{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:19:40Z","timestamp":1793715580094,"version":"4.6.1"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Vaccines have historically played a pivotal role in controlling epidemics. Effective vaccines for viruses causing significant human disease,\n                    <jats:italic>e.g.<\/jats:italic>\n                    , Ebola, Lassa fever, or Crimean Congo hemorrhagic fever virus, would be invaluable to public health strategies and counter-measure development missions. Here, we propose coverage metrics to quantify vaccine-induced CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell-mediated immune protection, as well as metrics to characterize immuno-dominant epitopes, in light of human genetic heterogeneity and viral evolution. Proof-of-principle of our approach and methods are demonstrated for Ebola virus, SARS-CoV-2, and\n                    <jats:italic>Burkholderia pseudomallei<\/jats:italic>\n                    (vaccine) proteins.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2024.1420284","type":"journal-article","created":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T23:23:30Z","timestamp":1731885810000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Quantification of heterogeneity in human CD8+ T cell responses to vaccine antigens: an HLA-guided perspective"],"prefix":"10.3389","volume":"15","author":[{"given":"Duane C.","family":"Harris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apoorv","family":"Shanker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makaela 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