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Our study revealed that \u03b3\u03b4 T cells promote the complete maturation and production of interleukin-12 and CXCR3-ligands specifically in type 1 cDCs (cDC1), with minimal impact on cDC2 and monocyte derived DCs (Mo-DCs). During the initial infection phase, \u03b3\u03b4 T cell activation and temporal accumulation in the splenic white pulp, alongside cDC1, occur via CCR7-signaling. Furthermore, cDC1\/\u03b3\u03b4 T cell interactions in the white pulp are amplified through CXCR3 signaling in \u03b3\u03b4 T cells, optimizing Th1 cell priming by cDC1. We also demonstrated how transitional Th1 cells arise in the white pulp before establishing their presence in the red pulp as fully differentiated Th1 cells. Additionally, we elucidate the reciprocal activation between \u03b3\u03b4 T cells and cDC1s. These findings suggest that Th1 cell priming is orchestrated by this reciprocal activation in the splenic white pulp during the early phase of blood-stage <jats:italic>Plasmodium<\/jats:italic> infection.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1426316","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T04:27:16Z","timestamp":1723696036000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["\u03b3\u03b4 T cell-mediated activation of cDC1 orchestrates CD4+ Th1 cell priming in malaria"],"prefix":"10.3389","volume":"15","author":[{"given":"Yarob","family":"Ibraheem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganchimeg","family":"Bayarsaikhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria 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