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This review outlines the mechanisms of PSTPIP2 in chronic multifocal osteomyelitis (CMO), rheumatoid arthritis (RA), synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome, liver diseases, renal diseases, pressure ulcer sepsis and diabetic obesity. The mechanisms include inhibiting the IL-1\u03b2 inflammatory responses, NF-\u03baB, ERK phosphorylation etc., promoting Er\u03b2, and modulating the polarization of macrophage to prevent the inflammatory diseases. This review summarized current findings and offered perspectives on future research directions, laying a foundation for applying of PSTPIP2 in inflammatory diseases.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1492878","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T01:26:54Z","timestamp":1732584414000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Advances of the multifaceted functions of PSTPIP2 in inflammatory 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