{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:39:27Z","timestamp":1789087167401,"version":"build-2803163510"},"reference-count":102,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Macrophages play a pivotal role in tissue homeostasis, pathogen defense, and inflammation resolution. M1 and M2 macrophage phenotypes represent two faces in a spectrum of responses to microenvironmental changes, crucial in both physiological and pathological conditions. Neuraminidase 1 (Neu1), a lysosomal and cell surface sialidase responsible for removing terminal sialic acid residues from glycoconjugates, modulates several macrophage functions, including phagocytosis and Toll-like receptor (TLR) signaling. Current evidence suggests that Neu1 expression influences M1\/M2 macrophage phenotype alterations in the context of cardiovascular diseases, indicating a potential role for Neu1 in macrophage polarization. For this reason, we investigated the impact of Neu1 deficiency on macrophage polarization <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. Using bone marrow-derived macrophages (BMDMs) and peritoneal macrophages from <jats:italic>Neu1<\/jats:italic> knockout (<jats:italic>Neu1<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic>) mice and wild-type (<jats:italic>WT<\/jats:italic>) littermate controls, we demonstrated that <jats:italic>Neu1<\/jats:italic>-deficient macrophages exhibit an aberrant M2-like phenotype, characterized by elevated macrophage mannose receptor 1 (MMR\/CD206) expression and reduced responsiveness to M1 stimuli. This M2-like phenotype was also observed <jats:italic>in vivo<\/jats:italic> in peritoneal and splenic macrophages. However, lymph node (LN) macrophages from <jats:italic>Neu1<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice exhibited phenotypic alterations with reduced CD206 expression. Further analysis revealed that peripheral LNs from <jats:italic>Neu1<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice were highly fibrotic, with overexpression of transforming growth factor-beta 1 (TGF-\u03b21) and hyperactivated TGF-\u03b2 signaling in LN macrophages. Consistently, TGF-\u03b21 was found to alter M1\/M2 macrophage polarization <jats:italic>in vitro<\/jats:italic>. Our findings showed that <jats:italic>Neu1<\/jats:italic> deficiency prompts macrophages towards an M2 phenotype and that microenvironmental changes, particularly increased TGF-\u03b21 in fibrotic tissues such as peripheral LNs in <jats:italic>Neu1<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice, further influence M1\/M2 macrophage polarization, highlighting its sensitivity to the local microenvironment. Therapeutic interventions targeting Neu1 or TGF-\u03b2 signaling pathways may offer the potential to regulate macrophage behavior across different diseases.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1462853","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T04:36:55Z","timestamp":1726202215000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Neu1 deficiency and fibrotic lymph node microenvironment lead to imbalance in M1\/M2 macrophage polarization"],"prefix":"10.3389","volume":"15","author":[{"given":"Emilia","family":"Escalona","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Olate-Briones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Albornoz-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Bonacic-Doric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Rodr\u00edguez-Arriaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s A.","family":"Herrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Escobedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00848-y","article-title":"Tissue-specific macrophages: how they develop and choreograph tissue biology","volume":"23","author":"Mass","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.617879","article-title":"Tissue-resident macrophage development and function","volume":"8","author":"Wu","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00423","article-title":"Ontogeny of myeloid cells","volume":"5","author":"De Kleer","year":"2014","journal-title":"Front Immunol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01066","article-title":"Phagocytosis: our current understanding of a universal biological process","volume":"11","author":"Uribe-Querol","year":"2020","journal-title":"Front Immunol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01774.x","article-title":"Antigen presentation by macrophages is enhanced by the uptake of necrotic, but not apoptotic, cells","volume":"127","author":"Barker","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1103149","article-title":"Tumor-associated macrophage polarization in the inflammatory tumor microenvironment","volume":"13","author":"Zou","year":"2023","journal-title":"Front Oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/ph16020141","article-title":"Epigenetic regulation of macrophage polarization in cardiovascular diseases","volume":"16","author":"Komal","year":"2023","journal-title":"Pharm (Basel)"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1352946","article-title":"Macrophage polarization: an important role in inflammatory diseases","volume":"15","author":"Luo","year":"2024","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cws057","article-title":"Mammalian sialidases: physiological and pathological roles in cellular functions","volume":"22","author":"Miyagi","year":"2012","journal-title":"Glycobiology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.devcel.2008.05.005","article-title":"Neuraminidase 1 is a negative regulator of lysosomal exocytosis","volume":"15","author":"Yogalingam","year":"2008","journal-title":"Dev Cell"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2318(10)64007-3","article-title":"Sialidases in vertebrates: a family of enzymes tailored for several cell functions","volume":"64","author":"Monti","year":"2010","journal-title":"Adv Carbohydr Chem Biochem"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605633200","article-title":"Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments","volume":"281","author":"Liang","year":"2006","journal-title":"J Biol Chem"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04679.x","article-title":"Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages","volume":"272","author":"Stamatos","year":"2005","journal-title":"FEBS J"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1209776","article-title":"LPS-induced cytokine production in human dendritic cells is regulated by sialidase activity","volume":"88","author":"Stamatos","year":"2010","journal-title":"J Leukoc Biol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-016-9664-4","article-title":"Sialylation and desialylation dynamics of monocytes upon differentiation and polarization to macrophages","volume":"33","author":"Wang","year":"2016","journal-title":"Glycoconj J"},{"key":"B17","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.vph.2018.01.005","article-title":"A positive feedback loop between IL-1beta, LPS and NEU1 may promote atherosclerosis by enhancing a pro-inflammatory state in monocytes and macrophages","author":"Sieve","year":"2018","journal-title":"Vascul Pharmacol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0503241","article-title":"Desialylation of glycoconjugates on the surface of monocytes activates the extracellular signal-related kinases ERK 1\/2 and results in enhanced production of specific cytokines","volume":"75","author":"Stamatos","year":"2004","journal-title":"J Leukoc Biol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.055475","article-title":"Regulation of phagocytosis in macrophages by neuraminidase 1","volume":"285","author":"Seyrantepe","year":"2010","journal-title":"J Biol Chem"},{"key":"B20","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1007\/s00018-018-2978-6","article-title":"Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex","volume":"76","author":"Kawecki","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02360","article-title":"Modulation of TLR4 sialylation mediated by a sialidase neu1 and impairment of its signaling in leishmania donovani infected macrophages","volume":"10","author":"Karmakar","year":"2019","journal-title":"Front Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.626110","article-title":"Interplay between sialic acids, siglec-E, and neu1 regulates myD88- and TRIF-dependent pathways for TLR4-activation during leishmania donovani infection","volume":"12","author":"Karmakar","year":"2021","journal-title":"Front Immunol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.788645","article-title":"Neuraminidase 1 exacerbating aortic dissection by governing a pro-inflammatory program in macrophages","volume":"8","author":"Wang","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s00395-020-00821-z","article-title":"Neuraminidase-1 promotes heart failure after ischemia\/reperfusion injury by affecting cardiomyocytes and invading monocytes\/macrophages","volume":"115","author":"Heimerl","year":"2020","journal-title":"Basic Res Cardiol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"35234","DOI":"10.1038\/srep35234","article-title":"Bone marrow-derived and peritoneal macrophages have different inflammatory response to oxLDL and M1\/M2 marker expression - implications for atherosclerosis research","volume":"6","author":"Bisgaard","year":"2016","journal-title":"Sci Rep"},{"key":"B26","doi-asserted-by":"publisher","first-page":"100246","DOI":"10.1016\/j.xpro.2020.100246","article-title":"Preparation and culture of bone marrow-derived macrophages from mice for functional analysis","volume":"2","author":"Toda","year":"2021","journal-title":"STAR Protoc"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e52749","DOI":"10.3791\/52749","article-title":"Isolation of murine peritoneal macrophages to carry out gene expression analysis upon Toll-like receptors stimulation","volume":"98","author":"Layoun","year":"2015","journal-title":"J Vis Exp"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.v7i32","article-title":"TGF-beta induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e51803","DOI":"10.3791\/51803","article-title":"Isolation of murine lymph node stromal cells","volume":"90","author":"Broggi","year":"2014","journal-title":"J Vis Exp"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e0145342","DOI":"10.1371\/journal.pone.0145342","article-title":"Novel markers to delineate murine M1 and M2 macrophages","volume":"10","author":"Jablonski","year":"2015","journal-title":"PloS One"},{"key":"B32","doi-asserted-by":"publisher","first-page":"5700853","DOI":"10.1155\/2022\/5700853","article-title":"Adapted murine sepsis score: improving the research in experimental sepsis mouse model","volume":"2022","author":"Sulzbacher","year":"2022","journal-title":"BioMed Res Int"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/biom11060837","article-title":"Macrophage plasticity and polarization are altered in the experimental model of multiple sclerosis","volume":"11","author":"Leuti","year":"2021","journal-title":"Biomolecules"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01084","article-title":"Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages","volume":"10","author":"Orecchioni","year":"2019","journal-title":"Front Immunol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-009-9239-8","article-title":"Dependence of pathogen molecule-induced toll-like receptor activation and cell function on Neu1 sialidase","volume":"26","author":"Amith","year":"2009","journal-title":"Glycoconj J"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15024","article-title":"Lipopolysaccharide activates microglia via neuraminidase 1 desialylation of Toll-like Receptor 4","volume":"155","author":"Allendorf","year":"2020","journal-title":"J Neurochem"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0915000107","article-title":"Two physically, functionally, and developmentally distinct peritoneal macrophage subsets","volume":"107","author":"Ghosn","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B38","doi-asserted-by":"publisher","first-page":"12421","DOI":"10.1038\/s41598-019-48741-w","article-title":"SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages","volume":"9","author":"Schroder","year":"2019","journal-title":"Sci Rep"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00480","article-title":"Splenic macrophage subsets and their function during blood-borne infections","volume":"6","author":"Borges da Silva","year":"2015","journal-title":"Front Immunol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1159\/000337007","article-title":"Lymph node macrophages","volume":"4","author":"Gray","year":"2012","journal-title":"J Innate Immun"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/nature07472","article-title":"Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis","volume":"457","author":"Kohyama","year":"2009","journal-title":"Nature"},{"key":"B42","doi-asserted-by":"publisher","first-page":"eaav3270","DOI":"10.1126\/sciadv.aav3270","article-title":"Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis","volume":"5","author":"van de Vlekkert","year":"2019","journal-title":"Sci Adv"},{"key":"B43","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev.immunol.24.021605.090737","article-title":"Transforming growth factor-beta regulation of immune responses","volume":"24","author":"Li","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/ni.2262","article-title":"Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks","volume":"13","author":"Malhotra","year":"2012","journal-title":"Nat Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/ni.3035","article-title":"The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture","volume":"16","author":"Astarita","year":"2015","journal-title":"Nat Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2015","article-title":"Muscle injury activates resident fibro\/adipogenic progenitors that facilitate myogenesis","volume":"12","author":"Joe","year":"2010","journal-title":"Nat Cell Biol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-024-01235-6","article-title":"Transforming growth factor-beta receptors: versatile mechanisms of ligand activation","volume":"45","author":"Chia","year":"2024","journal-title":"Acta Pharmacol Sin"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1635","article-title":"Adoptive transfer of immunomodulatory M2 macrophages prevents type 1 diabetes in NOD mice","volume":"61","author":"Parsa","year":"2012","journal-title":"Diabetes"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(99)00257-9","article-title":"Bidirectional regulation of macrophage function by TGF-beta","volume":"1","author":"Ashcroft","year":"1999","journal-title":"Microbes Infect"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.09.008","article-title":"Mitochondrial dysfunction prevents repolarization of inflammatory macrophages","volume":"17","author":"Van den Bossche","year":"2016","journal-title":"Cell Rep"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.11.065","article-title":"M2 polarized macrophages and giant cells contribute to myofibrosis in neuromuscular sarcoidosis","volume":"178","author":"Prokop","year":"2011","journal-title":"Am J Pathol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","author":"Murray","year":"2017","journal-title":"Annu Rev Physiol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"e1007657","DOI":"10.1371\/journal.pcbi.1007657","article-title":"Reprogramming of macrophages employing gene regulatory and metabolic network models","volume":"16","author":"Horhold","year":"2020","journal-title":"PloS Comput Biol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11071394","article-title":"Macrophage polarization and reprogramming in acute inflammation: A redox perspective","volume":"11","author":"Perez","year":"2022","journal-title":"Antioxid (Basel)"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.031419","article-title":"Heterodimerization of the sialidase NEU1 with the chaperone protective protein\/cathepsin A prevents its premature oligomerization","volume":"284","author":"Bonten","year":"2009","journal-title":"J Biol Chem"},{"key":"B56","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12915-017-0392-4","article-title":"Tissue macrophages: heterogeneity and functions","volume":"15","author":"Gordon","year":"2017","journal-title":"BMC Biol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s13340-023-00624-2","article-title":"Heterogeneity of adipose tissue-resident macrophages-beyond M1\/M2 paradigm","volume":"14","author":"Nawaz","year":"2023","journal-title":"Diabetol Int"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1042\/CS20220531","article-title":"M1\/M2 macrophages and their overlaps - myth or reality","volume":"137","author":"Strizova","year":"2023","journal-title":"Clin Sci (Lond)"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00541-3","article-title":"Macrophages and the maintenance of homeostasis","volume":"18","author":"Mosser","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/1348-0421.12228","article-title":"Functions and development of red pulp macrophages","volume":"59","author":"Kurotaki","year":"2015","journal-title":"Microbiol Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1038\/s41467-021-21814-z","article-title":"Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance","volume":"12","author":"Cao","year":"2021","journal-title":"Nat Commun"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2008.11.004","article-title":"Influence of the mannose receptor in host immune responses","volume":"214","author":"Gazi","year":"2009","journal-title":"Immunobiology"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031370","article-title":"Mannose ligands for mannose receptor targeting","volume":"25","author":"Paurevic","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1898753","DOI":"10.1080\/2162402X.2021.1898753","article-title":"Re-polarization of immunosuppressive macrophages to tumor-cytotoxic macrophages by repurposed metabolic drugs","volume":"10","author":"Oyarce","year":"2021","journal-title":"Oncoimmunology"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01097","article-title":"Regulation of human macrophage M1-M2 polarization balance by hypoxia and the triggering receptor expressed on myeloid cells-1","volume":"8","author":"Raggi","year":"2017","journal-title":"Front Immunol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069540","article-title":"Mannose receptor-mediated regulation of serum glycoprotein homeostasis","volume":"295","author":"Lee","year":"2002","journal-title":"Science"},{"key":"B67","doi-asserted-by":"publisher","first-page":"100368","DOI":"10.1016\/j.jbc.2021.100368","article-title":"Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206","volume":"296","author":"Feinberg","year":"2021","journal-title":"J Biol Chem"},{"key":"B68","doi-asserted-by":"publisher","first-page":"102591","DOI":"10.1016\/j.jbc.2022.102591","article-title":"N-glycosylation of mannose receptor (CD206) regulates glycan binding by C-type lectin domains","volume":"298","author":"Stavenhagen","year":"2022","journal-title":"J Biol Chem"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503457200","article-title":"Glycosylation influences the lectin activities of the macrophage mannose receptor","volume":"280","author":"Su","year":"2005","journal-title":"J Biol Chem"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2009.09.038","article-title":"Neu1 desialylation of sialyl alpha-2,3-linked beta-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling","volume":"22","author":"Amith","year":"2010","journal-title":"Cell Signal"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.04.159","article-title":"Detailed N-glycan analysis of mannose receptor purified from murine spleen indicates tissue specific sialylation","volume":"384","author":"Su","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.166470","article-title":"Severe kidney dysfunction in sialidosis mice reveals an essential role for neuraminidase 1 in reabsorption","volume":"8","author":"Kho","year":"2023","journal-title":"JCI Insight"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201301081","article-title":"M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway","volume":"202","author":"Madsen","year":"2013","journal-title":"J Cell Biol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200535685","article-title":"Carbohydrate-independent recognition of collagens by the macrophage mannose receptor","volume":"36","author":"Martinez-Pomares","year":"2006","journal-title":"Eur J Immunol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03481-3","article-title":"Cellular uptake of collagens and implications for immune cell regulation in disease","volume":"77","author":"Jurgensen","year":"2020","journal-title":"Cell Mol Life Sci"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.12.1455","article-title":"Systemic and neurologic abnormalities distinguish the lysosomal disorders sialidosis and galactosialidosis in mice","volume":"11","author":"de Geest","year":"2002","journal-title":"Hum Mol Genet"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2016\/19528.8561","article-title":"Lymph node fibrosis in a case of primary lymphoedema- A report of two cases","volume":"10","author":"Masamatti","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"B78","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41581-018-0050-2","article-title":"Lymph node fibrosis after ischaemic injury","volume":"14","author":"Wang","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.768412","article-title":"Kidney-draining lymph node fibrosis following unilateral ureteral obstruction","volume":"12","author":"Li","year":"2021","journal-title":"Front Immunol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.v9i51","article-title":"Fibrosis in metastatic lymph nodes is clinically correlated to poor prognosis in colorectal cancer","volume":"9","author":"Ikuta","year":"2018","journal-title":"Oncotarget"},{"key":"B81","doi-asserted-by":"publisher","first-page":"e9703","DOI":"10.1097\/MD.0000000000009703","article-title":"Prognostic value of fibrosis ratio in metastatic lymph nodes of node-positive advanced gastric cancer","volume":"97","author":"Hong","year":"2018","journal-title":"Med (Baltimore)"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97377","article-title":"Lymphoid tissue fibrosis is associated with impaired vaccine responses","volume":"128","author":"Kityo","year":"2018","journal-title":"J Clin Invest"},{"key":"B83","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3390\/ijms17030320","article-title":"CD86(+)\/CD206(+), diametrically polarized tumor-associated macrophages, predict hepatocellular carcinoma patient prognosis","volume":"17","author":"Dong","year":"2016","journal-title":"Int J Mol Sci"},{"key":"B84","doi-asserted-by":"publisher","first-page":"e8458","DOI":"10.7717\/peerj.8458","article-title":"CD86(+)\/CD206(+) tumor-associated macrophages predict prognosis of patients with intrahepatic cholangiocarcinoma","volume":"8","author":"Sun","year":"2020","journal-title":"PeerJ"},{"key":"B85","doi-asserted-by":"publisher","first-page":"e20190103","DOI":"10.1084\/jem.20190103","article-title":"Transforming growth factor-beta in tissue fibrosis","volume":"217","author":"Frangogiannis","year":"2020","journal-title":"J Exp Med"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00624.2012","article-title":"Macrophage-specific deletion of transforming growth factor-beta1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury","volume":"305","author":"Huen","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"e2250355","DOI":"10.1002\/eji.202250355","article-title":"Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages","volume":"53","author":"D\u2019Rozario","year":"2023","journal-title":"Eur J Immunol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2021.06.006","article-title":"Lymph node fibroblastic reticular cells steer immune responses","volume":"42","author":"Li","year":"2021","journal-title":"Trends Immunol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.v7i26","article-title":"Lymphatic endothelial cells attenuate inflammation via suppression of dendritic cell maturation","volume":"7","author":"Christiansen","year":"2016","journal-title":"Oncotarget"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aar8356","article-title":"PD-1 up-regulation on CD4(+) T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-beta1 production","volume":"10","author":"Celada","year":"2018","journal-title":"Sci Transl Med"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040254","article-title":"Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes","volume":"200","author":"Katakai","year":"2004","journal-title":"J Exp Med"},{"key":"B92","doi-asserted-by":"publisher","first-page":"2810","DOI":"10.1016\/j.celrep.2019.10.103","article-title":"Fibroblastic reticular cells control conduit matrix deposition during lymph node expansion","volume":"29","author":"Martinez","year":"2019","journal-title":"Cell Rep"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-022-09748-8","article-title":"WDR74 facilitates TGF-beta\/Smad pathway activation to promote M2 macrophage polarization and diabetic foot ulcer wound healing in mice","volume":"39","author":"Geng","year":"2023","journal-title":"Cell Biol Toxicol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701325","article-title":"TGF-beta1 suppresses the type I IFN response and induces mitochondrial dysfunction in alveolar macrophages","volume":"200","author":"Grunwell","year":"2018","journal-title":"J Immunol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201489293","article-title":"Chronic exposure to TGFbeta1 regulates myeloid cell inflammatory response in an IRF7-dependent manner","volume":"33","author":"Cohen","year":"2014","journal-title":"EMBO J"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.120.000223","article-title":"Therapeutic effect of neuraminidase-1-selective inhibition in mouse models of bleomycin-induced pulmonary inflammation and fibrosis","volume":"376","author":"Luzina","year":"2021","journal-title":"J Pharmacol Exp Ther"},{"key":"B97","doi-asserted-by":"publisher","first-page":"15069","DOI":"10.1038\/s41598-017-15198-8","article-title":"Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model","volume":"7","author":"Karhadkar","year":"2017","journal-title":"Sci Rep"},{"key":"B98","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/sj.cdd.4400680","article-title":"Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes","volume":"7","author":"Hart","year":"2000","journal-title":"Cell Death Differ"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.292888","article-title":"NEU1 sialidase expressed in human airway epithelia regulates epidermal growth factor receptor (EGFR) and MUC1 protein signaling","volume":"287","author":"Lillehoj","year":"2012","journal-title":"J Biol Chem"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194805","article-title":"Emergence of MUC1 in mammals for adaptation of barrier epithelia","volume":"14","author":"Kufe","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1002\/(ISSN)1098-1004","article-title":"Molecular pathology of NEU1 gene in sialidosis","volume":"22","author":"Seyrantepe","year":"2003","journal-title":"Hum Mutat"},{"key":"B102","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/1750-1172-8-114","article-title":"Galactosialidosis: review and analysis of CTSA gene mutations","volume":"8","author":"Caciotti","year":"2013","journal-title":"Orphanet J Rare Dis"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1462853\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T04:36:59Z","timestamp":1726202219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1462853\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,13]]},"references-count":102,"alternative-id":["10.3389\/fimmu.2024.1462853"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1462853","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,13]]},"article-number":"1462853"}}