{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T05:59:09Z","timestamp":1782194349201,"version":"3.54.5"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>To date, the pathogenesis of Kimura\u2019s disease remains unclear, there is no unified diagnostic criterion, the clinical phenotype shows considerable heterogeneity, and there is a lack of optimal treatment strategies. Due to its rarity, treatment strategies for KD are still under exploration. This paper reports a case of a 37-year-old Chinese female presenting with generalized erythematous papules and pruritic eruptions for 12 years, followed by the onset of limb swellings 3 years later, ultimately diagnosed as Kimura\u2019s disease. Considering the patient\u2019s multiple lymphadenopathies and limb swellings with concurrent atopic dermatitis, the treatment regimen included initial dupilumab dosage of 600 mg (300 mg administered in two injections), followed by subcutaneous injections of 300 mg every two weeks for four months. Concurrent oral corticosteroid therapy (methylprednisolone, initial dose 16 mg\/kg\/day, gradually tapered with tumor regression) was also administered. Following treatment, the patient did not experience severe adverse effects, and the multiple nodules markedly decreased in size. Additionally, serum IgE levels, eosinophil, and basophil counts showed significant reductions. These results demonstrate the significant efficacy of dupilumab combined with oral corticosteroids in treating Kimura\u2019s disease with concurrent atopic dermatitis.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1492547","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T04:31:15Z","timestamp":1729744275000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Dupilumab combined with corticosteroid therapy for Kimura disease with multiple systemic masses: a case report and literature review"],"prefix":"10.3389","volume":"15","author":[{"given":"Yansi","family":"Lyu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqian","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lvxin","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziping","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingkai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchun","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.5858\/2007-131-650-KD","article-title":"Kimura disease","volume":"131","author":"Abuel-Haija","year":"2007","journal-title":"Arch Pathol Lab Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s12893-020-00870-0","article-title":"Kimura\u2019s disease mimicking thoracic spine dumbbell neurogenic tumor: a case report and literature review","volume":"20","author":"Bi","year":"2020","journal-title":"BMC Surg"},{"key":"B3","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s12886-022-02378-y","article-title":"Kimura\u2019s disease successively affecting multiple body parts: a case-based literature review","volume":"22","author":"Yang","year":"2022","journal-title":"BMC Ophthalmol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.1002a30","article-title":"Remission of kimura disease with carotid hypervascularization after cyclosporine treatment","volume":"10","author":"Persechino","year":"2020","journal-title":"Dermatol Pract Concept"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-019-0673-7","article-title":"Clinical analysis of Kimura\u2019s disease in 24 cases from China","volume":"20","author":"Zhang","year":"2020","journal-title":"BMC Surg"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58121810","article-title":"A rare kimura\u2019s disease in the oral cavity with severe sleep apnea: case report and literature review","volume":"58","author":"Lei","year":"2022","journal-title":"Medicina (Kaunas)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050799","article-title":"Nephrotic syndrome associated with Kimura disease","volume":"14","author":"Rajpoot","year":"2000","journal-title":"Pediatr Nephrol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-023-00778-7","article-title":"A case of minimal change nephrotic syndrome complicated by Kimura disease treated with rituximab","volume":"12","author":"Yoshida","year":"2023","journal-title":"CEN Case Rep"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000003106","article-title":"Kimura disease of the thigh treated with surgical excision and dupilumab","volume":"88","author":"Huang","year":"2022","journal-title":"Ann Plast Surg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s13223-022-00683-1","article-title":"Kimura disease with Allergic Bronchopulmonary Aspergillosis: a case report","volume":"18","author":"Fan","year":"2022","journal-title":"Allergy Asthma Clin Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_373_19","article-title":"Mepolizumab as an effective treatment for Kimura\u2019s disease associated with ulcerative colitis: A case report","volume":"8","author":"Al Shammari","year":"2019","journal-title":"J Family Med Prim Care"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1080\/24725625.2020.1818366","article-title":"Is Kimura\u2019s disease associated with juvenile temporal arteritis? A case report and literature review of all juvenile temporal arteritis cases","volume":"5","author":"Tomizuka","year":"2021","journal-title":"Mod Rheumatol Case Rep"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/lahgfo","article-title":"Kimura\u2019s disease: clinical characteristics, management and outcome of 20 cases from China","volume":"40","author":"Zhang","year":"2022","journal-title":"Clin Exp Rheumatol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.7181\/acfs.2022.01053","article-title":"Current concepts of Kimura disease: pathophysiology and evolution of treatment","volume":"23","author":"Kim","year":"2022","journal-title":"Arch Craniofac Surg"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.1069102","article-title":"Kimura\u2019s disease: A clinicopathological study of 23 cases","volume":"9","author":"Lee","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e57811","DOI":"10.7759\/cureus.57811","article-title":"Repeated hemolytic streptococcal infections in soft tissue eosinophilic granulomatosis (Kimura\u2019s disease): A case report","volume":"16","author":"Togawa","year":"2024","journal-title":"Cureus"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e14858","DOI":"10.1111\/1756-185X.14858","article-title":"Kimura\u2019s disease as a mimicker of cavernous hemangioma: A case report and literature review","volume":"27","author":"Wen-Chieh","year":"2024","journal-title":"Int J Rheum Dis"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14858","article-title":"Diagnostic challenges in Kimura\u2019s disease","volume":"50","author":"Stuczynski","year":"2022","journal-title":"Pol Merkur Lekarski"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e34191","DOI":"10.1097\/MD.0000000000034191","article-title":"Diagnostic challenges and updated therapeutic strategies of Kimura\u2019s disease: A case report successfully treated by dupilumab and review","volume":"102","author":"Cordeil","year":"2023","journal-title":"Med (Baltimore)"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1997.tb01562.x","article-title":"In vivo expression of IL-4, IL-5, IL-13 and IFN-gamma mRNAs in peripheral blood mononuclear cells and effect of cyclosporin A in a patient with Kimura\u2019s disease","volume":"137","author":"Katagiri","year":"1997","journal-title":"Br J Dermatol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e417","DOI":"10.1016\/j.jaci.2022.03.034","article-title":"Distinct disease-specific Tfh cell populations in 2 different fibrotic diseases: IgG(4)-related disease and Kimura disease","author":"Munemura","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e15674","DOI":"10.1111\/dth.15674","article-title":"Dupilumab for recalcitrant Kimura disease","volume":"35","author":"Bellinato","year":"2022","journal-title":"Dermatol Ther"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcae048","article-title":"Efficacy and safety of dupilumab in the treatment of kimura\u2019s disease","volume":"117","author":"Liu","year":"2024","journal-title":"QJM."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303951","article-title":"Dupilumab for COPD with type 2 inflammation indicated by eosinophil counts","volume":"389","author":"Bhatt","year":"2023","journal-title":"N Engl J Med"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1492547\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T04:31:17Z","timestamp":1729744277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1492547\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,24]]},"references-count":24,"alternative-id":["10.3389\/fimmu.2024.1492547"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1492547","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,24]]},"article-number":"1492547"}}