{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:20:04Z","timestamp":1790864404489,"version":"4.1.0"},"reference-count":91,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>AIM2, a cytosolic innate immune receptor, has the capability to recognize double-stranded DNA (dsDNA). This paper delineates the structural features of AIM2 and its mechanisms of activation, emphasizing its capacity to detect cytosolic DNA and initiate inflammasome assembly. Additionally, we explore the diverse functions of AIM2 in different cells. Insights into AIM2-mediated neuroinflammation provide a foundation for investigating novel therapeutic strategies targeting AIM2 signaling pathways. Furthermore, we present a comprehensive review of the roles of AIM2 in neurodegenerative diseases, including Alzheimer\u2019s disease (AD) and Parkinson\u2019s disease (PD). Finally, we discuss its therapeutic implications. In conclusion, a profound understanding of AIM2 in neurodegenerative diseases may facilitate the development of effective interventions to mitigate neuronal damage and slow disease progression.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1441385","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T04:30:52Z","timestamp":1721017852000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["The roles of AIM2 in neurodegenerative diseases: insights and therapeutic implications"],"prefix":"10.3389","volume":"15","author":[{"given":"Kai","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihe","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taolei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.mrfmmm.2008.10.011","article-title":"Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases","volume":"667","author":"Migliore","year":"2009","journal-title":"Mutat Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13667","article-title":"Targeting innate immunity for neurodegenerative disorders of the central nervous system","volume":"138","author":"Andreasson","year":"2016","journal-title":"J Neurochem"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.10.016","article-title":"Emerging roles of innate and adaptive immunity in alzheimer's disease","volume":"55","author":"Chen","year":"2022","journal-title":"Immunity"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2022.08.001","article-title":"How the immune system shapes neurodegenerative diseases","volume":"45","author":"Mason","year":"2022","journal-title":"Trends Neurosci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","article-title":"Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets","volume":"8","author":"Gao","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"B6","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1186\/s12974-022-02605-9","article-title":"The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases","volume":"19","author":"DeMaio","year":"2022","journal-title":"J Neuroinflamm"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl249","article-title":"Role of toll-like receptor signalling in abeta uptake and clearance","volume":"129","author":"Tahara","year":"2006","journal-title":"Brain"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2019.05.004","article-title":"Microglia-mediated neuroinflammation in neurodegenerative diseases","volume":"94","author":"Subhramanyam","year":"2019","journal-title":"Semin Cell Dev Biol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"6237","DOI":"10.1038\/s41467-021-26519-x","article-title":"Microglia-specific overexpression of alpha-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity","volume":"12","author":"Bido","year":"2021","journal-title":"Nat Commun"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2017.04.001","article-title":"The role of astrocyte dysfunction in parkinson's disease pathogenesis","volume":"40","author":"Booth","year":"2017","journal-title":"Trends Neurosci"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104957","article-title":"Glia in neurodegeneration: drivers of disease or along for the ride","volume":"142","author":"Gleichman","year":"2020","journal-title":"Neurobiol Dis"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI18104","article-title":"Increased T cell reactivity to amyloid beta protein in older humans and patients with alzheimer disease","volume":"112","author":"Monsonego","year":"2003","journal-title":"J Clin Invest"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.8.1078","article-title":"Serum autoantibodies in patients with alzheimer's disease and vascular dementia and in nondemented control subjects","volume":"23","author":"Lopez","year":"1992","journal-title":"Stroke"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0055-7","article-title":"Inflammasome signalling in brain function and neurodegenerative disease","volume":"19","author":"Heneka","year":"2018","journal-title":"Nat Rev Neurosci"},{"key":"B15","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the nlrp3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat Rev Drug Discovery"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0165-0","article-title":"The nlrp3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.02.014","article-title":"Structures of the hin domain:DNA complexes reveal ligand binding and activation mechanisms of the aim2 inflammasome and ifi16 receptor","volume":"36","author":"Jin","year":"2012","journal-title":"Immunity"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/celldisc.2015.13","article-title":"Plasticity in pyd assembly revealed by cryo-em structure of the pyd filament of aim2","volume":"1","author":"Lu","year":"2015","journal-title":"Cell Discovery"},{"key":"B19","doi-asserted-by":"publisher","first-page":"7827","DOI":"10.1038\/ncomms8827","article-title":"Assembly-driven activation of the aim2 foreign-dsdna sensor provides a polymerization template for downstream asc","volume":"6","author":"Morrone","year":"2015","journal-title":"Nat Commun"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1702","article-title":"An orthogonal proteomic-genomic screen identifies aim2 as a cytoplasmic DNA sensor for the inflammasome","volume":"10","author":"Burckstummer","year":"2009","journal-title":"Nat Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/science.1169841","article-title":"Hin-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA","volume":"323","author":"Roberts","year":"2009","journal-title":"Science"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-9367-9_7","article-title":"Aim2 inflammasome assembly and signaling","volume":"1172","author":"Wang","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1712860115","article-title":"Digital signaling network drives the assembly of the aim2-asc inflammasome","volume":"115","author":"Matyszewski","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad090","article-title":"Filament assembly underpins the double-stranded DNA specificity of aim2-like receptors","volume":"51","author":"Garg","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24260","article-title":"Microglial aim2 alleviates antiviral-related neuro-inflammation in mouse models of parkinson's disease","volume":"70","author":"Rui","year":"2022","journal-title":"Glia"},{"key":"B26","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1159\/000477092","article-title":"Deletion of the inflammasome sensor aim2 mitigates abeta deposition and microglial activation but increases inflammatory cytokine expression in an alzheimer disease mouse model","volume":"24","author":"Wu","year":"2017","journal-title":"Neuroimmunomodulation"},{"key":"B27","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/JLB.3MA0321-745R","article-title":"Diabetes induces macrophage dysfunction through cytoplasmic dsdna\/aim2 associated pyroptosis","volume":"110","author":"Nie","year":"2021","journal-title":"J Leukoc Biol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab202","article-title":"Aim2-driven inflammasome activation in heart failure","volume":"117","author":"Onodi","year":"2021","journal-title":"Cardiovasc Res"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117490109","article-title":"Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a legionella effector functioning in membrane trafficking","volume":"109","author":"Ge","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1859","article-title":"The aim2 inflammasome is critical for innate immunity to francisella tularensis","volume":"11","author":"Fernandes-Alnemri","year":"2010","journal-title":"Nat Immunol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.2011.13.issue-10","article-title":"Elevated aim2-mediated pyroptosis triggered by hypercytotoxic francisella mutant strains is attributed to increased intracellular bacteriolysis","volume":"13","author":"Peng","year":"2011","journal-title":"Cell Microbiol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.04.004","article-title":"Listeria monocytogenes triggers aim2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol","volume":"7","author":"Sauer","year":"2010","journal-title":"Cell Host Microbe"},{"key":"B33","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/ni.1864","article-title":"The aim2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses","volume":"11","author":"Rathinam","year":"2010","journal-title":"Nat Immunol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1375-0","article-title":"Hpv16 activates the aim2 inflammasome in keratinocytes","volume":"305","author":"Reinholz","year":"2013","journal-title":"Arch Dermatol Res"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/190860","article-title":"Aim2 mediates inflammation-associated renal damage in hepatitis B virus-associated glomerulonephritis by regulating caspase-1, il-1beta, and il-18","volume":"2014","author":"Zhen","year":"2014","journal-title":"Mediators Inflammation"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1602419113","article-title":"Aim2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity","volume":"113","author":"Di Micco","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2023.09.012","article-title":"Genomic DNA activates the aim2 inflammasome and sting pathways to induce inflammation in lacrimal gland myoepithelial cells","volume":"30","author":"Yang","year":"2023","journal-title":"Ocul Surf"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102322","article-title":"Overexpression of nag-1\/gdf15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsdna release and aim2 inflammasome activation","volume":"52","author":"Wang","year":"2022","journal-title":"Redox Biol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/j.cell.2017.09.029","article-title":"Oxysterol restraint of cholesterol synthesis prevents aim2 inflammasome activation","volume":"171","author":"Dang","year":"2017","journal-title":"Cell"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e781","DOI":"10.1002\/ctm2.781","article-title":"The il-21-tet2-aim2-C-maf pathway drives the T follicular helper cell response in lupus-like disease","volume":"12","author":"Wu","year":"2022","journal-title":"Clin Transl Med"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03231-w","article-title":"Aim2 in regulatory T cells restrains autoimmune diseases","volume":"591","author":"Chou","year":"2021","journal-title":"Nature"},{"key":"B42","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/s41392-021-00725-x","article-title":"Aim2 deficiency in B cells ameliorates systemic lupus erythematosus by regulating blimp-1-bcl-6 axis-mediated B-cell differentiation","volume":"6","author":"Yang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201796","article-title":"Aim2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis","volume":"218","author":"Ma","year":"2021","journal-title":"J Exp Med"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1172\/JCI138234","article-title":"Huwe1 mediates inflammasome activation and promotes host defense against bacterial infection","volume":"130","author":"Guo","year":"2020","journal-title":"J Clin Invest"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1016\/j.celrep.2016.07.019","article-title":"Trim11 suppresses aim2 inflammasome by degrading aim2 via P62-dependent selective autophagy","volume":"16","author":"Liu","year":"2016","journal-title":"Cell Rep"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/srep32405","article-title":"Aim 2 inflammasomes regulate neuronal morphology and influence anxiety and memory in mice","volume":"6","author":"Wu","year":"2016","journal-title":"Sci Rep"},{"key":"B47","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/s41419-020-2248-z","article-title":"Inhibition of aim2 inflammasome activation alleviates gsdmd-induced pyroptosis in early brain injury after subarachnoid haemorrhage","volume":"11","author":"Yuan","year":"2020","journal-title":"Cell Death Dis"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.236","article-title":"Pyroptotic neuronal cell death mediated by the aim2 inflammasome","volume":"34","author":"Adamczak","year":"2014","journal-title":"J Cereb Blood Flow Metab"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.854671","article-title":"Probenecid-Blocked Pannexin-1 Channel Protects against Early Brain Injury Via Inhibiting Neuronal Aim2 Inflammasome Activation after Subarachnoid Hemorrhage","volume":"13","author":"Zheng","year":"2022","journal-title":"Front Neurol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005871","article-title":"Immune-complexed adenovirus induce aim2-mediated pyroptosis in human dendritic cells","volume":"12","author":"Eichholz","year":"2016","journal-title":"PloS Pathog"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200962","article-title":"Aim2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma","volume":"218","author":"Fukuda","year":"2021","journal-title":"J Exp Med"},{"key":"B52","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s00262-018-2144-x","article-title":"Cd137l dendritic cells induce potent response against cancer-associated viruses and polarize human cd8(+) T cells to tc1 phenotype","volume":"67","author":"Dharmadhikari","year":"2018","journal-title":"Cancer Immunol Immunother"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.07.009","article-title":"Human lung cancer-derived immunosuppressive plasmacytoid dendritic cells release il-1alpha in an aim2 inflammasome-dependent manner","volume":"185","author":"Sorrentino","year":"2015","journal-title":"Am J Pathol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.immuni.2021.02.004","article-title":"Post-injury immunosuppression and secondary infections are caused by an aim2 inflammasome-driven signaling cascade","volume":"54","author":"Roth","year":"2021","journal-title":"Immunity"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04702-4","article-title":"Fcgammar-mediated sars-cov-2 infection of monocytes activates inflammation","volume":"606","author":"Junqueira","year":"2022","journal-title":"Nature"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1042\/CS20220531","article-title":"M1\/M2 macrophages and their overlaps - myth or reality","volume":"137","author":"Strizova","year":"2023","journal-title":"Clin Sci (Lond)"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017080863","article-title":"Macrophage uptake of necrotic cell DNA activates the aim2 inflammasome to regulate a proinflammatory phenotype in ckd","volume":"29","author":"Komada","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101018","article-title":"Absent in melanoma 2-mediating M1 macrophages facilitate tumor rejection in renal carcinoma","volume":"14","author":"Chai","year":"2021","journal-title":"Transl Oncol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001466","article-title":"Blockade of aim2 inflammasome or alpha1-ar ameliorates il-1beta release and macrophage-mediated immunosuppression induced by car-T treatment","volume":"9","author":"Liu","year":"2021","journal-title":"J Immunother Cancer"},{"key":"B60","doi-asserted-by":"publisher","first-page":"e13860","DOI":"10.1111\/acel.13860","article-title":"Absent in melanoma 2 mediates aging-related cognitive dysfunction by acting on complement-dependent microglial phagocytosis","volume":"22","author":"Ye","year":"2023","journal-title":"Aging Cell"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14555","article-title":"Conditional knockout of aim2 in microglia ameliorates synaptic plasticity and spatial memory deficits in a mouse model of alzheimer's disease","volume":"30","author":"Ye","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"B62","doi-asserted-by":"publisher","first-page":"e0183268","DOI":"10.1371\/journal.pone.0183268","article-title":"Maturation-dependent expression of aim2 in human B-cells","volume":"12","author":"Svensson","year":"2017","journal-title":"PloS One"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.94035","article-title":"Aim2-mediated\/ifn-beta-independent regulation of gastric metaplastic lesions via cd8+ T cells","volume":"5","author":"El-Zaatari","year":"2020","journal-title":"JCI Insight"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23042230","article-title":"Absent in melanoma 2 (Aim2) regulates the stability of regulatory T cells","volume":"23","author":"Lozano-Ruiz","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B65","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/s12974-021-02327-4","article-title":"Downregulating expression of optn elevates neuroinflammation via aim2 inflammasome- and ripk1-activating mechanisms in app\/ps1 transgenic mice","volume":"18","author":"Cao","year":"2021","journal-title":"J Neuroinflamm"},{"key":"B66","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.brainresbull.2019.07.011","article-title":"Aim2 deletion promotes neuroplasticity and spatial memory of mice","volume":"152","author":"Chen","year":"2019","journal-title":"Brain Res Bull"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e25523","article-title":"Crocin attenuates the lipopolysaccharide-induced neuroinflammation via expression of aim2 and nlrp1 inflammasome in an experimental model of parkinson's disease","volume":"10","author":"Alizadehmoghaddam","year":"2024","journal-title":"Heliyon"},{"key":"B68","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.brainres.2018.06.008","article-title":"The pathological role of nlrs and aim2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury","volume":"1697","author":"Ge","year":"2018","journal-title":"Brain Res"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7879629","article-title":"Vx765 attenuates pyroptosis and hmgb1\/tlr4\/nf-kappab pathways to improve functional outcomes in tbi mice","volume":"2020","author":"Sun","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"B70","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s00441-020-03250-5","article-title":"The expressions of nlrp1, nlrp3, and aim2 inflammasome complexes in the contusive spinal cord injury rat model and their responses to hormonal therapy","volume":"381","author":"Majidpoor","year":"2020","journal-title":"Cell Tissue Res"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2021.0464","article-title":"Exosome-shuttled mir-672-5p from anti-inflammatory microglia repair traumatic spinal cord injury by inhibiting aim2\/asc\/caspase-1 signaling pathway mediated neuronal pyroptosis","volume":"39","author":"Zhou","year":"2022","journal-title":"J Neurotrauma"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110394","article-title":"Pre-treatment of rapamycin transformed M2 microglia alleviates traumatic cervical spinal cord injury via aim2 signaling pathway in vitro and in vivo","volume":"121","author":"Xiao","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2023.10.011","article-title":"The comparative effects of schwann cells and wharton's jelly mesenchymal stem cells on the aim2 inflammasome activity in an experimental model of spinal cord injury","volume":"535","author":"Kharazinejad","year":"2023","journal-title":"Neuroscience"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-03936-9","article-title":"Activating mc4r promotes functional recovery by repressing oxidative stress-mediated aim2 activation post-spinal cord injury","author":"Wang","year":"2024","journal-title":"Mol Neurobiol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0344-4","article-title":"Parkinson disease and the immune system - associations, mechanisms and therapeutics","volume":"16","author":"Tan","year":"2020","journal-title":"Nat Rev Neurol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00684-6","article-title":"Inflammation and immune dysfunction in parkinson disease","volume":"22","author":"Tansey","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2021.577543","article-title":"A selective nlrp3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of parkinson's disease","volume":"354","author":"Huang","year":"2021","journal-title":"J Neuroimmunol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1007\/s12565-024-00778-2","article-title":"Neuroinflammation and neurodegeneration following traumatic brain injuries","author":"Boulton","year":"2024","journal-title":"Anat Sci Int"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005258","article-title":"Progressive neurodegeneration following spinal cord injury: implications for clinical trials","volume":"90","author":"Ziegler","year":"2018","journal-title":"Neurology"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13179","article-title":"Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury","volume":"173","author":"Faden","year":"2016","journal-title":"Br J Pharmacol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2024.119691","article-title":"Importance of aim2 as a serum marker for reflecting severity and predicting a poor outcome of human severe traumatic brain injury: A prospective longitudinal cohort study","volume":"559","author":"Chen","year":"2024","journal-title":"Clin Chim Acta"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.245481","article-title":"Expression and localization of absent in melanoma 2 in the injured spinal cord","volume":"14","author":"Wang","year":"2019","journal-title":"Neural Regener Res"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.154951","article-title":"Efla 945 restricts aim2 inflammasome activation by preventing DNA entry for psoriasis treatment","volume":"127","author":"Chung","year":"2020","journal-title":"Cytokine"},{"key":"B84","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1038\/s41419-019-2195-8","article-title":"Inhibition of aim2 inflammasome-mediated pyroptosis by andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis","volume":"10","author":"Gao","year":"2019","journal-title":"Cell Death Dis"},{"key":"B85","doi-asserted-by":"publisher","first-page":"e2300204120","DOI":"10.1073\/pnas.2300204120","article-title":"Inhibition of aim2 inflammasome activation by sox\/orf37 promotes lytic replication of kaposi's sarcoma-associated herpesvirus","volume":"120","author":"Zhang","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106758","article-title":"Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the aim2 inflammasome","volume":"26","author":"Green","year":"2023","journal-title":"iScience"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300530","article-title":"Synthetic oligodeoxynucleotides containing suppressive ttaggg motifs inhibit aim2 inflammasome activation","volume":"191","author":"Kaminski","year":"2013","journal-title":"J Immunol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2019.113139","article-title":"Long non-coding rna meg3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting mir-485\/aim2 axis","volume":"325","author":"Liang","year":"2020","journal-title":"Exp Neurol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21134795","article-title":"Gonadal hormones E2 and P mitigate cerebral ischemia-induced upregulation of the aim2 and nlrc4 inflammasomes in rats","volume":"21","author":"Habib","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114194","article-title":"Discovery of a novel and potent inhibitor with differential species-specific effects against nlrp3 and aim2 inflammasome-dependent pyroptosis","volume":"232","author":"Jiao","year":"2022","journal-title":"Eur J Med Chem"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/srep41539","article-title":"Quercetin inhibits inflammasome activation by interfering with asc oligomerization and prevents interleukin-1 mediated mouse vasculitis","volume":"7","author":"Domiciano","year":"2017","journal-title":"Sci Rep"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1441385\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T04:30:55Z","timestamp":1721017855000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1441385\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,15]]},"references-count":91,"alternative-id":["10.3389\/fimmu.2024.1441385"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1441385","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,15]]},"article-number":"1441385"}}