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MMT is the process by which macrophages differentiate into myofibroblasts, leading to organ fibrosis following organ damage and playing an important role in fibrosis formation and progression. Recently, many new advances have been made in studying the mechanisms of MMT occurrence in fibrotic diseases. This article reviews some critical recent findings on MMT, including the origin of MMT in myofibroblasts, the specific mechanisms by which MMT develops, and the mechanisms and effects of MMT in the kidneys, lungs, heart, retina, and other fibrosis. By summarizing the latest research related to MMT, this paper provides a theoretical basis for elucidating the mechanisms of fibrosis in various organs and developing effective therapeutic targets for fibrotic diseases.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1461919","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T04:28:16Z","timestamp":1728448096000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":48,"title":["Advances in macrophage-myofibroblast transformation in fibrotic diseases"],"prefix":"10.3389","volume":"15","author":[{"given":"Jia-Qi","family":"Ban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hong","family":"Ao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2938-9","article-title":"Fibrosis: from mechanisms to medicines","volume":"587","author":"Henderson","year":"2020","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105316","article-title":"Deciphering the cellular mechanisms underlying fibrosis-associated diseases and therapeutic avenues","volume":"163","author":"Miao","year":"2021","journal-title":"Pharmacol Res"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0110-2","article-title":"Macrophages: versatile players in renal inflammation and fibrosis","volume":"15","author":"Tang","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.759199","article-title":"Control of tissue fibrosis by 5-methoxytryptophan, an innate anti-inflammatory metabolite","volume":"12","author":"Wu","year":"2021","journal-title":"Front Pharmacol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202012034","article-title":"Reprogramming of profibrotic macrophages for treatment of bleomycin-induced pulmonary fibrosis","volume":"12","author":"Zhang","year":"2020","journal-title":"EMBO Mol Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.934377","article-title":"The role of the macrophage-to-myofibroblast transition in renal fibrosis","volume":"13","author":"Wei","year":"2022","journal-title":"Front Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.402","article-title":"Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis","volume":"7","author":"Meng","year":"2016","journal-title":"Cell Death Dis"},{"key":"B8","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/ki.2014.287","article-title":"Origin of myofibroblasts and cellular events triggering fibrosis","volume":"87","author":"Mack","year":"2015","journal-title":"Kidney Int"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.07.010","article-title":"Drug targeting to myofibroblasts: Implications for fibrosis and cancer","volume":"121","author":"Yazdani","year":"2017","journal-title":"Advanced Drug Delivery Rev"},{"key":"B10","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/med.21596","article-title":"Small molecule inhibitors of epithelial-mesenchymal transition for the treatment of cancer and fibrosis","volume":"40","author":"Feng","year":"2020","journal-title":"Medicinal Res Rev"},{"key":"B11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41584-019-0324-5","article-title":"Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases","volume":"16","author":"Hinz","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12946","article-title":"Monocyte and macrophage derived myofibroblasts: Is it fate? 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