{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:00:01Z","timestamp":1790384401572,"version":"4.1.0"},"reference-count":86,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>SAPHO syndrome is a complex inflammatory disorder affecting the skin and bones, characterized by osteomyelitis, acne, and pustulosis. Cytokines play a pivotal role in the pathogenesis of SAPHO syndrome, especially in inflammatory responses and immune regulation. This article reviews the cytokines involved in the pathogenesis of SAPHO syndrome, such as tumor necrosis factor \u03b1 (TNF-\u03b1), interleukin 1\u03b2 (IL-1\u03b2), IL-6, IL-10, and transforming growth factor-\u03b2 (TGF-\u03b2), and discusses their potential as intervention points for treatment. These findings elucidate the intricate immune regulatory network of SAPHO syndrome and provide a theoretical foundation for the development of new targeted therapeutic strategies.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1427784","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T04:20:00Z","timestamp":1725250800000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["The role of cytokines in the pathogenesis of SAPHO syndrome"],"prefix":"10.3389","volume":"15","author":[{"given":"Yi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianzhu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05187-0","article-title":"The comparison analysis of clinical and radiological features in SAPHO syndrome","volume":"40","author":"Gao","year":"2021","journal-title":"Clin Rheumatol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1177\/02841851221142783","article-title":"Clinical and imaging features of six Han patients with SAPHO syndrome","volume":"65","author":"Ruan","year":"2024","journal-title":"Acta Radiol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key415","article-title":"Three patterns of osteoarticular involvement in SAPHO syndrome: a cluster analysis based on whole body bone scintigraphy of 157 patients","volume":"58","author":"Cao","year":"2019","journal-title":"Rheumatol (Oxford)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.09.004","article-title":"Spinal and sacroiliac involvement in SAPHO syndrome: A single center study of a cohort of 354 patients","volume":"48","author":"Cao","year":"2019","journal-title":"Semin Arthritis Rheumatism"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2000.8371","article-title":"SAPHO: Rare or just not recognized","volume":"30","author":"Van Doornum","year":"2000","journal-title":"Semin Arthritis Rheumatism"},{"key":"B6","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s11926-016-0583-y","article-title":"SAPHO syndrome: current developments and approaches to clinical treatment","volume":"18","author":"Firinu","year":"2016","journal-title":"Curr Rheumatol Rep"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.10184","article-title":"Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO); an interesting clinical syndrome","volume":"12","author":"Hussain","year":"2020","journal-title":"Cureus J Med Sci"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/scs.0000000000006161","article-title":"SAPHO syndrome involving the mandible treated with <SUP>99<\/SUP>Tc-MDP","volume":"31","author":"Shao","year":"2020","journal-title":"J Craniofacial Surg"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199611000-00008","article-title":"Osseous manifestations of SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome","volume":"20","author":"Reith","year":"1996","journal-title":"Am J Surg Pathology"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16071","article-title":"Successful treatment of SAPHO syndrome with apremilast","volume":"179","author":"Adamo","year":"2018","journal-title":"Br J Dermatol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.15.5.7501856","article-title":"SAPHO SYNDROME","volume":"15","author":"Cotten","year":"1995","journal-title":"Radiographics"},{"key":"B12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s00256-014-2025-0","article-title":"The SAPHO syndrome revisited with an emphasis on spinal manifestations","volume":"44","author":"Leone","year":"2015","journal-title":"Skeletal Radiology"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13740","article-title":"SAPHO syndrome associated with hidradenitis suppurativa and pyoderma gangrenosum successfully treated with adalimumab and methotrexate: a case report and review of the literature","volume":"57","author":"Vekic","year":"2018","journal-title":"Int J Dermatol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090456","article-title":"Genetic susceptibility factors in a cohort of 38 patients with SAPHO syndrome: A study of PSTPIP2, NOD2, and LPIN2 genes","volume":"37","author":"Hurtado-Nedelec","year":"2010","journal-title":"J Rheumatol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2011.01.017","article-title":"The SAPHO syndrome\u2013are microbes involved","volume":"25","author":"Assmann","year":"2011","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s13052-020-00933-1","article-title":"SAPHO syndrome: the supposed trigger by isotretinoin, the efficacy of adalimumab and the specter of depressive disorder: a case report","volume":"46","author":"Luzzati","year":"2020","journal-title":"Ital J Pediatr"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken185","article-title":"Characterization of the immune response in the synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome","volume":"47","author":"Hurtado-Nedelec","year":"2008","journal-title":"Rheumatology"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2018.1469580","article-title":"Serum levels of proinflammatory, anti-inflammatory cytokines, and RANKL\/OPG in synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome","volume":"29","author":"Zhang","year":"2019","journal-title":"Mod Rheumatol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1189\/jlb.0612293","article-title":"The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications","volume":"93","author":"Shachar","year":"2013","journal-title":"J Leukocyte Biol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2174\/138620712799218608","article-title":"Identification and functional study of cytokines and chemokines involved in tumorigenesis","volume":"15","author":"Zeng","year":"2012","journal-title":"Combinatorial Chem High Throughput Screening"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1172\/jci39065","article-title":"The tumor-promoting actions of TNF-\u03b1 involve TNFR1 and IL-17 in ovarian cancer in mice and humans","volume":"119","author":"Charles","year":"2009","journal-title":"J Clin Invest"},{"key":"B22","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3390\/vaccines8020340","article-title":"CD19+ CD24hi CD38hi regulatory B cells and memory B cells in periodontitis: association with pro-inflammatory and anti-inflammatory cytokines","volume":"8","author":"Hetta","year":"2020","journal-title":"Vaccines"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00110","article-title":"IL-10-producing CD1dhiCD5+ Regulatory B cells may play a critical role in modulating immune homeostasis in silicosis patients","volume":"8","author":"Chen","year":"2017","journal-title":"Front Immunol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100180","article-title":"Levels of transforming growth factor-\u03b2 Are low in systemic lupus erythematosus patients with active disease","volume":"37","author":"Becker-Merok","year":"2010","journal-title":"J Rheumatol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"297","DOI":"10.61872\/sdj-2023-05-947","article-title":"Inflammatory stimulation of osteoblasts and keratinocytes from a SAPHO patient for implant risk evaluation","volume":"133","author":"Schmidlin","year":"2023","journal-title":"Swiss Dent J"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200103223441207","article-title":"Mechanisms of disease: Cytokine pathways and joint inflammation in rheumatoid arthritis","volume":"344","author":"Choy","year":"2001","journal-title":"New Engl J Med"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00365","article-title":"The balance of TNF mediated pathways regulates inflammatory cell death signaling in healthy and diseased tissues","volume":"8","author":"Webster","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.091086","article-title":"Tumor necrosis factor-\u03b1 Blockers in SAPHO syndrome","volume":"37","author":"Ben Abdelghani","year":"2010","journal-title":"J Rheumatol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.3390\/ijms23031481","article-title":"Role of the interaction of tumor necrosis factor-\u03b1 and tumor necrosis factor receptors 1 and 2 in bone-related cells","volume":"23","author":"Kitaura","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1172\/jci11176","article-title":"TNF-\u03b1 induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand","volume":"106","author":"Lam","year":"2000","journal-title":"J Clin Invest"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0378-1119(03)00841-2","article-title":"Tumor necrosis factor-\u03b1:: molecular and cellular mechanisms in skeletal pathology","volume":"321","author":"Nanes","year":"2003","journal-title":"Gene"},{"key":"B32","doi-asserted-by":"publisher","first-page":"555","DOI":"10.3109\/08820139.2013.822766","article-title":"The role of cytokines in inflammatory bone loss","volume":"42","author":"Souza","year":"2013","journal-title":"Immunol Investigations"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.3390\/ijms22052719","article-title":"The role of tumor necrosis factor alpha (TNF-\u03b1) in autoimmune disease and current TNF-\u03b1 Inhibitors in therapeutics","volume":"22","author":"Jang","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B34","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.bbrc.2020.12.101","article-title":"Inhibition of ER stress-activated JNK pathway attenuates TNF-\u03b1-induced inflammatory response in bone marrow mesenchymal stem cells","volume":"541","author":"Zhao","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"B35","article-title":"Reduction of peripheral natural killer cells in patients with SAPHO syndrome","volume":"37","author":"Xu","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1186\/s13023-019-1169-3","article-title":"Enhanced migration and adhesion of peripheral blood neutrophils from SAPHO patients revealed by RNA-Seq","volume":"14","author":"Sun","year":"2019","journal-title":"Orphanet J Rare Dis"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.5.644","article-title":"Allelic variation at the interleukin 1beta gene is associated with decreased bone mass in patients with inflammatory bowel diseases","volume":"49","author":"Nemetz","year":"2001","journal-title":"Gut"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/785705","article-title":"Serum IL-6 and IL-23 levels and their correlation with angiogenic cytokines and disease activity in ankylosing spondylitis, psoriatic arthritis, and SAPHO syndrome","volume":"2015","author":"Przepiera-B\u0119dzak","year":"2015","journal-title":"Mediators Inflammation"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.07.025","article-title":"A critical role of the IL-1\u03b2-IL-1R signaling pathway in skin inflammation and psoriasis pathogenesis","volume":"139","author":"Cai","year":"2019","journal-title":"J Invest Dermatol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00332.x","article-title":"Fos\/AP-1 proteins in bone and the immune system","volume":"208","author":"Wagner","year":"2005","journal-title":"Immunol Rev"},{"key":"B42","doi-asserted-by":"publisher","first-page":"4993","DOI":"10.3892\/mmr.2019.10759","article-title":"IL\u22121\u03b2 increases the expression of inflammatory factors in synovial fluid\u2212derived fibroblast\u2212like synoviocytes via activation of the NF\u2212\u03baB\u2212mediated ERK\u2212STAT1 signaling pathway","volume":"20","author":"Yang","year":"2019","journal-title":"Mol Med Rep"},{"key":"B43","doi-asserted-by":"publisher","first-page":"6882","DOI":"10.1038\/s41598-019-42601-3","article-title":"MicroRNA-125b-5p regulates IL-1\u03b2 induced inflammatory genes via targeting TRAF6-mediated MAPKs and NF-\u03baB signaling in human osteoarthritic chondrocytes","volume":"9","author":"Rasheed","year":"2019","journal-title":"Sci Rep"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12401","article-title":"TANK-binding kinase 1 mediates osteoclast differentiation by regulating NF-\u03baB, MAPK and Akt signaling pathways","volume":"99","author":"Lin","year":"2021","journal-title":"Immunol Cell Biol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.08.055","article-title":"Interleukin 1\u03b2 Mediates intestinal inflammation in mice and patients with interleukin 10 receptor deficiency","volume":"151","author":"Shouval","year":"2016","journal-title":"Gastroenterology"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200743","article-title":"Anakinra treatment of SAPHO syndrome: short-term results of an open study","volume":"71","author":"Wendling","year":"2012","journal-title":"Ann Rheumatic Diseases"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex513","article-title":"Physiological effects of modulating the interleukin-6 axis","volume":"57","author":"Schett","year":"2018","journal-title":"Rheumatol (Oxford)"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1023177","article-title":"The role of IL-6\/JAK2\/STAT3 signaling pathway in cancers","volume":"12","author":"Huang","year":"2022","journal-title":"Front Oncol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.immunol.23.021704.115806","article-title":"Interleukin-6: from basic science to medicine\u201340 years in immunology","volume":"23","author":"Kishimoto","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1191782","article-title":"The paradigm of IL-23-independent production of IL-17F and IL-17A and their role in chronic inflammatory diseases","volume":"14","author":"Navarro-Comp\u00e1n","year":"2023","journal-title":"Front Immunol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.594735","article-title":"The IL-23\/IL-17 pathway in inflammatory skin diseases: from bench to bedside","volume":"11","author":"Liu","year":"2020","journal-title":"Front Immunol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2817","article-title":"IL-23 induces spondyloarthropathy by acting on ROR-\u03b3t+ CD3+CD4-CD8- entheseal resident T cells","volume":"18","author":"Sherlock","year":"2012","journal-title":"Nat Med"},{"key":"B54","doi-asserted-by":"publisher","first-page":"52ra72","DOI":"10.1126\/scitranslmed.3001107","article-title":"Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis","volume":"2","author":"Hueber","year":"2010","journal-title":"Sci Transl Med"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.637829","article-title":"Role of the IL-23\/IL-17 pathway in rheumatic diseases: an overview","volume":"12","author":"Schinocca","year":"2021","journal-title":"Front Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2017.05.016","article-title":"IL-23\/Th17 targeted therapies in SAPHO syndrome","volume":"84","author":"Wendling","year":"2017","journal-title":"A Case series. Joint Bone Spine"},{"key":"B57","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.bone.2018.01.027","article-title":"Efficacy of anti-IL-23 monotherapy versus combination therapy with anti-IL-17 in estrogen deficiency induced bone loss conditions","volume":"110","author":"Shukla","year":"2018","journal-title":"Bone"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.2147\/itt.S62870","article-title":"Current perspective on the role of the interleukin-23\/interleukin-17 axis in inflammation and disease (chronic arthritis and psoriasis)","volume":"4","author":"Cauli","year":"2015","journal-title":"Immunotargets Ther"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2020.1759562","article-title":"RANKL expression of primary osteoblasts is enhanced by an IL-17-mediated JAK2\/STAT3 pathway through autophagy suppression","volume":"62","author":"Wang","year":"2021","journal-title":"Connect Tissue Res"},{"key":"B60","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.jaci.2004.08.048","article-title":"Downmodulation of CXCL8\/IL-8 receptors on neutrophils after recruitment in the airways","volume":"115","author":"Pignatti","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.04.003","article-title":"Biologics in SAPHO syndrome: A systematic review","volume":"48","author":"Daoussis","year":"2019","journal-title":"Semin Arthritis Rheumatol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.808797","article-title":"The role of interleukin-8 in lung inflammation and injury: implications for the management of COVID-19 and hyperinflammatory acute respiratory distress syndrome","volume":"12","author":"Cesta","year":"2021","journal-title":"Front Pharmacol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1023\/b:Joci.0000018061.58504.75","article-title":"P38 mitogen activated protein kinase is involved in the downregulation of granulocyte CXC chemokine receptors 1 and 2 during human endotoxemia","volume":"24","author":"Van den Blink","year":"2004","journal-title":"J Clin Immunol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.exphem.2018.10.003","article-title":"Interleukin-18 plays a dispensable role in murine and likely also human bone marrow failure","volume":"69","author":"Wu","year":"2019","journal-title":"Exp Hematol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cytogfr.2019.11.001","article-title":"The role of interleukin-18 in pancreatitis and pancreatic cancer","volume":"50","author":"Li","year":"2019","journal-title":"Cytokine Growth Factor Rev"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-eular.6951","article-title":"CLINICAL SIGNIFICANCE OF INTERLEUKIN-18 AND INTERLEUKIN-6 ON DISEASE COURSE OF ADULT-ONSET STILL'S DISEASE","volume":"77","author":"Ahmed","year":"2018","journal-title":"Ann Rheumatic Diseases"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.951535","article-title":"Pathogenic roles and diagnostic utility of interleukin-18 in autoinflammatory diseases","volume":"13","author":"Shimizu","year":"2022","journal-title":"Front Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-eular.4145","article-title":"IMPACT OF INTERLEUKIN 17 BLOCKING AGENT ON CLINICAL OUTCOME IN SAPHO PATIENTS","volume":"78","author":"Assmann","year":"2019","journal-title":"Ann Rheumatic Diseases"},{"key":"B69","doi-asserted-by":"publisher","first-page":"4972","DOI":"10.3390\/ijms22094972","article-title":"IL-10 in mast cell-mediated immune responses: anti-inflammatory and proinflammatory roles","volume":"22","author":"Nagata","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2009.06.029","article-title":"TNF-\u03b1\/IL-10 ratio and C-reactive protein as markers of the inflammatory response in CAD-prone North Indian patients with acute myocardial infarction","volume":"408","author":"Goswami","year":"2009","journal-title":"Clinica Chimica Acta"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00091.2022","article-title":"Sex differences in IL-10's anti-inflammatory function: greater STAT3 activation and stronger inhibition of TNF-\u03b1 production in male blood leukocytes ex vivo","volume":"322","author":"Islam","year":"2022","journal-title":"Am J Physiol Cell Physiol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00604.2020","article-title":"The intersection of metformin and inflammation","volume":"320","author":"Bharath","year":"2021","journal-title":"Am J Physiol Cell Physiol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7461742","article-title":"Suppressors of cytokine signaling (SOCS)1 and SOCS3 proteins are mediators of interleukin-10 modulation of inflammatory responses induced by chlamydia muridarum and its major outer membrane protein (MOMP) in mouse J774 macrophages","volume":"2020","author":"Duncan","year":"2020","journal-title":"Mediators Inflamm"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(03)00194-2","article-title":"Myocardial and lung injury after cardiopulmonary bypass: Role of interleukin (IL)-10","volume":"76","author":"Giomarelli","year":"2003","journal-title":"Ann Thorac Surgery"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.159.9.4491","article-title":"Activation of p38mapk, MKK3, and MKK4 by TNF-alpha in mouse bone marrow-derived macrophages","volume":"159","author":"Winston","year":"1997","journal-title":"J Immunol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.03.003","article-title":"Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10","volume":"28","author":"Li","year":"2008","journal-title":"Immunity"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.024","article-title":"Transforming growth factor-\u03b2 Signaling in immunity and cancer","volume":"50","author":"Batlle","year":"2019","journal-title":"Immunity"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101330","article-title":"Synergistic and additive interactions between receptor signaling networks drive the regulatory T cell versus T helper 17 cell fate choice","volume":"297","author":"Prado","year":"2021","journal-title":"J Biol Chem"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00181.2007","article-title":"Intracisternal administration of transforming growth factor-\u03b2 evokes fever through the induction of cyclooxygenase-2 in brain endothelial cells","volume":"294","author":"Matsumura","year":"2008","journal-title":"Am J Physiol-Regul Integr Comp Physiol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/s1359-6101(02)00026-6","article-title":"Regulation of cytokine signaling and inflammation","volume":"13","author":"Hanada","year":"2002","journal-title":"Cytokine Growth Factor Rev"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022137","article-title":"Signaling cross talk between TGF-\u03b2\/smad and other signaling pathways","volume":"9","author":"Luo","year":"2017","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s10067-018-4083-5","article-title":"Paradoxical skin lesions induced by anti-TNF-\u03b1 agents in SAPHO syndrome","volume":"38","author":"Li","year":"2019","journal-title":"Clin Rheumatol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14758","article-title":"SAPHO syndrome successful treated with tildrakizumab","volume":"34","author":"Licata","year":"2021","journal-title":"Dermatologic Ther"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2023.2295239","article-title":"Paradoxical skin lesions induced by IL-17 inhibitors in SAPHO syndrome","volume":"35","author":"Li","year":"2024","journal-title":"J Dermatolog Treat"},{"key":"B85","doi-asserted-by":"publisher","first-page":"199","DOI":"10.2174\/1871528113666140520100402","article-title":"Biological treatments for SAPHO syndrome: an update","volume":"13","author":"Firinu","year":"2014","journal-title":"Inflammation Allergy Drug Targets"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-023-05491-3","article-title":"SAPHO syndrome: current clinical, diagnostic and treatment approaches","author":"Yildirim","year":"2023","journal-title":"Rheumatol Int"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1427784\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T04:20:06Z","timestamp":1725250806000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1427784\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,2]]},"references-count":86,"alternative-id":["10.3389\/fimmu.2024.1427784"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1427784","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,2]]},"article-number":"1427784"}}