{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:15:58Z","timestamp":1792793758388,"version":"4.5.0"},"reference-count":308,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Myalgic encephalomyelitis or chronic fatigue syndrome (ME\/CFS), long COVID (LC) and post-COVID-19 vaccine syndrome show similarities in their pathophysiology and clinical manifestations. These disorders are related to viral or adjuvant persistence, immunological alterations, autoimmune diseases and hormonal imbalances. A developmental model is postulated that involves the interaction between immune hyperactivation, autoimmune hypophysitis or pituitary hypophysitis, and immune depletion. This process might begin with a deficient CD4 T-cell response to viral infections in genetically predisposed individuals (HLA-DRB1), followed by an uncontrolled immune response with CD8 T-cell hyperactivation and elevated antibody production, some of which may be directed against autoantigens, which can trigger autoimmune hypophysitis or direct damage to the pituitary, resulting in decreased production of pituitary hormones, such as ACTH. As the disease progresses, prolonged exposure to viral antigens can lead to exhaustion of the immune system, exacerbating symptoms and pathology. It is suggested that these disorders could be included in the autoimmune\/adjuvant-induced inflammatory syndrome (ASIA) because of their similar clinical manifestations and possible relationship to genetic factors, such as polymorphisms in the HLA-DRB1 gene. In addition, it is proposed that treatment with antivirals, corticosteroids\/ginseng, antioxidants, and metabolic precursors could improve symptoms by modulating the immune response, pituitary function, inflammation and oxidative stress. Therefore, the purpose of this review is to suggest a possible autoimmune origin against the adenohypophysis and a possible improvement of symptoms after treatment with corticosteroid replacement therapy.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1422940","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T04:32:42Z","timestamp":1720499562000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Hypocortisolemic ASIA: a vaccine- and chronic infection-induced syndrome behind the origin of long COVID and myalgic encephalomyelitis"],"prefix":"10.3389","volume":"15","author":[{"given":"Manuel","family":"Ruiz-Pablos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aintzane","family":"Zabaleta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200010000-00008","article-title":"Post-herpes encephalitic anterior pituitary insufficiency with hypothermia and hypotension","volume":"320","author":"Vesely","year":"2000","journal-title":"Am J Med Sci"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5588.359","article-title":"Panhypopituitarism after cured tuberculous meningitis","volume":"1","author":"Summers","year":"1968","journal-title":"Br Med J"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350501","article-title":"The syndrome of hypothalamic hypopituitarism complicating viral meningoencephalitis","volume":"5","author":"Lichtenstein","year":"1982","journal-title":"J Endocrinol Invest"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0940433","article-title":"Post-encephalitic hypothalamic-pituitary insufficiency","volume":"94","author":"Kupari","year":"1980","journal-title":"Acta Endocrinol (Copenh)"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198405000-00008","article-title":"Meningoencephalitis complicated by pituitary insufficiency and a spontaneously resolving suprasellar mass","volume":"14","author":"Jew","year":"1984","journal-title":"Neurosurgery"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994998","article-title":"[Virus encephalitis with symptomatic Parkinson syndrome, diabetes insipidus and panhypopituitarism]","volume":"67","author":"Ickenstein","year":"1999","journal-title":"Fortschr Neurol Psychiatr"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1969.02100040905017","article-title":"Selective hypopituitarism following tuberculous menigitis","volume":"118","author":"Haslam","year":"1969","journal-title":"Am J Dis Child"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/J.0954-6820.1978.TB14862.X","article-title":"Persistent hypothalamic-pituitary insufficiency following acute meningoencephalitis","volume":"203","author":"H\u00e4gg","year":"1978","journal-title":"Acta Med Scand"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(73)90065-X","article-title":"Hypophysial tuberculoma with hypopituitarism","volume":"54","author":"Brooks","year":"1973","journal-title":"Am J Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1530\/EDM-16-0084","article-title":"Autoimmune polyendocrinopathy and hypophysitis after Puumala hantavirus infection","volume":"2016","author":"Tarvainen","year":"2016","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-1065","article-title":"DIAGNOSIS OF ENDOCRINE DISEASE: Expanding the cause of hypopituitarism","volume":"176","author":"Pekic","year":"2017","journal-title":"Eur J Endocrinol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2019.101371","article-title":"Hypophysitis: an update on the novel forms, diagnosis and management of disorders of pituitary inflammation","volume":"33","author":"Gubbi","year":"2019","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"B13","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12887-016-0596-8","article-title":"Tracking post-infectious fatigue in clinic using routine Lab tests","volume":"16","author":"Harvey","year":"2016","journal-title":"BMC Pediatr"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.endien.2023.01.001","article-title":"Executive summary of the consensus document on hypophysitis of the Neuroendocrinology Area of Knowledge of the Spanish Society of Endocrinology and Nutrition","volume":"70","author":"Iglesias","year":"2023","journal-title":"Endocrinolog\u00eda Diabetes y Nutrici\u00f3n (English ed)"},{"key":"B15","unstructured":"Infections of the hypothalamic-pituitary region\n            PekicS\n            MiljicD\n            PopovicV\n          Endotext2021"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00302","article-title":"The role of the blood\u2013brain barrier in the development and treatment of migraine and other pain disorders","volume":"8","author":"DosSantos","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.14670\/HH-11-881","article-title":"The circumventricular organs","volume":"32","author":"Kaur","year":"2017","journal-title":"Histol Histopathol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/joa.12771","article-title":"The origins of the circumventricular organs","volume":"232","author":"Kiecker","year":"2018","journal-title":"J Anat"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11101026","article-title":"Molecular and genetic immune biomarkers of primary and immune-therapy induced hypophysitis: from laboratories to the clinical practice","volume":"11","author":"Chiloiro","year":"2021","journal-title":"J Pers Med"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13081210","article-title":"Unveiling the etiopathogenic spectrum of hypophysitis: A narrative review","volume":"13","author":"Menotti","year":"2023","journal-title":"J Pers Med"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110312","article-title":"The glucocorticoid receptor modulator relacorilant reverses the immunosuppressive effects of cortisol","volume":"120","author":"Greenstein","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2007.06.001","article-title":"Hypercortisolemia and infection","volume":"21","author":"Fareau","year":"2007","journal-title":"Infect Dis Clin North Am"},{"key":"B23","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1749-6632.2012.06633.x","article-title":"Glucocorticoid regulation of inflammation and its behavioral and metabolic correlates: from HPA axis to glucocorticoid receptor dysfunction","volume":"1261","author":"Silverman","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1006\/brbi.1998.0536","article-title":"Hypothalamo-pituitary-adrenal axis responses to lipopolysaccharide in male and female rats with adjuvant-induced arthritis","volume":"13","author":"Harbuz","year":"1999","journal-title":"Brain Behav Immun"},{"key":"B25","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/s41435-020-0096-6","article-title":"Extra-adrenal glucocorticoid biosynthesis: Implications for autoimmune and inflammatory disorders","volume":"21","author":"Slominski","year":"2020","journal-title":"Genes Immun"},{"key":"B26","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/j.1365-2265.2005.02325.x","article-title":"Hypocortisolism in survivors of severe acute respiratory syndrome (SARS)","volume":"63","author":"Leow","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1139\/O10-022","article-title":"Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS)","volume":"88","author":"Wei","year":"2010","journal-title":"Biochem Cell Biol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvae003","article-title":"Explaining long COVID: A pioneer cross-sectional study supporting the endocrine hypothesis","volume":"8","author":"Ach","year":"2024","journal-title":"J Endocr Soc"},{"key":"B29","doi-asserted-by":"publisher","first-page":"153S","DOI":"10.1177\/01455613231179714","article-title":"SARS-coV-2 infection, A risk factor for pituitary apoplexy? A case series and literature review","volume":"103","author":"Hazzi","year":"2023","journal-title":"Ear Nose Throat J"},{"key":"B30","doi-asserted-by":"publisher","first-page":"255","DOI":"10.4103\/ijem.ijem_329_21","article-title":"Hypophysitis after COVID-19 infection","volume":"25","author":"Nonglait","year":"2021","journal-title":"Indian J Endocrinol Metab"},{"key":"B31","doi-asserted-by":"publisher","first-page":"222","DOI":"10.11604\/PAMJ.2021.38.222.28243","article-title":"Central adrenal insufficiency and diabetes insipidus as potential endocrine manifestations of COVID-19 infection: a case report","volume":"38","author":"Sheikh","year":"2021","journal-title":"Pan Afr Med J"},{"key":"B32","doi-asserted-by":"publisher","first-page":"50","DOI":"10.14341\/probl.2022683","article-title":"\u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0441\u043b\u0443\u0447\u0430\u0439 \u0433\u0438\u043f\u043e\u043f\u0438\u0442\u0443\u0438\u0442\u0430\u0440\u0438\u0437\u043c\u0430 \u0432\u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0438\u0435 \u0433\u0438\u043f\u043e\u0444\u0438\u0437\u0438\u0442\u0430 \u0432 \u043f\u0435\u0440\u0438\u043e\u0434\u0435 \u0440\u0435\u043a\u043e\u043d\u0432\u0430\u043b\u0435\u0441\u0446\u0435\u043d\u0446\u0438\u0438 \u043f\u043e\u0441\u043b\u0435 \u043f\u0435\u0440\u0435\u043d\u0435\u0441\u0435\u043d\u043d\u043e\u0439 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438 COVID-19","volume":"68","author":"Gorbova","year":"2022","journal-title":"Problems Endocrinol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1177\/2329048X221103051","article-title":"Post COVID-19 lymphocytic hypophysitis: A rare presentation","volume":"9","author":"Joshi","year":"2022","journal-title":"hild Neurol Open"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2855","DOI":"10.1007\/s40618-021-01627-z","article-title":"Central diabetes insipidus (Infundibuloneuro hypophysitis): A late complication of COVID-19 infection","volume":"44","author":"Misgar","year":"2021","journal-title":"J Endocrinol Invest"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2023.109218","article-title":"Coronavirus as a trigger of lymphocytic hypophysitis in an adolescent girl: An exceptional case report","volume":"115","author":"Zerrouki","year":"2024","journal-title":"Int J Surg Case Rep"},{"key":"B36","doi-asserted-by":"publisher","first-page":"381","DOI":"10.4103\/ijem.IJEM_440_20","article-title":"Endocrine involvement in COVID-19: mechanisms, clinical features, and implications for care","volume":"24","author":"Garg","year":"2020","journal-title":"Indian J Endocrinol Metab"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa108","article-title":"Endocrine significance of SARS-coV-2\u2019s reliance on ACE2","volume":"161","author":"Lazartigues","year":"2020","journal-title":"Endocrinology"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2021.708333\/BIBTEX","article-title":"Coronavirus disease 2019 and the thyroid - progress and perspectives","volume":"12","author":"Inaba","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B39","doi-asserted-by":"publisher","first-page":"486","DOI":"10.3390\/pathophysiology29030039","article-title":"Molecular mimicry between SARS-coV-2 and human endocrinocytes: A prerequisite of post-COVID-19 endocrine autoimmunity","volume":"29","author":"Churilov","year":"2022","journal-title":"Pathophysiology"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00700-8","article-title":"Is there a role for the adrenal glands in long COVID","volume":"18","author":"Kanczkowski","year":"2022","journal-title":"Nat Rev Endocrinol 2022 18:8"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2021.09.002","article-title":"Anti-ACTH antibodies in critically ill Covid-19 patients: A potential immune evasion mechanism of SARS-CoV-2","volume":"46","author":"P\u00e9rez-Torres","year":"2022","journal-title":"Med Intensiva"},{"key":"B42","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.mehy.2004.04.009","article-title":"Molecular mimicry of ACTH in SARS \u2013 implications for corticosteroid treatment and prophylaxis","volume":"63","author":"Wheatland","year":"2004","journal-title":"Med Hypotheses"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-0170-2","article-title":"Hypothalamic-pituitary-adrenal hypofunction in myalgic encephalomyelitis (ME)\/chronic fatigue syndrome (CFS) as a consequence of activated immune-inflammatory and oxidative and nitrosative pathways","volume":"54","author":"Morris","year":"2017","journal-title":"Mol Neurobiol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1159\/000095930","article-title":"Impairment of adrenocortical function associated with increased plasma tumor necrosis factor-alpha and interleukin-6 concentrations in african trypanosomiasis","volume":"1","author":"Reincke","year":"1994","journal-title":"Neuroimmunomodulation"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-1-101","article-title":"Tumor necrosis factor alpha inhibits the hormonal response of the pituitary gland to hypothalamic releasing factors","volume":"127","author":"Gaillard","year":"1990","journal-title":"Endocrinology"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-1149","article-title":"Critical illness-related corticosteroid insufficiency","volume":"135","author":"Marik","year":"2009","journal-title":"Chest"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-9861.2008.00033.x","article-title":"The associations between basal salivary cortisol and illness symptomatology in chronic fatigue syndrome","volume":"13","author":"Torres-Harding","year":"2008","journal-title":"J Appl Biobehav Res"},{"key":"B48","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.psyneuen.2014.01.017","article-title":"The role of hypocortisolism in chronic fatigue syndrome","volume":"42","author":"Nijhof","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yhbeh.2018.05.016","article-title":"Hair and salivary cortisol in a cohort of women with chronic fatigue syndrome","volume":"103","author":"Roerink","year":"2018","journal-title":"Horm Behav"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.01.146","article-title":"Cortisol levels in chronic fatigue syndrome and atypical depression measured using hair and saliva specimens","volume":"267","author":"Herane-Vives","year":"2020","journal-title":"J Affect Disord"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.184.2.136","article-title":"Salivary cortisol response to awakening in chronic fatigue syndrome","volume":"184","author":"Roberts","year":"2004","journal-title":"Br J Psychiatry"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/784520","article-title":"A review of hypothalamic-pituitary-adrenal axis function in chronic fatigue syndrome","volume":"2013","author":"Tomas","year":"2013","journal-title":"ISRN Neurosci"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(03)00625-1","article-title":"Associations between neuroendocrine responses to the Insulin Tolerance Test and patient characteristics in chronic fatigue syndrome","volume":"56","author":"Gaab","year":"2004","journal-title":"J Psychosom Res"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2020.00578\/FULL","article-title":"Autoimmunity-related risk variants in PTPN22 and CTLA4 are associated with ME\/CFS with infectious onset","volume":"11","author":"Steiner","year":"2020","journal-title":"Front Immunol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/978-1-4419-8216-2_7","article-title":"Epigenetic dysregulation of epstein-barr virus latency and development of autoimmune disease","volume":"711","author":"Niller","year":"2011","journal-title":"Adv Exp Med Biol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1530\/eje.1.02111","article-title":"Novel neuroanatomical pathways for thyroid hormone action in the human anterior pituitary","volume":"154","author":"Alkemade","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.07.007","article-title":"Pituitary dendritic cells communicate immune pathogenic signals","volume":"50","author":"Glennon","year":"2015","journal-title":"Brain Behav Immun"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.02.031","article-title":"Chronic ACTH autoantibodies are a significant pathological factor in the disruption of the hypothalamic\u2013pituitary\u2013adrenal axis in chronic fatigue syndrome, anorexia nervosa and major depression","volume":"65","author":"Wheatland","year":"2005","journal-title":"Med Hypotheses"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab429","article-title":"Hypothalamic-pituitary autoimmunity and related impairment of hormone secretions in chronic fatigue syndrome","volume":"106","author":"De Bellis","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/S11102-013-0526-9\/TABLES\/3","article-title":"Characterization of pituitary cells targeted by antipituitary antibodies in patients with isolated autoimmune diseases without pituitary insufficiency may help to foresee the kind of future hypopituitarism","volume":"17","author":"De Bellis","year":"2014","journal-title":"Pituitary"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biom10101436","article-title":"Classical examples of the concept of the ASIA syndrome","volume":"10","author":"Borba","year":"2020","journal-title":"Biomolecules"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1007\/s10067-022-06149-4","article-title":"Autoimmune post-COVID vaccine syndromes: does the spectrum of autoimmune\/inflammatory syndrome expand","volume":"41","author":"Jara","year":"2022","journal-title":"Clin Rheumatol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.31138\/mjr","article-title":"The ASIA syndrome: basic concepts","volume":"28","author":"Watad","year":"2017","journal-title":"Mediterr J Rheumatol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108377","article-title":"Immune-related adverse events of checkpoint inhibitors: Insights into immunological dysregulation","volume":"213","author":"Yang","year":"2020","journal-title":"Clin Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ejca.2019.04.035","article-title":"The evolving landscape of \u201cnext-generation\u201d immune checkpoint inhibitors: A review","volume":"117","author":"Mazzarella","year":"2019","journal-title":"Eur J Cancer"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1197364","article-title":"Immune-related adverse effects of checkpoint immunotherapy and implications for the treatment of patients with cancer and autoimmune diseases","volume":"14","author":"Ibis","year":"2023","journal-title":"Front Immunol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.4137\/CMED.S22469\/ASSET\/IMAGES\/LARGE\/10.4137_CMED.S22469-FIG2.JPEG","article-title":"Immune checkpoint inhibitor therapy associated hypophysitis","volume":"8","author":"Mahzari","year":"2015","journal-title":"Clin Med Insights Endocrinol Diabetes"},{"key":"B68","doi-asserted-by":"publisher","first-page":"929","DOI":"10.2217\/imt-2017-0056","article-title":"CNS side effects of immune checkpoint inhibitors: preclinical models, genetics and multimodality therapy","volume":"9","author":"McGinnis","year":"2017","journal-title":"Immunotherapy"},{"key":"B69","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/nrendo.2016.205","article-title":"Cancer immunotherapy\u2014immune checkpoint blockade and associated endocrinopathies","volume":"13","author":"Byun","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s12974-016-0663-y","article-title":"Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury","volume":"13","author":"Dong","year":"2016","journal-title":"J Neuroinflamm"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063429","article-title":"Cortisol patterns are associated with T cell activation in HIV","volume":"8","author":"Patterson","year":"2013","journal-title":"PloS One"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.589833","article-title":"Adjuvants for coronavirus vaccines","volume":"11","author":"Liang","year":"2020","journal-title":"Front Immunol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14860","article-title":"Increased incidence of Graves\u2019 disease during the SARS-CoV2 pandemic","volume":"98","author":"Barajas Galindo","year":"2023","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2023.103287","article-title":"Autoimmune\/inflammatory syndrome induced by adjuvants (ASIA) in 2023","volume":"22","author":"Cohen Tervaert","year":"2023","journal-title":"Autoimmun Rev"},{"key":"B75","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1007\/s40618-022-01863-x","article-title":"SARS-CoV-2 vaccine may trigger thyroid autoimmunity: real-life experience and review of the literature","volume":"45","author":"Ruggeri","year":"2022","journal-title":"J Endocrinol Invest"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12902-022-01095-3\/FIGURES\/2","article-title":"Isolated ACTH deficiency following immunization with the BNT162b2 SARS-CoV-2 vaccine: a case report","volume":"22","author":"Morita","year":"2022","journal-title":"BMC Endocr Disord"},{"key":"B77","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.aace.2022.06.001","article-title":"A case of hypophysitis associated with SARS-coV-2 vaccination","volume":"8","author":"Ankireddypalli","year":"2022","journal-title":"AACE Clin Case Rep"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2022.1027047\/BIBTEX","article-title":"Endocrine system after 2 years of COVID-19 vaccines: A narrative review of the literature","volume":"13","author":"Pezzaioli","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1177\/23247096211043386","article-title":"A case of hypophysitis following immunization with the mRNA-1273 SARS-coV-2 vaccine","volume":"9","author":"Murvelashvili","year":"2021","journal-title":"J Investig Med High Impact Case Rep"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10122004","article-title":"Pilot findings on SARS-coV-2 vaccine-induced pituitary diseases: A mini review from diagnosis to pathophysiology","volume":"10","author":"Taieb","year":"2022","journal-title":"Vaccines 2022 Vol 10 Page 2004"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12902-023-01296-4\/FIGURES\/1","article-title":"Central diabetes insipidus: a late sequela of BNT162b2 SARS-CoV-2 mRNA vaccine","volume":"23","author":"Ishay","year":"2023","journal-title":"BMC Endocr Disord"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41541-021-00369-6","article-title":"Distinguishing features of current COVID-19 vaccines: knowns and unknowns of antigen presentation and modes of action","volume":"6","author":"Heinz","year":"2021","journal-title":"NPJ Vaccines 2021 6:1"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1021\/ACSNANO.0C07197\/ASSET\/IMAGES\/MEDIUM\/NN0C07197_0004.GIF","article-title":"Covid-19 vaccine frontrunners and their nanotechnology design","volume":"14","author":"Chung","year":"2020","journal-title":"ACS Nano"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11020432","article-title":"Adenoviral vector-based vaccine platform for COVID-19: current status","volume":"11","author":"Chavda","year":"2023","journal-title":"Vaccines (Basel)"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00909","article-title":"Factors which contribute to the immunogenicity of non-replicating adenoviral vectored vaccines","volume":"11","author":"Coughlan","year":"2020","journal-title":"Front Immunol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-062117","article-title":"Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines","volume":"110","author":"Tatsis","year":"2007","journal-title":"Blood"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.243","article-title":"mRNA vaccines - a new era in vaccinology","volume":"17","author":"Pardi","year":"2018","journal-title":"Nat Rev Drug Discovery"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.654866","article-title":"Impact of ribosome activity on SARS-coV-2 LNP - based mRNA vaccines","volume":"8","author":"Tsiambas","year":"2021","journal-title":"Front Mol Biosci"},{"key":"B89","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.1111\/ajt.16818","article-title":"Cellular immunity predominates over humoral immunity after homologous and heterologous mRNA and vector-based COVID-19 vaccine regimens in solid organ transplant recipients","volume":"21","author":"Schmidt","year":"2021","journal-title":"Am J Transplant"},{"key":"B90","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.bbi.2017.01.007","article-title":"A systematic review of the association between fatigue and genetic polymorphisms","volume":"62","author":"Wang","year":"2017","journal-title":"Brain Behav Immun"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.022681","article-title":"Association of chronic fatigue syndrome with human leucocyte antigen class II alleles","volume":"58","author":"Smith","year":"2005","journal-title":"J Clin Pathol"},{"key":"B92","doi-asserted-by":"publisher","first-page":"5267","DOI":"10.1038\/s41598-020-62157-x","article-title":"Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS)","volume":"10","author":"Lande","year":"2020","journal-title":"Sci Rep"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.Supplement_1.S154","article-title":"Association between HLA class II antigens and the chronic fatigue immune dysfunction syndrome","author":"Keller","year":"1994","journal-title":"Clin Infect Dis"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2370.2001.00235.x","article-title":"Lack of association between HLA genotype and chronic fatigue syndrome","volume":"28","author":"Underhill","year":"2001","journal-title":"Eur J Immunogenetics"},{"key":"B95","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s40744-018-0100-z","article-title":"Role of human leukocyte antigens (HLA) in autoimmune diseases","volume":"5","author":"Bodis","year":"2018","journal-title":"Rheumatol Ther"},{"key":"B96","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s12026-016-8817-7","article-title":"HLA-DRB1 the notorious gene in the mosaic of autoimmunity","volume":"65","author":"Arango","year":"2017","journal-title":"Immunol Res"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363912","article-title":"Variation in immune response genes and chronic Q fever. Concepts: preliminary test with post-Q fever fatigue syndrome","volume":"4","author":"Helbig","year":"2003","journal-title":"Genes Immun"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2021.656797\/BIBTEX","article-title":"Epstein-barr virus and the origin of myalgic encephalomyelitis or chronic fatigue syndrome","volume":"12","author":"Ruiz-Pablos","year":"2021","journal-title":"Front Immunol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2006.00244.x","article-title":"Glucocorticoid receptor polymorphisms and haplotypes associated with chronic fatigue syndrome","volume":"6","author":"Rajeevan","year":"2007","journal-title":"Genes Brain Behav"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2009.06.002","article-title":"An integrated approach to infer causal associations among gene expression, genotype variation, and disease","volume":"94","author":"Lee","year":"2009","journal-title":"Genomics"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-020-01663-9","article-title":"Breast prosthesis syndrome: pathophysiology and management algorithm","volume":"44","author":"Caravantes-Cortes","year":"2020","journal-title":"Aesthetic Plast Surg"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002493","article-title":"Original research: Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors","volume":"9","author":"Kobayashi","year":"2021","journal-title":"J Immunother Cancer"},{"key":"B103","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.phrs.2014.08.002","article-title":"Predicting post-vaccination autoimmunity: Who might be at risk","volume":"92","author":"Soriano","year":"2015","journal-title":"Pharmacol Res"},{"key":"B104","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1086\/513807","article-title":"HLA-DR class II associations with rubella vaccine-induced joint manifestations","volume":"177","author":"Mitchell","year":"1998","journal-title":"J Infect Dis"},{"key":"B105","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3390\/VACCINES10030402\/S1","article-title":"HLA class II polymorphism and humoral immunity induced by the SARS-coV-2 mRNA-1273 vaccine","volume":"10","author":"Guti\u00e9rrez-Bautista","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02078-6","article-title":"Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection","volume":"29","author":"Mentzer","year":"2022","journal-title":"Nat Med 2023 29:1"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.734689","article-title":"HLA does not impact on short-medium-term antibody response to preventive anti-SARS-cov-2 vaccine","volume":"12","author":"Ragone","year":"2021","journal-title":"Front Immunol"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1111\/tan.15049","article-title":"The humoral and cellular response to mRNA SARS-CoV-2 vaccine is influenced by HLA polymorphisms","volume":"102","author":"Bertinetto","year":"2023","journal-title":"HLA"},{"key":"B109","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/imm.13450","article-title":"HLA-DR polymorphism in SARS-CoV-2 infection and susceptibility to symptomatic COVID-19","volume":"166","author":"Astbury","year":"2022","journal-title":"Immunology"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1111\/tan.14047","article-title":"HLA allele frequencies and susceptibility to COVID-19 in a group of 99 Italian patients","volume":"96","author":"Novelli","year":"2020","journal-title":"HLA"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.3390\/diseases10040099","article-title":"Association of alleles of human leukocyte antigen class II genes and severity of COVID-19 in patients of the \u2018Red zone\u2019 of the endocrinology research center, moscow, Russia","volume":"10","author":"Troshina","year":"2022","journal-title":"Diseases"},{"key":"B112","doi-asserted-by":"publisher","first-page":"513","DOI":"10.4049\/jimmunol.1201891","article-title":"HLA class II molecules influence susceptibility vs protection in inflammatory diseases by determining the cytokine profile","volume":"190","author":"Mangalam","year":"2013","journal-title":"J Immunol"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1999.tb01403.x","article-title":"Major histocompatibility complex class II polymorphisms in primates","volume":"167","author":"Bontrop","year":"1999","journal-title":"Immunol Rev"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201891","article-title":"HLA class II molecules influence susceptibility versus protection in inflammatory diseases by determining the cytokine profile","volume":"190","author":"Mangalam","year":"2013","journal-title":"J Immunol"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.3390\/MICROORGANISMS11071686\/S1","article-title":"Molecular mimicry and HLA polymorphisms may drive autoimmunity in recipients of the BNT-162b2 mRNA vaccine: A computational analysis","volume":"11","author":"Talotta","year":"2023","journal-title":"Microorganisms"},{"key":"B116","article-title":"Viral antibody titers are influenced by HLA-DR2 phenotype - PubMed","volume":"11","author":"Lio","year":"1994","journal-title":"Exp Clin Immunogenet"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.3.1674-1681.1992","article-title":"Analysis of T- and B-cell epitopes of capsid protein of rubella virus by using synthetic peptides","volume":"66","author":"Ou","year":"1992","journal-title":"J Virol"},{"key":"B118","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/0198-8859(86)90079-0","article-title":"Comparison of HLA-Dw1 and -Dw2 positive adherent cells in antigen presentation to heterozygous T-cell lines: a low rubella antigen\u2013specific response associated with HLA-Dw2","volume":"17","author":"Ilonen","year":"1986","journal-title":"Hum Immunol"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-39946-0_193","article-title":"Selection by typhoid and yellow fever epidemics witnessed by the HLA-DR locus","volume":"2","author":"de Vries","year":"1989","journal-title":"Immunobiology HLA"},{"key":"B120","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1093\/oxfordjournals.epirev.a036241","article-title":"The role of histocompatibility antigens (HLA) in infection","volume":"3","author":"Kaslow","year":"1981","journal-title":"Epidemiol Rev"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202049030","article-title":"Epstein Barr virus infection and immune defense related to HLA-DR15: consequences for multiple sclerosis","volume":"51","author":"Olsson","year":"2021","journal-title":"Eur J Immunol"},{"key":"B122","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/eji.202048655","article-title":"Attenuated immune control of Epstein-Barr virus in humanized mice is associated with the multiple sclerosis risk factor HLA-DR15","volume":"51","author":"Zdimerova","year":"2021","journal-title":"Eur J Immunol"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11080831","article-title":"CD4+ Cytotoxic T cells involved in the development of EBV-associated diseases","volume":"11","author":"Ruiz-Pablos","year":"2022","journal-title":"Pathog 2022 Vol 11 Page 831"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909448107","article-title":"Nuclear location of an endogenously expressed antigen, EBNA1, restricts access to macroautophagy and the range of CD4 epitope display","volume":"107","author":"Leung","year":"2010","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.10.1649","article-title":"Human CD4+ T lymphocytes consistently respond to the latent Epstein- Barr virus nuclear antigen EBNA1","volume":"191","author":"M\u00fcnz","year":"2000","journal-title":"J Exp Med"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00197","article-title":"Fighting viral infections and virus-driven tumors with cytotoxic CD4+ T cells","volume":"8","author":"Muraro","year":"2017","journal-title":"Front Immunol"},{"key":"B127","doi-asserted-by":"publisher","first-page":"e39","DOI":"10.1038\/cti.2015.13","article-title":"Granzyme B mediated function of Parvovirus B19-specific CD4+ T cells","volume":"4","author":"Kumar","year":"2015","journal-title":"Clin Transl Immunol"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2013.00105\/XML\/NLM","article-title":"CD4 T cell responses in latent and chronic viral infections","volume":"4","author":"Walton","year":"2013","journal-title":"Front Immunol"},{"key":"B129","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1186\/s12967-023-04515-7","article-title":"Epstein\u2013Barr virus-acquired immunodeficiency in myalgic encephalomyelitis\u2014Is it present in long COVID","volume":"21","author":"Ruiz-Pablos","year":"2023","journal-title":"J Transl Med"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1002\/art.38726","article-title":"Implication of Epstein-Barr virus infection in disease-specific autoreactive B cell activation in ectopic lymphoid structures of Sj\u00f6gren\u2019s syndrome","volume":"66","author":"Croia","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"B131","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.1084\/jem.20071030","article-title":"Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain","volume":"204","author":"Serafini","year":"2007","journal-title":"J Exp Med"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202352","article-title":"Epstein-Barr virus persistence and infection of autoreactive plasma cells in synovial lymphoid structures in rheumatoid arthritis","volume":"72","author":"Croia","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0413240","article-title":"The role of viruses in autoreactive B cell activation within tertiary lymphoid structures in autoimmune diseases","volume":"94","author":"Lucchesi","year":"2013","journal-title":"J Leukoc Biol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.3390\/biom12020227","article-title":"Viral dUTPases: modulators of innate immunity","volume":"12","author":"Ariza","year":"2022","journal-title":"Biomolecules"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-00280-9","article-title":"Metabolic and epigenetic regulation of T-cell exhaustion","volume":"2","author":"Franco","year":"2020","journal-title":"Nat Metab"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2022.12.008","article-title":"T cell exhaustion in Malignant gliomas","volume":"9","author":"Watowich","year":"2023","journal-title":"Trends Cancer"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081761","article-title":"Epstein-Barr virus (EBV)\u2013encoded small RNA is released from EBV-infected cells and activates signaling from toll-like receptor 3","volume":"206","author":"Iwakiri","year":"2009","journal-title":"J Exp Med"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030855","article-title":"EBV dUTPase: A novel modulator of inflammation and the tumor microenvironment in EBV-associated Malignancies","volume":"15","author":"Williams","year":"2023","journal-title":"Cancers (Basel)"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11050538","article-title":"The evolutionary dance between innate host antiviral pathways and SARS-coV-2","volume":"11","author":"Aliyari","year":"2022","journal-title":"Pathogens"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098065","article-title":"TLRs: innate immune sentries against SARS-coV-2 infection","volume":"24","author":"Mantovani","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B141","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.thromres.2022.09.025","article-title":"Tissue factor in COVID-19-associated coagulopathy","volume":"220","author":"Subramaniam","year":"2022","journal-title":"Thromb Res"},{"key":"B142","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.immuni.2013.10.001","article-title":"Systemic effects of inflammation on health during chronic HIV infection","volume":"39","author":"Deeks","year":"2013","journal-title":"Immunity"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119124","article-title":"SARS-CoV-2 infection: The role of PD-1\/PD-L1 and CTLA-4 axis","volume":"270","author":"Aghbash","year":"2021","journal-title":"Life Sci"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2020.00827\/FULL","article-title":"Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19)","volume":"11","author":"Diao","year":"2020","journal-title":"Front Immunol"},{"key":"B145","doi-asserted-by":"publisher","first-page":"4694","DOI":"10.1172\/JCI138554","article-title":"Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent","volume":"130","author":"Mazzoni","year":"2020","journal-title":"J Clin Invest"},{"key":"B146","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00011-014-0755-z","article-title":"Inflammation and vitamin D: the infection connection","volume":"63","author":"Mangin","year":"2014","journal-title":"Inflammation Res"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222313","article-title":"The role of vitamin D in increasing circulating T regulatory cell numbers and modulating T regulatory cell phenotypes in patients with inflammatory disease or in healthy volunteers: A systematic review","volume":"14","author":"Fisher","year":"2019","journal-title":"PloS One"},{"key":"B148","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-021-04109-7","article-title":"Association between vitamin D3 levels and insulin resistance: a large sample cross-sectional study","volume":"12","author":"Xu","year":"2022","journal-title":"Sci Rep 2022 12:1"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3390\/nu9121286","article-title":"Zinc as a gatekeeper of immune function","volume":"9","author":"Wessels","year":"2017","journal-title":"Nutrients 2017 Vol 9 Page 1286"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.739918","article-title":"Metallothionein 1: A new spotlight on inflammatory diseases","volume":"12","author":"Dai","year":"2021","journal-title":"Front Immunol"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2741","article-title":"Anemia from A to zinc: Hypocupremia in the setting of gastric bypass and zinc excess","volume":"8","author":"Tatineni","year":"2020","journal-title":"Clin Case Rep"},{"key":"B152","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3945\/an.110.000208","article-title":"Impact of copper limitation on expression and function of multicopper oxidases (Ferroxidases)","volume":"2","author":"Prohaska","year":"2011","journal-title":"Adv Nutr"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.1.30","article-title":"Plasma diamine oxidase activity is greater in copper-adequate than copper-marginal or copper-deficient rats","volume":"130","author":"Kehoe","year":"2000","journal-title":"J Nutr"},{"key":"B154","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.addr.2008.06.002","article-title":"Monoamine oxidase inactivation: from pathophysiology to therapeutics","volume":"60","author":"Bortolato","year":"2008","journal-title":"Adv Drug Delivery Rev"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biom10081181","article-title":"Histamine intolerance: the current state of the art","volume":"10","author":"Comas-Bast\u00e9","year":"2020","journal-title":"Biomolecules"},{"key":"B156","doi-asserted-by":"publisher","first-page":"e0195346","DOI":"10.1371\/journal.pone.0195346","article-title":"Naturally occurring antibodies against serum amyloid A reduce IL-6 release from peripheral blood mononuclear cells","volume":"13","author":"Kuret","year":"2018","journal-title":"PloS One"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.3390\/ph15080931","article-title":"The occurrence of hyperactivated platelets and fibrinaloid microclots in myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS)","volume":"15","author":"Nunes","year":"2022","journal-title":"Pharmaceuticals"},{"key":"B158","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-39056-x","article-title":"Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation","volume":"9","author":"Page","year":"2019","journal-title":"Sci Rep"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010373107","article-title":"Alzheimer\u2019s disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization","volume":"107","author":"Ahn","year":"2010","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B160","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/J.IMMUNI.2018.05.005","article-title":"Virus-induced interferon-\u03b3 Causes insulin resistance in skeletal muscle and derails glycemic control in obesity","volume":"49","author":"\u0160estan","year":"2018","journal-title":"Immunity"},{"key":"B161","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.immuni.2018.06.013","article-title":"Viral infection \u201cInterferes\u201d with glucose tolerance","volume":"49","author":"Kiernan","year":"2018","journal-title":"Immunity"},{"key":"B162","unstructured":"ICIMH 2022 abstracts2022"},{"key":"B163","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/J.MOLMET.2014.12.001","article-title":"Central insulin signaling modulates hypothalamus-pituitary-adrenal axis responsiveness","volume":"4","author":"Chong","year":"2014","journal-title":"Mol Metab"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030135","article-title":"Neonates with symptomatic hyperinsulinemic hypoglycemia generate inappropriately low serum cortisol counterregulatory hormonal responses","volume":"88","author":"Hussain","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"B165","doi-asserted-by":"publisher","first-page":"2021182","DOI":"10.23750\/ABM.V92I2.11396","article-title":"Defective Cortisol Secretion in Response to Spontaneous Hypoglycemia but Normal Cortisol Response to ACTH stimulation in neonates with Hyperinsulinemic Hypoglycemia (HH)","volume":"92","author":"Ahmed","year":"2021","journal-title":"Acta Bio Medica\u202f: Atenei Parmensis"},{"key":"B166","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2009\/187894","article-title":"Interleukin-10: A key cytokine in depression","volume":"2009","author":"Roque","year":"2009","journal-title":"Cardiovasc Psychiatry Neurol"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.578802","article-title":"Clinical heterogeneity of acquired idiopathic isolated adrenocorticotropic hormone deficiency","volume":"12","author":"Fujita","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B168","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0960-0760(92)90219-9","article-title":"Mechanisms of insulin inhibition of ACTH-stimulated steroid secretion by cultured bovine adrenocortical cells","volume":"41","author":"Klein","year":"1992","journal-title":"J Steroid Biochem Mol Biol"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2021.626427\/BIBTEX","article-title":"The interaction of insulin and pituitary hormone syndromes","volume":"12","author":"Schernthaner-Reiter","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2016.00031\/BIBTEX","article-title":"Gene expression control by glucocorticoid receptors during innate immune responses","volume":"7","author":"Xavier","year":"2016","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B171","doi-asserted-by":"publisher","first-page":"e310","DOI":"10.1371\/journal.pone.0000310","article-title":"Genes involved in the balance between neuronal survival and death during inflammation","volume":"2","author":"Glezer","year":"2007","journal-title":"PloS One"},{"key":"B172","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.clim.2013.02.010","article-title":"Autoimmune diseases and reproductive aging","volume":"149","author":"Bove","year":"2013","journal-title":"Clin Immunol"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1080\/10253890.2021.2024803","article-title":"DHEA-S production capacity in relation to perceived prolonged stress","volume":"25","author":"Lennartsson","year":"2022","journal-title":"Stress"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1177\/00912700222011274","article-title":"The influence of hormones and pharmaceutical agents on DHEA and DHEA-S concentrations: a review of clinical studies","volume":"42","author":"Salek","year":"2002","journal-title":"J Clin Pharmacol"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098235","article-title":"Androgen receptor imaging in the management of hormone-dependent cancers with emphasis on prostate cancer","volume":"24","author":"Kairemo","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B176","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1365-3083.2007.01952.x","article-title":"Altered cortisol\/DHEA ratio in tuberculosis patients and its relationship with abnormalities in the mycobacterial-driven cytokine production by peripheral blood mononuclear cells","volume":"66","author":"Bozza","year":"2007","journal-title":"Scand J Immunol"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.02.002","article-title":"Dehydroepiandrosterone modulates T-cell response after major abdominal surgery","volume":"189","author":"Pratschke","year":"2014","journal-title":"J Surg Res"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.597675","article-title":"Inflammation and skeletal muscle wasting during cachexia","volume":"11","author":"Webster","year":"2020","journal-title":"Front Physiol"},{"key":"B179","doi-asserted-by":"publisher","first-page":"e200","DOI":"10.1038\/oncsis.2016.3","article-title":"Understanding cachexia as a cancer metabolism syndrome","volume":"5","author":"Porporato","year":"2016","journal-title":"Oncogenesis"},{"key":"B180","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41590-019-0397-y","article-title":"CD8+ T cells induce cachexia during chronic viral infection","volume":"20","author":"Baazim","year":"2019","journal-title":"Nat Immunol"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.748254","article-title":"Crosstalk between intestinal serotonergic system and pattern recognition receptors on the microbiota-gut-brain axis","volume":"12","author":"Layunta","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1159\/000339057","article-title":"Toll-like receptor 3 activation affects serotonin transporter activity and expression in human enterocyte-like Caco-2 cells","volume":"30","author":"Mendoza","year":"2012","journal-title":"Cell Physiol Biochem"},{"key":"B183","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/164_2016_103","article-title":"Serotonergic mechanisms regulating the GI tract: experimental evidence and therapeutic relevance","volume":"239","author":"Terry","year":"2017","journal-title":"Handb Exp Pharmacol"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-178-42016","article-title":"Action of serotonin on the gastrointestinal tract","volume":"178","author":"Ormsbee","year":"1985","journal-title":"Proc Soc Exp Biol Med"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62264-X","article-title":"Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression","volume":"166","author":"Wang","year":"2005","journal-title":"Am J Pathol"},{"key":"B186","first-page":"112","article-title":"Small intestinal bacterial overgrowth: A comprehensive review","volume":"3","author":"Dukowicz","year":"2007","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2013.0775","article-title":"The malabsorption of commonly occurring mono and disaccharides: levels of investigation and differential diagnoses","volume":"110","author":"Raithel","year":"2013","journal-title":"Dtsch Arztebl Int"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.3390\/cells12141865","article-title":"Toll-like receptors as pro-thrombotic drivers in viral infections: A narrative review","volume":"12","author":"Panzer","year":"2023","journal-title":"Cells"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157894","article-title":"Platelet innate immune receptors and TLRs: A double-edged sword","volume":"22","author":"Ebermeyer","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2014.09.013","article-title":"Human platelets express Toll-like receptor 3 and respond to poly I:C","volume":"75","author":"Anabel","year":"2014","journal-title":"Hum Immunol"},{"key":"B191","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/s41593-020-00771-8","article-title":"The S1 protein of SARS-CoV-2 crosses the blood\u2013brain barrier in mice","volume":"24","author":"Rhea","year":"2021","journal-title":"Nat Neurosci"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2019.04.009","article-title":"Epstein-barr virus dUTPase induces neuroinflammatory mediators: implications for myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"41","author":"Williams PhD","year":"2019","journal-title":"Clin Ther"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.3389\/FNINS.2023.1108212\/BIBTEX","article-title":"Viral-induced neuroinflammation: Different mechanisms converging to similar exacerbated glial responses","volume":"17","author":"Rocamonde","year":"2023","journal-title":"Front Neurosci"},{"key":"B194","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-023-41240-z","article-title":"Viral-like TLR3 induction of cytokine networks and \u03b1-synuclein are reduced by complement C3 blockade in mouse brain","volume":"13","author":"Thomas","year":"2023","journal-title":"Sci Rep"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.04.022","article-title":"Linking the biological underpinnings of depression: Role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition","volume":"80","author":"Anderson","year":"2018","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.4137\/IJTR.S26862","article-title":"Tryptophan catabolism in chronic viral infections: handling uninvited guests","volume":"8","author":"Mehraj","year":"2015","journal-title":"Int J Tryptophan Res"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.3390\/cells11040706","article-title":"Interaction of mitochondrial calcium and ROS in neurodegeneration","volume":"11","author":"Baev","year":"2022","journal-title":"Cells"},{"key":"B198","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S00018-022-04380-5\/FIGURES\/2","article-title":"Could the kynurenine pathway be the key missing piece of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) complex puzzle","volume":"79","author":"Kavyani","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(01)00133-4","article-title":"Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes","volume":"40","author":"Tavares","year":"2002","journal-title":"Neurochem Int"},{"key":"B200","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1038\/jcbfm.2012.30","article-title":"Prevention of acute\/severe hypoglycemia-induced neuron death by lactate administration","volume":"32","author":"Won","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"key":"B201","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.bbrc.2022.03.122","article-title":"Chronic microglial inflammation promotes neuronal lactate supply but impairs its utilization in primary rat astrocyte-neuron co-cultures","volume":"607","author":"Wang","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"B202","doi-asserted-by":"publisher","first-page":"185","DOI":"10.18632\/aging.v2i4","article-title":"Transcriptional evidence for the \u201cReverse Warburg Effect\u201d in human breast cancer tumor stroma and metastasis: Similarities with oxidative stress, inflammation, Alzheimer\u2019s disease, and \u201cNeuron-Glia Metabolic Coupling","volume":"2","author":"Pavlides","year":"2010","journal-title":"Aging (Albany NY)"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1091\/MBC.E18-10-0650\/ASSET\/IMAGES\/LARGE\/MBC-30-2584-G008.JPEG","article-title":"NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival","volume":"30","author":"Murata","year":"2019","journal-title":"Mol Biol Cell"},{"key":"B204","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1752-0509-5-162\/TABLES\/1","article-title":"Astrocyte - neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions - in silico study supported by in vitro expression data","volume":"5","author":"Genc","year":"2011","journal-title":"BMC Syst Biol"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108690","article-title":"Cancer cells change their glucose metabolism to overcome increased ROS: One step from cancer cell to cancer stem cell","volume":"112","author":"Ghanbari Movahed","year":"2019","journal-title":"Biomedicine Pharmacotherapy"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-3831","article-title":"The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress","volume":"73","author":"Sahm","year":"2013","journal-title":"Cancer Res"},{"key":"B207","doi-asserted-by":"publisher","first-page":"104024","DOI":"10.1155\/2013\/104024","article-title":"Quinolinic acid: An endogenous neurotoxin with multiple targets","volume":"2013","author":"Lugo-Huitr\u00f3n","year":"2013","journal-title":"Oxid Med Cell Longev"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.3389\/FNAGI.2020.00255\/BIBTEX","article-title":"Nicotinamide, a poly [ADP-ribose] polymerase 1 (PARP-1) inhibitor, as an adjunctive therapy for the treatment of alzheimer\u2019s disease","volume":"12","author":"Salech","year":"2020","journal-title":"Front Aging Neurosci"},{"key":"B209","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/s41392-020-00311-7","article-title":"NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential","volume":"5","author":"Xie","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.3390\/biom13050735","article-title":"Role of sirtuin 3 in degenerative diseases of the central nervous system","volume":"13","author":"Zhang","year":"2023","journal-title":"Biomolecules"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6782872","article-title":"The beneficial roles of SIRT1 in neuroinflammation-related diseases","volume":"2020","author":"Jiao","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2021.748254\/XML\/NLM","article-title":"Crosstalk between intestinal serotonergic system and pattern recognition receptors on the microbiota\u2013gut\u2013brain axis","volume":"12","author":"Layunta","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00589","article-title":"Glial activation and expression of the serotonin transporter in chronic fatigue syndrome","volume":"9","author":"Noda","year":"2018","journal-title":"Front Psychiatry"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1366.020","article-title":"Brain cytokines and the 5-HT system during poly I:C-induced fatigue","volume":"1088","author":"Katafuchi","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"B215","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1007\/s11064-012-0967-y","article-title":"The pro-inflammatory cytokine TNF-\u03b1 Regulates the activity and expression of the serotonin transporter (SERT) in astrocytes","volume":"38","author":"Malynn","year":"2013","journal-title":"Neurochemical Res"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.3390\/ph11030066","article-title":"Bacterial lipopolysaccharide increases serotonin metabolism in both medial prefrontal cortex and nucleus accumbens in male wild type rats, but not in serotonin transporter knockout rats","volume":"11","author":"Korte-Bouws","year":"2018","journal-title":"Pharmaceuticals"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.02.087","article-title":"5-HT(1A) receptor and apoptosis contribute to interferon-\u03b1-induced \u201cdepressive-like\u201d behavior in mice","volume":"514","author":"Ping","year":"2012","journal-title":"Neurosci Lett"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-3-670","article-title":"Corticotropin and cortisol secretion after central 5-hydroxytryptamine-1A (5-HT1A) receptor activation: effects of 5-HT receptor and beta-adrenoceptor antagonists","volume":"70","author":"Lesch","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00395-2","article-title":"Regulation of glutamate release via NMDA and 5-HT1A receptors in Guinea pig dentate gyrus","volume":"728","author":"Matsuyama","year":"1996","journal-title":"Brain Res"},{"key":"B220","doi-asserted-by":"publisher","first-page":"686","DOI":"10.2174\/0929867323666160122115057","article-title":"Serotonin 1A receptors on astrocytes as a potential target for the treatment of parkinson\u2019s disease","volume":"23","author":"Miyazaki","year":"2016","journal-title":"Curr Med Chem"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12040894","article-title":"Multifunctional metallothioneins as a target for neuroprotection in parkinson\u2019s disease","volume":"12","author":"Miyazaki","year":"2023","journal-title":"Antioxidants"},{"key":"B222","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1126\/science.aaf6284","article-title":"Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism","volume":"354","author":"Peng","year":"2016","journal-title":"Science"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002328","article-title":"Exhausted cytotoxic control of epstein-barr virus in human lupus","volume":"7","author":"Larsen","year":"2011","journal-title":"PloS Pathog"},{"key":"B224","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative stress, inflammation, and cancer: How are they linked","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1177\/2326409817698994\/ASSET\/IMAGES\/LARGE\/10.1177_2326409817698994-FIG4.JPEG","article-title":"The link between hyperhomocysteinemia and hypomethylation: Implications for cardiovascular disease","volume":"5","author":"Barroso","year":"2017","journal-title":"J Inborn Errors Metab Screen"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3179421","article-title":"DNA oncogenic virus-induced oxidative stress, genomic damage, and aberrant epigenetic alterations","volume":"2017","author":"Kgatle","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.8.2361S","article-title":"Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology","volume":"132","author":"Jill James","year":"2002","journal-title":"J Nutr"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.3390\/NU15122734","article-title":"Vitamin B12\u2014Multifaceted in vivo functions and in vitro applications","volume":"15","author":"Kazmierczak-Bar\u00e1 Nska","year":"2023","journal-title":"Nutrients"},{"key":"B229","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.virol.2017.04.006","article-title":"PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter","volume":"507","author":"Lupey-Green","year":"2017","journal-title":"Virology"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00755-18","article-title":"PARP1 stabilizes CTCF binding and chromatin structure to maintain epstein-barr virus latency type","volume":"92","author":"Lupey-Green","year":"2018","journal-title":"J Virol"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2021.1887131","article-title":"Immune checkpoint inhibition in COVID-19: risks and benefits","volume":"21","author":"Pezeshki","year":"2021","journal-title":"Expert Opin Biol Ther"},{"key":"B232","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S41927-022-00297-5\/FIGURES\/3","article-title":"Immune-related adverse events in patients with pre-existing autoimmune rheumatologic disease on immune checkpoint inhibitor therapy","volume":"6","author":"Lusa","year":"2022","journal-title":"BMC Rheumatol"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00557","article-title":"Immune checkpoint inhibitor-related cytokine release syndrome: analysis of WHO global pharmacovigilance database","volume":"11","author":"Ceschi","year":"2020","journal-title":"Front Pharmacol"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.8.5439","article-title":"Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection","volume":"180","author":"CecChinato","year":"2008","journal-title":"J Immunol"},{"key":"B235","doi-asserted-by":"publisher","first-page":"e002840","DOI":"10.1136\/jitc-2021-002840","article-title":"Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation","volume":"9","author":"Qin","year":"2021","journal-title":"J Immunother Cancer"},{"key":"B236","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1084\/jem.20020052","article-title":"Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase\u2013expressing dendritic cells: mediation of suppression by tryptophan metabolites","volume":"196","author":"Terness","year":"2002","journal-title":"J Exp Med"},{"key":"B237","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1046\/j.1365-2567.2002.01526.x","article-title":"Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division","volume":"107","author":"Lee","year":"2002","journal-title":"Immunology"},{"key":"B238","doi-asserted-by":"publisher","first-page":"3148","DOI":"10.1172\/JCI33034","article-title":"Understanding the benign nature of SIV infection in natural hosts","volume":"117","author":"Silvestri","year":"2007","journal-title":"J Clin Invest"},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001145","article-title":"On the use of immune checkpoint inhibitors in patients with viral infections including COVID-19","volume":"8","author":"Gambichler","year":"2020","journal-title":"J Immunother Cancer"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2022.02.042","article-title":"Hepatitis B virus and hepatitis C virus reactivation in cancer patients receiving novel anticancer therapies","volume":"28","author":"Mustafayev","year":"2022","journal-title":"Clin Microbiol Infection"},{"key":"B241","article-title":"Hypophysitis\u00a0and other autoimmune complications related to immune checkpoints inhibitors\u00b4 treatment: Spectrum of imaging appearances","volume":"39","author":"Mal\u00edkov\u00e1","year":"2018","journal-title":"Neuro Endocrinol Lett"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.48.483","article-title":"Spontaneous recovery from hypopituitarism in a man with lymphocytic hypophysitis A case report","volume":"48","author":"Noto","year":"2001","journal-title":"Endocr J"},{"key":"B243","doi-asserted-by":"publisher","first-page":"1","DOI":"10.11604\/pamj.2020.36.28.22454","article-title":"Autoimmune hypophysitis and viral infection in a pregnant woman: a challengeable case","volume":"36","author":"Benabderrahim","year":"2020","journal-title":"Pan Afr Med J"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.3390\/BIOMEDICINES9111540\/S1","article-title":"A short corticosteroid course reduces symptoms and immunological alterations underlying long-COVID","volume":"9","author":"Utrero-Rico","year":"2021","journal-title":"Biomedicines"},{"key":"B245","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1210\/er.2004-0011","article-title":"Autoimmune hypophysitis","volume":"26","author":"Caturegli","year":"2005","journal-title":"Endocr Rev"},{"key":"B246","unstructured":"Infections in endocrinology: viruses\n            SomasundaramNP\n            GunatilakeSSC\n          Endotext2021"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30120766","article-title":"Exploring a rarity: incidence of and therapeutic approaches for neurological complications and hypophysitis in cancer patients on immune checkpoint inhibitors\u2014A single-center study","volume":"30","author":"Amylidi","year":"2023","journal-title":"Curr Oncol 2023 Vol 30 Pages 10509-10518"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.3389\/FENDO.2023.1091185\/BIBTEX","article-title":"Frequency and clinical characteristics of hypophysitis and hypopituitarism in patients undergoing immunotherapy \u2013 A systematic review","volume":"14","author":"Jacques","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B249","doi-asserted-by":"publisher","first-page":"0","DOI":"10.12659\/AJCR.936217","article-title":"Neuroleptic Malignant syndrome with adrenal insufficiency after BNT162b2 COVID-19 vaccination in a man taking valproate: A case report","volume":"23","author":"Mizuno","year":"2022","journal-title":"Am J Case Rep"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.38948","article-title":"Long-term usage of oral glucocorticoids leading to adrenal insufficiency: A comprehensive review of the literature","volume":"15","author":"Chac\u00f3n","year":"2023","journal-title":"Cureus"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2023.03.001","article-title":"Panax Ginseng in the treatment of Alzheimer\u2019s disease and vascular dementia","volume":"47","author":"Wang","year":"2023","journal-title":"J Ginseng Res"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076119","article-title":"Ginsenosides from panax ginseng as key modulators of NF-\u03baB signaling are powerful anti-inflammatory and anticancer agents","volume":"24","author":"Jang","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B253","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.853981","article-title":"Gut microbiota: therapeutic targets of ginseng against multiple disorders and ginsenoside transformation","volume":"12","author":"Chen","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"B254","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13046-023-02888-7\/FIGURES\/7","article-title":"Ginseng-derived nanoparticles reprogram macrophages to regulate arginase-1 release for ameliorating T cell exhaustion in tumor microenvironment","volume":"42","author":"Lv","year":"2023","journal-title":"J Exp Clin Cancer Res"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.1007\/S003930070004\/METRICS","article-title":"Replacement therapy with DHEA plus corticosteroids in patients with chronic inflamatory diseases - Substitutes of adrenal and sex hormones","volume":"59","author":"Straub","year":"2000","journal-title":"Z Rheumatol"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092073","article-title":"A review of dietary (Phyto)Nutrients for glutathione support","volume":"11","author":"Minich","year":"2019","journal-title":"Nutrients"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0725-2","article-title":"Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen","volume":"21","author":"Vardhana","year":"2020","journal-title":"Nat Immunol"},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.1177\/2040622313496126","article-title":"Gastrointestinal bacterial overgrowth: pathogenesis and clinical significance","volume":"4","author":"Sachdev","year":"2013","journal-title":"Ther Adv Chronic Dis"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.3390\/biom12030454","article-title":"Histamine intolerance\u2014A kind of pseudoallergic reaction","volume":"12","author":"Zhao","year":"2022","journal-title":"Biomolecules 2022 Vol 12 Page 454"},{"key":"B260","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1365-2249.2009.03958.x","article-title":"Histamine H1-receptor antagonists with immunomodulating activities: potential use for modulating T helper type 1 (Th1)\/Th2 cytokine imbalance and inflammatory responses in allergic diseases","volume":"157","author":"Okamoto","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"B261","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1600-065X.2012.01150.x","article-title":"Metabolic switching and fuel choice during T-cell differentiation and memory development","volume":"249","author":"van der Windt","year":"2012","journal-title":"Immunol Rev"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00739-7","article-title":"Sirtuins are crucial regulators of T cell metabolism and functions","volume":"54","author":"Hamaidi","year":"2022","journal-title":"Exp Mol Med 2022 54:3"},{"key":"B263","doi-asserted-by":"publisher","first-page":"4071","DOI":"10.1042\/BCJ20210181","article-title":"NAD+-consuming enzymes in immune defense against viral infection","volume":"478","author":"Shang","year":"2021","journal-title":"Biochem J"},{"key":"B264","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.micpath.2013.12.005","article-title":"Supplementation with Astragalus polysaccharides alters Aeromonas-induced tissue-specific cellular immune response","volume":"66","author":"Abuelsaad","year":"2014","journal-title":"Microb Pathog"},{"key":"B265","doi-asserted-by":"publisher","DOI":"10.3389\/fntpr.2022.971679","article-title":"Advances on immunoregulation effect of astragalus polysaccharides","volume":"1","author":"Wang","year":"2022","journal-title":"Front Natural Products"},{"key":"B266","doi-asserted-by":"publisher","first-page":"76","DOI":"10.4149\/av_2014_01_76","article-title":"The effect of Astragalus polysaccharide on the Epstein-Barr virus lytic cycle","volume":"58","author":"Guo","year":"2014","journal-title":"Acta Virol"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1017\/S000711450769936X","article-title":"Amino acids and immune function","volume":"98","author":"Li","year":"2007","journal-title":"Br J Nutr"},{"key":"B268","doi-asserted-by":"publisher","first-page":"162","DOI":"10.4103\/jpgm.jpgm_65_23","article-title":"Reduced tissue creatine levels in patients with long COVID-19: A cross-sectional study","volume":"69","author":"Ranisavljev","year":"2023","journal-title":"J Postgrad Med"},{"key":"B269","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu13020447","article-title":"Creatine in health and disease","volume":"13","author":"Kreider","year":"2021","journal-title":"Nutrients"},{"key":"B270","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2016.00697\/BIBTEX","article-title":"Vitamin D in autoimmunity: Molecular mechanisms and therapeutic potential","volume":"7","author":"Dankers","year":"2017","journal-title":"Front Immunol"},{"key":"B271","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.neuroscience.2023.10.010","article-title":"Melatonin protects injured spinal cord neurons from apoptosis by inhibiting mitochondrial damage via the SIRT1\/drp1 signaling pathway","volume":"534","author":"Zhong","year":"2023","journal-title":"Neuroscience"},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105210","article-title":"Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis","volume":"161","author":"Morvaridzadeh","year":"2020","journal-title":"Pharmacol Res"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1187163","article-title":"ME\/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature","volume":"10","author":"Komaroff","year":"2023","journal-title":"Front Med (Lausanne)"},{"key":"B274","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12967-023-03887-0\/FIGURES\/8","article-title":"The persistent viral infections in the development and severity of myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"21","author":"Rasa-Dzelzkaleja","year":"2023","journal-title":"J Transl Med"},{"key":"B275","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s12967-018-1644-y","article-title":"Chronic viral infections in myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS)","volume":"16","author":"Rasa","year":"2018","journal-title":"J Transl Med"},{"key":"B276","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.23021","article-title":"Secondary adrenal insufficiency after COVID-19 diagnosed by insulin tolerance test and corticotropin-releasing hormone test","volume":"14","author":"Hamazaki","year":"2022","journal-title":"Cureus"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ22-0093","article-title":"Hormonal trends in patients suffering from long COVID symptoms","volume":"69","author":"Sunada","year":"2022","journal-title":"Endocr J"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2021.100284","article-title":"COVID-19 and chronic fatigue syndrome: An endocrine perspective","volume":"27","author":"Bansal","year":"2022","journal-title":"J Clin Transl Endocrinol"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-244861","article-title":"Idiopathic combined adrenocorticotropin and growth hormone deficiency mimicking chronic fatigue syndrome","volume":"14","author":"Tokumasu","year":"2021","journal-title":"BMJ Case Rep"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.1097\/00124743-199904000-00004","article-title":"A pilot study employing Dehydroepiandrosterone (DHEA) in the treatment of chronic fatigue syndrome","volume":"5","author":"Himmel","year":"1999","journal-title":"J Clin Rheumatol"},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm","article-title":"Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome","volume":"1","author":"Kuratsune","year":"1998","journal-title":"Int J Mol Med"},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00169-4","article-title":"Differences in adrenal steroid profile in chronic fatigue syndrome, in depression and in health","volume":"54","author":"Scott","year":"1999","journal-title":"J Affect Disord"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00478-6","article-title":"Serum concentrations of some metals and steroids in patients with chronic fatigue syndrome with reference to neurological and cognitive abnormalities","volume":"55","author":"Van Rensburg","year":"2001","journal-title":"Brain Res Bull"},{"key":"B284","doi-asserted-by":"publisher","DOI":"10.1007\/S12020-022-03140-6\/FIGURES\/3","article-title":"COVID-19 patients with altered steroid hormone levels are more likely to have higher disease severity","volume":"78","author":"Sezer","year":"2022","journal-title":"Endocrine"},{"key":"B285","doi-asserted-by":"publisher","DOI":"10.1101\/2024.02.29.24303568","article-title":"Sex differences in symptomatology and immune profiles of Long COVID","author":"Silva","year":"2024","journal-title":"medRxiv"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11071955","article-title":"Detection of male hypogonadism in patients with post COVID-19 condition","volume":"11","author":"Yamamoto","year":"2022","journal-title":"J Clin Med"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12175478","article-title":"The potential role of hypothalamic phospholipid liposomes in the supportive therapy of some manifestations of post-COVID-19 condition: myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) and brain fog","volume":"12","author":"Menichetti","year":"2023","journal-title":"J Clin Med"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2011.02428.x","article-title":"Myalgic encephalomyelitis: international consensus criteria","volume":"270","author":"Carruthers","year":"2011","journal-title":"J Intern Med"},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000391","article-title":"Silicone breast implants and autoimmune rheumatic diseases: Myth or reality","volume":"29","author":"Cohen Tervaert","year":"2017","journal-title":"Curr Opin Rheumatol"},{"key":"B290","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108384","article-title":"Complex syndromes of chronic pain, fatigue and cognitive impairment linked to autoimmune dysautonomia and small fiber neuropathy","volume":"214","author":"Shoenfeld","year":"2020","journal-title":"Clin Immunol"},{"key":"B291","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2021.100100","article-title":"Functional autoantibodies against G-protein coupled receptors in patients with persistent Long-COVID-19 symptoms","volume":"4","author":"Wallukat","year":"2021","journal-title":"J Transl Autoimmun"},{"key":"B292","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/WOR-220581","article-title":"Post-exertional malaise among people with long COVID compared to myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS)","volume":"74","author":"Vernon","year":"2023","journal-title":"Work"},{"key":"B293","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/neurolint15010001","article-title":"ME\/CFS and post-exertional malaise among patients with long COVID","volume":"15","author":"Jason","year":"2022","journal-title":"Neurol Int 2023 Vol 15 Pages 1-11"},{"key":"B294","doi-asserted-by":"publisher","DOI":"10.1007\/S12026-014-8604-2\/TABLES\/2","article-title":"Chronic fatigue syndrome and fibromyalgia following immunization with the hepatitis B vaccine: another angle of the \u2018autoimmune (auto-inflammatory) syndrome induced by adjuvants\u2019 (ASIA)","volume":"60","author":"Agmon-Levin","year":"2014","journal-title":"Immunol Res"},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.1007\/S12026-018-9036-1\/TABLES\/1","article-title":"Autonomic dysfunction and HPV immunization: an overview","volume":"66","author":"Blitshteyn","year":"2018","journal-title":"Immunol Res"},{"key":"B296","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab373","article-title":"Three cases of subacute thyroiditis following SARS-coV-2 vaccine: postvaccination ASIA syndrome","volume":"106","author":"Iremli","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"B297","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2021.0142","article-title":"Two cases of graves\u2019 Disease following SARS-coV-2 vaccination: an autoimmune\/inflammatory syndrome induced by adjuvants","volume":"31","author":"Vera-Lastra","year":"2021","journal-title":"https:\/\/home.liebertpub.com\/thy"},{"key":"B298","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1084\/jem.20081720","article-title":"Priming of protective T cell responses against virus-induced tumors in mice with human immune system components","volume":"206","author":"Strowig","year":"2009","journal-title":"J Exp Med"},{"key":"B299","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1002\/eji.202049030","article-title":"Epstein Barr virus infection and immune defense related to HLA-DR15: consequences for multiple sclerosis","volume":"51","author":"Olsson","year":"2021","journal-title":"Eur J Immunol"},{"key":"B300","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/eji.202048655","article-title":"Attenuated immune control of Epstein\u2013Barr virus in humanized mice is associated with the multiple sclerosis risk factor HLA-DR15","volume":"51","author":"Zdimerova","year":"2021","journal-title":"Eur J Immunol"},{"key":"B301","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007748","article-title":"CD8+ T cells retain protective functions despite sustained inhibitory receptor expression during Epstein-Barr virus infection","volume":"15","author":"Chatterjee","year":"2019","journal-title":"vivo. PloS Pathog"},{"key":"B302","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1177\/10815589231158041","article-title":"The role of immune activation and antigen persistence in acute and long COVID","volume":"71","author":"Opsteen","year":"2023","journal-title":"J Invest Med"},{"key":"B303","doi-asserted-by":"publisher","DOI":"10.1038\/nri3740","article-title":"T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion? Speiser, Daniel E; Utzschneider, Daniel T; Oberle, Susanne G; M\u00fcnz, Christian; Romero, Pedro; Zehn, Dietmar (2014) T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion","volume":"14","author":"Speiser","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B304","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/j.1365-2567.2004.01821.x","article-title":"Factors affecting the susceptibility of the mouse pituitary gland to CD8 T-cell-mediated autoimmunity","volume":"111","author":"De Jersey","year":"2004","journal-title":"Immunology"},{"key":"B305","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)04074-4","article-title":"Low-dose hydrocortisone in chronic fatigue syndrome: A randomised crossover trial","volume":"353","author":"Cleare","year":"1999","journal-title":"Lancet"},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.12.1061","article-title":"Low-dose hydrocortisone for treatment of chronic fatigue syndrome: A randomized controlled trial","volume":"280","author":"McKenzie","year":"1998","journal-title":"JAMA"},{"key":"B307","doi-asserted-by":"publisher","first-page":"161","DOI":"10.2147\/JIR.S195165","article-title":"General theory of inflammation: patient self-administration of hydrocortisone safely achieves superior control of hydrocortisone-responding disorders by matching dosage with symptom intensity","volume":"12","author":"Irwin","year":"2019","journal-title":"J Inflammation Res"},{"key":"B308","doi-asserted-by":"publisher","DOI":"10.3389\/FMED.2021.672370\/BIBTEX","article-title":"Theory: treatments for prolonged ICU patients may provide new therapeutic avenues for myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS)","volume":"8","author":"Stanculescu","year":"2021","journal-title":"Front Med (Lausanne)"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1422940\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T04:32:57Z","timestamp":1720499577000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1422940\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,9]]},"references-count":308,"alternative-id":["10.3389\/fimmu.2024.1422940"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1422940","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,9]]},"article-number":"1422940"}}