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Immunol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>APOE gene polym orphisms have been linked to Alzheimer\u2019s disease and coronary heart diseases. However, their relationship with lung adenocarcinoma (LUAD) remains uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study analyzed a cohort of 600 individuals comprising 200 LUAD patients in the lung cancer group and 400 healthy individuals as controls. APOE gene variants were identified through Sanger sequencing. Statistical analyses were conducted to assess intergroup differences, and comparisons of lipid profiles were performed across individuals carrying different APOE alleles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:italic>APOE<\/jats:italic> \u03f52 allele had been significantly more frequently occurring in the LUAD group than in the control group (15.5% vs. 7%, P &amp;lt;0.001). <jats:italic>APOE<\/jats:italic> \u03f52\/\u03f52 and \u03f52\/\u03f53 genotypes increased susceptibility to LUAD by 3.78-fold and 3.22-fold. The APOE \u03f52\/\u03f53 genotype increased the risk of early-stage LUAD by 2.36-fold and advanced-stage LUAD by 4.05-fold. Individuals with the <jats:italic>APOE<\/jats:italic> \u03f52\/\u03f52 genotype had a 3.22-fold higher susceptibility to moderately differentiated and a 6.8-fold higher susceptibility to poorly differentiated LUAD. Patients with the \u03f52 allele in LUAD exhibited disrupted lipid metabolism, characterized by reduced HDL, TC, and FFA levels, along with increased ApoB, particularly in advanced and poorly differentiated cancer stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Individuals carrying the \u03f52 allele have an increased susceptibility to developing LUAD, accompanied by disrupted lipid metabolism. Additionally, the APOE \u03f52\/\u03f52 and \u03f52\/\u03f53 genotypes are associated with an increased risk of developing advanced and poorly differentiated LUAD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2024.1522761","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T06:39:35Z","timestamp":1734935975000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The role of APOE gene polymorphisms in lung adenocarcinoma susceptibility and lipid 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