{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:56:18Z","timestamp":1792511778218,"version":"4.5.0"},"reference-count":169,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020003","name":"Eutopia Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030780","name":"Wetenschappelijk Fonds Willy Gepts, Universitair Ziekenhuis Brussel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011851","name":"Kom op tegen Kanker","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Modest response rates to immunotherapy observed in advanced lung cancer patients underscore the need to identify reliable biomarkers and targets, enhancing both treatment decision-making and efficacy. Factors such as PD-L1 expression, tumor mutation burden, and a \u2018hot\u2019 tumor microenvironment with heightened effector T cell infiltration have consistently been associated with positive responses. In contrast, the predictive role of the abundantly present tumor-infiltrating myeloid cell (TIMs) fraction remains somewhat uncertain, partly explained by their towering variety in terms of ontogeny, phenotype, location, and function. Nevertheless, numerous preclinical and clinical studies established a clear link between lung cancer progression and alterations in intra- and extramedullary hematopoiesis, leading to emergency myelopoiesis at the expense of megakaryocyte\/erythroid and lymphoid differentiation. These observations affirm that a continuous crosstalk between solid cancers such as lung cancer and the bone marrow niche (BMN) must take place. However, the BMN, encompassing hematopoietic stem and progenitor cells, differentiated immune and stromal cells, remains inadequately explored in solid cancer patients. Subsequently, no clear consensus has been reached on the exact breadth of tumor installed hematopoiesis perturbing cues nor their predictive power for immunotherapy. As the current era of single-cell omics is reshaping our understanding of the hematopoietic process and the subcluster landscape of lung TIMs, we aim to present an updated overview of the hierarchical differentiation process of TIMs within the BMN of solid cancer bearing subjects. Our comprehensive overview underscores that lung cancer should be regarded as a systemic disease in which the cues governing the lung tumor-BMN crosstalk might bolster the definition of new biomarkers and druggable targets, potentially mitigating the high attrition rate of leading immunotherapies for NSCLC.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1397469","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T04:36:13Z","timestamp":1722486973000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["The crosstalk between lung cancer and the bone marrow niche fuels emergency myelopoiesis"],"prefix":"10.3389","volume":"15","author":[{"given":"Evelyn","family":"Calderon-Espinosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"De Ridder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Benoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanina","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domien","family":"Vanhonacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robbe","family":"Heestermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"De Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Van Riet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lore","family":"Decoster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleo","family":"Goyvaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00798-3","article-title":"The global burden of lung cancer: current status and future trends","volume":"20","author":"Leiter","year":"2023","journal-title":"Nat Rev Clin Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jtho.2022.11.001","article-title":"The anti\u2013programmed cell death protein-1\/programmed death-ligand 1 me-too drugs tsunami: hard to be millennials among baby boomers","volume":"18","author":"Ferrara","year":"2023","journal-title":"J Thorac Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00711-7","article-title":"Overcoming immunotherapy resistance in NSCLC","volume":"23","author":"MacManus","year":"2022","journal-title":"Lancet Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S40364-022-00355-7\/TABLES\/1","article-title":"The key to immunotherapy: how to choose better therapeutic biomarkers for patients with non-small cell lung cancer","volume":"10","author":"Pan","year":"2022","journal-title":"biomark Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41568-018-0081-9","article-title":"The lung microenvironment: an important regulator of tumour growth and metastasis","volume":"19","author":"Altorki","year":"2019","journal-title":"Nat Rev Cancer"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2022.914890\/BIBTEX","article-title":"Host-related factors as targetable drivers of immunotherapy response in non-small cell lung cancer patients","volume":"13","author":"Baci","year":"2022","journal-title":"Front Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14381","article-title":"Neutrophils dominate the immune cell composition in non-small cell lung cancer","volume":"8","author":"Kargl","year":"2017","journal-title":"Nat Commun"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03101","article-title":"Immune cell composition in human non-small cell lung cancer","volume":"9","author":"Stankovic","year":"2019","journal-title":"Front Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.04.009","article-title":"Fractionated radiation severely reduces the number of CD8+ T cells and mature antigen presenting cells within lung tumors","volume":"11","author":"Reijmen","year":"2021","journal-title":"Int J Radiat OncologyBiologyPhysics"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2022.811867\/BIBTEX","article-title":"TNF-\u03b1-secreting lung tumor-infiltrated monocytes play a pivotal role during anti-PD-L1 immunotherapy","volume":"13","author":"De Ridder","year":"2022","journal-title":"Front Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.cell.2017.04.014","article-title":"Innate immune landscape in early lung adenocarcinoma by paired single-cell analyses","volume":"169","author":"Lavin","year":"2017","journal-title":"Cell"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00587-0","article-title":"Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial","volume":"387","author":"Fehrenbacher","year":"2016","journal-title":"Lancet"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-3451\/73799\/AM\/INTERFERON-GAMMA-MESSENGER-RNA-SIGNATURE-IN-TUMOR","article-title":"Interferon gamma messenger RNA Signature in tumor biopsies predicts outcomes in patients with non\u2013small cell lung carcinoma or urothelial cancer treated with durvalumab","volume":"24","author":"Higgs","year":"2018","journal-title":"Clin Cancer Res"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-000974","article-title":"Gene signature of antigen processing and presentation machinery predicts response to checkpoint blockade in non-small cell lung cancer (NSCLC) and melanoma","volume":"8","author":"Thompson","year":"2020","journal-title":"J Immunother Cancer"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI91190","article-title":"IFN-\u03b3\u2013related mRNA profile predicts clinical response to PD-1 blockade","volume":"127","author":"Ayers","year":"2017","journal-title":"J Clin Invest"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e06438","article-title":"A novel immuno-oncology algorithm measuring tumor microenvironment to predict response to immunotherapies","volume":"7","author":"Nielsen","year":"2021","journal-title":"Heliyon"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0357-y","article-title":"A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma","volume":"25","author":"Huang","year":"2019","journal-title":"Nat Med"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-3329\/674450\/AM\/TRANSCRIPTOMIC-DETERMINANTS-OF-RESPONSE-TO","article-title":"Transcriptomic determinants of response to pembrolizumab monotherapy across solid tumor types","volume":"28","author":"Cristescu","year":"2022","journal-title":"Clin Cancer Res"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-57218-9","article-title":"Immune gene signatures for predicting durable clinical benefit of anti-PD-1 immunotherapy in patients with non-small cell lung cancer","volume":"10","author":"Hwang","year":"2020","journal-title":"Sci Rep"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0136-1","article-title":"Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response","volume":"24","author":"Jiang","year":"2018","journal-title":"Nat Med"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.723908","article-title":"Microdissection of the bulk transcriptome at single-cell resolution reveals clinical significance and myeloid cells heterogeneity in lung adenocarcinoma","volume":"12","author":"Wu","year":"2021","journal-title":"Front Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1016\/j.ccell.2022.10.008","article-title":"High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer","volume":"40","author":"Salcher","year":"2022","journal-title":"Cancer Cell"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1340","article-title":"Cellular dynamics in tumour microenvironment along with lung cancer progression underscore spatial and evolutionary heterogeneity of neutrophil","volume":"13","author":"Peng","year":"2023","journal-title":"Clin Transl Med"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-021-02916-5","article-title":"Myeloid cell heterogeneity in lung cancer: implication for immunotherapy","volume":"70","author":"Sangaletti","year":"2021","journal-title":"Cancer Immunol Immunother"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/j.immuni.2019.03.009","article-title":"Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species","volume":"50","author":"Zilionis","year":"2019","journal-title":"Immunity"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1016\/j.ccell.2021.10.009","article-title":"Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification","volume":"39","author":"Leader","year":"2021","journal-title":"Cancer Cell"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0096-5","article-title":"Phenotype molding of stromal cells in the lung tumor microenvironment","volume":"24","author":"Lambrechts","year":"2018","journal-title":"Nat Med"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01977","article-title":"Turn back the TIMe: targeting tumor infiltrating myeloid cells to revert cancer progression","volume":"9","author":"Awad","year":"2018","journal-title":"Front Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-019-10291-0","article-title":"A comprehensive single cell transcriptional landscape of human hematopoietic progenitors","volume":"10","author":"Pellin","year":"2019","journal-title":"Nat Commun"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.04.015","article-title":"Blood development: hematopoietic stem cell dependence and independence","volume":"22","author":"Dzierzak","year":"2018","journal-title":"Cell Stem Cell"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.024","article-title":"Tissue-resident macrophage ontogeny and homeostasis","volume":"44","author":"Ginhoux","year":"2016","journal-title":"Immunity"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1016\/j.cell.2019.08.009","article-title":"Fate mapping via ms4a3-expression history traces monocyte-derived cells","volume":"178","author":"Liu","year":"2019","journal-title":"Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/nature19348","article-title":"Single-cell analysis of mixed-lineage states leading to a binary cell fate choice","volume":"537","author":"Olsson","year":"2016","journal-title":"Nature"},{"key":"B34","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.immuni.2017.10.021","article-title":"Granulocyte-monocyte progenitors and monocyte-dendritic cell progenitors independently produce functionally distinct monocytes","volume":"47","author":"Y\u00e1\u00f1ez","year":"2017","journal-title":"Immunity"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0121-4","article-title":"Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis","volume":"20","author":"Giladi","year":"2018","journal-title":"Nat Cell Biol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.013","article-title":"Transcriptional heterogeneity and lineage commitment in myeloid progenitors","volume":"163","author":"Paul","year":"2015","journal-title":"Cell"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007876","article-title":"Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells","volume":"137","author":"Sommerkamp","year":"2021","journal-title":"Blood"},{"key":"B38","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.exphem.2021.09.007","article-title":"Simplified murine multipotent progenitor isolation scheme: Establishing a consensus approach for multipotent progenitor identification","volume":"104","author":"Challen","year":"2021","journal-title":"Exp Hematol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01167-5","article-title":"Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors","volume":"23","author":"Klein","year":"2022","journal-title":"Nat Immunol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/nature25168","article-title":"Clonal analysis of lineage fate in native haematopoiesis","volume":"553","author":"Rodriguez-Fraticelli","year":"2018","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/nature25022","article-title":"From haematopoietic stem cells to complex differentiation landscapes","volume":"553","author":"Laurenti","year":"2018","journal-title":"Nature"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0799-x","article-title":"A new lymphoid-primed progenitor marked by Dach1 downregulation identified with single cell multi-omics","volume":"21","author":"Amann-Zalcenstein","year":"2020","journal-title":"Nat Immunol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5470.1439","article-title":"Regulation of B lymphocyte and macrophage development by graded expression of PU.1","volume":"288","author":"DeKoter","year":"2000","journal-title":"Science"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1101\/2023.08.30.555623","article-title":"Unravelling human hematopoietic progenitor cell diversity through association with intrinsic regulatory factors","author":"Favaro","year":"2023","journal-title":"bioRxiv"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112618","article-title":"Distinct subsets of multi-lymphoid progenitors support ontogeny-related changes in human lymphopoiesis","volume":"42","author":"Keita","year":"2023","journal-title":"CellReports"},{"key":"B46","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41556-018-0227-8","article-title":"Haematopoiesis in the era of advanced single-cell technologies","volume":"21","author":"Jacobsen","year":"2019","journal-title":"Nat Cell Biol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.immuni.2019.08.008","article-title":"Single-cell analysis of human mononuclear phagocytes reveals subset-defining markers and identifies circulating inflammatory dendritic cells","volume":"51","author":"Dutertre","year":"2019","journal-title":"Immunity"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/j.immuni.2023.07.001","article-title":"Dendritic cell type 3 arises from Ly6C+ monocyte-dendritic cell progenitors","volume":"56","author":"Liu","year":"2023","journal-title":"Immunity"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0136-9","article-title":"Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells","volume":"19","author":"Rodrigues","year":"2018","journal-title":"Nat Immunol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1615","article-title":"The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues","volume":"9","author":"Waskow","year":"2008","journal-title":"Nat Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160800","article-title":"CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses","volume":"213","author":"Chong","year":"2016","journal-title":"J Exp Med"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01549-3","article-title":"ThPOK is a critical multifaceted regulator of myeloid lineage development","volume":"24","author":"Basu","year":"2023","journal-title":"Nat Immunol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.immuni.2018.02.002","article-title":"Developmental analysis of bone marrow neutrophils reveals populations specialized in expansion, trafficking, and effector functions","volume":"48","author":"Evrard","year":"2018","journal-title":"Immunity"},{"key":"B54","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.immuni.2020.06.005","article-title":"Combinatorial single-cell analyses of granulocyte-monocyte progenitor heterogeneity reveals an early uni-potent neutrophil progenitor","volume":"53","author":"Kwok","year":"2020","journal-title":"Immunity"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0736-z","article-title":"Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection","volume":"21","author":"Xie","year":"2020","journal-title":"Nat Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41649","article-title":"CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow","volume":"120","author":"Eash","year":"2010","journal-title":"J Clin Invest"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1126\/SCIIMMUNOL.AAU7148\/SUPPL_FILE\/AAU7148_TABLE_S5.XLSX","article-title":"Identification of two distinct pathways of human myelopoiesis","volume":"4","author":"Drissen","year":"2019","journal-title":"Sci Immunol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3412","article-title":"Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing","volume":"17","author":"Drissen","year":"2016","journal-title":"Nat Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/nature25741","article-title":"Population snapshots predict early haematopoietic and erythroid hierarchies","volume":"555","author":"Tusi","year":"2018","journal-title":"Nature"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/cddiscovery.2017.2","article-title":"Haematopoietic stem cells: Past, present and future","volume":"3","author":"Ng","year":"2017","journal-title":"Cell Death Discovery"},{"key":"B61","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41556-019-0439-6","article-title":"Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization","volume":"22","author":"Baccin","year":"2019","journal-title":"Nat Cell Biol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310679","article-title":"Hematopoiesis and mast cell development","volume":"24","author":"Ribatti","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-018-04770-z","article-title":"Quantitative spatial analysis of haematopoiesis-regulating stromal cells in the bone marrow microenvironment by 3D microscopy","volume":"9","author":"Gomariz","year":"2018","journal-title":"Nat Commun"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.81656","article-title":"Identification of phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow based on single-cell RNA sequencing","volume":"12","author":"Li","year":"2023","journal-title":"Elife"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/FCELL.2022.664261\/BIBTEX","article-title":"Hematopoietic stem cell factors: their functional role in self-renewal and clinical aspects","volume":"10","author":"Mann","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/nature11885","article-title":"Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches","volume":"495","author":"Ding","year":"2013","journal-title":"Nature"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.840044","article-title":"Megakaryocyte diversity in ontogeny, functions and cell-cell interactions","volume":"12","author":"Khatib-Massalha","year":"2022","journal-title":"Front Oncol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nature17624","article-title":"Distinct bone marrow blood vessels differentially regulate hematopoiesis","volume":"532","author":"Itkin","year":"2016","journal-title":"Nature"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/nature12612","article-title":"Arteriolar niches maintain haematopoietic stem cell quiescence","volume":"502","author":"Kunisaki","year":"2013","journal-title":"Nature"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/nature02040","article-title":"Osteoblastic cells regulate the haematopoietic stem cell niche","volume":"425","author":"Calvi","year":"2003","journal-title":"Nature"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-4011","article-title":"Hematopoiesis is severely altered in mice with an induced osteoblast deficiency","volume":"103","author":"Visnjic","year":"2004","journal-title":"Blood"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-282855","article-title":"Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo","volume":"117","author":"Lymperi","year":"2011","journal-title":"Blood"},{"key":"B73","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev.immunol.25.022106.141631","article-title":"The multiple roles of osteoclasts in host defense: bone remodeling and hematopoietic stem cell mobilization","volume":"25","author":"Kollet","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nature10783","article-title":"Endothelial and perivascular cells maintain haematopoietic stem cells","volume":"481","author":"Ding","year":"2012","journal-title":"Nature"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.10.016","article-title":"Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches","volume":"25","author":"Sugiyama","year":"2006","journal-title":"Immunity"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/nature15250","article-title":"Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal","volume":"526","author":"Acar","year":"2015","journal-title":"Nature"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/nature13071","article-title":"Foxc1 is a critical regulator of haematopoietic stem\/progenitor cell niche formation","volume":"508","author":"Omatsu","year":"2014","journal-title":"Nature"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and haematopoietic stem cells form a unique bone marrow niche","volume":"466","author":"M\u00e9ndez-Ferrer","year":"2010","journal-title":"Nature"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.02.019","article-title":"Mesenchymal cell contributions to the stem cell niche","volume":"16","author":"Kfoury","year":"2015","journal-title":"Cell Stem Cell"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.10.002","article-title":"Regulation of hematopoietic stem cells by bone marrow stromal cells","volume":"35","author":"Anthony","year":"2014","journal-title":"Trends Immunol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.11.004","article-title":"Hematopoietic stem cell niches produce lineage-instructive signals to control multipotent progenitor differentiation","volume":"45","author":"Cordeiro Gomes","year":"2016","journal-title":"Immunity"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/nature11926","article-title":"CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance","volume":"495","author":"Greenbaum","year":"2013","journal-title":"Nature"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-023-41691-y","article-title":"Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner","volume":"14","author":"Luis","year":"2023","journal-title":"Nat Commun"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd9738","article-title":"Decoding the multicellular ecosystem of lung adenocarcinoma manifested as pulmonary subsolid nodules by single-cell RNA sequencing","volume":"7","author":"Xing","year":"2021","journal-title":"Sci Adv"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-021-22801-0","article-title":"Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer","volume":"12","author":"Wu","year":"2021","journal-title":"Nat Commun"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0750-6","article-title":"Regenerative lineages and immune-mediated pruning in lung cancer metastasis","volume":"26","author":"Laughney","year":"2020","journal-title":"Nat Med"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16164-1","article-title":"Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma","volume":"11","author":"Kim","year":"2020","journal-title":"Nat Commun"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2134-y","article-title":"A conserved dendritic-cell regulatory program limits antitumour immunity","volume":"580","author":"Maier","year":"2020","journal-title":"Nature"},{"key":"B89","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.cell.2021.01.010","article-title":"A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells","volume":"184","author":"Cheng","year":"2021","journal-title":"Cell"},{"key":"B90","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13073-023-01164-9","article-title":"Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing","volume":"15","author":"Hu","year":"2023","journal-title":"Genome Med"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1285","article-title":"Resolving the spatial and cellular architecture of lung adenocarcinoma by multiregion single-cell sequencing","volume":"11","author":"Sinjab","year":"2021","journal-title":"Cancer Discovery"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03651-8","article-title":"Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells","volume":"595","author":"Casanova-Acebes","year":"2021","journal-title":"Nature"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1002\/TOX.24018","article-title":"Multidimensional progressive single-cell sequencing reveals cell microenvironment composition and cancer heterogeneity in lung cancer","volume":"39","author":"Chen","year":"2023","journal-title":"Environ Toxicol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abm9409","article-title":"Human dendritic cells in cancer","volume":"7","author":"Kvedaraite","year":"2022","journal-title":"Sci Immunol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.3596599","article-title":"T cell immunotherapies trigger neutrophil activation to eliminate tumor antigen escape variants","author":"Hirschhorn-Cymerman","year":"2020","journal-title":"SSRN Electronic J"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220011","article-title":"Neutrophil phenotypes and functions in cancer: A consensus statement","volume":"219","author":"Quail","year":"2022","journal-title":"J Exp Med"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2023.107447","article-title":"Colony stimulating factor-1 (CSF-1) signalling is predictive of response to immune checkpoint inhibitors in advanced non-small cell lung cancer","volume":"188","author":"Takam Kamga","year":"2024","journal-title":"Lung Cancer"},{"key":"B98","article-title":"Challenges and prospects of CSF1R targeting for advanced Malignancies","volume":"13","author":"Moeller","year":"2023","journal-title":"Am J Cancer Res"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910460217","article-title":"Myelopoiesis-associated suppressor-cell activity in mice with lewis lung carcinoma tumors: Interferon-\u03b3 plus tumor necrosis factor-\u03b1 synergistically reduce suppressor cell activity","volume":"46","author":"Young","year":"1990","journal-title":"Int J Cancer"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00754-7","article-title":"Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of Kit-ligand","volume":"109","author":"Heissig","year":"2002","journal-title":"Cell"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1038\/nm1101-1194","article-title":"Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth","volume":"7","author":"Lyden","year":"2001","journal-title":"Nat Med"},{"key":"B102","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1097\/01.moh.0000219664.26528.da","article-title":"Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue","volume":"13","author":"Kopp","year":"2006","journal-title":"Curr Opin Hematol"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00240-X","article-title":"Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors","volume":"4","author":"Ruzinova","year":"2003","journal-title":"Cancer Cell"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/nature04186","article-title":"VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche","volume":"438","author":"Kaplan","year":"2005","journal-title":"Nature"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3317","article-title":"Hematopoietic cells regulate the angiogenic switch during tumorigenesis","volume":"105","author":"Okamoto","year":"2005","journal-title":"Blood"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1507","article-title":"Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis","volume":"8","author":"Hiratsuka","year":"2006","journal-title":"Nat Cell Biol"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1323","article-title":"Tumor refractoriness to anti-VEGF treatment is mediated by CD11b +Gr1+ myeloid cells","volume":"25","author":"Shojaei","year":"2007","journal-title":"Nat Biotechnol"},{"key":"B108","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s10549-009-0622-8","article-title":"GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- bone marrow progenitor cells into myeloid-derived suppressor cells","volume":"123","author":"Morales","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"B109","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/eji.200939903","article-title":"Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF","volume":"40","author":"Dolcetti","year":"2010","journal-title":"Eur J Immunol"},{"key":"B110","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ccr.2008.11.012","article-title":"Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche","volume":"15","author":"Erler","year":"2009","journal-title":"Cancer Cell"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43757","article-title":"Human tumors instigate granulin-expressing hematopoietic cells that promote Malignancy by activating stromal fibroblasts in mice","volume":"121","author":"Elkabets","year":"2011","journal-title":"J Clin Invest"},{"key":"B112","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.cell.2008.04.045","article-title":"Systemic endocrine instigation of indolent tumor growth requires osteopontin","volume":"133","author":"McAllister","year":"2008","journal-title":"Cell"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018054","article-title":"Components of the hematopoietic compartments in tumor stroma and tumor-bearing mice","volume":"6","author":"Huynh","year":"2011","journal-title":"PloS One"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2753","article-title":"Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET","volume":"18","author":"Peinado","year":"2012","journal-title":"Nat Med"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.04.024","article-title":"Oncogenic kras-induced GM-CSF production promotes the development of pancreatic neoplasia","volume":"21","author":"Pylayeva-Gupta","year":"2012","journal-title":"Cancer Cell"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.04.025","article-title":"Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer","volume":"21","author":"Bayne","year":"2012","journal-title":"Cancer Cell"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.1113744109\/SUPPL_FILE\/PNAS.201113744SI.PDF","article-title":"Origins of tumor-associated macrophages and neutrophils","volume":"109","author":"Cortez-Retamozo","year":"2012","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B118","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.immuni.2012.10.015","article-title":"Angiotensin II drives the production of tumor-promoting macrophages","volume":"38","author":"Cortez-Retamozo","year":"2013","journal-title":"Immunity"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181952","article-title":"Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs","volume":"216","author":"Mastio","year":"2019","journal-title":"J Exp Med"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2526","article-title":"Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer","volume":"14","author":"Youn","year":"2013","journal-title":"Nat Immunol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-0842","article-title":"Dysregulated hematopoiesis caused by mammary cancer is associated with epigenetic changes and Hox gene expression in hematopoietic cells","volume":"73","author":"Sio","year":"2013","journal-title":"Cancer Res"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.1320753111\/SUPPL_FILE\/PNAS.201320753SI.PDF","article-title":"Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients","volume":"111","author":"Wu","year":"2014","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1038\/nature14282","article-title":"IL-17-producing \u03b3\u03b4 T cells and neutrophils conspire to promote breast cancer metastasis","volume":"522","author":"Coffelt","year":"2015","journal-title":"Nature"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1424927112","article-title":"Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils","volume":"112","author":"Casbon","year":"2015","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B125","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep23115","article-title":"Identification of early myeloid progenitors as immunosuppressive cells","volume":"6","author":"Pu","year":"2016","journal-title":"Sci Rep"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0204","article-title":"Activation of hematopoietic stem\/progenitor cells promotes immunosuppression within the pre-metastatic niche","volume":"76","author":"Giles","year":"2016","journal-title":"Cancer Res"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal5081","article-title":"Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils","volume":"358","author":"Engblom","year":"2017","journal-title":"Science"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108164","article-title":"Tumor-promoting ly-6G+ SiglecFhigh cells are mature and long-lived neutrophils","volume":"32","author":"Pfirschke","year":"2020","journal-title":"Cell Rep"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0229-5","article-title":"Unique pattern of neutrophil migration and function during tumor progression","volume":"19","author":"Patel","year":"2018","journal-title":"Nat Immunol"},{"key":"B130","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-018-03600-6","article-title":"Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance","volume":"9","author":"Meyer","year":"2018","journal-title":"Nat Commun"},{"key":"B131","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1016\/j.celrep.2018.07.097","article-title":"Identification of an early unipotent neutrophil progenitor with pro-tumoral activity in mouse and human bone marrow","volume":"24","author":"Zhu","year":"2018","journal-title":"Cell Rep"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-3026","article-title":"T-cell-secreted TNF\u03b1 Induces emergency myelopoiesis and myeloid-derived suppressor cell differentiation in cancer","volume":"79","author":"Al Sayed","year":"2019","journal-title":"Cancer Res"},{"key":"B133","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.immuni.2020.07.017","article-title":"Coexpression of CD71 and CD117 identifies an early unipotent neutrophil progenitor population in human bone marrow","volume":"53","author":"Dinh","year":"2020","journal-title":"Immunity"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0892-6","article-title":"Systemic dysfunction and plasticity of the immune macroenvironment in cancer models","volume":"26","author":"Allen","year":"2020","journal-title":"Nat Med"},{"key":"B135","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.ccell.2022.04.018","article-title":"Tumor-induced erythroid precursor-differentiated myeloid cells mediate immunosuppression and curtail anti-PD-1\/PD-L1 treatment efficacy","volume":"40","author":"Long","year":"2022","journal-title":"Cancer Cell"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0205-5","article-title":"Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells","volume":"24","author":"Zhao","year":"2018","journal-title":"Nat Med"},{"key":"B137","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13287-020-02120-9","article-title":"Inhibition of TGF\u03b2 improves hematopoietic stem cell niche and ameliorates cancer-related anemia","volume":"12","author":"Wang","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"B138","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1016\/j.cell.2021.03.011","article-title":"The bone microenvironment invigorates metastatic seeds for further dissemination","volume":"184","author":"Zhang","year":"2021","journal-title":"Cell"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-1425","article-title":"Transcriptional profiles and stromal changes reveal bone marrow adaptation to early breast cancer in association with deregulated circulating microRNAs","volume":"80","author":"Chiodoni","year":"2020","journal-title":"Cancer Res"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-22-0651","article-title":"ATF3 reprograms the bone marrow niche in response to early breast cancer transformation","volume":"83","author":"Perrone","year":"2022","journal-title":"Cancer Res"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-023-01291-w","article-title":"Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche","volume":"25","author":"Gerber-Ferder","year":"2023","journal-title":"Nat Cell Biol"},{"key":"B142","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.stem.2023.04.005","article-title":"Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal","volume":"30","author":"Hao","year":"2023","journal-title":"Cell Stem Cell"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06797-9","article-title":"An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis","volume":"625","author":"LaMarche","year":"2024","journal-title":"Nature"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97973","article-title":"Spleen mediates a distinct hematopoietic progenitor response supporting tumor-promoting myelopoiesis","volume":"128","author":"Wu","year":"2018","journal-title":"J Clin Invest"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.8.5791","article-title":"Subsets of myeloid-derived suppressor cells in tumor-bearing mice","volume":"181","author":"Youn","year":"2008","journal-title":"J Immunol"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.3389\/FONC.2020.01399\/BIBTEX","article-title":"Systemic reprogramming of monocytes in cancer","volume":"10","author":"Kiss","year":"2020","journal-title":"Front Oncol"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2463","article-title":"Tumor-produced interleukin-8 attracts human myeloid-derived suppressor cells and elicits extrusion of neutrophil extracellular traps (NETs)","volume":"22","author":"Alfaro","year":"2016","journal-title":"Clin Cancer Res"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.AAA4268\/SUPPL_FILE\/AAA4268-WEBER-SM.PDF","article-title":"Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis","volume":"347","author":"Weber","year":"2015","journal-title":"Sci (1979)"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.06.021","article-title":"Tumor exosomal RNAs promote lung pre-metastatic niche formation by activating alveolar epithelial TLR3 to recruit neutrophils","volume":"30","author":"Liu","year":"2016","journal-title":"Cancer Cell"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001273R","article-title":"Polyfunctionality of the CXCR4\/CXCL12 axis in health and disease: Implications for therapeutic interventions in cancer and immune-mediated diseases","volume":"35","author":"Britton","year":"2021","journal-title":"FASEB J"},{"key":"B151","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.bbcan.2009.05.001","article-title":"Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression","volume":"1796","author":"Gao","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"B152","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.ccell.2022.04.004","article-title":"Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity","volume":"40","author":"Hailemichael","year":"2022","journal-title":"Cancer Cell"},{"key":"B153","unstructured":"A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)ClinicalTrials.gov"},{"key":"B154","unstructured":"Tocilizumab and Atezolizumab in Adults With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Refractory to 1st Line Immune Checkpoint Inhibitor-Based TherapyClinicalTrials.gov"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1007\/S00280-013-2099-8\/FIGURES\/2","article-title":"A first-in-human, first-in-class, phase i study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors","volume":"71","author":"Sandhu","year":"2013","journal-title":"Cancer Chemother Pharmacol"},{"key":"B156","unstructured":"A Study of PDR001 in Combination With CJM112, EGF816, Ilaris\u00ae (Canakinumab) or Mekinist\u00ae (Trametinib)ClinicalTrials.gov"},{"key":"B157","unstructured":"Canakinumab and Durvalumab and Chemotherapy in Non-small Cell Lung Cancer - Clinical Trials Registry - ICH GCP"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00910","article-title":"Canakinumab as adjuvant therapy in patients with completely resected non\u2013small-cell lung cancer: results from the CANOPY-A double-blind, randomized clinical trial","volume":"42","author":"Garon","year":"2023","journal-title":"J Clin Oncol"},{"key":"B159","unstructured":"Canakinumab for the Prevention of Lung Cancer, the Can-Prevent-Lung Trial - Full Text ViewClinicalTrials.gov"},{"key":"B160","unstructured":"Phase III Study Evaluating Efficacy and Safety of Canakinumab in Combination With Docetaxel in Adult Subjects With Non-small Cell Lung Cancers as a Second or Third Line TherapyClinicalTrials.gov"},{"key":"B161","unstructured":"PDR001 in Combination With Platinum-doublet Chemotherapy and Other Immunology Agents in PD-L1 Unselected, Metastatic NSCLC PatientsClinicalTrials.gov"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.2217\/FON-2020-1098\/ASSET\/IMAGES\/LARGE\/FIGURE2.JPEG","article-title":"Canakinumab with and without pembrolizumab in patients with resectable non-small-cell lung cancer: CANOPY-N study design","volume":"17","author":"Garrido","year":"2021","journal-title":"Future Oncol"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061884","article-title":"Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer","volume":"355","author":"Sandler","year":"2006","journal-title":"N Engl J Med"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60845-X","article-title":"Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): A multicentre, double-blind, randomised phase 3 trial","volume":"384","author":"Garon","year":"2014","journal-title":"Lancet"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-0903","article-title":"A phase I study of APX005M and cabiralizumab with or without nivolumab in patients with melanoma, kidney cancer, or non-small cell lung cancer resistant to anti-PD-1\/PD-L1","volume":"27","author":"Weiss","year":"2021","journal-title":"Clin Cancer Res"},{"key":"B166","unstructured":"A Combination Clinical Study of PLX3397 and Pembrolizumab To Treat Advanced Melanoma and Other Solid TumorsClinicalTrials.gov"},{"key":"B167","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1007\/s10637-011-9715-4","article-title":"Figitumumab combined with carboplatin and paclitaxel in treatment-na\u00efve Japanese patients with advanced non-small cell lung cancer","volume":"30","author":"Goto","year":"2012","journal-title":"Invest New Drugs"},{"key":"B168","unstructured":"Dupilumab_Metastatic NSCLCClinicalTrials.gov"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1007\/S10637-012-9869-8\/FIGURES\/2","article-title":"Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer","volume":"31","author":"Pienta","year":"2013","journal-title":"Invest New Drugs"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1397469\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T04:36:25Z","timestamp":1722486985000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1397469\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,1]]},"references-count":169,"alternative-id":["10.3389\/fimmu.2024.1397469"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1397469","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,1]]},"article-number":"1397469"}}