{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:23:49Z","timestamp":1760081029914,"version":"3.41.2"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Anti-GQ1b antibody syndrome is a spectrum of autoimmune disorders affecting nervous systems. We report a case of a 53-year-old woman presenting mydriasis with acute onset of periorbital pain, photophobia, and subsequently, diplopia. Despite weakly positive anti-GQ1b IgG antibody, the patient exhibited atypical features with isolated ophthalmoplegia and absence of classic Miller-Fisher syndrome triad. Symptoms improved spontaneously without specific immunotherapy. This case highlights the variable clinical presentations of anti-GQ1b antibody syndrome, emphasizing the importance of considering this diagnosis in patients with unexplained iris abnormalities and ophthalmoplegia.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1474354","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T05:10:26Z","timestamp":1734412226000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case report on anti-GQ1b antibody syndrome: initial symptoms of pupil palsy and periorbital pain"],"prefix":"10.3389","volume":"15","author":[{"given":"Yang","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.1.50","article-title":"Anti-GQ1b IgG antibody syndrome: clinical and immunological range","volume":"70","author":"Odaka","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324266.95814.74","article-title":"Acute ophthalmoplegia (without ataxia) associated with anti-GQ1b antibody","volume":"71","author":"Lee","year":"2008","journal-title":"Neurology"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.8.1104","article-title":"Clinical features and prognosis of Miller Fisher syndrome","volume":"56","author":"Mori","year":"2001","journal-title":"Neurology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1186\/s12883-022-02939-0","article-title":"Benign food-borne type B botulism presenting as unilateral internal ophthalmoplegia: a case report","volume":"22","author":"Crescenzo","year":"2022","journal-title":"BMC Neurol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e38137","DOI":"10.7759\/cureus.38137","article-title":"West nile virus (WNV) infection-associated acute flaccid paralysis with ophthalmoplegia","volume":"15","author":"Adidam Venkata","year":"2023","journal-title":"Cureus"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-023-11634-0","article-title":"Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD) - revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). 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