{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:05:14Z","timestamp":1791821114022,"version":"4.3.4"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Failure to adequate decidualization leads to adverse pregnancy outcomes including pregnancy loss. Although there are plenty of reports underscoring immune dysfunction as the main cause of abortion in CBA\/J females mated with DBA\/2 males (CBA\/J \u00d7 DBA\/2), little is known about the potential role of impaired endometrial decidualization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Endometrial stromal cells (ESCs) from CBA\/J mice were <jats:italic>in-vitro<\/jats:italic> decidualized, and the proteome profile of the secretome was investigated by membrane-based array. CBA\/J mice were perfused <jats:italic>In-utero<\/jats:italic> with either decidualized ESCs (C\u00d7D\/D), undecidualized ESCs (C\u00d7D\/ND), or PBS (C\u00d7D\/P) 12 days before mating with DBA\/2 males. Control mice were not manipulated and were mated with male DBA\/2 (C\u00d7D) or Balb\/c (C\u00d7B) mice. On day 13.5 of pregnancy, reproductive parameters were measured. <jats:italic>In-vivo<\/jats:italic> tracking of EdU-labeled ESCs was performed using fluorescence microscopy. The frequency of regulatory T cells (Tregs) in paraaortic\/renal and inguinal lymph nodes was measured by flow cytometry. The proliferation of pregnant CBA\/J splenocytes in response to stimulation with DBA\/2 splenocytes was assessed by 5,6-carboxyfluorescein diacetate succinimidyl ester (CFSE) flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In C\u00d7D\/D mice, the resorption rate was reduced to match that seen in the C\u00d7B group. Intrauterine perfused ESCs appeared in uterine stroma after 2 days, which remained there for at least 12 days. There was no difference in the number of implantation sites and embryo weight across all groups. The frequency of Tregs in the inguinal lymph nodes was similar across all groups, but it increased in the paraaortic\/renal lymph nodes of C\u00d7D\/D mice to the level found in C\u00d7B mice. No significant changes were observed in the proliferation of splenocytes from pregnant C\u00d7D\/D compared to those of the C\u00d7D group in response to stimulation with DBA\/2 splenocytes. Decidualization of ESCs was associated with a profound alteration in ESC secretome exemplified by alteration in proteins involved in extracellular matrix (ECM) remodeling, response to inflammation, senescence, and immune cell trafficking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our results showed that the deficiency of Tregs is not the primary driver of abortion in the CBA\/J \u00d7 DBA\/2 model and provided evidence that impaired endometrial decidualization probably triggers endometrial immune dysfunction and abortion in this model.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2024.1440388","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T18:10:57Z","timestamp":1727201457000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["In-utero transfer of decidualized endometrial stromal cells increases the frequency of regulatory T cells and normalizes the abortion rate in the CBA\/J \u00d7 DBA\/2 abortion model"],"prefix":"10.3389","volume":"15","author":[{"given":"Kayhan","family":"Zarnani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimia","family":"Zarnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Maslehat-Lay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahman","family":"Zeynali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedigheh","family":"Vafaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad-Reza","family":"Shokri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Vanaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haleh","family":"Soltanghoraee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebrahim","family":"Mirzadegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haleh","family":"Edalatkhah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad-Mehdi","family":"Naderi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Sarvari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnoosh","family":"Attari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Jeddi-Tehrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir-Hassan","family":"Zarnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.116","article-title":"Fertile ground: human endometrial programming and lessons in health and disease","volume":"12","author":"Evans","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12088","article-title":"Decidualization of the human endometrium","volume":"17","author":"Okada","year":"2018","journal-title":"Reprod Med Biol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic decidualization of the human endometrium in reproductive health and failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocr Rev"},{"key":"B5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s42003-020-0763-1","article-title":"Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window","volume":"3","author":"Lucas","year":"2020","journal-title":"Commun Biol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806219105","article-title":"Implantation of the human embryo requires rac1-dependent endometrial stromal cell migration","volume":"105","author":"Grewal","year":"2008","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041424","article-title":"Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos","volume":"7","author":"Weimar","year":"2012","journal-title":"PloS One"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-991042","article-title":"Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives","volume":"25","author":"Gellersen","year":"2007","journal-title":"Semin Reprod Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1055\/s-0029-1242989","article-title":"Endometrial decidualization: of mice and men","volume":"28","author":"Ramathal","year":"2010","journal-title":"Semin Reprod Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2498","article-title":"Deregulation of the serum- and glucocorticoid-inducible kinase sgk1 in the endometrium causes reproductive failure","volume":"17","author":"Salker","year":"2011","journal-title":"Nat Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052252","article-title":"Disordered il-33\/st2 activation in decidualizing stromal cells prolongs uterine receptivity in women with recurrent pregnancy loss","volume":"7","author":"Salker","year":"2012","journal-title":"PloS One"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2222","article-title":"Loss of endometrial plasticity in recurrent pregnancy loss","volume":"34","author":"Lucas","year":"2016","journal-title":"Stem Cells"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31274","article-title":"Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium","volume":"6","author":"Brighton","year":"2017","journal-title":"eLife"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1530\/rep-09-0007","article-title":"Altered decidual leucocyte populations in the placental bed in pre-eclampsia and foetal growth restriction: A comparison with late normal pregnancy","volume":"138","author":"Williams","year":"2009","journal-title":"Reproduction"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215332","article-title":"Endometrial immune dysfunction in recurrent pregnancy loss","volume":"20","author":"Ticconi","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.082763jb","article-title":"Immune cells in the placental bed","volume":"54","author":"Bulmer","year":"2010","journal-title":"Int J Dev Biol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1530\/REP-13-0583","article-title":"To drive or be driven: the path of a mouse model of recurrent pregnancy loss","volume":"147","author":"Bonney","year":"2014","journal-title":"REPRODUCTION"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2008.00612.x","article-title":"Original article: how should data on murine spontaneous abortion rates be expressed and analyzed","volume":"60","author":"Clark","year":"2008","journal-title":"Am J Reprod Immunol"},{"key":"B19","article-title":"Low 17\u03b2-estradiol levels are better inducers of regulatory conditioned T cells in-vitro","volume":"14","author":"Fatemi","year":"2017","journal-title":"Iran J Immunol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62302-4","article-title":"Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced cd4+Cd25+ T regulatory cells prevents fetal rejection in a murine abortion model","volume":"166","author":"Zenclussen","year":"2005","journal-title":"Am J Pathol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2009.00737.x","article-title":"Pd-1 but not ctla-4 blockage abrogates the protective effect of regulatory T cells in a pregnancy murine model","volume":"62","author":"Wafula","year":"2009","journal-title":"Am J Reprod Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1071\/rd20063","article-title":"Adoptive cell therapy with induced regulatory T cells normalises the abortion rate in abortion-prone mice","volume":"33","author":"Idali","year":"2021","journal-title":"Reprod Fertil Dev"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202413","article-title":"Self-specific memory regulatory T cells protect embryos at implantation in mice","volume":"191","author":"Chen","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1995.tb01142.x","article-title":"Is spontaneous resorption in the dba\/2-mated cba\/J mouse due to a defect in \"Seed\" or in \"Soil\"","volume":"33","author":"Muzikova","year":"1995","journal-title":"Am J Reprod Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1095\/biolreprod.113.113142","article-title":"Generalized disturbance of DNA methylation in the uterine decidua in the cba\/J X dba\/2 mouse model of pregnancy failure","volume":"89","author":"Brown","year":"2013","journal-title":"Biol Reprod"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.06.063","article-title":"Failure of decidual arteriolar remodeling in the cba\/J X dba\/2 murine model of recurrent pregnancy loss is linked to increased expression of tissue inhibitor of metalloproteinase 2 (Timp-2)","volume":"194","author":"Dixon","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"10007","DOI":"10.1038\/s41598-019-46316-3","article-title":"Human menstrual blood-derived stromal\/stem cells modulate functional features of natural killer cells","volume":"9","author":"Shokri","year":"2019","journal-title":"Sci Rep"},{"key":"B28","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1186\/s13287-021-02603-3","article-title":"Endometrial mesenchymal stem\/stromal cells: the enigma to code messages for generation of functionally active regulatory T cells","volume":"12","author":"Aleahmad","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2020.103252","article-title":"Menscs exert a supportive role in establishing a pregnancy-friendly microenvironment by inhibiting th17 polarization","volume":"144","author":"Ghanavatinejad","year":"2021","journal-title":"J Reprod Immunol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1385762","article-title":"Placenta: an old organ with new functions","volume":"15","author":"Khorami-Sarvestani","year":"2024","journal-title":"Front Immunol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3791\/55168","article-title":"Isolation of mouse endometrial epithelial and stromal cells for in vitro decidualization","volume":"12","author":"De Clercq","year":"2017","journal-title":"J Vis Exp"},{"key":"B32","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jri.2006.01.003","article-title":"Analysis of endometrial myeloid and lymphoid dendritic cells during mouse estrous cycle","volume":"71","author":"Zarnani","year":"2006","journal-title":"J Reprod Immunol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31159","article-title":"Vaccination with human amniotic epithelial cells confer effective protection in a murine model of colon adenocarcinoma","volume":"142","author":"Tabatabaei","year":"2018","journal-title":"Int J Cancer"},{"key":"B34","article-title":"A technique for facile and precise transfer of mouse embryos","volume":"5","author":"Sarvari","year":"2013","journal-title":"AVICENNA J OF Med Biotechnol (AJMB)"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3109\/14653240903180084","article-title":"Labeling and tracking of mesenchymal stromal cells with edu","volume":"11","author":"Lin","year":"2009","journal-title":"Cytotherapy"},{"key":"B36","unstructured":"Overview of proinflammatory and profibrotic mediators (WP5095)\n            RaatsS\n            JadhavA\n            MartensM\n            SenerDD\n            WeitzE"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.11.7777","article-title":"Identification of signaling pathways in macrophage exposed to porphyromonas gingivalis or to its purified cell wall components","volume":"179","author":"Zhou","year":"2007","journal-title":"J Immunol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioab183","article-title":"Single-cell analysis of prostaglandin E2-induced human decidual cell in vitro differentiation: A minimal ancestral deciduogenic signal\u2020","volume":"106","author":"Stadtmauer","year":"2022","journal-title":"Biol Reprod"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/j.cmet.2021.03.008","article-title":"Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis","volume":"33","author":"Wiley","year":"2021","journal-title":"Cell Metab"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2012.0092","article-title":"Bone marrow cells stained by azide-conjugated alexa fluors in the absence of an alkyne label","volume":"21","author":"Lin","year":"2012","journal-title":"Stem Cells Dev"},{"key":"B41","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jri.2013.03.006","article-title":"Seminal plasma peptides may determine maternal immune response that alters success or failure of pregnancy in the abortion-prone cbaxdba\/2 model","volume":"99","author":"Clark","year":"2013","journal-title":"J Reprod Immunol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2019","article-title":"Physiology of the endometrium and regulation of menstruation","volume":"100","author":"Critchley","year":"2020","journal-title":"Physiol Rev"},{"key":"B43","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1095\/biolreprod.114.122846","article-title":"The human endometrium as a sensor of embryo quality","volume":"91","author":"Macklon","year":"2014","journal-title":"Biol Reprod"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010258","article-title":"Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation","volume":"5","author":"Teklenburg","year":"2010","journal-title":"PloS One"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/srep03894","article-title":"Uterine selection of human embryos at implantation","volume":"4","author":"Brosens","year":"2014","journal-title":"Sci Rep"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-019-00122-4","article-title":"Time-to-pregnancy in women with unexplained recurrent pregnancy loss: A controlled study","volume":"27","author":"Ticconi","year":"2020","journal-title":"Reprod Sci"},{"key":"B47","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/s41572-020-00228-z","article-title":"Recurrent pregnancy loss","volume":"6","author":"Dimitriadis","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00528","article-title":"Expansion of cd25-negative forkhead box P3-positive T cells during hiv and mycobacterium tuberculosis infection","volume":"8","author":"Angerami","year":"2017","journal-title":"Front Immunol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.12.023","article-title":"Adoptive transfer of cd4+Cd25+ Regulatory T cells for prevention and treatment of spontaneous abortion","volume":"161","author":"Yin","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01571","article-title":"Decidualization process induces maternal monocytes to tolerogenic il-10-producing dendritic cells (Dc-10)","volume":"11","author":"Gori","year":"2020","journal-title":"Front Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1223539","article-title":"Decidualized human decidual stromal cells inhibit chemotaxis of activated T cells: A potential mechanism of maternal-fetal immune tolerance","volume":"14","author":"Llorca","year":"2023","journal-title":"Front Immunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gene.2014.08.047","article-title":"Endometrial stromal cells and decidualized stromal cells: origins, transformation and functions","volume":"551","author":"Zhu","year":"2014","journal-title":"Gene"},{"key":"B53","doi-asserted-by":"publisher","first-page":"4271","DOI":"10.1016\/j.cell.2023.08.020","article-title":"Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells","volume":"186","author":"Yang","year":"2023","journal-title":"Cell"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2018.0056","article-title":"The fate of autologous endometrial mesenchymal stromal cells after application in the healthy equine uterus","volume":"27","author":"Rink","year":"2018","journal-title":"Stem Cells Dev"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1177\/1933719114537715","article-title":"Uterine infusion with bone marrow mesenchymal stem cells improves endometrium thickness in a rat model of thin endometrium","volume":"22","author":"Zhao","year":"2015","journal-title":"Reprod Sci"},{"key":"B56","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1186\/s13287-022-03054-0","article-title":"Clinical application of mesenchymal stem cell in regenerative medicine: A narrative review","volume":"13","author":"Margiana","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1093\/emph\/eou022","article-title":"Malignant cancer and invasive placentation: A case for positive pleiotropy between endometrial and Malignancy phenotypes","volume":"2014","author":"D'Souza","year":"2014","journal-title":"Evolution Medicine Public Health"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.22005.09.019","article-title":"Involvement of gap junctions in placental functions and development","volume":"1719","author":"Malassin\u00e9","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"B59","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1189\/jlb.0708395","article-title":"Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment","volume":"85","author":"van Mourik","year":"2009","journal-title":"J Leukocyte Biol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh450","article-title":"Human chorionic gonadotropin and growth factors at the embryonic-endometrial interface control leukemia inhibitory factor (Lif) and interleukin 6 (Il-6) secretion by human endometrial epithelium","volume":"19","author":"Perrier d'Hauterive","year":"2004","journal-title":"Hum Reprod"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det060","article-title":"Control of extravillous trophoblast function by the eotaxins ccl11, ccl24 and ccl26","volume":"28","author":"Chau","year":"2013","journal-title":"Hum Reprod"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1102","article-title":"Chemerin regulates nk cell accumulation and endothelial cell morphogenesis in the decidua during early pregnancy","volume":"97","author":"Carlino","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-2-76","article-title":"Uterine extracellular matrix components are altered during defective decidualization in interleukin-11 receptor alpha deficient mice","volume":"2","author":"White","year":"2004","journal-title":"Reprod Biol Endocrinol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev117","article-title":"Nedd8-mediated neddylation is required for human endometrial stromal proliferation and decidualization","volume":"30","author":"Liao","year":"2015","journal-title":"Hum Reprod"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1478","article-title":"The role of exchange protein directly activated by cyclic amp 2-mediated calreticulin expression in the decidualization of human endometrial stromal cells","volume":"155","author":"Kusama","year":"2014","journal-title":"Endocrinology"},{"key":"B66","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/s41419-019-1511-7","article-title":"Resveratrol inhibits decidualization by accelerating downregulation of the crabp2-rar pathway in differentiating human endometrial stromal cells","volume":"10","author":"Ochiai","year":"2019","journal-title":"Cell Death Dis"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.03.205","article-title":"Influence of resveratrol supplementation on ivf-embryo transfer cycle outcomes","volume":"39","author":"Ochiai","year":"2019","journal-title":"Reprod BioMed Online"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03374-0","article-title":"The link between endometrial stromal cell senescence and decidualization in female fertility: the art of balanc","volume":"77","author":"Deryabin","year":"2020","journal-title":"Cell Mol Life Sci"},{"key":"B69","doi-asserted-by":"publisher","first-page":"494","DOI":"10.3389\/fcell.2020.00497","article-title":"Endometrial and menstrual blood mesenchymal stem\/stromal cells: biological properties and clinical application","volume":"8","author":"Bozorgmehr","year":"2020","journal-title":"Front Cell Dev Biol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1440388\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T18:11:00Z","timestamp":1727201460000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1440388\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,23]]},"references-count":69,"alternative-id":["10.3389\/fimmu.2024.1440388"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1440388","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,23]]},"article-number":"1440388"}}