{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:15:05Z","timestamp":1793074505862,"version":"4.5.0"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Macrophage dysfunction is a common feature of inflammatory disorders such as asthma, which is characterized by a strong circadian rhythm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We monitored the protein expression pattern of the molecular circadian clock in human peripheral blood monocytes from healthy, allergic, and asthmatic donors during a whole day. Monocytes cultured of these donors allowed us to examine circadian protein expression in human monocyte-derived macrophages, M1- and M2- polarized macrophages. In monocytes, particularly from allergic asthmatics, the oscillating expression of circadian proteins CLOCK, BMAL, REV ERBs, and RORs was significantly altered. Similar changes in BMAL1 were observed in polarized macrophages from allergic donors and in tissue-resident macrophages from activated precision cut lung slices. We confirmed clock modulating, anti-inflammatory, and lung-protective properties of the inverse ROR agonist SR1001 by reduced secretion of macrophage inflammatory protein and increase in phagocytosis. Using a house dust mite model, we verified the therapeutic effect of SR1001\n                      <jats:italic>in vivo<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      Overall, our data suggest an interaction between the molecular circadian clock and monocytes\/macrophages effector function in inflammatory lung diseases. The use of SR1001 leads to inflammatory resolution\n                      <jats:italic>in vitro<\/jats:italic>\n                      and\n                      <jats:italic>in vivo<\/jats:italic>\n                      and represents a promising clock-based therapeutic approach for chronic pulmonary diseases such as asthma.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2024.1408772","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T01:07:35Z","timestamp":1716858455000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["The disrupted molecular circadian clock of monocytes and macrophages in allergic inflammation"],"prefix":"10.3389","volume":"15","author":[{"given":"Julia","family":"Teppan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Schwanzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Rittchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"B\u00e4rnthaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Lindemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barsha","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Reiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Luschnig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aitak","family":"Farzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akos","family":"Heinemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Sturm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s41030\u2013018-0058\u20136","article-title":"The role of the body clock in asthma and COPD: implication for treatment","volume":"4","author":"Krakowiak","year":"2018","journal-title":"Pulm Ther"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.03.010","article-title":"Time-of-day-dependent trafficking and function of leukocyte subsets","volume":"40","author":"Pick","year":"2019","journal-title":"Trends Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/0021\u20138707(69)90034\u20133","article-title":"Circadian reactivity rhythm of human skin to house dust, penicillin, and histamine","volume":"44","author":"Reinberg","year":"1969","journal-title":"J Allergy"},{"key":"B4","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1136\/thoraxjnl-2020\u2013215218","article-title":"Night shift work is associated with an increased risk of asthma","volume":"76","author":"Maidstone","year":"2021","journal-title":"Thorax"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S302508","article-title":"Disrupted expression of circadian clock genes in patients with bronchial asthma","volume":"14","author":"Chen","year":"2021","journal-title":"JAA"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/s41606\u2013017-0019\u20132","article-title":"A circadian based inflammatory response \u2013 implications for respiratory disease and treatment","volume":"1","author":"Comas","year":"2017","journal-title":"Sleep Sci Pract"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2022.04.002","article-title":"Circadian molecular clock disruption in chronic pulmonary diseases","volume":"28","author":"Giri","year":"2022","journal-title":"Trends Mol Med"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001026","article-title":"Dysregulation of inflammatory responses by chronic circadian disruption","volume":"185","author":"Castanon-Cervantes","year":"2010","journal-title":"J Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3599","article-title":"An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action","volume":"20","author":"Gibbs","year":"2014","journal-title":"Nat Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000101","article-title":"Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders","volume":"82","author":"Sato","year":"2014","journal-title":"Neurology"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20210020","article-title":"Nuclear receptors: from molecular mechanisms to therapeutics","volume":"65","author":"Frigo","year":"2021","journal-title":"Essays Biochem"},{"key":"B12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nrd4100","article-title":"REV-ERB and ROR nuclear receptors as drug targets","volume":"13","author":"Kojetin","year":"2014","journal-title":"Nat Rev Drug Discovery"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3RU1015-451R","article-title":"A matter of time: study of circadian clocks and their role in inflammation","volume":"99","author":"Carter","year":"2016","journal-title":"J Leukoc Biol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114701","article-title":"REV-ERB\u03b1 agonist SR9009 suppresses IL-1\u03b2 production in macrophages through BMAL1-dependent inhibition of inflammasome","volume":"192","author":"Hong","year":"2021","journal-title":"Biochem Pharmacol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.03.070","article-title":"Suppression of atherosclerosis by synthetic REV-ERB agonist","volume":"460","author":"Sitaula","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.07.819","article-title":"Topical ROR inverse agonists suppress inflammation in mouse models of atopic dermatitis and acute irritant dermatitis","volume":"137","author":"Dai","year":"2017","journal-title":"J\u00a0Invest Dermatol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014\u20131677","article-title":"ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes","volume":"156","author":"Solt","year":"2015","journal-title":"Endocrinology"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23343","article-title":"Targeting Th17-IL-17 pathway in prevention of micro-invasive prostate cancer in a mouse model","volume":"77","author":"Zhang","year":"2017","journal-title":"Prostate"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.14744\/AnatolJCardiol.2016.7411","article-title":"Role of simvastatin and ROR\u03b1 activity in the macrophage apoptotic pathway","volume":"17","author":"Coban","year":"2017","journal-title":"Anatol J Cardiol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.berh.2003.09.009","article-title":"The process of identifying and understanding cytokines: from basic studies to treating rheumatic diseases","volume":"18","author":"Dayer","year":"2004","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.immuni.2020.12.003","article-title":"Distinct developmental pathways from blood monocytes generate human lung macrophage diversity","volume":"54","author":"Evren","year":"2021","journal-title":"Immunity"},{"key":"B22","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1165\/rcmb.2017-0328ED","article-title":"Monocyte-derived alveolar macrophages: the dark side of lung repair","volume":"58","author":"McQuattie-Pimentel","year":"2018","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s11882\u2013017-0681\u20136","article-title":"Alveolar macrophages in allergic asthma: the forgotten cell awakes","volume":"17","author":"Draijer","year":"2017","journal-title":"Curr Allergy Asthma Rep"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.2741\/2692","article-title":"Macrophage activation and polarization","volume":"13","author":"Martinez","year":"2008","journal-title":"Front Biosci"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000647","article-title":"The different faces of the macrophage in asthma","volume":"26","author":"van der Veen","year":"2020","journal-title":"Curr Opin Pulm Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020\u2013216421","article-title":"Asthma diagnosis: into the fourth dimension","volume":"76","author":"Wang","year":"2021","journal-title":"Thorax"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-005-0091-z","article-title":"Nocturnal asthma: underlying mechanisms and treatment","volume":"5","author":"Sutherland","year":"2005","journal-title":"Curr Allergy Asthma Rep"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00161\u20132023","article-title":"Identification of diurnal rhythmic blood markers in bronchial asthma","volume":"9","author":"Krakowiak","year":"2023","journal-title":"ERJ Open Res"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1904226116","article-title":"SR9009 has REV-ERB-independent effects on cell proliferation and metabolism","volume":"116","author":"Dierickx","year":"2019","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1021\/cb100223d","article-title":"Identification of SR1078, a synthetic agonist for the orphan nuclear receptors ROR\u03b1 and ROR\u03b3","volume":"5","author":"Wang","year":"2010","journal-title":"ACS Chem Biol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111697","article-title":"Monocytes and macrophages serve as potent prostaglandin D2 sources during acute, non-allergic pulmonary inflammation","volume":"22","author":"Rittchen","year":"2021","journal-title":"IJMS"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200505-686OC","article-title":"A distinctive alveolar macrophage activation state induced by cigarette smoking","volume":"172","author":"Woodruff","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.3892\/etm.2021.10918","article-title":"Environmental allergens house dust mite-induced asthma is associated with ferroptosis in the lungs","volume":"22","author":"Tang","year":"2021","journal-title":"Exp Ther Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/all.13619","article-title":"Tight junction, mucin, and inflammasome-related molecules are differentially expressed in eosinophilic, mixed, and neutrophilic experimental asthma in mice","volume":"74","author":"Tan","year":"2019","journal-title":"Allergy"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113786","article-title":"ROR\u03b1 is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis","volume":"43","author":"Cheng","year":"2024","journal-title":"Cell Rep"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/nature10075","article-title":"Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand","volume":"472","author":"Solt","year":"2011","journal-title":"Nature"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033804","article-title":"Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor \u03b1 (ROR\u03b1)","volume":"7","author":"Crumbley","year":"2012","journal-title":"PloS One"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.08.011","article-title":"Synergistic effects of NOD1 or NOD2 and TLR4 activation on mouse sickness behavior in relation to immune and brain activity markers","volume":"44","author":"Farzi","year":"2015","journal-title":"Brain Behav Immun"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1904226116","article-title":"SR9009 has REV-ERB\u2013independent effects on cell proliferation and metabolism","volume":"116","author":"Dierickx","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2002.01344.x","article-title":"Chemokines in allergic lung inflammation","volume":"105","author":"Lloyd","year":"2002","journal-title":"Immunology"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.5.9610064","article-title":"Release of RANTES, MIP-1 alpha, and MCP-1 into asthmatic airways following endobronchial allergen challenge","volume":"156","author":"Holgate","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"B42","doi-asserted-by":"crossref","first-page":"PA934","DOI":"10.1183\/13993003.congress-2016.PA934","article-title":"MIP-1\u03b2 is associated with eosinophilic airway inflammation","volume-title":"3.2 Airway Cell Biology and Immunopathology","author":"Kobayashi","year":"2016"},{"key":"B43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B0-12-370879-6\/00229-5","article-title":"MACROPHAGE INFLAMMATORY PROTEIN","volume-title":"Encyclopedia of Respiratory Medicine","author":"Keane","year":"2006"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.280.2.L369","article-title":"Association between airway hyperreactivity and bronchial macrophage dysfunction in individuals with mild asthma","volume":"280","author":"Alexis","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1700196","DOI":"10.1183\/13993003.00196\u20132017","article-title":"Macrophage dysfunction in the pathogenesis and treatment of asthma","volume":"50","author":"Fricker","year":"2017","journal-title":"Eur Respir J"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/1465\u20139921-15\u201372","article-title":"Impaired macrophage phagocytosis of bacteria in severe asthma","volume":"15","author":"Liang","year":"2014","journal-title":"Respir Res"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1915932117","article-title":"The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia","volume":"117","author":"Kitchen","year":"2020","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B48","doi-asserted-by":"publisher","first-page":"293","DOI":"10.2147\/JAA.S121092","article-title":"Animal models of asthma: utility and limitations","volume":"10","author":"Aun","year":"2017","journal-title":"JAA"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.07.018","article-title":"A functional genomics strategy reveals rora as a component of the mammalian circadian clock","volume":"43","author":"Sato","year":"2004","journal-title":"Neuron"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201801682R","article-title":"Genome-wide effect of pulmonary airway epithelial cell\u2013specific Bmal1 deletion","volume":"33","author":"Zhang","year":"2019","journal-title":"FASEB J"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195262","article-title":"Temperature as a universal resetting cue for mammalian circadian oscillators","volume":"330","author":"Buhr","year":"2010","journal-title":"Science"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012\u20131486","article-title":"Glucocorticoids as entraining signals for peripheral circadian oscillators","volume":"153","author":"Pez\u00fck","year":"2012","journal-title":"Endocrinology"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003\u201303-0779","article-title":"Circadian clock genes oscillate in human peripheral blood mononuclear cells","volume":"102","author":"Boivin","year":"2003","journal-title":"Blood"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12157","article-title":"The circadian clock is functional in eosinophils and mast cells","volume":"140","author":"Baumann","year":"2013","journal-title":"Immunology"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1099503","article-title":"BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system","volume":"17","author":"Kondratov","year":"2003","journal-title":"Genes Dev"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00899-y","article-title":"Molecular regulations of circadian rhythm and implications for physiology and diseases","volume":"7","author":"Fagiani","year":"2022","journal-title":"Sig Transduct Target Ther"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.826738","article-title":"Macrophage meets the circadian clock: implication of the circadian clock in the role of macrophages in acute lower respiratory tract infection","volume":"12","author":"Shirato","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13431","article-title":"Ror \u03b2 expression in activated macrophages and dental pulp stem cells","volume":"54","author":"Gopinath","year":"2021","journal-title":"Int Endod J"},{"key":"B59","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1093\/intbio\/zyac007","article-title":"Macrophage circadian rhythms are differentially affected based on stimuli","volume":"14","author":"Lellupitiyage Don","year":"2022","journal-title":"Integr Biol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14817","article-title":"Precision-cut lung slices: A powerful ex vivo model to investigate respiratory infectious diseases","volume":"117","author":"Viana","year":"2022","journal-title":"Mol Microbiol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"57042","DOI":"10.3791\/57042","article-title":"Assessment of the cytotoxic and immunomodulatory effects of substances in human precision-cut lung slices","volume":"117","author":"Neuhaus","year":"2018","journal-title":"J Vis Exp"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207767","article-title":"Human lung tissue provides highly relevant data about efficacy of new anti-asthmatic drugs","volume":"13","author":"Danov","year":"2018","journal-title":"PloS One"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/nri3386","article-title":"Circadian control of the immune system","volume":"13","author":"Scheiermann","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106750109","article-title":"The nuclear receptor REV-ERB\u03b1 mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines","volume":"109","author":"Gibbs","year":"2012","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1172\/JCI93910","article-title":"Circadian clock component REV-ERB\u03b1 controls homeostatic regulation of pulmonary inflammation","volume":"128","author":"Pariollaud","year":"2018","journal-title":"J Clin Invest"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1021\/jm400458q","article-title":"Optimized chemical probes for REV-ERB\u03b1","volume":"56","author":"Trump","year":"2013","journal-title":"J Med Chem"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232416149","article-title":"CCL4 regulates eosinophil activation in eosinophilic airway inflammation","volume":"23","author":"Chu","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1186\/1476\u20139255-4\u201319","article-title":"Alveolar macrophages lack CCR2 expression and do not migrate to CCL2","volume":"4","author":"Opalek","year":"2007","journal-title":"J Inflammation (Lond)"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1159\/000488824","article-title":"Palmitate activates CCL4 expression in human monocytic cells via TLR4\/MyD88 dependent activation of NF-\u03baB\/MAPK\/ PI3K signaling systems","volume":"46","author":"Kochumon","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0908551","article-title":"An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta\/CCL4 signaling and chemotaxis of primary human macrophages","volume":"86","author":"Cheung","year":"2009","journal-title":"J Leukoc Biol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jaci.2016.11.020","article-title":"Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways","volume":"140","author":"Draijer","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1165\/rcmb.2009-0016OC","article-title":"Macrophages: regulators of sex differences in asthma","volume":"42","author":"Melgert","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1673\u20130860.2018.10.007","article-title":"[Effect of RORC inhibitor on HIF-1\u03b1 and VEGF in nasal mucosa of allergic rhinitis of mice]","volume":"53","author":"Wei","year":"2018","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1408772\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T01:07:41Z","timestamp":1716858461000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1408772\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,28]]},"references-count":73,"alternative-id":["10.3389\/fimmu.2024.1408772"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1408772","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,28]]},"article-number":"1408772"}}