{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T01:35:23Z","timestamp":1789263323874,"version":"build-2803163510"},"reference-count":212,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Ferroptosis, a form of regulated cell death distinct from apoptosis, necrosis, and autophagy, is increasingly recognized for its role in skin disease pathology. Characterized by iron accumulation and lipid peroxidation, ferroptosis has been implicated in the progression of various skin conditions, including psoriasis, photosensitive dermatitis, and melanoma. This review provides an in-depth analysis of the molecular mechanisms underlying ferroptosis and compares its cellular effects with other forms of cell death in the context of skin health and disease. We systematically examine the role of ferroptosis in five specific skin diseases, including ichthyosis, psoriasis, polymorphous light eruption (PMLE), vitiligo, and melanoma, detailing its influence on disease pathogenesis and progression. Moreover, we explore the current clinical landscape of ferroptosis-targeted therapies, discussing their potential in managing and treating skin diseases. Our aim is to shed light on the therapeutic potential of modulating ferroptosis in skin disease research and practice.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1485523","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:33:34Z","timestamp":1728002014000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Unveiling ferroptosis: a new frontier in skin disease research"],"prefix":"10.3389","volume":"15","author":[{"given":"Ke","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-024-09917-9","article-title":"Ic100, a humanized therapeutic monoclonal anti-asc antibody alleviates oxygen-induced retinopathy in mice","volume":"27","author":"Yuan","year":"2024","journal-title":"Angiogenesis"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adn4556","article-title":"Targeting the postsynaptic scaffolding protein psd-95 enhances bdnf signaling to mitigate depression-like behaviors in mice","volume":"17","author":"Shi","year":"2024","journal-title":"Sci Signaling"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/nph.16636","article-title":"Ferroptosis contributes to developmental cell death in rice blast","volume":"227","author":"Shen","year":"2020","journal-title":"New Phytol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56580","article-title":"Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging caenorhabditis elegans","volume":"9","author":"Jenkins","year":"2020","journal-title":"eLife"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202402073","article-title":"Self-assembled fe-phenolic acid network synergizes with ferroptosis to enhance tumor nanotherapy","author":"Chen","year":"2024","journal-title":"Small (Weinheim an der Bergstrasse Germany)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102541","article-title":"Inhibition of ferroptosis promotes retina ganglion cell survival in experimental optic neuropathies","volume":"58","author":"Guo","year":"2022","journal-title":"Redox Biol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrs116","article-title":"Effects of low-dose heavy ions on embryonic development in mice and on melanocyte differentiation in the epidermis and hair bulb","volume":"54","author":"Hirobe","year":"2013","journal-title":"J Radiat Res"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2024.130703","article-title":"Synergistic improvement of humus formation in compost residue by fenton-like and effective microorganism composite agents","volume":"400","author":"Zhuo Cai","year":"2024","journal-title":"Biores Technol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s13046-024-03061-4","article-title":"Plag1 interacts with gpx4 to conquer vulnerability to sorafenib induced ferroptosis through a pvt1\/mir-195-5p axis-dependent manner in hepatocellular carcinoma","volume":"43","author":"Li","year":"2024","journal-title":"J Exp Clin Cancer research: CR"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c01134","article-title":"Quercetin inhibits neuronal pyroptosis and ferroptosis by modulating microglial M1\/M2 polarization in atherosclerosis","volume":"72","author":"Li","year":"2024","journal-title":"J Agric Food Chem"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3495","article-title":"Iron and cancer: more ore to be mined","volume":"13","author":"Torti","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00985.x","article-title":"Ferroportin 1 is expressed basolaterally in rat kidney proximal tubule cells and iron excess increases its membrane trafficking","volume":"15","author":"Wolff","year":"2011","journal-title":"J Cell Mol Med"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-740092","article-title":"Momelotinib inhibits acvr1\/alk2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents","volume":"129","author":"Asshoff","year":"2017","journal-title":"Blood"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae284","article-title":"Impact of egfr and mek inhibition on hair follicles: partial hair follicle immune privilege collapse and excessive il-33 secretion","author":"Fukuda","year":"2024","journal-title":"Br J Dermatol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12929-024-01005-w","article-title":"Hesperetin activates cisd2 to attenuate senescence in human keratinocytes from an older person and rejuvenates naturally aged skin in mice","volume":"31","author":"Shen","year":"2024","journal-title":"J Biomed Sci"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.17551","article-title":"Ferrostatin-1 inhibits fibroblast fibrosis in keloid by inhibiting ferroptosis","volume":"12","author":"Yang","year":"2024","journal-title":"PeerJ"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2400426121","article-title":"Myxococcus xanthus encapsulin cargo protein encd is a flavin-binding protein with ferric reductase activity","volume":"121","author":"Eren","year":"2024","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12484","article-title":"Mitochondrial dysfunction: A neglected component of skin diseases","volume":"23","author":"Feichtinger","year":"2014","journal-title":"Exp Dermatol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1186\/s12951-024-02508-2","article-title":"Iron (Ii)-based metal-organic framework nanozyme for boosting tumor ferroptosis through inhibiting DNA damage repair and system xc()","volume":"22","author":"Xue","year":"2024","journal-title":"J nanobiotechnol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.17.11455","article-title":"Cloning and expression of a plasma membrane cystine\/glutamate exchange transporter composed of two distinct proteins","volume":"274","author":"Sato","year":"1999","journal-title":"J Biol Chem"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.03.019","article-title":"Ironing out the role of ferroptosis in immunity","volume":"57","author":"Bell","year":"2024","journal-title":"Immunity"},{"key":"B23","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.1016\/j.molcel.2023.08.004","article-title":"Lysosomal cystine governs ferroptosis sensitivity in cancer via cysteine stress response","volume":"83","author":"Swanda","year":"2023","journal-title":"Mol Cell"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s13534-024-00378-z","article-title":"Enhancing pressure ulcer healing and tissue regeneration by using N-acetyl-cysteine loaded carboxymethyl cellulose\/gelatin\/sodium alginate hydrogel","volume":"14","author":"Aldaghi","year":"2024","journal-title":"Biomed Eng Lett"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1344878","article-title":"Tick cysteine protease inhibitors suppress immune responses in mannan-induced psoriasis-like inflammation","volume":"15","author":"Wu","year":"2024","journal-title":"Front Immunol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202404073","article-title":"Selenoi functions as a key modulator of ferroptosis pathway in colitis and colorectal cancer","volume":"11","author":"Huang","year":"2024","journal-title":"Advanced Sci (Weinheim Baden-Wurttemberg Germany)"},{"key":"B27","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1089\/ars.2017.7115","article-title":"Gpx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues","volume":"29","author":"Maiorino","year":"2018","journal-title":"Antioxid Redox Signal"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103165","article-title":"Modeling ferroptosis in human dopaminergic neurons: pitfalls and opportunities for neurodegeneration research","volume":"73","author":"Renner","year":"2024","journal-title":"Redox Biol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2008.02.010","article-title":"Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-ras-harboring cancer cells","volume":"15","author":"Yang","year":"2008","journal-title":"Chem Biol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109235","article-title":"The glutathione peroxidase gpx4 prevents lipid peroxidation and ferroptosis to sustain treg cell activation and suppression of antitumor immunity","volume":"35","author":"Xu","year":"2021","journal-title":"Cell Rep"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.09.002","article-title":"Driving adult tissue repair via re-engagement of a pathway required for fetal healing","volume":"31","author":"Ghatak","year":"2023","journal-title":"Mol Ther"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1038\/s41467-024-46718-6","article-title":"Regulation of meiotic telomere dynamics through membrane fluidity promoted by adipor2-elovl2","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat Commun"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B34","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic pes navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat Chem Biol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1179877","article-title":"Single-cell transcriptomic landscape of immunometabolism reveals intervention candidates of ascorbate and aldarate metabolism, fatty-acid degradation and pufa metabolism of T-cell subsets in healthy controls, psoriasis and psoriatic arthritis","volume":"14","author":"Peng","year":"2023","journal-title":"Front Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"4482","DOI":"10.3390\/ijms23094482","article-title":"Free fatty acid receptor 4 (Ffa4) activation ameliorates imiquimod-induced psoriasis in mice","volume":"23","author":"Son","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B37","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3390\/antiox13030276","article-title":"Comparison of the regenerative metabolic efficiency of lipid extracts from microalgae nannochloropsis oceanica and chlorococcum amblystomatis on fibroblasts","volume":"13","author":"Stasiewicz","year":"2024","journal-title":"Antioxid (Basel Switzerland)"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1159\/000538106","article-title":"A deep insight into ferroptosis in renal disease: facts and perspectives","volume":"10","author":"Han","year":"2024","journal-title":"Kidney Dis (Basel Switzerland)"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1440309","article-title":"Ferroptosis: A novel mechanism of cell death in ophthalmic conditions","volume":"15","author":"Yang","year":"2024","journal-title":"Front Immunol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.2147\/jir.S432111","article-title":"Targeting ferroptosis in bone-related diseases: facts and perspectives","volume":"16","author":"Chen","year":"2023","journal-title":"J Inflammation Res"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1424954","article-title":"Ferroptosis and hepatocellular carcinoma: the emerging role of lncrnas","volume":"15","author":"Chen","year":"2024","journal-title":"Front Immunol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.06.025","article-title":"A streptococcus pneumoniae endolysin mutant protein \u0394a146ply elicits rapid broad-spectrum mucosal protection in mice via upregulation of gpx4 through tlr4\/irg1\/nrf2 to alleviate macrophage ferroptosis","volume":"222","author":"Yuan","year":"2024","journal-title":"Free Radical Biol Med"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c00969","article-title":"Physiologically based kinetic modeling-facilitated quantitative in vitro to in vivo extrapolation to predict the effects of aloe-emodin in rats and humans","volume":"72","author":"Ren","year":"2024","journal-title":"J Agric Food Chem"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103261","article-title":"Mutant nrf2(E79q) enhances the promotion and progression of a subset of oncogenic ras keratinocytes and skin tumors","volume":"75","author":"Witherspoon","year":"2024","journal-title":"Redox Biol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112617","article-title":"Oleanolic acid alleviating ischemia-reperfusion injury in rat severe steatotic liver via keap1\/nrf2\/are","volume":"138","author":"Pi","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/1061186x.2024.2374037","article-title":"S-(N,N-Diethyldithiocarbamoyl)-N-Acetyl-L-Cysteine for the Treatment of Non-Small Cell Lung Cancer through Regulating Nf-Kb Signaling Pathway without Neurotoxicity","author":"Lv","year":"2024","journal-title":"J Drug Targeting"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.03.005","article-title":"A clinical-stage nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis","volume":"36","author":"Dong","year":"2024","journal-title":"Cell Metab"},{"key":"B48","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s13659-024-00454-y","article-title":"Pacidusin B isolated from phyllanthus acidus triggers ferroptotic cell death in ht1080 cells","volume":"14","author":"Zhu","year":"2024","journal-title":"Natural products bioprospecting"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176699","article-title":"Atorvastatin ameliorates diabetic nephropathy through inhibiting oxidative stress and ferroptosis signaling","volume":"976","author":"Zhang","year":"2024","journal-title":"Eur J Pharmacol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155815","article-title":"[amp]]Gamma;-mangosteen, an autophagy enhancer, prevents skin-aging via activating keap1\/nrf2 signaling and downregulating mapks\/ap-1\/nf-Kb-mediated mmps","volume":"132","author":"Kim","year":"2024","journal-title":"Phytomed: Int J phytother phytopharmacol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155676","article-title":"Salvianolic acid B protects against uvb-induced skin aging via activation of nrf2","volume":"130","author":"Sun","year":"2024","journal-title":"Phytomed: Int J phytother phytopharmacol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"748","DOI":"10.3390\/antiox13060748","article-title":"The antioxidant paplal protects against allergic contact dermatitis in experimental models","volume":"13","author":"Shibuya","year":"2024","journal-title":"Antioxid (Basel Switzerland)"},{"key":"B53","doi-asserted-by":"publisher","first-page":"817","DOI":"10.3390\/antiox13070817","article-title":"Ganoderma microsporum immunomodulatory protein alleviates inflammaging and oxidative stress in diabetes-associated periodontitis via nrf2 signaling activation: an in vitro study","volume":"13","author":"Su","year":"2024","journal-title":"Antioxid (Basel Switzerland)"},{"key":"B54","doi-asserted-by":"publisher","first-page":"733","DOI":"10.3390\/ph17060733","article-title":"Wound healing efficacy of cucurbitaceae seed oils in rats: comprehensive phytochemical, pharmacological, and histological studies tackling age\/rage and nrf2\/ho-1 cue","volume":"17","author":"Emad","year":"2024","journal-title":"Pharm (Basel Switzerland)"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1111\/all.15967","article-title":"Forsythia velutina nakai extract: A promising therapeutic option for atopic dermatitis through multiple cell type modulation","volume":"79","author":"Kwon","year":"2024","journal-title":"Allergy"},{"key":"B56","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/s41419-023-06234-9","article-title":"Sulforaphane alleviates psoriasis by enhancing antioxidant defense through keap1-nrf2 pathway activation and attenuating inflammatory signaling","volume":"14","author":"Ma","year":"2023","journal-title":"Cell Death Dis"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113295","article-title":"Keap1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance","volume":"42","author":"Zavitsanou","year":"2023","journal-title":"Cell Rep"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1097\/hc9.0000000000000396","article-title":"The cell fate regulator dach1 modulates ferroptosis through affecting P53\/slc25a37 signaling in fibrotic disease","volume":"8","author":"Guo","year":"2024","journal-title":"Hepatol Commun"},{"key":"B59","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s10020-023-00714-6","article-title":"Meteorin-like\/meteorin-B Protects lps-induced acute lung injury by activating sirt1-P53-slc7a11 mediated ferroptosis pathway","volume":"29","author":"Chen","year":"2023","journal-title":"Mol Med (Cambridge Mass)"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.06.020","article-title":"The involvement of irp2-induced ferroptosis through the P53-slc7a11-alox12 pathway in Parkinson\u2019s disease","volume":"222","author":"Yao","year":"2024","journal-title":"Free Radical Biol Med"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111954","article-title":"Harmine alleviated stz-induced rat diabetic nephropathy: A potential role via regulating ampk\/nrf2 pathway and deactivating ataxia-telangiectasia mutated (Atm) signaling","volume":"132","author":"Tabaa","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-024-01211-9","article-title":"Cordycepin ameliorates psoriasis-like skin lesion by regulating P53\/mdm2 feedback loop","author":"Chen","year":"2024","journal-title":"Mol Biotechnol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.2174\/0118715206302216240628072554","article-title":"Molecular targets of plant-based alkaloids and polyphenolics in liver and breast cancer- an insight into anticancer drug development","author":"Batool","year":"2024","journal-title":"Anti-cancer Agents medicinal Chem"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.65.8.11","article-title":"Bet bromodomain inhibition potentiates ocular melanoma therapy by inducing cell cycle arrest","volume":"65","author":"Chen","year":"2024","journal-title":"Invest Ophthalmol Visual Sci"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-024-09817-0","article-title":"Transcriptomic differences in medullary thyroid carcinoma according to grade","volume":"35","author":"Ruz-Caracuel","year":"2024","journal-title":"Endocr Pathol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"13985","DOI":"10.1038\/s41598-024-64758-2","article-title":"Folic acid-modified nanocrystalline cellulose for enhanced delivery and anti-cancer effects of crocin","volume":"14","author":"Soltani","year":"2024","journal-title":"Sci Rep"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2024.112957","article-title":"Organic light-emitting diode therapy promotes longevity through the upregulation of sirt1 in senescence-accelerated mouse prone 8 mice","volume":"257","author":"Deng","year":"2024","journal-title":"J Photochem Photobiol B Biol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.32","article-title":"Hspb1 as a novel regulator of ferroptotic cancer cell death","volume":"34","author":"Sun","year":"2015","journal-title":"Oncogene"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-1979","article-title":"Hspa5 regulates ferroptotic cell death in cancer cells","volume":"77","author":"Zhu","year":"2017","journal-title":"Cancer Res"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c00870","article-title":"Mitochondria-mediated hsp inhibition strategy for enhanced low-temperature photothermal therapy","volume":"15","author":"Liu","year":"2023","journal-title":"ACS Appl mater interf"},{"key":"B71","doi-asserted-by":"publisher","first-page":"9635","DOI":"10.3390\/ijms24119635","article-title":"Skeletal muscle-specific bis depletion leads to muscle dysfunction and early death accompanied by impairment in protein quality control","volume":"24","author":"Jung","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c00873","article-title":"Cancer cell-mimicking prussian blue nanoplatform for synergistic mild photothermal\/chemotherapy via heat shock protein inhibition","author":"Wang","year":"2024","journal-title":"ACS Appl mater interf"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-018-0920-3","article-title":"Characteristics of accstip1 in apis cerana cerana and its role during oxidative stress responses","volume":"23","author":"Zhai","year":"2018","journal-title":"Cell Stress chaperones"},{"key":"B74","doi-asserted-by":"publisher","first-page":"6692","DOI":"10.1038\/s41598-023-33799-4","article-title":"Forensic application of epidermal expression of hsp27 and hsp70 for the determination of wound vitality in human compressed neck skin","volume":"13","author":"Zhang","year":"2023","journal-title":"Sci Rep"},{"key":"B75","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.msec.2018.10.061","article-title":"Structure-based drug designing and identification of woodfordia fruticosa inhibitors targeted against heat shock protein (Hsp70-1) as suppressor for imiquimod-induced psoriasis like skin inflammation in mice model","volume":"95","author":"Raghuwanshi","year":"2019","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050212","article-title":"Immunohistochemical characterization of hsp, alpha-msh, merkel cells and neuronal markers in acute uv dermatitis and acute contact dermatitis in vivo","volume":"46","author":"Bayerl","year":"1997","journal-title":"Inflammation Res"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.03.015","article-title":"Idebenone alleviates doxorubicin-induced cardiotoxicity by stabilizing fsp1 to inhibit ferroptosis","volume":"14","author":"Qiu","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"B78","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.1016\/j.cell.2023.05.003","article-title":"Ferroptosis surveillance independent of gpx4 and differentially regulated by sex hormones","volume":"186","author":"Liang","year":"2023","journal-title":"Cell"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.641498","article-title":"Apoptosis-inducing factor (Aif) and its family member protein, amid, are rotenone-sensitive nadh: ubiquinone oxidoreductases (Ndh-2)","volume":"290","author":"Elguindy","year":"2015","journal-title":"J Biol Chem"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1705-2","article-title":"The coq oxidoreductase fsp1 acts parallel to gpx4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1159\/000445613","article-title":"Multiple directional differentiation difference of neonatal rat fibroblasts from six organs","volume":"39","author":"Chang","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.2147\/ccid.S433071","article-title":"Variation of ferroptosis-related markers in hacat cell photoaging models induced by uvb","volume":"16","author":"Zhang","year":"2023","journal-title":"Clinical cosmetic investig Dermatol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.11.017","article-title":"Fsp1+ Fibroblasts promote skin carcinogenesis by maintaining mcp-1-mediated macrophage infiltration and chronic inflammation","volume":"178","author":"Zhang","year":"2011","journal-title":"Am J Pathol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1291099","article-title":"Gongying-jiedu-xiji recipe promotes the healing of venous ulcers by inhibiting ferroptosis via the coq-fsp1 axis","volume":"14","author":"Lu","year":"2023","journal-title":"Front Pharmacol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c02912","article-title":"The flavonoid glycoside from abrus cantoniensis hance alleviates alcoholic liver injury by inhibiting ferroptosis in an ampk-dependent manner","volume":"72","author":"Zhang","year":"2024","journal-title":"J Agric Food Chem"},{"key":"B86","doi-asserted-by":"publisher","first-page":"9453","DOI":"10.3390\/ijms22179453","article-title":"New insight into the effects of metformin on diabetic retinopathy, aging and cancer: nonapoptotic cell death, immunosuppression, and effects beyond the ampk pathway","volume":"22","author":"Hsu","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2024.2374692","article-title":"Metabolic stress induces a double-positive feedback loop between ampk and sqstm1\/P62 conferring dual activation of ampk and nfe2l2\/nrf2 to synergize antioxidant defense","author":"Choi","year":"2024","journal-title":"Autophagy"},{"key":"B88","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/s41392-020-00297-2","article-title":"Lkb1-ampk axis negatively regulates ferroptosis by inhibiting fatty acid synthesis","volume":"5","author":"Li","year":"2020","journal-title":"Signal transduct target Ther"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-0461-8","article-title":"Energy-stress-mediated ampk activation inhibits ferroptosis","volume":"22","author":"Lee","year":"2020","journal-title":"Nat Cell Biol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8198","article-title":"Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the ampk-mtor-tfeb axis","volume":"38","author":"Gu","year":"2024","journal-title":"Phytother research: PTR"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102398","article-title":"Neolignans in magnolia officinalis as natural anti-Alzheimer\u2019s disease agents: A systematic review","volume":"99","author":"Li","year":"2024","journal-title":"Ageing Res Rev"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115815","article-title":"Madecassoside ameliorates hepatic steatosis in high-fat diet-fed mice through ampk\/autophagy-mediated suppression of er stress","volume":"217","author":"Choi","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwad227","article-title":"Ythdf2-mediated regulations bifurcate bhpf-induced programmed cell deaths","volume":"10","author":"Lin","year":"2023","journal-title":"Natl Sci Rev"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176379","article-title":"Mechanisms underlying the efficacy and limitation of dopa and tetrahydrobiopterin therapies for the deficiency of gtp cyclohydrolase 1 revealed in a novel mouse model","volume":"967","author":"Jiang","year":"2024","journal-title":"Eur J Pharmacol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-024-01208-z","article-title":"Tetrahydrobiopterin Metabolism Attenuates Ros Generation and Radiosensitivity through Ldha S-Nitrosylation: Novel Insight into Radiogenic Lung Injury","volume":"56","author":"Feng","year":"2024","journal-title":"Exp Mol Med"},{"key":"B96","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1007\/s00284-024-03770-1","article-title":"In vivo and in vitro mitigation of salmonella typhimurium isolates by fortunella japonica fruit extract","volume":"81","author":"Alotaibi","year":"2024","journal-title":"Curr Microbiol"},{"key":"B97","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","article-title":"Gtp cyclohydrolase 1\/tetrahydrobiopterin counteract ferroptosis through lipid remodeling","volume":"6","author":"Kraft","year":"2020","journal-title":"ACS Cent Sci"},{"key":"B98","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/s41419-024-06842-z","article-title":"Nos2-derived low levels of no drive psoriasis pathogenesis","volume":"15","author":"K\u00f6hler","year":"2024","journal-title":"Cell Death Dis"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.02.017","article-title":"A combined nanotherapeutic approach targeting farnesoid X receptor, ferroptosis, and fibrosis for nonalcoholic steatohepatitis treatment","volume":"14","author":"Fu","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.10.023","article-title":"Polymorphisms in the gtp cyclohydrolase gene (Gch1) are associated with ratings of capsaicin pain","volume":"141","author":"Campbell","year":"2009","journal-title":"Pain"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.85454","article-title":"Effects of DNA, rna, and protein methylation on the regulation of ferroptosis","volume":"19","author":"Wang","year":"2023","journal-title":"Int J Biol Sci"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefro.2020.03.005","article-title":"Ferroptosis and kidney disease","volume":"40","author":"Martin-Sanchez","year":"2020","journal-title":"Nefrol (Engl Ed)"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6654887","article-title":"The cross-link between ferroptosis and kidney diseases","volume":"2021","author":"Wang","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"B104","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s11255-019-02335-7","article-title":"Ferroptosis and kidney diseases","volume":"52","author":"Tang","year":"2020","journal-title":"Int Urol Nephrol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.84710","article-title":"Mitochondrial defects caused by parl deficiency lead to arrested spermatogenesis and ferroptosis","volume":"12","author":"Radaelli","year":"2023","journal-title":"eLife"},{"key":"B106","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1186\/s12967-023-04432-9","article-title":"Glutathione peroxidase 3 induced mitochondria-mediated apoptosis via ampk\/erk1\/2 pathway and resisted autophagy-related ferroptosis via ampk\/mtor pathway in hyperplastic prostate","volume":"21","author":"Li","year":"2023","journal-title":"J Trans Med"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.979678","article-title":"Tap the sap - investigation of latex-bearing plants in the search of potential anticancer biopharmaceuticals","volume":"13","author":"Mazur","year":"2022","journal-title":"Front Plant Sci"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2009.01.028","article-title":"Distinguishing between apoptosis and necrosis using a capacitance sensor","volume":"24","author":"Lee","year":"2009","journal-title":"Biosens bioelectron"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.01.030","article-title":"Simultaneous induction of apoptotic, autophagic, and necrosis-like cell death by monoclonal antibodies recognizing chicken transferrin receptor","volume":"367","author":"Ohno","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.05.001","article-title":"An ultrasound-activated nanoplatform remodels tumor microenvironment through diverse cell death induction for improved immunotherapy","volume":"370","author":"Ma","year":"2024","journal-title":"J Controlled release"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23741","article-title":"Alkaliptosis induction counteracts paclitaxel-resistant ovarian cancer cells via atp6v0d1-mediated abcb1 inhibition","volume":"63","author":"Chen","year":"2024","journal-title":"Mol carcinogen"},{"key":"B112","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3892\/mmr.2024.13242","article-title":"Gpx7 reduces chondrocyte inflammation and extracellular matrix degradation triggered by il\u22121\u03b2, via a mechanism mediated by ferroptosis","volume":"30","author":"Chen","year":"2024","journal-title":"Mol Med Rep"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112258","article-title":"The association between ferroptosis-related patterns and tumor microenvironment in colorectal cancer","volume":"134","author":"He","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102143","article-title":"Keratinocyte death by ferroptosis initiates skin inflammation after uvb exposure","volume":"47","author":"Vats","year":"2021","journal-title":"Redox Biol"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202402795","article-title":"Mapk signaling-mediated rfng phosphorylation and nuclear translocation restrain oxaliplatin-induced apoptosis and ferroptosis","author":"Di","year":"2024","journal-title":"Advanced Sci (Weinheim Baden-Wurttemberg Germany)"},{"key":"B116","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal transduct target Ther"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2023-330995","article-title":"The peptidoglycan recognition protein 1 confers immune evasive properties on pancreatic cancer stem cells","volume":"73","author":"L\u00f3pez-Gil","year":"2024","journal-title":"Gut"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.015609","article-title":"Neuronal death after hemorrhagic stroke in vitro and in vivo shares features of ferroptosis and necroptosis","volume":"48","author":"Zille","year":"2017","journal-title":"Stroke"},{"key":"B119","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/s41392-024-01772-w","article-title":"Targeting carnitine palmitoyl transferase 1a (Cpt1a) induces ferroptosis and synergizes with immunotherapy in lung cancer","volume":"9","author":"Ma","year":"2024","journal-title":"Signal transduct target Ther"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18076","article-title":"Loss of nephric augmenter of liver regeneration facilitates acute kidney injury via acsl4-mediated ferroptosis","volume":"28","author":"Huang","year":"2024","journal-title":"J Cell Mol Med"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2016.02.005","article-title":"Death is my heir\u201d\u2013ferroptosis connects cancer pharmacogenomics and ischemia-reperfusion injury","volume":"23","author":"Tonnus","year":"2016","journal-title":"Cell Chem Biol"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202309369","article-title":"New sight of renal toxicity caused by uv-aged polystyrene nanoplastics: induced ferroptosis via adsorption of transferrin","volume":"20","author":"He","year":"2024","journal-title":"Small (Weinheim an der Bergstrasse Germany)"},{"key":"B123","doi-asserted-by":"publisher","first-page":"688","DOI":"10.3390\/bioengineering11070688","article-title":"An experimental and clinical study of flap monitoring with an analysis of the clinical course of the flap using an infrared thermal camera","volume":"11","author":"Kim","year":"2024","journal-title":"Bioeng (Basel Switzerland)"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.124.046736","article-title":"Slc22a17 as a cell death-linked regulator of tight junctions in cerebral ischemia","volume":"55","author":"Li","year":"2024","journal-title":"Stroke"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103303","article-title":"Vitamin E and gpx4 cooperatively protect treg cells from ferroptosis and alleviate intestinal inflammatory damage in necrotizing enterocolitis","volume":"75","author":"Luo","year":"2024","journal-title":"Redox Biol"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2023.0490","article-title":"Nogo-B promotes endoplasmic reticulum stress-mediated autophagy in endothelial cells of diabetic nephropathy","author":"Zhang","year":"2024","journal-title":"Antioxid Redox Signaling"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2024.126141","article-title":"Visualization of polarity changes in endoplasmic reticulum (Er) autophagy and rheumatoid arthritis mice with near-infrared er-targeted fluorescent probe","volume":"275","author":"Li","year":"2024","journal-title":"Talanta"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2024.2341588","article-title":"The wolfram-like variant wfs1(E864k) destabilizes mam and compromises autophagy and mitophagy in human and mice","author":"Patergnani","year":"2024","journal-title":"Autophagy"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1187366","article-title":"Autophagy promotes ferroptosis by degradation of ferritin","volume":"12","author":"Hou","year":"2016","journal-title":"Autophagy"},{"key":"B130","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.semcancer.2019.03.002","article-title":"Ferroptosis is a type of autophagy-dependent cell death","volume":"66","author":"Zhou","year":"2020","journal-title":"Semin Cancer Biol"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.135550","article-title":"Ferritin-dependent cellular autophagy pathway promotes ferroptosis in beef during cold storage","volume":"412","author":"Liu","year":"2023","journal-title":"Food Chem"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-024-01238-0","article-title":"Impaired autophagy in myeloid cells aggravates psoriasis-like skin inflammation through the il-1\u03b2\/cxcl2\/neutrophil axis","volume":"14","author":"Lee","year":"2024","journal-title":"Cell biosci"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116256","article-title":"Celastrol regulates psoriatic inflammation and autophagy by targeting il-17a","volume":"172","author":"Park","year":"2024","journal-title":"Biomed pharmacother = Biomed pharmacother"},{"key":"B134","doi-asserted-by":"publisher","first-page":"5387","DOI":"10.3390\/ijms25105387","article-title":"Deciphering the genetic links between psychological stress, autophagy, and dermatological health: insights from bioinformatics, single-cell analysis, and machine learning in psoriasis and anxiety disorders","volume":"25","author":"Liu","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae248","article-title":"Confetti cure: reversing the genetic kaleidoscope of ichthyosis","volume":"191","author":"Fischer","year":"2024","journal-title":"Br J Dermatol"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae193","article-title":"Treating epidermolytic ichthyosis and ichthyosis with confetti with epidermal autografts cultured from revertant skin","volume":"191","author":"Tanahashi","year":"2024","journal-title":"Br J Dermatol"},{"key":"B137","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.redox.2015.08.006","article-title":"The role of lipoxygenases in pathophysiology; new insights and future perspectives","volume":"6","author":"Mashima","year":"2015","journal-title":"Redox Biol"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2006.09.002","article-title":"Human and mouse elox3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin","volume":"455","author":"Yu","year":"2006","journal-title":"Arch Biochem biophys"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1079548","article-title":"Ferroptosis: mechanism and connections with cutaneous diseases","volume":"10","author":"Liu","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107263","article-title":"Histone methyltransferase mll4 protects against pressure overload-induced heart failure via a thbs4-mediated protection in er stress","volume":"205","author":"Meng","year":"2024","journal-title":"Pharmacol Res"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj9141","article-title":"Mll4 mediates differentiation and tumor suppression through ferroptosis","volume":"7","author":"Egolf","year":"2021","journal-title":"Sci Adv"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700825","article-title":"A mouse mutation in the 12r-lipoxygenase, alox12b, disrupts formation of the epidermal permeability barrier","volume":"127","author":"Moran","year":"2007","journal-title":"J Invest Dermatol"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.410","article-title":"Development of an ichthyosiform phenotype in alox12b-deficient mouse skin transplants","volume":"129","author":"de Juanes","year":"2009","journal-title":"J Invest Dermatol"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1111\/exd.15142","article-title":"The involvement of keratinocytes in pruritus of chronic inflammatory dermatosis","volume":"33","author":"Lin","year":"2024","journal-title":"Exp Dermatol"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-024-02103-5","article-title":"Biochanin a ameliorates imiquimod-induced psoriasis-like skin inflammation in mice by modulating the nf-Kb and mapk signaling pathways","author":"Walvekar","year":"2024","journal-title":"Inflammation"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103255","article-title":"Inhibition of ferroptosis rescues M2 macrophages and alleviates arthritis by suppressing the hmgb1\/tlr4\/stat3 axis in M1 macrophages","volume":"75","author":"Feng","year":"2024","journal-title":"Redox Biol"},{"key":"B147","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/s41419-021-04284-5","article-title":"Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation","volume":"12","author":"Shou","year":"2021","journal-title":"Cell Death Dis"},{"key":"B148","doi-asserted-by":"publisher","first-page":"10841","DOI":"10.3390\/ijms221910841","article-title":"Skin barrier dysregulation in psoriasis","volume":"22","author":"Orsmond","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.18632\/aging.206035","article-title":"Types of cell death and their relations to host immunological pathways","volume":"16","author":"Lu","year":"2024","journal-title":"Aging"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155917","article-title":"Tetrastigma hemsleyanum polysaccharides alleviate imiquimod-induced psoriasis-like skin lesions in mice by modulating the jak\/stat3 signaling pathway","volume":"133","author":"Lv","year":"2024","journal-title":"Phytomed: Int J phytother phytopharmacol"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1075804","article-title":"Dual targeting of mtor\/il-17a and autophagy by fisetin alleviates psoriasis-like skin inflammation","volume":"13","author":"Roy","year":"2022","journal-title":"Front Immunol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2023.08.012","article-title":"Beyond ferrostatin-1: A comprehensive review of ferroptosis inhibitors","volume":"44","author":"Scarpellini","year":"2023","journal-title":"Trends Pharmacol Sci"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202311733","article-title":"Transformable supramolecular self-assembled peptides for cascade self-enhanced ferroptosis primed cancer immunotherapy","volume":"36","author":"Wang","year":"2024","journal-title":"Advanced mater (Deerfield Beach Fla)"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101209","article-title":"Nir laser-activated phthalocyanine loaded lipid nanoparticles targeting M2 macrophage for improved photoacoustic imaging-guided photothermal therapy","volume":"28","author":"Peng","year":"2024","journal-title":"Mater Today Bio"},{"key":"B155","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.jaci.2010.12.009","article-title":"Human slan (6-sulfo lacnac) dendritic cells are inflammatory dermal dendritic cells in psoriasis and drive strong th17\/th1 T-cell responses","volume":"127","author":"H\u00e4nsel","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1111\/all.15538","article-title":"Delayed type hypersensitivity reactions to various allergens may differently model inflammatory skin diseases","volume":"78","author":"Pavel","year":"2023","journal-title":"Allergy"},{"key":"B157","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s12951-022-01360-6","article-title":"Biomimetic gbm-targeted drug delivery system boosting ferroptosis for immunotherapy of orthotopic drug-resistant gbm","volume":"20","author":"Liu","year":"2022","journal-title":"J nanobiotechnol"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1038\/srep12633","article-title":"Interleukin-35 administration counteracts established murine type 1 diabetes\u2013possible involvement of regulatory T cells","volume":"5","author":"Singh","year":"2015","journal-title":"Sci Rep"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01488","article-title":"Cla(+) T cell response to microbes in psoriasis","volume":"9","author":"De Jes\u00fas-Gil","year":"2018","journal-title":"Front Immunol"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17529","article-title":"Ferroptosis in tumor immunity and therapy","volume":"26","author":"Gong","year":"2022","journal-title":"J Cell Mol Med"},{"key":"B161","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1038\/s41467-021-21841-w","article-title":"Mtorc1 couples cyst(E)Ine availability with gpx4 protein synthesis and ferroptosis regulation","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat Commun"},{"key":"B162","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","article-title":"Selenium utilization by gpx4 is required to prevent hydroperoxide-induced ferroptosis","volume":"172","author":"Ingold","year":"2018","journal-title":"Cell"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210518","article-title":"Ferroptosis in infection, inflammation, and immunity","volume":"218","author":"Chen","year":"2021","journal-title":"J Exp Med"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2023.0360","article-title":"Tofacitinib: A treatment option for recalcitrant polymorphic light eruption and its mechanistic rationale","volume":"35","author":"Sardana","year":"2024","journal-title":"Dermatitis: contact atopic occupational Drug"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18364","article-title":"Association of polymorphous light eruption with nod-2 and tlr-5 gene polymorphisms","volume":"36","author":"Kurz","year":"2022","journal-title":"J Eur Acad Dermatol Venereol: JEADV"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12679","article-title":"Research progress of keratinocyte-programmed cell death in uv-induced skin photodamage","volume":"37","author":"Tang","year":"2021","journal-title":"Photodermatol photoimmunol photomed"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2021.166287","article-title":"Nmn recruits gsh to enhance gpx4-mediated ferroptosis defense in uv irradiation induced skin injury","volume":"1868","author":"Feng","year":"2022","journal-title":"Biochim Biophys Acta Mol basis Dis"},{"key":"B168","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/jdv.20252","article-title":"Punch grafting can be used as a supplementary treatment for perilesional halo after melanocyte grafting for vitiligo","volume":"20","author":"Luo","year":"2024","journal-title":"J Eur Acad Dermatol Venereol: JEADV"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.07.1449","article-title":"Jaad game changers: \u201cComorbid autoimmune diseases in patients with vitiligo: A cross-sectional study","author":"Friedman","year":"2024","journal-title":"J Am Acad Dermatol"},{"key":"B170","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1186\/s12967-022-03566-6","article-title":"Evidence of pyroptosis and ferroptosis extensively involved in autoimmune diseases at the single-cell transcriptome level","volume":"20","author":"Zhang","year":"2022","journal-title":"J Trans Med"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.839167","article-title":"Metabolomics signature and potential application of serum polyunsaturated fatty acids metabolism in patients with vitiligo","volume":"13","author":"Ye","year":"2022","journal-title":"Front Immunol"},{"key":"B172","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.freeradbiomed.2019.05.011","article-title":"Oxidative stress-induced il-15 trans-presentation in keratinocytes contributes to cd8(+) T cells activation via jak-stat pathway in vitiligo","volume":"139","author":"Chen","year":"2019","journal-title":"Free Radical Biol Med"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2017.1402303","article-title":"Levels of oxidative damage and proinflammatory cytokines are enhanced in patients with active vitiligo","volume":"51","author":"Mitra","year":"2017","journal-title":"Free Radical Res"},{"key":"B174","doi-asserted-by":"publisher","first-page":"624","DOI":"10.4103\/ijd.ijd_917_20","article-title":"Assessment of oxidative\/nitrosative stress and raftlin in vitiligo","volume":"67","author":"Mulayim","year":"2022","journal-title":"Indian J Dermatol"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16634","article-title":"Gata3 ameliorates melanocyte injuries in vitiligo through sirt3-mediated hmgb1 deacetylation","volume":"50","author":"Nie","year":"2023","journal-title":"J Dermatol"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201701242RR","article-title":"Il-17 induces cellular stress microenvironment of melanocytes to promote autophagic cell apoptosis in vitiligo","volume":"32","author":"Zhou","year":"2018","journal-title":"FASEB J"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8498472","article-title":"The role of oxidative stress in the pathogenesis of vitiligo: A culprit for melanocyte death","volume":"2022","author":"Xuan","year":"2022","journal-title":"Oxid Med Cell Longevity"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.2147\/ott.S254995","article-title":"The role of erastin in ferroptosis and its prospects in cancer therapy","volume":"13","author":"Zhao","year":"2020","journal-title":"OncoTargets Ther"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.06.090","article-title":"Improving melanoma reporting: the Ohio model","author":"DaCunha","year":"2024","journal-title":"J Am Acad Dermatol"},{"key":"B180","doi-asserted-by":"publisher","first-page":"6146","DOI":"10.1038\/s41467-024-50233-z","article-title":"The genetic evolution of acral melanoma","volume":"15","author":"Wang","year":"2024","journal-title":"Nat Commun"},{"key":"B181","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ccell.2019.12.007","article-title":"Epigenetic silencing of cdr1as drives igf2bp3-mediated melanoma invasion and metastasis","volume":"37","author":"Hanniford","year":"2020","journal-title":"Cancer Cell"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33262","article-title":"Loss of the cystine\/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice","volume":"147","author":"Sato","year":"2020","journal-title":"Int J Cancer"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12197","article-title":"Melanoma-derived extracellular vesicles mediate lymphatic remodeling and impair tumor immunity in draining lymph nodes","volume":"11","author":"Leary","year":"2022","journal-title":"J extracell vesicles"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2623-z","article-title":"Lymph protects metastasizing melanoma cells from ferroptosis","volume":"585","author":"Ubellacker","year":"2020","journal-title":"Nature"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1186\/s40170-022-00281-0","article-title":"Combined inhibition of hmgcoa reductase and mitochondrial complex I induces tumor regression of braf inhibitor-resistant melanomas","volume":"10","author":"de Groot","year":"2022","journal-title":"Cancer Metab"},{"key":"B186","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1038\/s41419-019-2143-7","article-title":"Aldo-keto reductases protect metastatic melanoma from er stress-independent ferroptosis","volume":"10","author":"Gagliardi","year":"2019","journal-title":"Cell Death Dis"},{"key":"B187","doi-asserted-by":"publisher","first-page":"4203","DOI":"10.3390\/ijms20174203","article-title":"Physiologically relevant oxygen concentration (6% O(2)) as an important component of the microenvironment impacting melanoma phenotype and melanoma response to targeted therapeutics in vitro","volume":"20","author":"Osrodek","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1170-y","article-title":"Cd8(+) T cells regulate tumor ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1172\/jci139434","article-title":"Tyro3 induces anti-pd-1\/pd-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis","volume":"131","author":"Jiang","year":"2021","journal-title":"J Clin Invest"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0314-0","article-title":"Targeting the upstream transcriptional activator of pd-L1 as an alternative strategy in melanoma therapy","volume":"37","author":"Zhu","year":"2018","journal-title":"Oncogene"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18306","article-title":"Deferoxamine topical cream superior to patch in rescuing radiation-induced fibrosis of unwounded and wounded skin","volume":"28","author":"Berry","year":"2024","journal-title":"J Cell Mol Med"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1393673","article-title":"Role of antioxidants supplementation in the treatment of atopic dermatitis: A critical narrative review","volume":"11","author":"De Simoni","year":"2024","journal-title":"Front Nutr"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1765","article-title":"Immunostimulatory effects of toll-like receptor ligands as adjuvants in establishing a novel mouse model for pemphigus vulgaris","volume":"14","author":"Gao","year":"2024","journal-title":"Clin Trans Med"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.167004","article-title":"Unraveling the molecular mechanisms of cell migration impairment and apoptosis associated with steroid sulfatase deficiency: implications for X-linked ichthyosis","volume":"1870","author":"Kwon","year":"2024","journal-title":"Biochim Biophys Acta Mol basis Dis"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17203","article-title":"Management of congenital ichthyoses: european guidelines of care, part one","volume":"180","author":"Mazereeuw-Hautier","year":"2019","journal-title":"Br J Dermatol"},{"key":"B196","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1186\/s13023-022-02430-6","article-title":"New developments in the molecular treatment of ichthyosis: review of the literature","volume":"17","author":"Joosten","year":"2022","journal-title":"Orphanet J rare Dis"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16882","article-title":"Management of congenital ichthyoses: european guidelines of care, part two","volume":"180","author":"Mazereeuw-Hautier","year":"2019","journal-title":"Br J Dermatol"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.7150\/thno.93764","article-title":"Energy competition remodels the metabolic glucose landscape of psoriatic epidermal cells","volume":"14","author":"Liu","year":"2024","journal-title":"Theranostics"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000003164","article-title":"Molecular and therapeutic landscape of ferroptosis in skin diseases","volume":"137","author":"Le","year":"2024","journal-title":"Chin Med J"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1407782","article-title":"Reactive oxygen species-responsive supramolecular deucravacitinib self-assembly polymer micelles alleviate psoriatic skin inflammation by reducing mitochondrial oxidative stress","volume":"15","author":"Yao","year":"2024","journal-title":"Front Immunol"},{"key":"B201","doi-asserted-by":"publisher","first-page":"e59140","DOI":"10.7759\/cureus.59140","article-title":"Lupus erythematosus tumidus as a distinct uncommon subtype of cutaneous lupus erythematosus: A case report and review","volume":"16","author":"Camisa","year":"2024","journal-title":"Cureus"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-024-01360-8","article-title":"A guideline on the molecular ecosystem regulating ferroptosis","volume":"26","author":"Dai","year":"2024","journal-title":"Nat Cell Biol"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.13032","article-title":"Altered expression of ferroptosis markers and iron metabolism reveals a potential role of ferroptosis in vitiligo","volume":"35","author":"Wu","year":"2022","journal-title":"Pigment Cell melanoma Res"},{"key":"B205","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/s12864-024-10147-y","article-title":"Identification and validation of rna-binding protein slc3a2 regulates melanocyte ferroptosis in vitiligo by integrated analysis of single-cell and bulk rna-sequencing","volume":"25","author":"Zhang","year":"2024","journal-title":"BMC Genomics"},{"key":"B206","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1186\/s12951-024-02624-z","article-title":"Correction: combination of ferroptosis and pyroptosis dual induction by triptolide nano-mofs for immunotherapy of melanoma","volume":"22","author":"Wang","year":"2024","journal-title":"J nanobiotechnol"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.07.002","article-title":"Erdafitinib promotes ferroptosis in human uveal melanoma by inducing ferritinophagy and lysosome biogenesis via modulating the fgfr1\/mtorc1\/tfeb signaling axis","volume":"222","author":"Zhu","year":"2024","journal-title":"Free Radical Biol Med"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.14960","article-title":"The erk5 pathway in brafv600e melanoma cells plays a role in development of acquired resistance to dabrafenib but not vemurafenib","volume":"598","author":"Mondru","year":"2024","journal-title":"FEBS Lett"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1080\/2162402x.2024.2376782","article-title":"Differential impact of genetic deletion of tigit or pd-1 on melanoma-specific T-lymphocytes","volume":"13","author":"Cadiou","year":"2024","journal-title":"Oncoimmunology"},{"key":"B210","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/pcmr.13009","article-title":"The role of ferroptosis in melanoma","volume":"35","author":"Talty","year":"2022","journal-title":"Pigment Cell melanoma Res"},{"key":"B211","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1186\/s12964-023-01296-w","article-title":"Targeting ferroptosis in melanoma: cancer therapeutics","volume":"21","author":"Khorsandi","year":"2023","journal-title":"Cell commun signal: CCS"},{"key":"B212","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.ccell.2018.03.017","article-title":"Multi-stage differentiation defines melanoma subtypes with differential vulnerability to drug-induced iron-dependent oxidative stress","volume":"33","author":"Tsoi","year":"2018","journal-title":"Cancer Cell"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1485523\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:33:37Z","timestamp":1728002017000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1485523\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,4]]},"references-count":212,"alternative-id":["10.3389\/fimmu.2024.1485523"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1485523","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,4]]},"article-number":"1485523"}}