{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:06:50Z","timestamp":1783508810865,"version":"3.55.0"},"reference-count":115,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Rheumatoid arthritis (RA) is an important autoimmune disease that affects synovial tissues, accompanied by redness, pain, and swelling as main symptoms, which will limit the quality of daily life and even cause disability. Multiple coupling effects among the various cells in the synovial micro-environment modulate the poor progression and development of diseases. Respectively, synovium is the primary target tissue of inflammatory articular pathologies; synovial hyperplasia, and excessive accumulation of immune cells lead to joint remodelling and destroyed function. In general, epigenetic modification is an effective strategy to regulate dynamic balance of synovial homeostasis. Several typical post-transcriptional changes in cellular RNA can control the post-transcriptional modification of RNA structure. It can inhibit important processes, including degradation of RNA and nuclear translocation. Recent studies have found that RNA modification regulates the homeostasis of the synovial micro-environment and forms an intricate network in the \u201cbone-cartilage-synovium\u201d feedback loop. Aberrant regulation of RNA methylation triggers the pathological development of RA. Collectively, this review summarises recent advanced research about RNA modification in modulating synovial homeostasis by making close interaction among resident synovial macrophages, fibroblasts, T cells, and B cells, which could display the dramatic role of RNA modifications in RA pathophysiological process and perform the promising therapeutic target for treating RA.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1494873","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T06:31:25Z","timestamp":1733725885000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Emerging influence of RNA post-transcriptional modifications in the synovial homeostasis of rheumatoid arthritis"],"prefix":"10.3389","volume":"15","author":[{"given":"Madiha","family":"Fatima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengmei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102400","article-title":"The etiology of rheumatoid arthritis","volume":"110","author":"Scherer","year":"2020","journal-title":"J Autoimmun"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0413-5","article-title":"Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes","volume":"16","author":"Nygaard","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.862161","article-title":"Synovial macrophage and fibroblast heterogeneity in joint homeostasis and inflammation","volume":"9","author":"Knab","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11061153","article-title":"The role of reactive oxygen species in the rheumatoid arthritis-associated synovial microenvironment","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxidants"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020905","article-title":"Rheumatoid arthritis: pathogenic roles of diverse immune cells","volume":"23","author":"Jang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108613","article-title":"The role of m6A RNA methylation in cancer","volume":"112","author":"Sun","year":"2019","journal-title":"Biomedicine Pharmacotherapy"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-101921-045401","article-title":"RNA modification in the immune system","volume":"41","author":"Han","year":"2023","journal-title":"Annu Rev Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00793-5","article-title":"Mechanisms of joint destruction in rheumatoid arthritis \u2014 immune cell\u2013fibroblast\u2013bone interactions","volume":"18","author":"Komatsu","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2023.2246256","article-title":"RNA modification-mediated translational control in immune cells","volume":"20","author":"Zhang","year":"2023","journal-title":"RNA Biol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.06.008","article-title":"Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA","volume":"23","author":"Karik\u00f3","year":"2005","journal-title":"Immunity"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153871","article-title":"N6-methyladenosine modification of TGM2 mRNA contributes to the inhibitory activity of sarsasapogenin in rheumatoid arthritis fibroblast-like synoviocytes","volume":"95","author":"Lin","year":"2022","journal-title":"Phytomedicine"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab378","article-title":"A comprehensive review of m6A\/m6Am RNA methyltransferase structures","volume":"49","author":"Oerum","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-01868-1","article-title":"Role of m6A methyltransferase component VIRMA in multiple human cancers (Review)","volume":"21","author":"Zhu","year":"2021","journal-title":"Cancer Cell Int"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.687","article-title":"N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nat Chem Biol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.4161\/rna.24711","article-title":"Sprouts of RNA epigenetics: The discovery of mammalian RNA demethylases","volume":"10","author":"Zheng","year":"2013","journal-title":"RNA Biol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201900901","article-title":"Identification of flavin mononucleotide as a cell-active artificial N 6 -methyladenosine RNA demethylase","volume":"131","author":"Xie","year":"2019","journal-title":"Angewandte Chemie"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N 6 -methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"Huang","year":"2018","journal-title":"Nat Cell Biol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-00947-0","article-title":"Insight into the structure, physiological function, and role in cancer of m6A readers\u2014YTH domain-containing proteins","volume":"8","author":"Liao","year":"2022","journal-title":"Cell Death Discovery"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29186","article-title":"The emerging roles of hnRNPK","volume":"235","author":"Wang","year":"2020","journal-title":"J Cell Physiol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102828","article-title":"RNA-binding protein hnRNP UL1 binds \u03baB sites to attenuate NF-\u03baB-mediated inflammation","volume":"129","author":"Ma","year":"2022","journal-title":"J Autoimmun"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00911","article-title":"Regulatory role of RNA N6-methyladenosine modification in bone biology and osteoporosis","volume":"10","author":"Chen","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.783322","article-title":"m6A methylation regulates osteoblastic differentiation and bone remodeling","volume":"9","author":"Huang","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(61)90668-0","article-title":"The occurence of 1-methyladenine in ribonucleic acid","volume":"46","author":"Dunn","year":"1961","journal-title":"BBA - Biochim Biophys Acta"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12428","article-title":"The emerging role of mRNA methylation in normal and pathological behavior","volume":"17","author":"Engel","year":"2018","journal-title":"Genes Brain Behav"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2022.11.045","article-title":"N1-methyladenosine modification in cancer biology: Current status and future perspectives","volume":"20","author":"Li","year":"2022","journal-title":"Comput Struct Biotechnol J"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2019.115300","article-title":"3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line","volume":"28","author":"Malacrida","year":"2020","journal-title":"Bioorg Med Chem"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2016.1276150","article-title":"Eukaryotic stand-alone pseudouridine synthases\u2013RNA modifying enzymes and emerging regulators of gene expression","volume":"14","author":"Rintala-Dempsey","year":"2017","journal-title":"RNA Biol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/biom7010020","article-title":"m1A post-transcriptional modification in tRNAs","volume":"7","author":"Oerum","year":"2017","journal-title":"Biomolecules"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-020-00295-8","article-title":"The epitranscriptome beyond m6A","volume":"22","author":"Wiener","year":"2021","journal-title":"Nat Rev Genet"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.91.394","article-title":"Discovery of m7G-cap in eukaryotic mRNAs","volume":"91","author":"Furuichi","year":"2015","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/genes13071289","article-title":"The epitranscriptome in miRNAs: crosstalk, detection, and function in cancer","volume":"13","author":"del Valle-Morales","year":"2022","journal-title":"Genes (Basel)"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01679-w","article-title":"Emerging roles of RNA methylation in gastrointestinal cancers","volume":"20","author":"Xie","year":"2020","journal-title":"Cancer Cell Int"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.049858","article-title":"Structural insights into parasite eIF4E binding specificity for m7G and m2,2,7G mRNA caps","volume":"284","author":"Liu","year":"2009","journal-title":"J Biol Chem"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw551","article-title":"mRNA capping: Biological functions and applications","volume":"44","author":"Ramanathan","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05566-4","article-title":"Structural basis of regulated m7G tRNA modification by METTL1\u2013WDR4","volume":"613","author":"Li","year":"2023","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05565-5","article-title":"Structures and mechanisms of tRNA methylation by METTL1\u2013WDR4","volume":"613","author":"Ruiz-Arroyo","year":"2023","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3390\/genes10020102","article-title":"Eukaryotic 5-methylcytosine (M 5 C) RNA methyltransferases: Mechanisms, cellular functions, and links to disease","volume":"10","author":"Bohnsack","year":"2019","journal-title":"Genes (Basel)"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01263-w","article-title":"The role of m6A, m5C and \u03a8 RNA modifications in cancer: Novel therapeutic opportunities","volume":"20","author":"Nombela","year":"2021","journal-title":"Mol Cancer"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0407-z","article-title":"The emerging role of RNA modifications in the regulation of mRNA stability","volume":"52","author":"Boo","year":"2020","journal-title":"Exp Mol Med"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1639","article-title":"Dynamic transcriptomic m5C and its regulatory role in RNA processing","volume":"12","author":"Chen","year":"2021","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01175-9","article-title":"RNA modifications: importance in immune cell biology and related diseases","volume":"7","author":"Cui","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.04.021","article-title":"Epigenetics: Roles and therapeutic implications of non-coding RNA modifications in human cancers","volume":"25","author":"Rong","year":"2021","journal-title":"Mol Ther Nucleic Acids"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.55","article-title":"5-methylcytosine promotes mRNA export-NSUN2 as the methyltransferase and ALYREF as an m 5 C reader","volume":"27","author":"Yang","year":"2017","journal-title":"Cell Res"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3390\/cells9081758","article-title":"The RNA methyltransferase NSUN2 and its potential roles in cancer","volume":"9","author":"Chellamuthu","year":"2020","journal-title":"Cells"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.73","article-title":"5-methylcytosine mediates nuclear export of mRNA","volume":"27","author":"Dominissini","year":"2017","journal-title":"Cell Res"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2023.03.023","article-title":"Mechanisms of NAT10 as ac4C writer in diseases","volume":"32","author":"Xie","year":"2023","journal-title":"Mol Ther Nucleic Acids"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.01.037","article-title":"The processing, gene regulation, biological functions, and clinical relevance of N4-acetylcytidine on RNA: A systematic review","volume":"20","author":"Jin","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.06.001","article-title":"Mettl1\/Wdr4-Mediated m 7 G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation","volume":"71","author":"Lin","year":"2018","journal-title":"Mol Cell"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-020-05963-w","article-title":"Emerging role of N4-acetylcytidine modification of RNA in gene regulation and cellular functions","volume":"47","author":"Karthiya","year":"2020","journal-title":"Mol Biol Rep"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1080\/152165400410182","article-title":"Pseudouridine in RNA: What, where, how, and why","volume":"49","author":"Charette","year":"2000","journal-title":"IUBMB Life"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad8711","article-title":"Messenger RNA modifications: Form, distribution, and function","volume":"352","author":"Gilbert","year":"2016","journal-title":"Sci (1979)"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-17249-1","article-title":"N 1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs","volume":"12","author":"Chen","year":"2022","journal-title":"Sci Rep"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.4161\/15476286.2014.992278","article-title":"Pseudouridine: Still mysterious, but never a fake (uridine)","volume":"11","author":"Spenkuch","year":"2014","journal-title":"RNA Biol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac069","article-title":"Glycine increased ferroptosis via SAM-mediated GPX4 promoter methylation in rheumatoid arthritis","volume":"61","author":"Ling","year":"2022","journal-title":"Rheumatol (United Kingdom)"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-014-0247-7","article-title":"Synovial joints: from development to homeostasis","volume":"13","author":"Longobardi","year":"2015","journal-title":"Curr Osteoporos Rep"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.02.028","article-title":"Resident macrophages cloak tissue microlesions to prevent neutrophil-driven inflammatory damage","volume":"177","author":"Uderhardt","year":"2019","journal-title":"Cell"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.10.006","article-title":"Tissue-resident macrophages are locally programmed for silent clearance of apoptotic cells","volume":"47","author":"Roberts","year":"2017","journal-title":"Immunity"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/nm0610-641","article-title":"Shifting HIFs in osteoarthritis","volume":"16","author":"Husa","year":"2010","journal-title":"Nat Med"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.10.006","article-title":"HIF-2\u03b1 as a possible therapeutic target of osteoarthritis","volume":"18","author":"Saito","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00859.x","article-title":"Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis","volume":"233","author":"Bartok","year":"2010","journal-title":"Immunol Rev"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12939","article-title":"Fibroblast-like synoviocytes: Role in synovial fibrosis associated with osteoarthritis","volume":"29","author":"Maglaviceanu","year":"2021","journal-title":"Wound Repair Regeneration"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107392","article-title":"Fibroblast-like synoviocytes in rheumatoid arthritis: Surface markers and phenotypes","volume":"93","author":"Wu","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S296006","article-title":"Transcriptome-wide high-throughput m6a sequencing of differential m6a methylation patterns in the human rheumatoid arthritis fibroblast-like synoviocytes cell line mh7a","volume":"14","author":"Jiang","year":"2021","journal-title":"J Inflammation Res"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.607585","article-title":"METTL3 promotes activation and inflammation of FLSs through the NF-\u03baB signaling pathway in rheumatoid arthritis","volume":"8","author":"Shi","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.12.007","article-title":"The role of macrophages in osteoarthritis and cartilage repair","volume":"28","author":"Wu","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221091","article-title":"METTL3-mediated m6A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression","volume":"81","author":"Chen","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00958-y","article-title":"N6-adenosine methylation (m6A) is involved in the life and death decisions of T cells","volume":"20","author":"Calis","year":"2023","journal-title":"Cell Mol Immunol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.91","article-title":"Macrophage heterogeneity in the context of rheumatoid arthritis","volume":"12","author":"Udalova","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102758","article-title":"Novel insights into macrophage diversity in rheumatoid arthritis synovium","volume":"20","author":"Boutet","year":"2021","journal-title":"Autoimmun Rev"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220458corr1","article-title":"Correction: Loss of balance between protective and pro-inflammatory synovial tissue T-cell polyfunctionality predates clinical onset of rheumatoid arthritis","volume":"82","author":"Floudas","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.918983","article-title":"N7-methylguanosine genes related prognostic biomarker in hepatocellular carcinoma","volume":"13","author":"Regmi","year":"2022","journal-title":"Front Genet"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.914577","article-title":"Comprehensive analysis of m5C methylation regulatory genes and tumor microenvironment in prostate cancer","volume":"13","author":"Yu","year":"2022","journal-title":"Front Immunol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.630417","article-title":"Prognostic and Immunological Role of mRNA ac4C Regulator NAT10 in Pan-Cancer: New Territory for Cancer Research","volume":"11","author":"Yang","year":"2021","journal-title":"Front Oncol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3390\/cells11244115","article-title":"Synovial fluid in knee osteoarthritis extends proinflammatory niche for macrophage polarization","volume":"11","author":"Kulkarni","year":"2022","journal-title":"Cells"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.01.015","article-title":"Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee","volume":"28","author":"Bailey","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109553","article-title":"N6-methyladenosine demethylase FTO promotes M1 and M2 macrophage activation","volume":"69","author":"Gu","year":"2020","journal-title":"Cell Signal"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4766992","article-title":"Comprehensive analysis and functional characteristics of differential expression of N6-methyladenosine methylation modification in the whole transcriptome of rheumatoid arthritis","volume":"2022","author":"Wan","year":"2022","journal-title":"Mediators Inflammation"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.883155","article-title":"N1-methyladenosine (m1A) regulation associated with the pathogenesis of abdominal aortic aneurysm through YTHDF3 modulating macrophage polarization","volume":"9","author":"Wu","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.727595","article-title":"Gene expression-based predication of RNA pseudouridine modification in tumor microenvironment and prognosis of glioma patients","volume":"9","author":"Wang","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.947636","article-title":"Migration and homeostasis of regulatory T cells in rheumatoid arthritis","volume":"9","author":"Kotschenreuther","year":"2022","journal-title":"Front Immunol"},{"key":"B83","article-title":"Role of T lymphocytes in collagen II induced arthritis in rats","volume":"51","author":"Klareskog","year":"1983","journal-title":"Clin Exp Immunol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.827215","article-title":"CLP1 is a prognosis-related biomarker and correlates with immune infiltrates in rheumatoid arthritis","volume":"13","author":"Zhao","year":"2022","journal-title":"Front Pharmacol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.670711","article-title":"N6-methyladenosine RNA modification in inflammation: roles, mechanisms, and applications","volume":"9","author":"Luo","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9744771","article-title":"The role of N6-methyladenosine in inflammatory diseases","volume":"2022","author":"Xu","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"B87","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s13075-023-03149-w","article-title":"M6A methylation modification in autoimmune diseases, a promising treatment strategy based on epigenetics","volume":"25","author":"Huang","year":"2023","journal-title":"Arthritis Res Ther"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2018.12.001","article-title":"The role of the thymus in the immune response","volume":"29","author":"Thapa","year":"2019","journal-title":"Thorac Surg Clin"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.5114\/pjp.2022.117173","article-title":"Roles of CD3, CD4 and CD8 in synovial lymphocytes of rheumatoid arthritis","volume":"73","author":"Xiong","year":"2022","journal-title":"Polish J Pathol"},{"key":"B90","article-title":"The central role of T cells in rheumatoid arthritis","volume":"25","author":"Cope","year":"2007","journal-title":"Clin Exp Rheumatol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.10.016","article-title":"Monocytes in rheumatoid arthritis: Circulating precursors of macrophages and osteoclasts and, their heterogeneity and plasticity role in RA pathogenesis","volume":"65","author":"Rana","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00430","article-title":"Disease Activity-Associated Alteration of mRNA m5 C Methylation in CD4+ T Cells of Systemic Lupus Erythematosus","volume":"8","author":"Guo","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg0470","article-title":"M6A demethylase ALKBH5 controls CD4+T cell pathogenicity and promotes autoimmunity","volume":"7","author":"Zhou","year":"2021","journal-title":"Sci Adv"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1038\/nature23450","article-title":"M 6 A mRNA methylation controls T cell homeostasis by targeting the IL-7\/STAT5\/SOCS pathways","volume":"548","author":"Li","year":"2017","journal-title":"Nature"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/nature20810","article-title":"Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis","volume":"542","author":"Rao","year":"2017","journal-title":"Nature"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21594-6","article-title":"METTL3-dependent m6A modification programs T follicular helper cell differentiation","volume":"12","author":"Yao","year":"2021","journal-title":"Nat Commun"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab465","article-title":"Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation","volume":"49","author":"Galloway","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00842","article-title":"Epitranscriptomic N4-acetylcytidine profiling in CD4+ T cells of systemic lupus erythematosus","volume":"8","author":"Guo","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S385050","article-title":"The m7G modification level and immune infiltration characteristics in patients with COVID-19","volume":"15","author":"Lu","year":"2022","journal-title":"J Multidiscip Healthc"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.750753","article-title":"B cells in rheumatoid arthritis: Pathogenic mechanisms and treatment prospects","volume":"12","author":"Wu","year":"2021","journal-title":"Front Immunol"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13412","article-title":"Crosstalk between B cells and neutrophils in rheumatoid arthritis","volume":"164","author":"Karmakar","year":"2021","journal-title":"Immunology"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8118577","article-title":"Deletion of mettl3 at the pro-B stage marginally affects B cell development and profibrogenic activity of B cells in liver fibrosis","volume":"2022","author":"Kang","year":"2022","journal-title":"J Immunol Res"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01510-2","article-title":"m6A modification: recent advances, anticancer targeted drug discovery and beyond","volume":"21","author":"Deng","year":"2022","journal-title":"Mol Cancer"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2101071","article-title":"Mettl14-mediated m6A modification is essential for germinal center B cell response","volume":"208","author":"Huang","year":"2022","journal-title":"J Immunol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1007\/82_2015_479","article-title":"Roles of the NF-\u03baB pathway in B-lymphocyte biology","volume":"393","author":"Sasaki","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110778","article-title":"YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation","volume":"39","author":"Grenov","year":"2022","journal-title":"Cell Rep"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.07.037","article-title":"Mechanism of noncoding RNA-associated N6-methyladenosine recognition by an RNA processing complex during IgH DNA recombination","volume":"81","author":"Nair","year":"2021","journal-title":"Mol Cell"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303272","article-title":"Fc\u03b3RIIb on myeloid cells rather than on B cells protects from collagen-induced arthritis","volume":"192","author":"Yilmaz-Elis","year":"2014","journal-title":"J Immunol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2022.104533","article-title":"Age-associated B cells indicate disease activity in rheumatoid arthritis","volume":"377","author":"Bao","year":"2022","journal-title":"Cell Immunol"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1186\/ar128","article-title":"Cell-cell interactions in synovitis: Interactions between T cells and B cells in rheumatoid arthritis","volume":"2","author":"Weyand","year":"2000","journal-title":"Arthritis Res"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.1c00102","article-title":"Novel small molecule RNA m6A demethylase alkBH5 inhibitors for treating cancer","volume":"12","author":"Sabnis","year":"2021","journal-title":"ACS Med Chem Lett"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00353","article-title":"Effector functions of CD4+ T cells at the site of local autoimmune inflammation-lessons from rheumatoid arthritis","volume":"10","author":"Chemin","year":"2019","journal-title":"Front Immunol"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c01289","article-title":"Rational design of novel anticancer small-molecule RNA m6A demethylase ALKBH5 inhibitors","volume":"6","author":"Selberg","year":"2021","journal-title":"ACS Omega"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1002\/med.21565","article-title":"Health benefits of resveratrol: Evidence from clinical studies","volume":"39","author":"Singh","year":"2019","journal-title":"Med Res Rev"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.3390\/nu14173519","article-title":"Effects of resveratrol, curcumin and quercetin supplementation on bone metabolism\u2014A systematic review","volume":"14","author":"Inchingolo","year":"2022","journal-title":"Nutrients"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1494873\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T06:31:29Z","timestamp":1733725889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1494873\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,9]]},"references-count":115,"alternative-id":["10.3389\/fimmu.2024.1494873"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1494873","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,9]]},"article-number":"1494873"}}