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This study focuses on decidual \u03b3\u03b4T cell populations and examines their expression of receptors that bind to non-classical HLA molecules, HLA-E and HLA-G. We demonstrate that decidual \u03b3\u03b4T cell subsets, including V\u03b41, V\u03b42, and double-negative (DN) V\u03b41-\/V\u03b42- cells express HLA-specific regulatory receptors, such as NKG2C, NKG2A, ILT2, and KIR2DL4, each with varying dominance. Furthermore, decidual \u03b3\u03b4T cells produce cytokines (G-CSF, FGF2) and cytotoxic mediators (Granulysin, IFN-\u03b3), suggesting functions in placental growth and pathogen defense. However, these processes seem to be controlled by factors other than trophoblast-derived non-classical HLA molecules. These findings indicate that decidual \u03b3\u03b4T cells have the potential to actively contribute to the maintenance of healthy human pregnancy.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1382424","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T01:12:28Z","timestamp":1711501948000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Decidual \u03b3\u03b4T cells of early human pregnancy produce angiogenic and immunomodulatory proteins while also possessing cytotoxic 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