{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:47:35Z","timestamp":1791546455733,"version":"4.3.4"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Agriculture dust contains many organic immunogenic compounds, and organic dust exposure is strongly associated with the development of immune-mediated chronic pulmonary diseases such as chronic obstructive pulmonary disease (COPD). Chronic organic dust exposure from agriculture sources induces chronic lung inflammatory diseases and organic dust exposure has recently been linked to an increased risk of developing dementia. The cytokine interleukin-22 (IL-22) has been established as an important mediator in the resolution and repair of lung tissues. The omega-3 fatty acid metabolite aspirin-triggered Resolvin D1 (AT-RvD1) has shown efficacy in modulating the immune response in both pulmonary and neurological inflammation but has not been explored as a therapeutic in organic dust exposure-induced neuroinflammation. Investigating the link between IL-22 and AT-RvD1 may help in developing effective therapies for these immune-mediated diseases. We aimed to investigate the link between organic dust exposure and neuroinflammation, the role of IL-22 in the pulmonary and neurological immune response to organic dust exposure, and the immune-modulating therapeutic applications of AT-RvD1 in an IL-22 knock-out mouse model of organic dust exposure. C57BL\/6J (WT) and IL-22 knock-out (KO) mice were repetitively exposed to aqueous agriculture organic dust extract (DE) 5 days per week for 3 weeks (15 total instillations) and treated with AT-RvD1 either once per week (3 total injections) or 5 times per week (15 total injections) for 3 weeks and allowed to recover for 3 days. We observed a significant pulmonary and neurological immune response to DE characterized by the development of inducible bronchus associated lymphoid tissue in the lung and gliosis in the frontal areas of the brain. We also observed that IL-22 knock-out increased pulmonary and neurological inflammation severity. Animals exposed to DE and treated with AT-RvD1 displayed reduced lung pathology severity and gliosis. Our data demonstrate that DE exposure contributes to neurological inflammation and that IL-22 is crucial to effective tissue repair processes. Our data further suggest that AT-RvD1 may have potential as a novel therapeutic for organic dust exposure-induced, immune-mediated pulmonary and neurological inflammation, improving outcomes of those with these diseases.<\/jats:p>","DOI":"10.3389\/fimmu.2024.1495581","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T05:11:05Z","timestamp":1734412265000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Aspirin-triggered resolvin D1 modulates pulmonary and neurological inflammation in an IL-22 knock-out organic dust exposure mouse model"],"prefix":"10.3389","volume":"15","author":[{"given":"Alissa N.","family":"Threatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Klepper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Brier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan S.","family":"Dean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ash","family":"Ibarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macallister","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylee","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00eblis J. L.","family":"Wahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melea","family":"Barahona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel O.","family":"Oyewole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Pauly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara M.","family":"Nordgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"B1","unstructured":"Mortality in the United States National center for health statistics\n          \n          2021"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1157652","article-title":"Gliosis, misfolded protein aggregation, and neuronal loss in a Guinea pig model of pulmonary tuberculosis","volume":"17","author":"Latham","year":"2023","journal-title":"Front Neurosci"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.967174","article-title":"A review of respirable fine particulate matter (PM2.5)-induced brain damage","volume":"7","author":"Li","year":"2022","journal-title":"Front Mol Neurosci"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.882569","article-title":"The physiological effects of air pollution: particulate matter, physiology and disease","volume":"10","author":"Pryor","year":"2022","journal-title":"Front Public Health"},{"key":"B5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12929-022-00799-x","article-title":"The pathogenic effects of particulate matter on neurodegeneration: a review","volume":"29","author":"You","year":"2022","journal-title":"J Biomed Sci"},{"key":"B6","unstructured":"About alzheimer\u2019s disease\n          \n          2023"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.13031\/2013.13684","article-title":"The respiratory inflammatory response to the swine confinement building environment","volume":"9","author":"Von Essen","year":"2003","journal-title":"J Agric Saf Health"},{"key":"B8","unstructured":"Agriculture occupational exposures and factors affecting health effects\n          \n          \n            \n              Nordgren\n              TM\n            \n            \n              Charavaryamath\n              C\n            \n          \n          \n          2018"},{"key":"B9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13601-020-00334-x","article-title":"Respiratory diseases and allergy in farmers working with livestock: a EAACI position paper","volume":"10","author":"Sigsgaard","year":"2020","journal-title":"Clin Transl Allergy"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000247","article-title":"Pulmonary health effects of agriculture","volume":"22","author":"Nordgren","year":"2016","journal-title":"Curr Opin Pulmonary Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2015.1116089","article-title":"Occupational agriculture organic dust exposure and its relationship to asthma and airway inflammation in adults","volume":"53","author":"Wunschel","year":"2016","journal-title":"J Asthma."},{"key":"B12","doi-asserted-by":"crossref","unstructured":"Bailey\n              K\n            \n            \n              Meza\n              J\n            \n            \n              Smith\n              L\n            \n            \n              Von Essen\n              S\n            \n            \n              Romberger\n              D\n            \n          \n          Agricultural exposures in patients with COPD in health systems serving rural areas\n          \n          2008","DOI":"10.1080\/10599240801887918"},{"key":"B13","unstructured":"Syamlal\n              G\n            \n            \n              Kurth\n              LM\n            \n            \n              Dodd\n              KE\n            \n            \n              Blackley\n              J\n            \n            \n              Hall\n              NB\n            \n          \n          Morbidity and mortality weekly report chronic obstructive pulmonary disease mortality by industry and occupation-United States\n          \n          2020"},{"key":"B14","unstructured":"Shotgun pyrosequencing metagenomic analyses of dusts from swine confinement and grain facilities\n          \n          \n            \n              Boissy\n              RJ\n            \n            \n              Romberger\n              DJ\n            \n            \n              Roughead\n              WA\n            \n            \n              Weissenburger-Moser\n              L\n            \n            \n              Poole\n              JA\n            \n            \n              LeVan\n              TD\n            \n          \n          \n          2014"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.023","article-title":"Repetitive organic dust exposure in vitro impairs macrophage differentiation and function","volume":"122","author":"Poole","year":"2008","journal-title":"J Allergy Clin Immunol."},{"key":"B16","unstructured":"Immunological and inflammatory responses to organic dust in agriculture\n          \n          \n            \n              Poole\n              JA\n            \n            \n              Romberger\n              DJ\n            \n          \n          \n          2012"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90622.2008","article-title":"Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice","volume":"296","author":"Poole","year":"2009","journal-title":"Am J Physiology-Lung Cell Mol Physiol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2021.108797","article-title":"A high docosahexaenoic acid diet alters lung inflammation and recovery following repetitive exposure to aqueous organic dust extracts","volume":"97","author":"Ulu","year":"2021","journal-title":"J Nutr Biochem"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.785193","article-title":"Sex-specific differences in resolution of airway inflammation in fat-1 transgenic mice following repetitive agricultural dust exposure","volume":"12","author":"Ulu","year":"2022","journal-title":"Front Pharmacol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.3300","article-title":"Comparison of particulate air pollution from different emission sources and incident dementia in the US","volume":"183","author":"Zhang","year":"2023","journal-title":"JAMA Intern Med"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00018908","article-title":"Multifaceted mechanisms in COPD: Inflammation, immunity, and tissue repair and destruction","volume":"31","author":"Chung","year":"2008","journal-title":"Eur Respir J"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2015.11.008","article-title":"Neurotoxicity of traffic-related air pollution","volume":"59","author":"Costa","year":"2017","journal-title":"Neurotoxicology."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1177\/0898264314552419","article-title":"Chronic obstructive pulmonary disease, hospital visits, and comorbidities: National Survey of Residential Care Facilities, 2010","volume":"27","author":"Wheaton","year":"2015","journal-title":"J Aging Health"},{"key":"B24","unstructured":"Agricultural workers and mental health\n          \n          2021"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1080\/01926230490520232","article-title":"Brain inflammation and Alzheimer\u2019s-like pathology in individuals exposed to severe air pollution","volume":"32","author":"Calder\u00f3n-Garcidue\u00f1as","year":"2004","journal-title":"Toxicol Pathol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"251686572095487","DOI":"10.1177\/2516865720954873","article-title":"Influence of woodsmoke exposure on molecular mechanisms underlying alzheimer\u2019s disease: existing literature and gaps in our understanding","volume":"13","author":"Schuller","year":"2020","journal-title":"Epigenet Insights"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.5888\/pcd13.150428","article-title":"Association of chronic obstructive pulmonary disease with increased confusion or memory loss and functional limitations among adults in 21 states, 2011 behavioral risk factor surveillance system","volume":"13","author":"Greenlund","year":"2016","journal-title":"Prev Chronic Dis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"75","DOI":"10.2147\/COPD.S53676","article-title":"The association of chronic obstructive pulmonary disease, disability, engagement in social activities, and mortality among US adults aged 70 years or older, 1994-2006","volume":"9","author":"Liu","year":"2014","journal-title":"Int J COPD."},{"key":"B29","volume-title":"National trends - chronic obstructive pulmonary disease (COPD)","year":"2020"},{"key":"B30","unstructured":"Novel pro-resolving lipid mediators in inflammation are leads for resolution physiology\n          \n          \n            \n              Serhan\n              CN\n            \n          \n          \n          2014"},{"key":"B31","unstructured":"Novel anti-inflammatory \u2013 pro-resolving mediators and their receptors\n          \n          \n            \n              Serhan\n              CN\n            \n            \n              Krishnamoorthy\n              S\n            \n            \n              Recchiuti\n              A\n            \n            \n              Chiang\n              N\n            \n          \n          \n          2011"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14081900","article-title":"Aspirin-triggered resolvin D1 reduces chronic dust-induced lung pathology without altering susceptibility to dust-enhanced carcinogenesis","volume":"14","author":"Dominguez","year":"2022","journal-title":"Cancers (Basel)."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.66","article-title":"Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury","volume":"6","author":"Eickmeier","year":"2013","journal-title":"Mucosal Immunol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97943","article-title":"Resolvins in inflammation: Emergence of the pro-resolving superfamily of mediators","author":"Serhan","year":"2018","journal-title":"Vol. 128 J Clin Invest Am Soc Clin Investigation;"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.673549","article-title":"Specialized pro-resolving lipid mediators and glial cells: emerging candidates for brain homeostasis and repair","volume":"15","author":"Tiberi","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"B36","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.lfs.2018.12.028","article-title":"Aspirin-triggered resolvin D1 alleviates paraquat-induced acute lung injury in mice","volume":"218","author":"Hu","year":"2019","journal-title":"Life Sci"},{"key":"B37","unstructured":"Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers\n          \n          \n            \n              Serhan\n              CN\n            \n            \n              Arita\n              M\n            \n            \n              Hong\n              S\n            \n            \n              Gotlinger\n              K\n            \n          \n          \n          2004"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609212200","article-title":"Resolvin D1 and its aspirin-triggered 17R epimer: Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation","volume":"282","author":"Sun","year":"2007","journal-title":"J Biol Chem"},{"key":"B39","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1146\/annurev-immunol-032414-112123","article-title":"Interleukin-22: immunobiology and pathology","volume":"33","author":"Dudakov","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401244","article-title":"IL-22 fate reporter reveals origin and control of IL-22 production in homeostasis and infection","volume":"193","author":"Ahlfors","year":"2014","journal-title":"J Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01160","article-title":"IL-22 plays a critical role in maintaining epithelial integrity during pulmonary infection","volume":"11","author":"Alcorn","year":"2020","journal-title":"Front Immunol"},{"key":"B42","unstructured":"Interleukin-22 level is negatively correlated with neutrophil recruitment in the lungs in a Pseudomonas aeruginosa pneumonia model\n          \n          \n            \n              Broquet\n              A\n            \n            \n              Jacqueline\n              C\n            \n            \n              Davieau\n              M\n            \n            \n              Besbes\n              A\n            \n            \n              Roquilly\n              A\n            \n            \n              Martin\n              J\n            \n          \n          \n          2017"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/imr.2014.260.issue-1","article-title":"Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense","volume":"260","author":"Mcaleer","year":"2014","journal-title":"Immunol Rev"},{"key":"B44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpath.2012.12.007","article-title":"IL-22 is essential for lung epithelial repair following influenza infection","volume":"182","author":"Pociask","year":"2013","journal-title":"Am J Pathol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2022.116044","article-title":"IL-22 regulates inflammatory responses to agricultural dust-induced airway inflammation","volume":"446","author":"Ulu","year":"2022","journal-title":"Toxicol Appl Pharmacol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.trsl.2015.01.001","article-title":"Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust","volume":"166","author":"Nordgren","year":"2015","journal-title":"Trans Res"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00815.2001","article-title":"Hog barn dust extract stimulates IL-8 and IL-6 release in human bronchial epithelial cells via PKC activation","volume":"93","author":"Romberger","year":"2002","journal-title":"J Appl Physiol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"695","DOI":"10.3390\/nu4070695","article-title":"Alcohol exposure alters mouse lung inflammation in response to inhaled dust","volume":"4","author":"McCaskill","year":"2012","journal-title":"Nutrients"},{"key":"B49","doi-asserted-by":"publisher","first-page":"695","DOI":"10.3390\/nu4070695","article-title":"Alcohol exposure alters mouse lung inflammation in response to inhaled dust","volume":"4","author":"McCaskill","year":"2012","journal-title":"Nutrients."},{"key":"B50","unstructured":"Post-injury and resolution response to repetitive inhalation exposure to agricultural organic dust in mice\n          \n          \n            \n              Warren\n              KJ\n            \n            \n              Wyatt\n              TA\n            \n            \n              Romberger\n              DJ\n            \n            \n              Ailts\n              I\n            \n            \n              West\n              WW\n            \n            \n              Nelson\n              AJ\n            \n          \n          \n          2017"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90622.2008","article-title":"Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice","volume":"296","author":"Poole","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu12082334","article-title":"A high docosahexaenoic acid diet alters the lung inflammatory response to acute dust exposure","volume":"12","author":"Dominguez","year":"2020","journal-title":"Nutrients."},{"key":"B53","doi-asserted-by":"crossref","DOI":"10.1164\/ajrccm-conference.2011.183.1_MeetingAbstracts.A4802","article-title":"Repetitive intranasal inhalation of organic dust induces A predominant th17-polarized airway inflammatory response","volume-title":"American thoracic society international conference meetings abstracts","author":"Poole","year":"2011"},{"key":"B54","article-title":"Translocation of inhaled ultrafine particles to the brain","volume-title":"Inhalation toxicology","author":"Oberd\u00f6rster","year":"2004"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-27086-x","article-title":"Inhibition of inflammatory microglia by dietary fiber and short-chain fatty acids","volume":"13","author":"Caetano-Silva","year":"2023","journal-title":"Sci Rep"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-47540-8","article-title":"Anti-inflammatory reprogramming of microglia cells by metabolic modulators to counteract neurodegeneration; a new role for Ranolazine","volume":"13","author":"Piano","year":"2023","journal-title":"Sci Rep"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00846","article-title":"Targeting neuroinflammation by pharmacologic downregulation of inflammatory pathways is neuroprotective in protein misfolding disorders","volume":"15","author":"Risen","year":"2024","journal-title":"ACS Chem Neurosci"},{"key":"B58","article-title":"Air pollution ultrafine particles: toxicity beyond the lung","volume":"14","author":"Terzano","year":"2010","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1177\/1533317515577186","article-title":"Increased risk of dementia among patients with pulmonary tuberculosis","volume":"30","author":"Peng","year":"2015","journal-title":"Am J Alzheimer\u2019s Dis Other Dementiasr."},{"key":"B60","volume-title":"Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets","author":"Gao","year":"2023"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00072","article-title":"An inflammation-centric view of neurological disease: Beyond the neuron","volume":"12","author":"Skaper","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"B62","unstructured":"Repetitive organic dust exposure in vitro impairs macrophage differentiation and function\n          \n          \n            \n              Poole\n              JA\n            \n            \n              Alexis\n              NE\n            \n            \n              Parks\n              C\n            \n            \n              MacInnes\n              AK\n            \n            \n              Gentry-Nielsen\n              MJ\n            \n            \n              Fey\n              PD\n            \n          \n          \n          2008"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13302-6","article-title":"Lipopolysaccharide enters the rat brain by a lipoprotein-mediated transport mechanism in physiological conditions","volume":"7","author":"Vargas-Caraveo","year":"2017","journal-title":"Sci Rep"},{"key":"B64","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.chom.2018.12.006","article-title":"Innate and adaptive immune memory: an evolutionary continuum in the host\u2019s response to pathogens","volume":"25","author":"Netea","year":"2019","journal-title":"Cell Host Microbe Cell Press;"},{"key":"B65","unstructured":"Resolvins and protectins in inflammation-resolution\n          \n          \n            \n              Serhan\n              CN\n            \n            \n              Petasis\n              NA\n            \n          \n          \n          2011"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00304.2016","article-title":"B cells in chronic obstructive pulmonary disease: moving to center stage","volume":"311","author":"Polverino","year":"2016","journal-title":"Am J Physiology-Lung Cell Mol Physiol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-017-0703-x","article-title":"A role for B cells in organic dust induced lung inflammation","volume":"18","author":"Poole","year":"2017","journal-title":"Respir Res"},{"key":"B68","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/82_2019_191","article-title":"Role of iBALT in respiratory immunity","author":"Silva-Sanchez","year":"2020","journal-title":"In: Curr Topics Microbiol Immunol Springer Sci Business Media Deutschland GmbH;"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02148","article-title":"A double edged sword role of interleukin-22 in wound healing and tissue regeneration","volume":"11","author":"Arshad","year":"2020","journal-title":"Front Immunol"},{"key":"B70","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00273.2017","article-title":"Docosahexaenoic acid enhances amphiregulin-mediated bronchial epithelial cell repair processes following organic dust exposure","volume":"314","author":"Nordgren","year":"2018","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-017-0641-7","article-title":"IL-18 associated with lung lymphoid aggregates drives IFN\u03b3 production in severe COPD","volume":"18","author":"Briend","year":"2017","journal-title":"Respir Res"},{"key":"B72","article-title":"Regulation of inducible BALT formation and contribution to immunity and pathology. Vol. 3","volume-title":"Mucosal immunology","author":"Foo","year":"2010"},{"key":"B73","first-page":"n engl j med. 2004","article-title":"The nature of small-airway obstruction in chronic obstructive pulmonary disease","volume":"26","author":"Hogg","year":"2004","journal-title":"N Engl J Med"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0170fje","article-title":"Regulation of TNF-alpha- and IFN-gamma-induced CXCL10 expression: participation of the airway smooth muscle in the pulmonary inflammatory response in chronic obstructive pulmonary disease","volume":"18","author":"Hardaker","year":"2004","journal-title":"FASEB journal : Off Publ Fed Am Societies Exp Biol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.909864","article-title":"Inhibition of C-X-C motif chemokine 10 (CXCL10) protects mice from cigarette smoke-induced chronic obstructive pulmonary disease","volume":"24","author":"Jing","year":"2018","journal-title":"Med Sci Monitor."},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.12.013","article-title":"Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro","volume":"55","author":"Rey","year":"2016","journal-title":"Brain Behav Immun"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1495581\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T09:09:37Z","timestamp":1735895377000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2024.1495581\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,17]]},"references-count":77,"alternative-id":["10.3389\/fimmu.2024.1495581"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2024.1495581","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,17]]},"article-number":"1495581"}}