{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:58:15Z","timestamp":1753891095292,"version":"3.41.2"},"reference-count":131,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Periodontitis is a highly prevalent chronic disease. Despite decades of extensive research on the topic, a complete understanding of its immunopathogenesis, especially when linked to other inflammatory comorbidities, is lacking. <jats:italic>Ex vivo<\/jats:italic> human and <jats:italic>in vivo<\/jats:italic> animal experiments have shown the host inflammatory response\u2019s crucial role in both the disease\u2019s onset and its systemic implications. These approaches, however, remain questionable when translating these findings into real-world scenarios linked to periodontitis. A clear need for new <jats:italic>in vivo<\/jats:italic> human models is discussed, especially within the context of understanding the host response to key pathogens linked to periodontitis, such as <jats:italic>Porphyromonas gingivalis<\/jats:italic> (<jats:italic>P. gingivalis<\/jats:italic>). Therefore, a skin blister model was employed to describe the stages of the host immune response in humans after challenges by microbial and\/or sterile insults. A novel human challenge model using UV-killed <jats:italic>P. gingivalis<\/jats:italic> holds promise in producing new evidence and bridging the gap of the host response to periodontitis and its links with other common chronic diseases.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1469828","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T05:10:10Z","timestamp":1734325810000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The translational potential of inflammation-induced skin blister human models in exploring the pathogenesis of periodontitis and its systemic health implications"],"prefix":"10.3389","volume":"15","author":[{"given":"Rizky 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