Dendritic cells (DCs) are major antigen-presenting cells that connect innate and adaptive immunity. Hepatic DCs are less activated and contribute to maintain the tolerogenic environment of the liver under steady state. Several studies indicated DCs in metabolic dysfunction-associated steatohepatitis (MASH), representing a substantial burden on healthcare systems due to its association with liver-related morbidity and mortality. Studies highlighted the potential disease-promoting role of liver DCs in the development of MASH while other experimental systems suggested their protective role. This review discusses this controversy and the current understanding of how DCs affect the pathogenesis of MASH.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1379225","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T04:47:01Z","timestamp":1712551621000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["The role of dendritic cells in MASH: friends or foes?"],"prefix":"10.3389","volume":"15","author":[{"given":"Antonio T.","family":"Pinto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Lukacs-Kornek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","article-title":"MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000520","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"78","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i36.6571","article-title":"Nonalcoholic fatty liver disease: Evolving paradigms","volume":"23","author":"Lonardo","year":"2017","journal-title":"World J Gastroenterol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.41","article-title":"Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis","volume":"10","author":"Anstee","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315691","article-title":"Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation","volume":"67","author":"Ibrahim","year":"2018","journal-title":"Gut"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12272","article-title":"Abdominal subcutaneous adipose tissue insulin resistance and lipolysis in patients with non-alcoholic steatohepatitis","volume":"16","author":"Armstrong","year":"2014","journal-title":"Diabetes Obes Metab"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.06.012","article-title":"Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease - novel insights into cellular communication circuits","volume":"77","author":"Peiseler","year":"2022","journal-title":"J Hepatol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-051116-052415","article-title":"Immune responses in the liver","volume":"36","author":"Kubes","year":"2018","journal-title":"Annu Rev Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.08.002","article-title":"Liver macrophages in health and disease","volume":"55","author":"Guilliams","year":"2022","journal-title":"Immunity"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318382","article-title":"Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis","volume":"69","author":"Krenkel","year":"2020","journal-title":"Gut"},{"key":"B13","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.cell.2021.12.018","article-title":"Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches","volume":"185","author":"Guilliams","year":"2022","journal-title":"Cell"},{"key":"B14","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.immuni.2020.08.004","article-title":"Osteopontin expression identifies a subset of recruited macrophages distinct from kupffer cells in the fatty liver","volume":"53","author":"Remmerie","year":"2020","journal-title":"Immunity"},{"key":"B15","doi-asserted-by":"publisher","first-page":"103233","DOI":"10.1016\/j.isci.2021.103233","article-title":"Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver","volume":"24","author":"Su","year":"2021","journal-title":"iScience"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-061020-053707","article-title":"Dendritic cells revisited","volume":"39","author":"Cabeza-Cabrerizo","year":"2021","journal-title":"Annu Rev Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1615","article-title":"The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues","volume":"9","author":"Waskow","year":"2008","journal-title":"Nat Immunol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2467","article-title":"Re(de)fining the dendritic cell lineage","volume":"13","author":"Satpathy","year":"2012","journal-title":"Nat Immunol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100348","article-title":"Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells","volume":"207","author":"Bachem","year":"2010","journal-title":"J Exp Med"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-406967","article-title":"DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues","volume":"119","author":"Poulin","year":"2012","journal-title":"Blood"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag3009","article-title":"Mapping the human DC lineage through the integration of high-dimensional techniques","volume":"356","author":"See","year":"2017","journal-title":"Science"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4573","article-title":"Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors","volume":"356","author":"Villani","year":"2017","journal-title":"Science"},{"key":"B23","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.immuni.2012.04.012","article-title":"Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells","volume":"37","author":"Haniffa","year":"2012","journal-title":"Immunity"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/j.immuni.2023.07.001","article-title":"Dendritic cell type 3 arises from Ly6C(+) monocyte-dendritic cell progenitors","volume":"56","author":"Liu","year":"2023","journal-title":"Immunity"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm5658","article-title":"Multimodal control of dendritic cell functions by nociceptors","volume":"379","author":"Hanc","year":"2023","journal-title":"Science"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/j.cell.2020.04.022","article-title":"Microbiota-induced type I interferons instruct a poised basal state of dendritic cells","volume":"181","author":"Schaupp","year":"2020","journal-title":"Cell"},{"key":"B27","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1189\/jlb.0912452","article-title":"Human blood mDC subsets exhibit distinct TLR repertoire and responsiveness","volume":"93","author":"Hemont","year":"2013","journal-title":"J Leukoc Biol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.02.028","article-title":"Differential expression of pathogen-recognition molecules between dendritic cell subsets revealed by plasma membrane proteomic analysis","volume":"47","author":"Segura","year":"2010","journal-title":"Mol Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1146\/annurev.iy.12.040194.005015","article-title":"Tolerance, danger, and the extended family","volume":"12","author":"Matzinger","year":"1994","journal-title":"Annu Rev Immunol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.04.017","article-title":"Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming","volume":"25","author":"Allan","year":"2006","journal-title":"Immunity"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-020-00680-4","article-title":"Molecular mechanisms of dendritic cell migration in immunity and cancer","volume":"209","author":"de Winde","year":"2020","journal-title":"Med Microbiol Immunol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1126\/science.1136080","article-title":"Differential antigen processing by dendritic cell subsets in vivo","volume":"315","author":"Dudziak","year":"2007","journal-title":"Science"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.6.769","article-title":"Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo","volume":"194","author":"Hawiger","year":"2001","journal-title":"J Exp Med"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070176","article-title":"A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo","volume":"204","author":"Soares","year":"2007","journal-title":"J Exp Med"},{"key":"B35","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.it.2020.11.001","article-title":"Tolerogenic dendritic cells in autoimmunity and inflammatory diseases","volume":"42","author":"Morante-Palacios","year":"2021","journal-title":"Trends Immunol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.07.019","article-title":"Broad and largely concordant molecular changes characterize tolerogenic and immunogenic dendritic cell maturation in thymus and periphery","volume":"45","author":"Ardouin","year":"2016","journal-title":"Immunity"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.11.012","article-title":"Self-antigen presentation by dendritic cells and lymphoid stroma and its implications for autoimmunity","volume":"23","author":"Lukacs-Kornek","year":"2011","journal-title":"Curr Opin Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41577-019-0210-z","article-title":"Dendritic cells in cancer immunology and immunotherapy","volume":"20","author":"Wculek","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/nature13814","article-title":"Dendritic cells control fibroblastic reticular network tension and lymph node expansion","volume":"514","author":"Acton","year":"2014","journal-title":"Nature"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.591741","article-title":"Angiogenesis in lymph nodes is a critical regulator of immune response and lymphoma growth","volume":"11","author":"Menzel","year":"2020","journal-title":"Front Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.immuni.2020.06.023","article-title":"The cytokine TGF-beta induces interleukin-31 expression from dermal dendritic cells to activate sensory neurons and stimulate wound itching","volume":"53","author":"Xu","year":"2020","journal-title":"Immunity"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/nri3865","article-title":"The multifaceted biology of plasmacytoid dendritic cells","volume":"15","author":"Swiecki","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41577-022-00806-0","article-title":"Reclassifying plasmacytoid dendritic cells as innate lymphocytes","volume":"23","author":"Ziegler-Heitbrock","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1038\/s41467-018-04985-0","article-title":"Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway","volume":"9","author":"Tang-Huau","year":"2018","journal-title":"Nat Commun"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.06.001","article-title":"Inflammatory dendritic cells in mice and humans","volume":"34","author":"Segura","year":"2013","journal-title":"Trends Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.immuni.2020.04.005","article-title":"Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection","volume":"52","author":"Bosteels","year":"2020","journal-title":"Immunity"},{"key":"B47","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/imcb.12559","article-title":"The liver contains distinct interconnected networks of CX3CR1(+) macrophages, XCR1(+) type 1 and CD301a(+) type 2 conventional dendritic cells embedded within portal tracts","volume":"100","author":"English","year":"2022","journal-title":"Immunol Cell Biol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.03.023","article-title":"Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation","volume":"57","author":"Barbier","year":"2012","journal-title":"J Hepatol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/978-1-4757-9966-8_13","article-title":"The liver sinusoids as a specialized site for blood-lymph translocation of rat dendritic cells","volume":"417","author":"Matsuno","year":"1997","journal-title":"Adv Exp Med Biol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.05.033","article-title":"Dendritic cells in liver injury and fibrosis: shortcomings and promises","volume":"59","author":"Lukacs-Kornek","year":"2013","journal-title":"J Hepatol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.08.024","article-title":"Combination of mass cytometry and imaging analysis reveals origin, location, and functional repopulation of liver myeloid cells in mice","volume":"151","author":"David","year":"2016","journal-title":"Gastroenterology"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00179","article-title":"The complex myeloid network of the liver with diverse functional capacity at steady state and in inflammation","volume":"6","author":"Eckert","year":"2015","journal-title":"Front Immunol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/nri2858","article-title":"Antigen-presenting cell function in the tolerogenic liver environment","volume":"10","author":"Thomson","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aai7616","article-title":"Type I interferon responses drive intrahepatic T cells to promote metabolic syndrome","volume":"2","author":"Ghazarian","year":"2017","journal-title":"Sci Immunol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26937","article-title":"The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease","volume":"59","author":"Gadd","year":"2014","journal-title":"Hepatology"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.08.007","article-title":"CD141(+) myeloid dendritic cells are enriched in healthy human liver","volume":"60","author":"Kelly","year":"2014","journal-title":"J Hepatol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"97","DOI":"10.4049\/jimmunol.1501175","article-title":"Progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis is marked by a higher frequency of th17 cells in the liver and an increased th17\/resting regulatory T cell ratio in peripheral blood and in the liver","volume":"196","author":"Rau","year":"2016","journal-title":"J Immunol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1042\/CS20150405","article-title":"The balance between IL-17 and IL-22 produced by liver-infiltrating T-helper cells critically controls NASH development in mice","volume":"130","author":"Rolla","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.09.003","article-title":"Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes","volume":"26","author":"Wolf","year":"2014","journal-title":"Cancer Cell"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/nature16969","article-title":"NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis","volume":"531","author":"Ma","year":"2016","journal-title":"Nature"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03233-8","article-title":"Auto-aggressive CXCR6(+) CD8 T cells cause liver immune pathology in NASH","volume":"592","author":"Dudek","year":"2021","journal-title":"Nature"},{"key":"B62","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.jhep.2023.04.037","article-title":"Intestinal B cells license metabolic T-cell activation in NASH microbiota\/antigen-independently and contribute to fibrosis by IgA-FcR signalling","volume":"79","author":"Kotsiliti","year":"2023","journal-title":"J Hepatol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.057968","article-title":"Immune response towards lipid peroxidation products as a predictor of progression of non-alcoholic fatty liver disease to advanced fibrosis","volume":"54","author":"Albano","year":"2005","journal-title":"Gut"},{"key":"B64","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/hep.26267","article-title":"Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice","volume":"58","author":"Henning","year":"2013","journal-title":"Hepatology"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.01.008","article-title":"Murine CD103(+) dendritic cells protect against steatosis progression towards steatohepatitis","volume":"66","author":"Heier","year":"2017","journal-title":"J Hepatol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01344-3","article-title":"XCR1(+) type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis","volume":"27","author":"Deczkowska","year":"2021","journal-title":"Nat Med"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3390\/cells8091099","article-title":"CX(3)CR1 mediates the development of monocyte-derived dendritic cells during hepatic inflammation","volume":"8","author":"Sutti","year":"2019","journal-title":"Cells"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0076-1","article-title":"Transcriptional Network Analysis Implicates Altered Hepatic Immune Function in NASH development and resolution","volume":"1","author":"Haas","year":"2019","journal-title":"Nat Metab"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.157","article-title":"The transcription factor Batf3 inhibits the differentiation of regulatory T cells in the periphery","volume":"49","author":"Lee","year":"2017","journal-title":"Exp Mol Med"},{"key":"B70","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.cytogfr.2017.07.004","article-title":"IL-9 and Th9 cells in health and diseases-From tolerance to immunopathology","volume":"37","author":"Li","year":"2017","journal-title":"Cytokine Growth Factor Rev"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/nri3700","article-title":"Ectopic lymphoid-like structures in infection, cancer and autoimmunity","volume":"14","author":"Pitzalis","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0220","article-title":"ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming","volume":"106","author":"Segura","year":"2005","journal-title":"Blood"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06114-4","article-title":"Tumour extracellular vesicles and particles induce liver metabolic dysfunction","volume":"618","author":"Wang","year":"2023","journal-title":"Nature"},{"key":"B74","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.cell.2017.12.013","article-title":"Western diet triggers NLRP3-dependent innate immune reprogramming","volume":"172","author":"Christ","year":"2018","journal-title":"Cell"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1379225\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T04:47:04Z","timestamp":1712551624000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1379225\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,8]]},"references-count":74,"alternative-id":["10.3389\/fimmu.2024.1379225"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1379225","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,8]]},"article-number":"1379225"}}