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Immunol."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study was performed to identify predictive markers of worse outcomes in patients with severe COVID-19 in an intensive care unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty patients with severe COVID-19, hospitalized in the Intensive Care Unit (ICU) between March and July 2021, were stratified into two groups according to the outcome survivors and non-survivors. After admission to the ICU, blood samples were collected directly for biomarker analysis. Routine hematological and biochemical biomarkers, as well as serum levels of cytokines, chemokines, and immunoglobulins, were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lymphopenia, neutrophilia, and thrombocytopenia were more pronounced in non-surviving patients, while the levels of CRP, AST, creatinine, ferritin, AST, troponin I, urea, magnesium, and potassium were higher in the non-surviving group than the survival group. In addition, serum levels of IL-10, CCL2, CXCL9, and CXCL10 were significantly increased in patients who did not survive. These changes in the biomarkers evaluated were associated with increased mortality in patients with severe COVID-19.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study confirmed and expanded the validity of laboratory biomarkers as indicators of mortality in severe COVID-19.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2024.1416715","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T04:58:01Z","timestamp":1724993881000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Predictive biomarkers of mortality in patients with severe COVID-19 hospitalized in intensive care unit"],"prefix":"10.3389","volume":"15","author":[{"given":"Sandrelli Meridiana de F\u00e1tima Ramos","family":"dos Santos Medeiros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Maria Nepomuceno","family":"Sousa 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