{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:42:07Z","timestamp":1791362527961,"version":"4.3.1"},"reference-count":112,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Invariant natural killer T (iNKT) cells are a subset of lipid-reactive, unconventional T cells that have anti-tumor properties that make them a promising target for cancer immunotherapy. Recent studies have deciphered the developmental pathway of human MAIT and V\u03b39V\u03b42 \u03b3\u03b4-T cells as well as murine iNKT cells, yet our understanding of human NKT cell development is limited. Here, we provide an update in our understanding of how NKT cells develop in the human body and how knowledge regarding their development could enhance human treatments by targeting these cells.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1441634","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T05:01:12Z","timestamp":1724907672000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Thymic development of human natural killer T cells: recent advances and implications for immunotherapy"],"prefix":"10.3389","volume":"15","author":[{"given":"Daniel G.","family":"Pellicci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naeimeh","family":"Tavakolinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Perriman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart P.","family":"Berzins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Menne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3298","article-title":"The burgeoning family of unconventional T cells","volume":"16","author":"Godfrey","year":"2015","journal-title":"Nat Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.5.741","article-title":"Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers","volume":"192","author":"Matsuda","year":"2000","journal-title":"J Exp Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.11.1895","article-title":"In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers","volume":"191","author":"Benlagha","year":"2000","journal-title":"J Exp Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051604498","article-title":"Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography","volume":"98","author":"Karadimitris","year":"2001","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B5","doi-asserted-by":"publisher","first-page":"14111","DOI":"10.1002\/cpim.33","article-title":"Isolation and functional use of human NKT cells","volume":"119","author":"Exley","year":"2017","journal-title":"Curr Protoc Immunol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737389","article-title":"Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop","volume":"38","author":"Exley","year":"2008","journal-title":"Eur J Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800537","article-title":"LFA-1 ligation by high-density ICAM-1 is sufficient to activate IFN-gamma release by innate T lymphocytes","volume":"201","author":"Sharma","year":"2018","journal-title":"J Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/nri3369","article-title":"Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions","volume":"13","author":"Brennan","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.998378","article-title":"Harnessing invariant natural killer T cells to control pathological inflammation","volume":"13","author":"Bharadwaj","year":"2022","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011786","article-title":"Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining","volume":"195","author":"Gumperz","year":"2002","journal-title":"J Exp Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12248","article-title":"The peripheral differentiation of human natural killer T cells","volume":"97","author":"Liu","year":"2019","journal-title":"Immunol Cell Biol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01817","article-title":"Culture-expanded human invariant natural killer T cells suppress T-cell alloreactivity and eradicate leukemia","volume":"9","author":"Schmid","year":"2018","journal-title":"Front Immunol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028648","article-title":"Distinct and overlapping effector functions of expanded human CD4+, CD8alpha+ and CD4-CD8alpha- invariant natural killer T cells","volume":"6","author":"O\u2019Reilly","year":"2011","journal-title":"PloS One"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.6.3114","article-title":"Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells","volume":"167","author":"Metelitsa","year":"2001","journal-title":"J Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13104","article-title":"Human intestinal and circulating invariant natural killer T cells are cytotoxic against colorectal cancer cells via the perforin-granzyme pathway","volume":"15","author":"Diaz-Basabe","year":"2021","journal-title":"Mol Oncol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/nri2904","article-title":"Presumed guilty: natural killer T cell defects and human disease","volume":"11","author":"Berzins","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.03.009","article-title":"Unconventional T cell targets for cancer immunotherapy","volume":"48","author":"Godfrey","year":"2018","journal-title":"Immunity"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939349","article-title":"Invariant NKT cells and CD1d(+) cells amass in human omentum and are depleted in patients with cancer and obesity","volume":"39","author":"Lynch","year":"2009","journal-title":"Eur J Immunol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI62739","article-title":"Natural killer T cells in adipose tissue prevent insulin resistance","volume":"122","author":"Schipper","year":"2012","journal-title":"J Clin Invest"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.11.5514","article-title":"Valpha24-JalphaQ-independent, CD1d-restricted recognition of alpha-galactosylceramide by human CD4(+) and CD8alphabeta(+) T lymphocytes","volume":"168","author":"Gadola","year":"2002","journal-title":"J Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nri2116","article-title":"Control points in NKT-cell development","volume":"7","author":"Godfrey","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2567.2007.02647.x","article-title":"Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11","volume":"122","author":"Montoya","year":"2007","journal-title":"Immunology"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12045","article-title":"Ex-vivo analysis of human natural killer T cells demonstrates heterogeneity between tissues and within established CD4(+) and CD4(-) subsets","volume":"172","author":"Chan","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011908","article-title":"Distinct functional lineages of human V(alpha)24 natural killer T cells","volume":"195","author":"Lee","year":"2002","journal-title":"J Exp Med"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0705421","article-title":"Comparative gene expression analysis of NKT cell subpopulations","volume":"80","author":"Lin","year":"2006","journal-title":"J Leukoc Biol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00384","article-title":"Single-cell RNA-seq analysis uncovers distinct functional human NKT cell sub-populations in peripheral blood","volume":"8","author":"Zhou","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0345-y","article-title":"Thymic development of unconventional T cells: how NKT cells, MAIT cells and gammadelta T cells emerge","volume":"20","author":"Pellicci","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01450","article-title":"How lipid-specific T cells become effectors: the differentiation of iNKT subsets","volume":"9","author":"Wang","year":"2018","journal-title":"Front Immunol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2731","article-title":"Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells","volume":"14","author":"Lee","year":"2013","journal-title":"Nat Immunol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003043","article-title":"Proinflammatory environment dictates the IL-17-producing capacity of human invariant NKT cells","volume":"186","author":"Moreira-Teixeira","year":"2011","journal-title":"J Immunol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015412","article-title":"A comprehensive ex vivo functional analysis of human NKT cells reveals production of MIP1-alpha and MIP1-beta, a lack of IL-17, and a Th1-bias in males","volume":"5","author":"Snyder-Cappione","year":"2010","journal-title":"PloS One"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096151","article-title":"Potential role of IL-17-producing iNKT cells in type 1 diabetes","volume":"9","author":"Li","year":"2014","journal-title":"PloS One"},{"key":"B33","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41467-018-07911-6","article-title":"RORgammat inhibition selectively targets IL-17 producing iNKT and gammadelta-T cells enriched in Spondyloarthritis patients","volume":"10","author":"Venken","year":"2019","journal-title":"Nat Commun"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00217","article-title":"Characterization of T-bet and eomes in peripheral human immune cells","volume":"5","author":"Knox","year":"2014","journal-title":"Front Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.immuni.2008.07.011","article-title":"The transcription factor PLZF directs the effector program of the NKT cell lineage","volume":"29","author":"Savage","year":"2008","journal-title":"Immunity"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1641","article-title":"The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions","volume":"9","author":"Kovalovsky","year":"2008","journal-title":"Nat Immunol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72308","article-title":"IL-10-producing NKT10 cells are a distinct regulatory invariant NKT cell subset","volume":"124","author":"Sag","year":"2014","journal-title":"J Clin Invest"},{"key":"B38","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/ni.3047","article-title":"Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue","volume":"16","author":"Lynch","year":"2015","journal-title":"Nat Immunol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000359","article-title":"Identification of regulatory Foxp3+ invariant NKT cells induced by TGF-beta","volume":"185","author":"Monteiro","year":"2010","journal-title":"J Immunol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102281","article-title":"Rapamycin combined with TGF-beta converts human invariant NKT cells into suppressive Foxp3+ regulatory cells","volume":"188","author":"Moreira-Teixeira","year":"2012","journal-title":"J Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/ni.2166","article-title":"Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses","volume":"13","author":"Chang","year":"2011","journal-title":"Nat Immunol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069017","article-title":"A thymic precursor to the NK T cell lineage","volume":"296","author":"Benlagha","year":"2002","journal-title":"Science"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011544","article-title":"A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage","volume":"195","author":"Pellicci","year":"2002","journal-title":"J Exp Med"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3437","article-title":"Innate-like functions of natural killer T cell subsets result from highly divergent gene programs","volume":"17","author":"Engel","year":"2016","journal-title":"Nat Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"108116","DOI":"10.1016\/j.celrep.2020.108116","article-title":"High dimensional single-cell analysis reveals iNKT cell developmental trajectories and effector fate decision","volume":"32","author":"Baranek","year":"2020","journal-title":"Cell Rep"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3565","article-title":"A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage","volume":"17","author":"Koay","year":"2016","journal-title":"Nat Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.1016\/j.celrep.2019.05.012","article-title":"Quantitative difference in PLZF protein expression determines iNKT lineage fate and controls innate CD8 T cell generation","volume":"27","author":"Park","year":"2019","journal-title":"Cell Rep"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2230","article-title":"Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling","volume":"13","author":"Seiler","year":"2012","journal-title":"Nat Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/s41467-017-00882-0","article-title":"A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development","volume":"8","author":"Mao","year":"2017","journal-title":"Nat Commun"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3146","article-title":"Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function","volume":"16","author":"Pobezinsky","year":"2015","journal-title":"Nat Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research","article-title":"Recent advances in iNKT cell development","volume":"9","author":"Hogquist","year":"2020","journal-title":"F1000Res"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305986101","article-title":"Development of innate CD4+ alpha-chain variable gene segment 24 (Valpha24) natural killer T cells in the early human fetal thymus is regulated by IL-7","volume":"101","author":"Sandberg","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.13","article-title":"Invariant natural killer T cells developing in the human fetus accumulate and mature in the small intestine","volume":"7","author":"Loh","year":"2014","journal-title":"Mucosal Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.9.5338","article-title":"TCR gamma delta+ and CD161+ thymocytes express HIV-1 in the SCID-hu mouse, potentially contributing to immune dysfunction in HIV infection","volume":"169","author":"Gurney","year":"2002","journal-title":"J Immunol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425958","article-title":"Limited correlation between human thymus and blood NKT cell content revealed by an ontogeny study of paired tissue samples","volume":"35","author":"Berzins","year":"2005","journal-title":"Eur J Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1629","article-title":"Distinct homeostatic requirements of CD4+ and CD4- subsets of Valpha24-invariant natural killer T cells in humans","volume":"104","author":"Baev","year":"2004","journal-title":"Blood"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/10.10.1491","article-title":"Three day neonatal thymectomy selectively depletes NK1.1+ T cells","volume":"10","author":"Hammond","year":"1998","journal-title":"Int Immunol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/ni710","article-title":"NKT cells derive from double-positive thymocytes that are positively selected by CD1d","volume":"2","author":"Gapin","year":"2001","journal-title":"Nat Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.03.011","article-title":"Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors","volume":"22","author":"Egawa","year":"2005","journal-title":"Immunity"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408449102","article-title":"Commitment toward the natural T (iNKT) cell lineage occurs at the CD4 + 8+ stage of thymic ontogeny","volume":"102","author":"Bezbradica","year":"2005","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.6.2091","article-title":"Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes","volume":"182","author":"Bendelac","year":"1995","journal-title":"J Exp Med"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.7.4415","article-title":"Innate-like effector differentiation of human invariant NKT cells driven by IL-7","volume":"180","author":"de Lalla","year":"2008","journal-title":"J Immunol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/ni.1841","article-title":"Raising the NKT cell family","volume":"11","author":"Godfrey","year":"2010","journal-title":"Nat Immunol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801631105","article-title":"Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population","volume":"105","author":"Coquet","year":"2008","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiad113","article-title":"Single-cell transcriptomics reveal different maturation stages and sublineage commitment of human thymic invariant natural killer T cells","volume":"115","author":"Maas-Bauer","year":"2024","journal-title":"J Leukoc Biol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"113651","DOI":"10.1016\/j.jim.2024.113651","article-title":"Methodological optimisation of thymocyte isolation and cryopreservation of human thymus samples","volume":"528","author":"Hagen","year":"2024","journal-title":"J Immunol Methods"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200006)30:6<1544::AID-IMMU1544>3.0.CO;2-I","article-title":"Neonatal invariant Valpha24+ NKT lymphocytes are activated memory cells","volume":"30","author":"D\u2019Andrea","year":"2000","journal-title":"Eur J Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.7.2440","article-title":"Human natural killer T cells acquire a memory-activated phenotype before birth","volume":"95","author":"van Der Vliet","year":"2000","journal-title":"Blood"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1101\/2023.12.07.570707","article-title":"Unraveling the phenotypic states of human innate-like T cells: comparative insights with conventional T cells and mouse models","author":"Loh","year":"2023","journal-title":"bioRxiv"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20231487","article-title":"A conserved transcriptional program for MAIT cells across mammalian evolution","volume":"221","author":"Bugaut","year":"2024","journal-title":"J Exp Med"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024441","article-title":"Altered development of NKT cells, gammadelta T cells, CD8 T cells and NK cells in a PLZF deficient patient","volume":"6","author":"Eidson","year":"2011","journal-title":"PloS One"},{"key":"B72","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1084\/jem.20042432","article-title":"Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product","volume":"201","author":"Pasquier","year":"2005","journal-title":"J Exp Med"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/nm1189","article-title":"Regulation of NKT cell development by SAP, the protein defective in XLP","volume":"11","author":"Nichols","year":"2005","journal-title":"Nat Med"},{"key":"B74","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1749-6632.2011.06380.x","article-title":"Primary immunodeficiency associated with defects in CD1 and CD1-restricted T cells","volume":"1250","author":"Zeissig","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081773","article-title":"The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function","volume":"206","author":"Locci","year":"2009","journal-title":"J Exp Med"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/nature05257","article-title":"XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome","volume":"444","author":"Rigaud","year":"2006","journal-title":"Nature"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-456095","article-title":"Human iNKT and MAIT cells exhibit a PLZF-dependent proapoptotic propensity that is counterbalanced by XIAP","volume":"121","author":"Gerart","year":"2013","journal-title":"Blood"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aay6039","article-title":"A divergent transcriptional landscape underpins the development and functional branching of MAIT cells","volume":"4","author":"Koay","year":"2019","journal-title":"Sci Immunol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abo4365","article-title":"A three-stage developmental pathway for human Vgamma9Vdelta2 T cells within the postnatal thymus","volume":"8","author":"Perriman","year":"2023","journal-title":"Sci Immunol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1111\/imcb.12039","article-title":"Development of mucosal-associated invariant T cells","volume":"96","author":"Koay","year":"2018","journal-title":"Immunol Cell Biol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.3390\/cells12141875","article-title":"Flow cytometry: the next revolution","volume":"12","author":"Robinson","year":"2023","journal-title":"Cells"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12594","article-title":"A high-dimensional cytometry atlas of peripheral blood over the human life span","volume":"100","author":"Jalali","year":"2022","journal-title":"Immunol Cell Biol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.24213","article-title":"OMIP-069: forty-color full spectrum flow cytometry panel for deep immunophenotyping of major cell subsets in human peripheral blood","volume":"97","author":"Park","year":"2020","journal-title":"Cytometry A"},{"key":"B84","doi-asserted-by":"publisher","first-page":"113726","DOI":"10.1016\/j.jim.2024.113726","article-title":"A 38-colour high dimensional immunophenotyping panel for human peripheral blood mononuclear cells","volume":"532","author":"Anderson","year":"2024","journal-title":"J Immunol Methods"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01095","article-title":"Multi-omics\u201d Analyses of the development and function of natural killer cells","volume":"8","author":"Zhou","year":"2017","journal-title":"Front Immunol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00519","article-title":"Therapeutic potential of invariant natural killer T cells in autoimmunity","volume":"9","author":"Van Kaer","year":"2018","journal-title":"Front Immunol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00900","article-title":"Invariant natural killer T cells as suppressors of graft-versus-host disease in allogeneic hematopoietic stem cell transplantation","volume":"8","author":"Mavers","year":"2017","journal-title":"Front Immunol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.718350.5","article-title":"NKT cells contribute to the control of microbial infections","volume":"11","author":"Vogt","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/nri2451","article-title":"Harnessing invariant NKT cells in vaccination strategies","volume":"9","author":"Cerundolo","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"5174","DOI":"10.3390\/cancers13205174","article-title":"The current landscape of NKT cell immunotherapy and the hills ahead","volume":"13","author":"Nelson","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/nri3725","article-title":"Natural killer T cells: drivers or passengers in preventing human disease","volume":"14","author":"Berzins","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq457","article-title":"Numerical and functional deficiencies of natural killer T cells in systemic lupus erythematosus: their deficiency related to disease activity","volume":"50","author":"Cho","year":"2011","journal-title":"Rheumatol (Oxford)"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2001.5060","article-title":"Circulating V(alpha24+) Vbeta11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage","volume":"100","author":"van der Vliet","year":"2001","journal-title":"Clin Immunol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.897750","article-title":"Adoptive immunotherapy with engineered iNKT cells to target cancer cells and the suppressive microenvironment","volume":"9","author":"Delfanti","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00384","article-title":"Novel approaches to exploiting invariant NKT cells in cancer immunotherapy","volume":"9","author":"Wolf","year":"2018","journal-title":"Front Immunol"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01178","article-title":"Natural killer T cells in cancer immunotherapy","volume":"8","author":"Nair","year":"2017","journal-title":"Front Immunol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402943","article-title":"Expression of CD1d by myelomonocytic leukemias provides a target for cytotoxic NKT cells","volume":"17","author":"Metelitsa","year":"2003","journal-title":"Leukemia"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01542","article-title":"Invariant NKT Cells From Donor Lymphocyte Infusions (DLI-iNKTs) Promote ex vivo Lysis of Leukemic Blasts in a CD1d-Dependent Manner","volume":"10","author":"Jahnke","year":"2019","journal-title":"Front Immunol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"3909","DOI":"10.3390\/ijms21113909","article-title":"License to kill: when iNKT cells are granted the use of lethal cytotoxicity","volume":"21","author":"Diaz-Basabe","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B100","article-title":"Antitumor cytotoxicity mediated by ligand-activated human V alpha24 NKT cells","volume":"59","author":"Kawano","year":"1999","journal-title":"Cancer Res"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37869","article-title":"Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages","volume":"119","author":"Song","year":"2009","journal-title":"J Clin Invest"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1176724","article-title":"Towards a better understanding of human iNKT cell subpopulations for improved clinical outcomes","volume":"14","author":"Look","year":"2023","journal-title":"Front Immunol"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2017.69361","article-title":"A brief review of clinical trials involving manipulation of invariant NKT cells as a promising approach in future cancer therapies","volume":"42","author":"Waldowska","year":"2017","journal-title":"Cent Eur J Immunol"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016201","article-title":"Natural killer T cells and other innate-like T lymphocytes as emerging platforms for allogeneic cancer cell therapy","volume":"141","author":"Courtney","year":"2023","journal-title":"Blood"},{"key":"B105","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0065-230X(08)00408-9","article-title":"The role of NKT cells in tumor immunity","volume":"101","author":"Terabe","year":"2008","journal-title":"Adv Cancer Res"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06797-9","article-title":"An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis","volume":"625","author":"LaMarche","year":"2024","journal-title":"Nature"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000402","article-title":"Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop","volume":"8","author":"Matulis","year":"2010","journal-title":"PloS Biol"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1172\/JCI83476","article-title":"CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo","volume":"126","author":"Tian","year":"2016","journal-title":"J Clin Invest"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abj8760","article-title":"A circulating subset of iNKT cells mediates antitumor and antiviral immunity","volume":"7","author":"Cui","year":"2022","journal-title":"Sci Immunol"},{"key":"B110","doi-asserted-by":"publisher","first-page":"100449","DOI":"10.1016\/j.xcrm.2021.100449","article-title":"Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy","volume":"2","author":"Li","year":"2021","journal-title":"Cell Rep Med"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1349184","article-title":"Insights into the heterogeneity of iNKT cells: tissue-resident and circulating subsets shaped by local microenvironmental cues","volume":"15","author":"Cui","year":"2024","journal-title":"Front Immunol"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000050","article-title":"Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions","volume":"1","author":"Eger","year":"2006","journal-title":"PloS One"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1441634\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T05:01:17Z","timestamp":1724907677000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1441634\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,29]]},"references-count":112,"alternative-id":["10.3389\/fimmu.2024.1441634"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1441634","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,29]]},"article-number":"1441634"}}