{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:37:05Z","timestamp":1789141025396,"version":"build-2803163510"},"reference-count":189,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MH127"],"award-info":[{"award-number":["ZR2023MH127"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Autoimmune diseases encompass a wide range of disorders characterized by disturbed immunoregulation leading to the development of specific autoantibodies, which cause inflammation and multiple organ involvement. However, its pathogenesis remains unelucidated. Furthermore, the cumulative medical and economic burden of autoimmune diseases is on the rise, making these diseases a ubiquitous global phenomenon that is predicted to further increase in the coming decades. Coumarins, a class of aromatic natural products with benzene and alpha-pyrone as their basic structures, has good therapeutic effects on autoimmune diseases. In this review, we systematically highlighted the latest evidence on coumarins and autoimmune diseases data from clinical and animal studies. Coumarin acts on immune cells and cytokines and plays a role in the treatment of autoimmune diseases by regulating NF-\u03baB, Keap1\/Nrf2, MAPKs, JAK\/STAT, Wnt\/\u03b2-catenin, PI3K\/AKT, Notch and TGF-\u03b2\/Smad signaling pathways. This systematic review will provide insight into the interaction of coumarin and autoimmune diseases, and will lay a groundwork for the development of new drugs for autoimmune diseases.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1432846","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T04:30:49Z","timestamp":1730349049000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Therapeutic potential of natural coumarins in autoimmune diseases with underlying mechanisms"],"prefix":"10.3389","volume":"15","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2019-0002","article-title":"Immunometabolism: an overview and therapeutic prospects in autoimmune diseases","volume":"11","author":"Stathopoulou","year":"2019","journal-title":"Immunotherapy"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.semcancer.2019.06.001","article-title":"Antibody therapeutics and immunoregulation in cancer and autoimmune disease","volume":"64","author":"Yasunaga","year":"2020","journal-title":"Semin Cancer Biol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/joim.2015.278.issue-4","article-title":"Human autoimmune diseases: a comprehensive update","volume":"278","author":"Wang","year":"2015","journal-title":"J Internal Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.251","article-title":"SCT for severe autoimmune diseases: consensus guidelines of the European Society for Blood and Marrow Transplantation for immune monitoring and biobanking","volume":"50","author":"Alexander","year":"2014","journal-title":"Bone Marrow Transplant"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.746998","article-title":"Causal relationship between gut microbiota and autoimmune diseases: a two-sample mendelian randomization study","volume":"12","author":"Xu","year":"2022","journal-title":"Front Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"102266","DOI":"10.1016\/j.coi.2022.102266","article-title":"The increasing prevalence of autoimmunity and autoimmune diseases: an urgent call to action for improved understanding, diagnosis, treatment, and prevention","volume":"80","author":"Miller","year":"2023","journal-title":"Curr Opin Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12339","article-title":"Rare genetic variants in systemic autoimmunity","volume":"98","author":"Jiang","year":"2020","journal-title":"Immunol Cell Biol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/bs.ai.2019.09.002","article-title":"Autoimmune diseases in China","volume":"144","author":"Li","year":"2019","journal-title":"Adv Immunol China - Part A"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-0602-4_28","article-title":"Autophagy and immune tolerance","volume":"1206","author":"Wu","year":"2019","journal-title":"Autophagy: Biol Dis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1016\/j.drudis.2018.06.003","article-title":"Therapeutic application of antibody fragments in autoimmune diseases: current state and prospects","volume":"23","author":"Fernandes","year":"2018","journal-title":"Drug Discovery Today"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201900380","article-title":"Coumarin-containing hybrids and their antibacterial activities","volume":"353","author":"Feng","year":"2020","journal-title":"Archiv der Pharmazie"},{"key":"B12","doi-asserted-by":"publisher","first-page":"4618","DOI":"10.3390\/ijms21134618","article-title":"An overview of coumarin as a versatile and readily accessible scaffold with broad-ranging biological activities","volume":"21","author":"Annunziata","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"104163","DOI":"10.1016\/j.bioorg.2020.104163","article-title":"Recent advancements of coumarin-based anticancer agents: an up-to-date review","volume":"103","author":"Al-Warhi","year":"2020","journal-title":"Bioorganic Chem"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2018.09.008","article-title":"Restoring self-tolerance in autoimmune diseases by enhancing regulatory T-cells","volume":"339","author":"Kumar","year":"2019","journal-title":"Cell Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nri3818","article-title":"The ins and outs of MHC class II-mediated antigen processing and presentation","volume":"15","author":"Roche","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/advan.00066.2013","article-title":"T cell responses: na\u00efve to memory and everything in between","volume":"37","author":"Pennock","year":"2013","journal-title":"Adv Physiol Educ"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01088","article-title":"Aberrant T cell signaling and subsets in systemic lupus erythematosus","volume":"9","author":"Katsuyama","year":"2018","journal-title":"Front Immunol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/nri1957","article-title":"Toll-like receptors in systemic autoimmune disease","volume":"6","author":"Marshak-Rothstein","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1177\/0192623311428481","article-title":"Cellular and molecular mechanisms of autoimmune disease","volume":"40","author":"Bolon","year":"2011","journal-title":"Toxicologic Pathol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1046\/j.1344-3941.2002.00054.x","article-title":"Genes and autoimmune diseases - a complex inheritance","volume":"6","author":"Mariani","year":"2004","journal-title":"MedGenMed: Medscape Gen Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jaut.2009.09.008","article-title":"Recent insights in the epidemiology of autoimmune diseases: Improved prevalence estimates and understanding of clustering of diseases","volume":"33","author":"Cooper","year":"2009","journal-title":"J Autoimmun"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-35708","article-title":"Mechanisms of autoimmunity","volume":"22","author":"Rose","year":"2002","journal-title":"Semin liver Dis"},{"key":"B23","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s13075-019-1874-2","article-title":"Iguratimod represses B cell terminal differentiation linked with the inhibition of PKC\/EGR1 axis","volume":"21","author":"Ye","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"B24","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.cyto.2014.11.020","article-title":"Involvement of the IL-23\/IL-17 axis and the Th17\/Treg balance in the pathogenesis and control of autoimmune arthritis","volume":"74","author":"Astry","year":"2015","journal-title":"Cytokine"},{"key":"B25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3109\/08916934.2015.1134511","article-title":"Epigenetic alterations underlying autoimmune diseases","volume":"49","author":"Aslani","year":"2016","journal-title":"Autoimmunity"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1126\/science.8097338","article-title":"Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages","volume":"260","author":"Hsieh","year":"1993","journal-title":"Sci (New York N.Y.)"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/ni1254","article-title":"Interleukin 17\u2013producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"8011","DOI":"10.3390\/ijms21218011","article-title":"CD4 T helper cell subsets and related human immunological disorders","volume":"21","author":"Zhu","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2018.09.005","article-title":"Mechanisms and functions of IL-17 signaling in renal autoimmune diseases","volume":"104","author":"Schmidt","year":"2018","journal-title":"Mol Immunol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2011.04.003","article-title":"Making sense of regulatory T cell suppressive function","volume":"23","author":"Shalev","year":"2011","journal-title":"Semin Immunol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2013.06.007","article-title":"Biased Treg\/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms","volume":"262","author":"Jamshidian","year":"2013","journal-title":"J Neuroimmunology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1007\/s12031-016-0789-5","article-title":"Altered expression of specific transcription factors of Th17 (ROR\u03b3t, ROR\u03b1) and Treg lymphocytes (FOXP3) by peripheral blood mononuclear cells from patients with multiple sclerosis","volume":"60","author":"Etesam","year":"2016","journal-title":"J Mol neuroscience: MN"},{"key":"B33","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/07315724.2002.10719248","article-title":"Omega-3 fatty acids in inflammation and autoimmune diseases","volume":"21","author":"Simopoulos","year":"2002","journal-title":"J Am Coll Nutr"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2012.07.002","article-title":"Emerging role of interleukin-22 in autoimmune diseases","volume":"24","author":"Pan","year":"2013","journal-title":"Cytokine Growth Factor Rev"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.11.005","article-title":"The IL-23\/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses","volume":"34","author":"Lowes","year":"2013","journal-title":"Trends Immunol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(02)00027-8","article-title":"IL-6 in autoimmune disease and chronic inflammatory proliferative disease","volume":"13","author":"Ishihara","year":"2002","journal-title":"Cytokine Growth Factor Rev"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.12.004","article-title":"Th17 and regulatory T cell balance in autoimmune and inflammatory diseases","volume":"13","author":"Noack","year":"2014","journal-title":"Autoimmun Rev"},{"key":"B38","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/nrgastro.2016.186","article-title":"PARP inhibition protective against alcoholic steatohepatitis and NASH","volume":"14","author":"Ray","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy131","article-title":"The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics","volume":"141","author":"Camara-Lemarroy","year":"2018","journal-title":"Brain"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxw002","article-title":"Genetics of autoimmune diseases: perspectives from genome-wide association studies","volume":"28","author":"Kochi","year":"2016","journal-title":"Int Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg0470","article-title":"m (6)A demethylase ALKBH5 controls CD4(+) T cell pathogenicity and promotes autoimmunity","volume":"7","author":"Zhou","year":"2021","journal-title":"Sci Adv"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202201548R","article-title":"METTL3 inhibits autoreactive Th17 cell responses in experimental autoimmune uveitis via stabilizing ASH1L mRNA","volume":"37","author":"Zhao","year":"2023","journal-title":"FASEB J"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14879","article-title":"The m6A modification of Il17a in CD4+ T cells promotes inflammation in psoriasis","volume":"33","author":"Yuan","year":"2023","journal-title":"Exp Dermatol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12940-015-0052-5","article-title":"Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature","volume":"14","author":"Liu","year":"2015","journal-title":"Environ Health"},{"key":"B45","doi-asserted-by":"publisher","first-page":"15818","DOI":"10.1038\/ncomms15818","article-title":"Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity","volume":"8","author":"Xia","year":"2017","journal-title":"Nat Commun"},{"key":"B46","doi-asserted-by":"publisher","first-page":"105489","DOI":"10.1016\/j.fitote.2023.105489","article-title":"Coumarins from Rutaceae: Chemical diversity and biological activities","volume":"168","author":"Santos Junior","year":"2023","journal-title":"Fitoterapia"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/8885093","article-title":"Osthole induces apoptosis and inhibits proliferation, invasion, and migration of human cervical carcinoma HeLa cells","volume":"2021","author":"Yin","year":"2021","journal-title":"Evidence-Based Complementary Altern Med"},{"key":"B48","doi-asserted-by":"publisher","first-page":"5813","DOI":"10.3390\/ijms23105813","article-title":"Anti-Inflammatory effects of psoralen derivatives on RAW264.7 cells via regulation of the NF-\u03baB and MAPK signaling pathways","volume":"23","author":"Lee","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B49","doi-asserted-by":"publisher","first-page":"940","DOI":"10.3892\/etm.2021.10372","article-title":"Psoralen accelerates osteogenic differentiation of human bone marrow mesenchymal stem cells by activating the TGF\u2212\u03b2\/Smad3 pathway","volume":"22","author":"Huang","year":"2021","journal-title":"Exp Ther Med"},{"key":"B50","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s13020-020-00383-1","article-title":"Neuroprotective effect of Angelica gigas root in a mouse model of ischemic brain injury through MAPK signaling pathway regulation","volume":"15","author":"Lee","year":"2020","journal-title":"Chin Med"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.3390\/molecules22071098","article-title":"Antibacterial activities of pyrenylated coumarins from the roots of prangos hulusii","volume":"22","author":"Tan","year":"2017","journal-title":"Molecules"},{"key":"B52","doi-asserted-by":"publisher","first-page":"102050","DOI":"10.1016\/j.tube.2020.102050","article-title":"Coumarin hybrid derivatives as promising leads to treat tuberculosis: Recent developments and critical aspects of structural design to exhibit anti-tubercular activity","volume":"127","author":"Reddy","year":"2021","journal-title":"Tuberculosis"},{"key":"B53","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.det.2019.08.002","article-title":"The science and (lost) art of psoralen plus UVA phototherapy","volume":"38","author":"Richard","year":"2020","journal-title":"Dermatologic Clinics"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12846","article-title":"Bath-PUVA still represents a valuable treatment option for the subsets of psoriatic patients who are not eligible to or rejecting systemic treatments and are not responsive to NB-UVB phototherapy","volume":"39","author":"Calzavara-Pinton","year":"2022","journal-title":"Photodermatology Photoimmunology Photomedicine"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2021.2022187","article-title":"Assessment of efficacy and safety of UV-based therapy for psoriasis: a network meta-analysis of randomized controlled trials","volume":"54","author":"Li","year":"2022","journal-title":"Ann Med"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.2013.169.issue-3","article-title":"Efficacy of bath psoralen plus ultraviolet A (PUVA) vs. system PUVA in psoriasis: a prospective, open, randomized, multicentre study","volume":"169","author":"Berneburg","year":"2013","journal-title":"Br J Dermatol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_249_16","article-title":"A non-inferiority randomized controlled clinical trial comparing Unani formulation & psoralen plus ultraviolet A sol in chronic plaque psoriasis","volume":"147","author":"Khanna","year":"2018","journal-title":"Indian J Med Res"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05692.x","article-title":"Comparison of clinical and cost-effectiveness of psoralen + ultraviolet A versus psoralen + sunlight in the treatment of chronic plaque psoriasis in a developing economy","volume":"52","author":"Aggarwal","year":"2013","journal-title":"Int J Dermatol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.04.053","article-title":"Randomized, double-blind, placebo-controlled evaluation of the efficacy of oral psoralen plus ultraviolet A for the treatment of plaque-type psoriasis using the Psoriasis Area Severity Index score (improvement of 75% or greater) at 12 weeks","volume":"61","author":"Sivanesan","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-0781.2006.00196.x","article-title":"Paired comparison of bathwater versus oral delivery of 8-methoxypsoralen in psoralen plus ultraviolet: A therapy for chronic palmoplantar psoriasis","volume":"22","author":"Hofer","year":"2006","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.044","article-title":"Treatment of psoriasis in patients with hepatitis C: From the Medical Board of the National Psoriasis Foundation","volume":"61","author":"Frankel","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09514.x","article-title":"5-Methoxypsoralen plus ultraviolet (UV) A is superior to medium-dose UVA1 in the treatment of severe atopic dermatitis: a randomized crossover trial","volume":"162","author":"Tzaneva","year":"2010","journal-title":"Br J Dermatol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1046\/j.1365-2133.2000.03239.x","article-title":"Half-side comparison study on the efficacy of 8-methoxypsoralen bath-PUVA versus narrow-band ultraviolet B phototherapy in patients with severe chronic atopic dermatitis","volume":"142","author":"Der-Petrossian","year":"2000","journal-title":"Br J Dermatol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70440-8","article-title":"Long-term application of extracorporeal photochemotherapy in severe atopic dermatitis","volume":"40","author":"Prinz","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15310","article-title":"Efficacy and safety of bexarotene combined with photo(chemo)therapy for cutaneous T-cell lymphoma","volume":"47","author":"Morita","year":"2020","journal-title":"J Dermatol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e3182287f59","article-title":"Treatment of ankylosing spondylitis by extracorporeal photochemotherapy given for mycosis fungoides","volume":"17","author":"Akay","year":"2011","journal-title":"JCR: J Clin Rheumatol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.110060","article-title":"The PUVA-turban as a new option of applying a dilute psoralen solution selectively to the scalp of patients with alopecia areata","volume":"44","author":"Behrens-Williams","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01226.x","article-title":"Alopecia areata treatment with a phototoxic dose of UVA and topical 8-methoxypsoralen","volume":"19","author":"Mohamed","year":"2005","journal-title":"J Eur Acad Dermatol Venereology"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.IJD_400_18","article-title":"Effectiveness of paint psoralen and ultraviolet-A in alopecia areata \u2013 Our experience in the national skin center","volume":"65","author":"Tan","year":"2020","journal-title":"Indian J Dermatol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1974.tb01781.x","article-title":"Effects of psoralen and bergapten on irradiated skin","volume":"13","author":"Costa Martins","year":"1974","journal-title":"Int J Dermatol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70048-1","article-title":"5-Methoxypsoralen (Bergapten) for photochemotherapy. Bioavailability, phototoxicity, and clinical efficacy in psoriasis of a new drug preparation","volume":"18","author":"Tanew","year":"1988","journal-title":"J Am Acad Dermatol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01419.x","article-title":"Plasma and skin concentration of 5-methoxypsoralen in psoriatic patients after oral administration","volume":"117","author":"Zucchi","year":"2001","journal-title":"J Invest Dermatol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cyto.2017.02.017","article-title":"Expression of soluble CD83 in plasma from early-stage rheumatoid arthritis patients is not modified by anti-TNF-\u03b1 therapy","volume":"96","author":"Kristensen","year":"2017","journal-title":"Cytokine"},{"key":"B74","doi-asserted-by":"publisher","first-page":"R202","DOI":"10.1186\/ar4393","article-title":"Evidence that TNF-\u03b2 (lymphotoxin \u03b1) can activate the inflammatory environment in human chondrocytes","volume":"15","author":"Buhrmann","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.91","article-title":"SREBP-regulated lipid metabolism: convergent physiology \u2014 divergent pathophysiology","volume":"13","author":"Shimano","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3MA0320-440RR","article-title":"Imperatorin and \u03b2-sitosterol have synergistic activities in alleviating collagen-induced arthritis","volume":"108","author":"Guo","year":"2020","journal-title":"J Leukocyte Biol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO01748K","article-title":"Apoptosis effects of imperatorin on synoviocytes in rheumatoid arthritis through mitochondrial\/caspase-mediated pathways","volume":"9","author":"Zhai","year":"2018","journal-title":"Food Funct"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.03.012","article-title":"Association of MIF in serum and synovial fluid with severity of knee osteoarthritis","volume":"45","author":"Liu","year":"2012","journal-title":"Clin Biochem"},{"key":"B79","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/s13075-021-02619-3","article-title":"Isopsoralen ameliorates rheumatoid arthritis by targeting MIF","volume":"23","author":"Han","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"B80","doi-asserted-by":"publisher","first-page":"v4","DOI":"10.1093\/rheumatology\/keaa379","article-title":"Classifying and diagnosing systemic lupus erythematosus in the 21st century","volume":"59","author":"Aringer","year":"2020","journal-title":"Rheumatology"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.12.8761","article-title":"Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys","volume":"181","author":"Crisp\u00edn","year":"2008","journal-title":"J Immunol (Baltimore Md.: 1950)"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02172","article-title":"Hyaluronic acid synthesis contributes to tissue damage in systemic lupus erythematosus","volume":"10","author":"Suarez-Fueyo","year":"2019","journal-title":"Front Immunol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/s41467-019-14118-w","article-title":"Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis","volume":"11","author":"Schafflick","year":"2020","journal-title":"Nat Commun"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.55782\/ane-2022-026","article-title":"Daphnetin alleviates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells and upregulating Th2 and regulatory T cells","volume":"82","author":"Soltanmohammadi","year":"2022","journal-title":"Acta neurobiologiae experimentalis"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-020-02960-0","article-title":"Daphnetin ameliorates experimental autoimmune encephalomyelitis through regulating heme oxygenase-1","volume":"45","author":"Wang","year":"2020","journal-title":"Neurochemical Res"},{"key":"B86","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jneuroim.2014.05.014","article-title":"Plumbagin suppresses dendritic cell functions and alleviates experimental autoimmune encephalomyelitis","volume":"273","author":"Zhang","year":"2014","journal-title":"J Neuroimmunology"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1525086113","article-title":"Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization","volume":"113","author":"Kuipers","year":"2016","journal-title":"Proc Natl Acad Sci"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.12.008","article-title":"Attenuation of experimental autoimmune encephalomyelitis in C57 BL\/6 mice by osthole, a natural coumarin","volume":"629","author":"Chen","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1254\/jphs.13144FP","article-title":"Osthole augments therapeutic efficiency of neural stem cells\u2013based therapy in experimental autoimmune encephalomyelitis","volume":"124","author":"Gao","year":"2014","journal-title":"J Pharmacol Sci"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01612-z","article-title":"Bimekizumab for the treatment of psoriasis","volume":"81","author":"Freitas","year":"2021","journal-title":"Drugs"},{"key":"B91","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s40659-020-00316-0","article-title":"Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice","volume":"53","author":"Gao","year":"2020","journal-title":"Biol Res"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0290637","article-title":"The therapeutic effect of glycyrrhizic acid compound ointment on imiquimod-induced psoriasis-like disease in mice","volume":"18","author":"Murayama","year":"2023","journal-title":"PloS One"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtm.2017.08.017","article-title":"Jung, J.-w.; Ryu, D.-S., Protective effect of decursin and decursinol angelate-rich Angelica gigas Nakai extract on dextran sulfate sodium-induced murine ulcerative colitis","volume":"10","author":"Oh","year":"2017","journal-title":"Asian Pacific J Trop Med"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2019.004","article-title":"Decursinol angelate ameliorates dextran sodium sulfate-induced colitis by modulating type 17 helper T cell responses","volume":"27","author":"Thapa","year":"2019","journal-title":"Biomolecules Ther"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1021\/np3008792","article-title":"Interventional effects of plumbagin on experimental ulcerative colitis in mice","volume":"76","author":"Pile","year":"2013","journal-title":"J Natural Products"},{"key":"B97","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.biopha.2018.01.104","article-title":"Therapeutic efficacy of osthole against dinitrobenzene sulphonic acid induced-colitis in rats","volume":"100","author":"Khairy","year":"2018","journal-title":"Biomedicine Pharmacotherapy"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802659RR","article-title":"Daphnetin ameliorates experimental colitis by modulating microbiota composition and Treg\/Th17 balance","volume":"33","author":"Ji","year":"2019","journal-title":"FASEB J"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2013.09.001","article-title":"Antioxidant and intestinal anti-inflammatory effects of plant-derived coumarin derivatives","volume":"21","author":"Witaicenis","year":"2014","journal-title":"Phytomedicine"},{"key":"B100","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.fitote.2015.03.013","article-title":"HIF-prolyl hydroxylase is a potential molecular target for esculetin-mediated anti-colitic effects","volume":"103","author":"Yum","year":"2015","journal-title":"Fitoterapia"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e04710","article-title":"Protective effect of bergapten in acetic acid-induced colitis in rats","volume":"6","author":"Adakudugu","year":"2020","journal-title":"Heliyon"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2010.03.045","article-title":"Intestinal anti-inflammatory activity of esculetin and 4-methylesculetin in the trinitrobenzenesulphonic acid model of rat colitis","volume":"186","author":"Witaicenis","year":"2010","journal-title":"Chemico-Biological Interact"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1172\/JCI120843","article-title":"Altered mitochondrial function in insulin-deficient and insulin-resistant states","volume":"128","author":"Ruegsegger","year":"2018","journal-title":"J Clin Invest"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12815","article-title":"The pharmacokinetics and dosing of oral 4-methylumbelliferone for inhibition of hyaluronan synthesis in mice","volume":"185","author":"Kuipers","year":"2016","journal-title":"Clin Exp Immunol"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.3390\/nu9111192","article-title":"The dietary furocoumarin imperatorin increases plasma GLP-1 levels in type 1-like diabetic rats","volume":"9","author":"Wang","year":"2017","journal-title":"Nutrients"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1002\/pros.v81.14","article-title":"4-Methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy for chronic prostatitis","volume":"81","author":"Chen","year":"2021","journal-title":"Prostate"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-015-1472-2","article-title":"Compromised MAPK signaling in human diseases: an update","volume":"89","author":"Kim","year":"2015","journal-title":"Arch Toxicol"},{"key":"B108","doi-asserted-by":"publisher","first-page":"544","DOI":"10.3390\/biom13030544","article-title":"MAPK is a mutual pathway targeted by anxiety-related miRNAs, and E2F5 is a putative target for anxiolytic miRNAs","volume":"13","author":"Amini","year":"2023","journal-title":"Biomolecules"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2009.08.002","article-title":"Regulation of JNK and p38 MAPK in the immune system: Signal integration, propagation and termination","volume":"48","author":"Huang","year":"2009","journal-title":"Cytokine"},{"key":"B110","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1124\/pr.107.00106","article-title":"Mitogen-activated protein (MAP) kinase\/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer","volume":"60","author":"Boutros","year":"2008","journal-title":"Pharmacol Rev"},{"key":"B111","doi-asserted-by":"publisher","first-page":"152864","DOI":"10.1016\/j.phymed.2019.152864","article-title":"The in vitro and in vivo anti-inflammatory effect of osthole, the major natural coumarin from Cnidium monnieri (L.) Cuss, via the blocking of the activation of the NF-\u03baB and MAPK\/p38 pathways","volume":"58","author":"Fan","year":"2019","journal-title":"Phytomedicine"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.71","article-title":"Osthole pretreatment alleviates TNBS-induced colitis in mice via both cAMP\/PKA-dependent and independent pathways","volume":"38","author":"Sun","year":"2017","journal-title":"Acta Pharmacologica Sin"},{"key":"B113","doi-asserted-by":"publisher","first-page":"155187","DOI":"10.1016\/j.phymed.2023.155187","article-title":"Fraxetin reduces endometriotic lesions through activation of ER stress, induction of mitochondria-mediated apoptosis, and generation of ROS","volume":"123","author":"Ham","year":"2024","journal-title":"Phytomedicine"},{"key":"B114","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1089\/ars.2019.7835","article-title":"Imperatorin alleviates psoriasiform dermatitis by blocking neutrophil respiratory burst, adhesion, and chemotaxis through selective phosphodiesterase 4 inhibition","volume":"35","author":"Tsai","year":"2021","journal-title":"Antioxidants Redox Signaling"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c02766","article-title":"Imperatorin inhibits proliferation, migration, and inflammation via blocking the NF-\u03baB and MAPK pathways in rheumatoid fibroblast-like synoviocytes","volume":"7","author":"Lin","year":"2022","journal-title":"ACS Omega"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1172\/JCI79271","article-title":"Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis","volume":"125","author":"Nagy","year":"2015","journal-title":"J Clin Invest"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.08.026","article-title":"Oxidative stress modulates the cytokine response of differentiated Th17 and Th1 cells","volume":"99","author":"Abimannan","year":"2016","journal-title":"Free Radical Biol Med"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1039\/D2FO02518C","article-title":"Daphnetin contributes to allergen-induced Th2 cytokine expression and type 2-immune responses in atopic dermatitis and asthma","volume":"13","author":"Zhang","year":"2022","journal-title":"Food Funct"},{"key":"B119","doi-asserted-by":"publisher","first-page":"115489","DOI":"10.1016\/j.jep.2022.115489","article-title":"Aesculetin exhibited anti-inflammatory activities through inhibiting NF-\u043aB and MAPKs pathway in vitro and in vivo","volume":"296","author":"Wang","year":"2022","journal-title":"J Ethnopharmacology"},{"key":"B120","doi-asserted-by":"publisher","first-page":"154640","DOI":"10.1016\/j.phymed.2022.154640","article-title":"Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis","volume":"110","author":"Jiang","year":"2023","journal-title":"Phytomedicine"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.89568","article-title":"The role of TGF-\u03b2\/SMAD signaling in hepatocellular carcinoma: from mechanism to therapy and prognosis","volume":"20","author":"Xin","year":"2024","journal-title":"Int J Biol Sci"},{"key":"B122","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ceb.2019.07.007","article-title":"TGF-\u03b2 signaling in cell fate control and cancer","volume":"61","author":"Yu","year":"2019","journal-title":"Curr Opin Cell Biol"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-8871-2_16","article-title":"TGF-\u03b2\/Smad and renal fibrosis","author":"Ma","year":"2019","journal-title":"Renal Fibrosis: Mech Therapies"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2017.04.005","article-title":"Transforming growth factor-\u03b2 receptors and smads: regulatory complexity and functional versatility","volume":"27","author":"Budi","year":"2017","journal-title":"Trends Cell Biol"},{"key":"B125","doi-asserted-by":"publisher","first-page":"259368","DOI":"10.1155\/ecam.v2014.1","article-title":"Fenugreek prevents the development of STZ-induced diabetic nephropathy in a rat model of diabetes","volume":"2014","author":"Jin","year":"2014","journal-title":"Evidence-Based complementary Altern medicine: eCAM"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2006.12.012","article-title":"Estimation of transforming growth factor-beta 1 as a marker of renal injury in type II diabetes mellitus","volume":"28","author":"Ibrahim","year":"2007","journal-title":"Saudi Med J"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2017.06.014","article-title":"Attenuation of renal damage in type I diabetic rats by umbelliferone \u2013 a coumarin derivative","volume":"69","author":"Garud","year":"2017","journal-title":"Pharmacol Rep"},{"key":"B128","doi-asserted-by":"publisher","first-page":"115004","DOI":"10.1016\/j.jep.2022.115004","article-title":"Esculetin alleviates murine lupus nephritis by inhibiting complement activation and enhancing Nrf2 signaling pathway","volume":"288","author":"Zhang","year":"2022","journal-title":"J Ethnopharmacology"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1530\/JME-10-0154","article-title":"Esculetin induced changes in Mmp13 and Bmp6 gene expression and histone H3 modifications attenuate development of glomerulosclerosis in diabetic rats","volume":"46","author":"Surse","year":"2011","journal-title":"J Mol Endocrinol"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.12.045","article-title":"Coumarin glycosides from Hydrangea paniculata slow down the progression of diabetic nephropathy by targeting Nrf2 anti-oxidation and smad2\/3-mediated profibrosis","volume":"57","author":"Sen","year":"2019","journal-title":"Phytomedicine"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1002\/med.21842","article-title":"The immunosuppressive activity of artemisinin-type drugs towards inflammatory and autoimmune diseases","volume":"41","author":"Efferth","year":"2021","journal-title":"Medicinal Res Rev"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.848957","article-title":"Astilbin activates the reactive oxidative species\/PPAR\u03b3 pathway to suppress effector CD4+ T cell activities via direct binding with cytochrome P450 1B1","volume":"13","author":"Ding","year":"2022","journal-title":"Front Pharmacol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.06.031","article-title":"Astilbin suppresses acute heart allograft rejection by inhibiting maturation and function of dendritic cells in mice","volume":"42","author":"Zou","year":"2010","journal-title":"Transplant Proc"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.12.035","article-title":"Astilbin inhibits Th17 cell differentiation and ameliorates imiquimod-induced psoriasis-like skin lesions in BALB\/c mice via Jak3\/Stat3 signaling pathway","volume":"32","author":"Di","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-\u03baB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.946210","article-title":"Umbelliferone and scopoletin target tyrosine kinases on fibroblast-like synoviocytes to block NF-\u03baB signaling to combat rheumatoid arthritis","volume":"13","author":"Chen","year":"2022","journal-title":"Front Pharmacol"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-021-01418-x","article-title":"Umbelliferone ameliorates complete freund adjuvant\u2013induced arthritis via reduction of NF-\u03baB signaling pathway in osteoclast differentiation","volume":"44","author":"Wu","year":"2021","journal-title":"Inflammation"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00863","article-title":"Scopoletin suppresses activation of dendritic cells and pathogenesis of experimental autoimmune encephalomyelitis by inhibiting NF-\u03baB signaling","volume":"10","author":"Zhang","year":"2019","journal-title":"Front Pharmacol"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.900274","article-title":"A modified hyaluronic acid\u2013based dissolving microneedle loaded with daphnetin improved the treatment of psoriasis","volume":"10","author":"Peng","year":"2022","journal-title":"Front Bioengineering Biotechnol"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1111\/cns.2016.22.issue-7","article-title":"Daphnetin alleviates experimental autoimmune encephalomyelitis via regulating dendritic cell activity","volume":"22","author":"Wang","year":"2016","journal-title":"CNS Neurosci Ther"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3971","article-title":"Daphnetin inhibits inflammation in the NZB\/W F1 systemic lupus erythematosus murine model via inhibition of NF-\u03baB activity","volume":"13","author":"Li","year":"2017","journal-title":"Exp Ther Med"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2081756","article-title":"Plumbagin relieves rheumatoid arthritis through nuclear factor kappa-B (NF-\u03baB) pathway","volume":"13","author":"Shu","year":"2022","journal-title":"Bioengineered"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1146-5","article-title":"Interleukin-1 cluster gene polymorphisms in childhood IgA nephropathy","volume":"24","author":"Hahn","year":"2009","journal-title":"Pediatr Nephrol"},{"key":"B144","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/728417","article-title":"Serum IL-18 is closely associated with renal tubulointerstitial injury and predicts renal prognosis in IgA nephropathy","volume":"2012","author":"Shi","year":"2012","journal-title":"Mediators Inflammation"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.11.025","article-title":"Regulation of adaptive immunity by the NLRP3 inflammasome","volume":"11","author":"Chen","year":"2011","journal-title":"Int Immunopharmacol"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077794","article-title":"Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-\u03baB\/NLRP3 pathway","volume":"8","author":"Moura","year":"2013","journal-title":"PloS One"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02092","article-title":"Esculetin ameliorates psoriasis-like skin disease in mice by inducing CD4+Foxp3+ Regulatory T cells","volume":"9","author":"Chen","year":"2018","journal-title":"Front Immunol"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1111\/bph.v175.17","article-title":"Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium-induced colitis in mice","volume":"175","author":"Liu","year":"2018","journal-title":"Br J Pharmacol"},{"key":"B150","doi-asserted-by":"publisher","first-page":"2308","DOI":"10.3390\/ijms19082308","article-title":"Sargassum serratifolium extract attenuates interleukin-1\u03b2-induced oxidative stress and inflammatory response in chondrocytes by suppressing the activation of NF-\u03baB, p38 MAPK, and PI3K\/Akt","volume":"19","author":"Park","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.02.027","article-title":"The PI3K\/AKT\/mTOR signaling pathway in osteoarthritis: a narrative review","volume":"28","author":"Sun","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"key":"B152","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ctrv.2003.07.007","article-title":"PI3K\/Akt signalling pathway and cancer","volume":"30","author":"Vara","year":"2004","journal-title":"Cancer Treat Rev"},{"key":"B153","doi-asserted-by":"publisher","first-page":"119291","DOI":"10.1016\/j.lfs.2021.119291","article-title":"Imperatorin alleviated endometriosis by inhibiting the activation of PI3K\/Akt\/NF-\u03baB pathway in rats","volume":"274","author":"Ma","year":"2021","journal-title":"Life Sci"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.28609","article-title":"Umbelliferone prevents lipopolysaccharide-induced bone loss and suppresses RANKL-induced osteoclastogenesis by attenuating Akt-c-Fos-NFATc1 signaling","volume":"15","author":"Kwak","year":"2019","journal-title":"Int J Biol Sci"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-020-05669-z","article-title":"Artemisinin and its derivatives: a promising cancer therapy","volume":"47","author":"Kiani","year":"2020","journal-title":"Mol Biol Rep"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00515","article-title":"Bioactive ingredients in chinese herbal medicines that target non-coding RNAs: promising new choices for disease treatment","volume":"10","author":"Dong","year":"2019","journal-title":"Front Pharmacol"},{"key":"B157","doi-asserted-by":"publisher","first-page":"116727","DOI":"10.1016\/j.jep.2023.116727","article-title":"Therapeutic effects of columbianadin from Angelicae Pubescentis radix on the progression of collagen-induced rheumatoid arthritis by regulating inflammation and oxidative stress","volume":"316","author":"Chen","year":"2023","journal-title":"J Ethnopharmacology"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01353-3","article-title":"Imperatorin relieved ulcerative colitis by regulating the Nrf-2\/ARE\/HO-1 pathway in rats","volume":"44","author":"Luo","year":"2020","journal-title":"Inflammation"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.2019.124.issue-6","article-title":"The effect of 7-hydroxycoumarin on dextran sulfate sodium-induced ulcerative colitis","volume":"124","author":"Wang","year":"2019","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.04.036","article-title":"Esculetin attenuates alterations in Ang II and acetylcholine mediated vascular reactivity associated with hyperinsulinemia and hyperglycemia","volume":"461","author":"Kadakol","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"B161","doi-asserted-by":"publisher","first-page":"101063","DOI":"10.1016\/j.arr.2020.101063","article-title":"Wnt signaling pathway in aging-related tissue fibrosis and therapies","volume":"60","author":"Hu","year":"2020","journal-title":"Ageing Res Rev"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/\u03b2-Catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X22500835","article-title":"Umbelliferone inhibits migration, invasion and inflammation of rheumatoid arthritis fibroblast-like synoviocytes and relieves adjuvant-induced arthritis in rats by blockade of Wnt\/\u03b2-Catenin signaling pathway","volume":"50","author":"Cai","year":"2022","journal-title":"Am J Chin Med"},{"key":"B164","doi-asserted-by":"publisher","first-page":"153841","DOI":"10.1016\/j.phymed.2021.153841","article-title":"7-Hydroxycoumarin mitigates the severity of collagen-induced arthritis in rats by inhibiting proliferation and inducing apoptosis of fibroblast-like synoviocytes via suppression of Wnt\/\u03b2-catenin signaling pathway","volume":"94","author":"Cai","year":"2022","journal-title":"Phytomedicine"},{"key":"B165","doi-asserted-by":"publisher","first-page":"106210","DOI":"10.1016\/j.intimp.2020.106210","article-title":"The role of JAK\/STAT signaling pathway and its inhibitors in diseases","volume":"80","author":"Xin","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-051113-024537","article-title":"The JAK-STAT pathway: impact on human disease and therapeutic intervention","volume":"66","author":"O\u2019Shea","year":"2015","journal-title":"Annu Rev Med"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3534-8","article-title":"Retinoic acid amide inhibits JAK\/STAT pathway in lung cancer which leads to apoptosis","volume":"36","author":"Li","year":"2015","journal-title":"Tumor Biol"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-020-01282-7","article-title":"Development of JAK inhibitors for the treatment of immune-mediated diseases: kinase-targeted inhibitors and pseudokinase-targeted inhibitors","volume":"43","author":"Kim","year":"2020","journal-title":"Arch Pharmacal Res"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1069057","article-title":"The potential roles of JAK\/STAT signaling in the progression of osteoarthritis","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Endocrinol"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027006","article-title":"Amelioration of experimental autoimmune encephalomyelitis by plumbagin through down-regulation of JAK-STAT and NF-\u03baB signaling pathways","volume":"6","author":"Tansey","year":"2011","journal-title":"PloS One"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23837","article-title":"Daphnetin attenuates intestinal inflammation, oxidative stress, and apoptosis in ulcerative colitis via inhibiting REG3A-dependent JAK2\/STAT3 signaling pathway","volume":"38","author":"He","year":"2023","journal-title":"Environ Toxicol"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-17779-7","article-title":"Real-world PM2.5 exposure induces pathological injury and DNA damage associated with miRNAs and DNA methylation alteration in rat lungs","volume":"29","author":"Zhao","year":"2022","journal-title":"Environ Sci pollut Res"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1111\/php.2014.90.issue-3","article-title":"Novel photodynamic effect of a psoralen-conjugated oligonucleotide for the discrimination of the methylation of cytosine in DNA","volume":"90","author":"Yamayoshi","year":"2014","journal-title":"Photochem Photobiol"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.09.067","article-title":"Esculetin ameliorates vascular perturbation by intervening in the occupancy of H2BK120Ub at At1, At2, Tgf\u03b21 and Mcp1 promoter gene in thoracic aorta of IR and T2D rats","volume":"95","author":"Kadakol","year":"2017","journal-title":"Biomedicine Pharmacotherapy"},{"key":"B175","doi-asserted-by":"publisher","first-page":"5556","DOI":"10.1038\/s41598-018-23775-8","article-title":"Global proteomics deciphered novel-function of osthole against pulmonary arterial hypertension","volume":"8","author":"Yao","year":"2018","journal-title":"Sci Rep"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgz117","article-title":"BRCA1 promoter hypermethylation in human placenta: a hidden link with \u03b2-hCG expression","volume":"41","author":"Nadhan","year":"2020","journal-title":"Carcinogenesis"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-18252-1","article-title":"Umbelliferone ameliorates ulcerative colitis induced by acetic acid via modulation of TLR4\/NF-\u03baB-p65\/iNOS and SIRT1\/PPAR\u03b3 signaling pathways in rats","volume":"29","author":"Abdel-Wahab","year":"2022","journal-title":"Environ Sci pollut Res"},{"key":"B178","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s12967-014-0287-x","article-title":"Therapeutic effect of daphnetin on the autoimmune arthritis through demethylation of proapoptotic genes in synovial cells","volume":"12","author":"Shu","year":"2014","journal-title":"J Trans Med"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.v4.2","article-title":"Osthole regulates N6-methyladenosine-modified TGM2 to inhibit the progression of rheumatoid arthritis and associated interstitial lung disease","volume":"4","author":"Lin","year":"2023","journal-title":"MedComm"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"B181","doi-asserted-by":"publisher","first-page":"13210","DOI":"10.3390\/ijms241713210","article-title":"GelMA hydrogel as a promising delivery system for osthole in the treatment of rheumatoid arthritis: targeting the miR-1224-3p\/AGO1 axis","volume":"24","author":"Zhang","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B182","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2011.05.009","article-title":"Notch-ing from T-cell to B-cell lymphoid Malignancies","volume":"308","author":"Mirandola","year":"2011","journal-title":"Cancer Lett"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0937-3","article-title":"PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis","volume":"35","author":"Garcia","year":"2020","journal-title":"Leukemia"},{"key":"B184","doi-asserted-by":"publisher","first-page":"108967","DOI":"10.1016\/j.celrep.2021.108967","article-title":"Self-renewal of double-negative 3 early thymocytes enables thymus autonomy but compromises the \u03b2-selection checkpoint","volume":"35","author":"Paiva","year":"2021","journal-title":"Cell Rep"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201903131R","article-title":"Deletion of delta-like 1 homologue accelerates renal inflammation by modulating the Th17 immune response","volume":"35","author":"Marquez-Exposito","year":"2020","journal-title":"FASEB J"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e33803","article-title":"Agrimonolide mitigated DSS-induced colitis by modulating the balance between Treg and Th17 cells through the suppression of the Notch and JAK2\/STAT3 signaling pathways","volume":"10","author":"Jiang","year":"2024","journal-title":"Heliyon"},{"key":"B187","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.3390\/ijms23063171","article-title":"Hedgehog signalling modulates immune response and protects against experimental autoimmune encephalomyelitis","volume":"23","author":"Ballester","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B188","doi-asserted-by":"publisher","first-page":"3016","DOI":"10.3390\/cells11193016","article-title":"Hedgehog signaling as a therapeutic target for airway remodeling and inflammation in allergic asthma","volume":"11","author":"Tam","year":"2022","journal-title":"Cells"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02847","article-title":"Sonic hedgehog signaling pathway mediates proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via MAPK\/ERK signaling pathway","volume":"9","author":"Liu","year":"2018","journal-title":"Front Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1432846\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T04:30:54Z","timestamp":1730349054000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1432846\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,31]]},"references-count":189,"alternative-id":["10.3389\/fimmu.2024.1432846"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1432846","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,31]]},"article-number":"1432846"}}