{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:15:33Z","timestamp":1787026533531,"version":"build-2736575974"},"reference-count":168,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009377","name":"Education Department of Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Acne vulgaris is one of the most common skin diseases. The current understanding of acne primarily revolves around inflammatory responses, sebum metabolism disorders, aberrant hormone and receptor expression, colonization by\n                    <jats:italic>Cutibacterium acnes<\/jats:italic>\n                    , and abnormal keratinization of follicular sebaceous glands. Although the precise mechanism of action remains incompletely understood, it is plausible that macrophages exert an influence on these pathological features. Macrophages, as a constituent of the human innate immune system, typically manifest distinct phenotypes across various diseases. It has been observed that the polarization of macrophages toward the M1 phenotype plays a pivotal role in the pathogenesis of acne. In recent years, extensive research on acne has revealed an increasing number of natural remedies exhibiting therapeutic efficacy through the modulation of macrophage polarization. This review investigates the role of cutaneous macrophages, elucidates their potential significance in the pathogenesis of acne, a prevalent chronic inflammatory skin disorder, and explores the therapeutic mechanisms of natural plant products targeting macrophages. Despite these insights, the precise role of macrophages in the pathogenesis of acne remains poorly elucidated. Subsequent investigations in this domain will further illuminate the pathogenesis of acne and potentially offer guidance for identifying novel therapeutic targets for this condition.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2024.1383263","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:34:00Z","timestamp":1714091640000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Research progress on the role of macrophages in acne and regulation by natural plant products"],"prefix":"10.3389","volume":"15","author":[{"given":"Dan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s40257-020-00531-1","article-title":"The skin microbiome: A new actor in inflammatory acne","volume":"21","author":"Dr\u00e9no","year":"2020","journal-title":"Am J Clin Dermatol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14951","article-title":"A cross-sectional cohort study on the skin microbiota in patients with different acne durations","volume":"32","author":"Sun","year":"2023","journal-title":"Exp Dermatol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18792","article-title":"Change in Cutibacterium acnes phylotype abundance and improvement of clinical parameters using a new dermo-cosmetic product containing Myrtus communis and Celastrol enriched plant cell culture extracts in patients with acne vulgaris","volume":"37","author":"Mias","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"5293","DOI":"10.3390\/nu14245293","article-title":"The impact of common acne on the well-being of young people aged 15-35 years and the influence of nutrition knowledge and diet on acne development","volume":"14","author":"Kostecka","year":"2022","journal-title":"Nutrients"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13191","article-title":"Acne and quality of life - impact and management","volume":"29","author":"Gieler","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2015.11.009","article-title":"Evaluation of acne scars: how to assess them and what to tell the patient","volume":"34","author":"Fife","year":"2016","journal-title":"Dermatol Clinics"},{"key":"B7","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1186\/1471-2458-9-340","article-title":"Is the association between acne and mental distress influenced by diet? 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