{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T18:04:24Z","timestamp":1767204264809,"version":"build-2238731810"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      A hallmark of many lysosomal storage diseases (LSD) is the alteration of immune responses, often starting before the onset of clinical disease. The present study aimed to investigate how G\n                      <jats:sub>M1<\/jats:sub>\n                      gangliosidosis impacted the course of an acute central nervous system (CNS) virus infection before the clinical onset of LSD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      For this purpose,\n                      <jats:italic>Glb1<\/jats:italic>\n                      <jats:sup>-\/-<\/jats:sup>\n                      and wildtype control mice (both C57BL\/6 background) were intracerebrally infected with the BeAn strain of Theiler\u2019s murine encephalomyelitis virus (TMEV) at the age of 5 weeks and sacrificed 4, 7, 14 and 98 days post infection, respectively. Histology, immunohistochemistry, and flow cytometry was used to assess viral load and immune cell activation and infiltration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both wildtype and\n                      <jats:italic>Glb1<\/jats:italic>\n                      <jats:sup>-\/-<\/jats:sup>\n                      mice were able to clear the virus from the CNS and did not develop any clinical symptoms of TMEV-associated disease, thus indicating no overt alteration in susceptibility to TMEV infection. However, in the early phase post infection,\n                      <jats:italic>Glb1<\/jats:italic>\n                      <jats:sup>-\/-<\/jats:sup>\n                      mice displayed a slightly delayed T cell response as well as an increase in the number and activation of CNS microglia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      These results suggest that already in the early stage of disease (before clinical onset) G\n                      <jats:sub>M1<\/jats:sub>\n                      gangliosidosis causes an impaired T cell response and microglial hyperreactivity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2025.1467207","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T01:22:43Z","timestamp":1744161763000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Infection of a \u03b2-galactosidase-deficient mouse strain with Theiler\u2019s murine encephalomyelitis virus reveals limited immunological dysregulations in this lysosomal storage disease"],"prefix":"10.3389","volume":"16","author":[{"given":"Rouven","family":"Wannemacher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Stegmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Eikelberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"B\u00fchler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayali Kalidas","family":"Kohale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanaporn","family":"Asawapattanakul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Ebbecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Kristin","family":"Raulf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Baumg\u00e4rtner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Lepenies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Gerhauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1126\/science.160.3831.1002","article-title":"Generalized gangliosidosis - beta-galactosidase deficiency","volume":"160","author":"Okada","year":"1968","journal-title":"Science"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1126\/science.174.4011.838","article-title":"Neuronal GM1 gangliosidosis in a Siamese cat with beta-galactosidase deficiency","volume":"174","author":"Baker","year":"1971","journal-title":"Science"},{"key":"B3","article-title":"Animal model: feline GM1 gangliosidosis","volume":"74","author":"Baker","year":"1974","journal-title":"Am J Pathol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1042\/bj2350151","article-title":"GM1\u00a0gangliosidosis (type 1) in a cat","volume":"235","author":"Barker","year":"1986","journal-title":"Biochem J"},{"key":"B5","article-title":"Canine GM1-gangliosidosis. A clinical, morphologic, histochemical, and biochemical comparison of two different models","volume":"140","author":"Alroy","year":"1992","journal-title":"Am J Pathol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/1746-6148-9-132","article-title":"Molecular epidemiology of canine GM1 gangliosidosis in the Shiba Inu breed in Japan: relationship between regional prevalence and carrier frequency","volume":"9","author":"Uddin","year":"2013","journal-title":"BMC Vet Res"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.105.042580","article-title":"A duplication in the\u00a0canine beta-galactosidase gene GLB1 causes exon skipping and GM1-gangliosidosis in Alaskan huskies","volume":"170","author":"Kreutzer","year":"2005","journal-title":"Genetics"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/science.824730","article-title":"Neuronal-visceral GM1 gangliosidosis in a dog with beta-galactosidase deficiency","volume":"194","author":"Read","year":"1976","journal-title":"Science"},{"key":"B9","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/ajmg.1320310108","article-title":"Inherited lysosomal storage disease associated with deficiencies of beta-galactosidase and alpha-neuraminidase in sheep","volume":"31","author":"Ahern-Rindell","year":"1988","journal-title":"Am J Med Genet"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1994.tb03220.x","article-title":"Clinical and clinicopathologic characteristics of ovine GM-1 gangliosidosis","volume":"8","author":"Murnane","year":"1994","journal-title":"J Vet Intern Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/BF00309632","article-title":"A new form of ovine GM1-gangliosidosis","volume":"89","author":"Skelly","year":"1995","journal-title":"Acta Neuropathol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s004010000267","article-title":"A lysosomal storage disease of Romney sheep that resembles human type 3 GM1 gangliosidosis","volume":"101","author":"Ryder","year":"2001","journal-title":"Acta Neuropathol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)33872-4","article-title":"Beta-galactosidase deficiency in GM1 gangliosidosis of Friesian calves","volume":"15","author":"Donnelly","year":"1973","journal-title":"Res Vet Sci"},{"key":"B14","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/BF00685324","article-title":"Enzyme histochemical and ultrastructural alterations in the brains of Friesian calves with GM1 gangliosidosis","volume":"30","author":"Sheahan","year":"1974","journal-title":"Acta Neuropathol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"292","DOI":"10.2307\/1591870","article-title":"Gangliosidosis in emus (Dromaius novaehollandiae)","volume":"39","author":"Bermudez","year":"1995","journal-title":"Avian Dis"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2307\/1592337","article-title":"Heritability and biochemistry of gangliosidosis in emus (Dromaius novaehollandiae)","volume":"41","author":"Bermudez","year":"1997","journal-title":"Avian Dis"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2014.02.002","article-title":"GM1-gangliosidosis in American black bears: clinical, pathological, biochemical and molecular genetic characterization","volume":"111","author":"Muthupalani","year":"2014","journal-title":"Mol Genet Metab"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.2.205","article-title":"Generalized CNS disease and massive GM1-ganglioside accumulation in mice defective in lysosomal acid beta-galactosidase","volume":"6","author":"Hahn","year":"1997","journal-title":"Hum Mol Genet"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018573518127","article-title":"Beta-galactosidase-deficient mouse as an animal model for GM1-gangliosidosis","volume":"14","author":"Matsuda","year":"1997","journal-title":"Glycoconj J"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2018.11.002","article-title":"Comprehensive behavioral and biochemical outcomes of novel murine models of GM1-gangliosidosis and Morquio syndrome type B","volume":"126","author":"Przybilla","year":"2019","journal-title":"Mol Genet Metab"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.3390\/jcm9041004","article-title":"Axonopathy and reduction of membrane resistance: key features in a new murine model of human GM1-gangliosidosis","volume":"9","author":"Eikelberg","year":"2020","journal-title":"J Clin Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"107508","DOI":"10.1016\/j.ymgme.2023.107508","article-title":"Glb1 knockout mouse model shares natural history with type II GM1 gangliosidosis patients","volume":"138","author":"Nicoli","year":"2023","journal-title":"Mol Genet Metab"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.gene.2015.04.078","article-title":"Recurrent and novel GLB1 mutations in India","volume":"567","author":"Bidchol","year":"2015","journal-title":"Gene"},{"key":"B24","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.ymgme.2008.04.012","article-title":"GM1 gangliosidosis: review of clinical, molecular, and therapeutic aspects","volume":"94","author":"Brunetti-Pierri","year":"2008","journal-title":"Mol Genet Metab"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s00401-007-0296-4","article-title":"Immune system irregularities in lysosomal storage disorders","volume":"115","author":"Castaneda","year":"2008","journal-title":"Acta Neuropathol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.imlet.2017.07.004","article-title":"Overview of immune abnormalities in lysosomal storage disorders","volume":"188","author":"Rigante","year":"2017","journal-title":"Immunol Lett"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg089","article-title":"Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis","volume":"126","author":"Jeyakumar","year":"2003","journal-title":"Brain"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200419639","article-title":"Possible role of autoantibodies in the pathophysiology of GM2 gangliosidoses","volume":"113","author":"Yamaguchi","year":"2004","journal-title":"J Clin Invest"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1084\/jem.65.5.705","article-title":"Spontaneous encephalomyelitis of mice, a new virus disease","volume":"65","author":"Theiler","year":"1937","journal-title":"J Exp Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1084\/jem.72.1.79","article-title":"Encephalomyelitis of mice: III. epidemiology","volume":"72","author":"Theiler","year":"1940","journal-title":"J Exp Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1084\/jem.72.1.49","article-title":"Encephalomyelitis of mice: I. characteristics and pathogenesis of the virus","volume":"72","author":"Theiler","year":"1940","journal-title":"J Exp Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"448","DOI":"10.3390\/ijms20020448","article-title":"Facets of Theiler\u2019s murine encephalomyelitis virus-induced diseases: An update","volume":"20","author":"Gerhauser","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.40.2.560-567.1981","article-title":"Theiler\u2019s murine encephalomyelitis virus group includes two distinct genetic subgroups that differ pathologically and biologically","volume":"40","author":"Lorch","year":"1981","journal-title":"J Virol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3109\/13550289509111014","article-title":"The effect of Theiler\u2019s murine encephalomyelitis virus (TMEV) VP1 carboxyl region on the virusinduced central nervous system disease","volume":"1","author":"Senkowski","year":"1995","journal-title":"J Neurovirol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0168-1702(01)00256-8","article-title":"Serological evidence that Mus musculus is the natural host of Theiler\u2019s murine encephalomyelitis virus","volume":"76","author":"Lipton","year":"2001","journal-title":"Virus Res"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1128\/iai.11.5.1147-1155.1975","article-title":"Theiler\u2019s virus infection in mice: an unusual biphasic disease process leading to demyelination","volume":"11","author":"Lipton","year":"1975","journal-title":"Infect Immun"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1159\/000336563","article-title":"Periventricular demyelination and axonal pathology is associated with subependymal virus spread in a murine model for multiple sclerosis","volume":"55","author":"Kummerfeld","year":"2012","journal-title":"Intervirology"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.11.8592-8601.1997","article-title":"The immune system preferentially clears Theiler\u2019s virus from the gray matter of the central nervous system","volume":"71","author":"Njenga","year":"1997","journal-title":"J Virol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1006\/meth.1996.0123","article-title":"Theiler\u2019s murine encephalomyelitis virus (TMEV)-induced demyelination: A model for human Multiple Sclerosis","volume":"10","author":"Dal Canto","year":"1996","journal-title":"Methods"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324007","article-title":"Clearance of Theiler\u2019s virus infection depends on the ability to generate a CD8+ T cell response against a single immunodominant viral peptide","volume":"33","author":"Mendez-Fernandez","year":"2003","journal-title":"Eur J Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.135.2.1408","article-title":"Theiler\u2019s murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: Correlation with TMEV-specific delayed-type hypersensitivity","volume":"135","author":"Clatch","year":"1985","journal-title":"J Immunol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.138.5.1429","article-title":"Variations in genetic control of susceptibility to Theiler\u2019s murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Differences between susceptible SJL\/J and resistant BALB\/c strains map near the T cell beta-chain constant gene on chromosome 6","volume":"138","author":"Melvold","year":"1987","journal-title":"J Immunol"},{"key":"B43","article-title":"Viral infection and dissemination through the olfactory pathway and the limbic system by Theiler\u2019s virus","volume":"143","author":"Wada","year":"1993","journal-title":"Am J Pathol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(76)90267-7","article-title":"Chronic neurologic disease in Theiler\u2019s virus infection of SJL\/J mice","volume":"30","author":"Lipton","year":"1976","journal-title":"J Neurol Sci"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-002-0105-z","article-title":"Inside-Out versus Outside-In models for virus induced demyelination: axonal damage triggering demyelination","volume":"24","author":"Tsunoda","year":"2002","journal-title":"Springer Semin Immunopathol"},{"key":"B46","first-page":"497","article-title":"Multiple sclerosis. Animal model: Theiler\u2019s virus infection in mice","volume":"88","author":"Dal Canto","year":"1977","journal-title":"Am J Pathol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070320305","article-title":"Two models of multiple sclerosis: Experimental allergic encephalomyelitis (EAE) and Theiler\u2019s murine encephalomyelitis virus (TMEV) infection. A pathological and immunological comparison","volume":"32","author":"Dal Canto","year":"1995","journal-title":"Microsc Res Tech"},{"key":"B48","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1128\/CMR.17.1.174-207.2004","article-title":"Theiler\u2019s virus infection: A model for multiple sclerosis","volume":"17","author":"Oleszak","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"Compston","year":"2008","journal-title":"Lancet"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.08.014","article-title":"Motor and reflex testing in GM1-gangliosidosis model mice","volume":"29","author":"Ichinomiya","year":"2007","journal-title":"Brain Dev"},{"key":"B51","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/S0006-8993(98)01258-X","article-title":"Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests","volume":"835","author":"Crawley","year":"1999","journal-title":"Brain Res"},{"key":"B52","doi-asserted-by":"publisher","first-page":"4588","DOI":"10.1038\/s41598-019-40964-1","article-title":"Virus-triggered spinal cord demyelination is followed by a peripheral neuropathy resembling features of Guillain-Barre Syndrome","volume":"9","author":"Leitzen","year":"2019","journal-title":"Sci Rep"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2011.00541.x","article-title":"Axonopathy is associated with complex axonal transport defects in a model of multiple sclerosis","volume":"22","author":"Kreutzer","year":"2012","journal-title":"Brain Pathol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1136\/vr.103425","article-title":"Immunolabelling of non-phosphorylated neurofilament indicates damage of spinal cord axons in TSE-infected goats","volume":"178","author":"Nadeem","year":"2016","journal-title":"Vet Rec"},{"key":"B55","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jneuroim.2012.04.010","article-title":"Interleukin-10 expression during the acute phase is a putative prerequisite for delayed viral elimination in a murine model for multiple sclerosis","volume":"249","author":"Herder","year":"2012","journal-title":"J Neuroimmunol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"13915","DOI":"10.1038\/s41598-017-14246-7","article-title":"Canine dorsal root ganglia satellite glial cells represent an exceptional cell population with astrocytic and oligodendrocytic properties","volume":"7","author":"Tongtako","year":"2017","journal-title":"Sci Rep"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1194842","article-title":"Ovalbumin-specific CD4(+) and CD8(+) T cells contribute to different susceptibility for Theiler\u2019s murine encephalomyelitis virus persistence","volume":"14","author":"Wannemacher","year":"2023","journal-title":"Front Immunol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"key":"B59","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12974-023-02737-6","article-title":"IFNAR signaling of neuroectodermal cells is essential for the survival of C57BL\/6 mice infected with Theiler\u2019s murine encephalomyelitis virus","volume":"20","author":"B\u00fchler","year":"2023","journal-title":"J\u00a0Neuroinflamm"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.786940","article-title":"IFN-beta deficiency results in fatal or demyelinating disease in C57BL\/6 mice infected with theiler\u2019s murine encephalomyelitis viruses","volume":"13","author":"B\u00fchler","year":"2022","journal-title":"Front Immunol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21061906","article-title":"Novel molecular mechanisms of gangliosides in the nervous system elucidated by genetic engineering","volume":"21","author":"Furukawa","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/35036052","article-title":"Lipid rafts and signal transduction","volume":"1","author":"Simons","year":"2000","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2018.02.001","article-title":"Ganglioside GM1 protects against high altitude cerebral edema in rats by suppressing the oxidative stress and inflammatory response via the PI3K\/AKT-Nrf2 pathway","volume":"95","author":"Gong","year":"2018","journal-title":"Mol Immunol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.2014.130.issue-4","article-title":"GM1 ganglioside enhances Ret signaling in striatum","volume":"130","author":"Newburn","year":"2014","journal-title":"J\u00a0Neurochem"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9136-z","article-title":"GM1 ganglioside: past studies and future potential","volume":"53","author":"Aureli","year":"2016","journal-title":"Mol Neurobiol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19990601)38:11<1532::AID-ANIE1532>3.0.CO;2-U","article-title":"Sphingolipids-their metabolic pathways and the\u00a0pathobiochemistry of neurodegenerative diseases","volume":"38","author":"Kolter","year":"1999","journal-title":"Angew Chem Int Ed Engl"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91298-2","article-title":"GM1 ganglioside stimulates the regeneration of dopaminergic neurons in the central nervous system","volume":"261","author":"Toffano","year":"1983","journal-title":"Brain Res"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1983.tb07363.x","article-title":"Neurotensin in vitro markedly reduces the affinity in subcortical limbic 3H-N-propylnorapomorphine binding sites","volume":"119","author":"Agnati","year":"1983","journal-title":"Acta Physiol Scand"},{"key":"B69","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/j.1471-4159.1984.tb02678.x","article-title":"Promotion of neuritogenesis in mouse neuroblastoma cells by\u00a0exogenous gangliosides. Relationship between the effect and the cell association of\u00a0ganglioside GM1","volume":"42","author":"Facci","year":"1984","journal-title":"J Neurochem"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19980901)53:5<605::AID-JNR10>3.0.CO;2-#","article-title":"Binding of cholera toxin B subunit: a surface marker for murine microglia but not oligodendrocytes or astrocytes","volume":"53","author":"Nedelkoska","year":"1998","journal-title":"J Neurosci Res"},{"key":"B71","doi-asserted-by":"publisher","first-page":"5380","DOI":"10.1038\/s41598-020-61852-z","article-title":"Neurotrophic effects of G(M1) ganglioside, NGF, and FGF2 on canine dorsal root ganglia neurons in vitro","volume":"10","author":"Schwarz","year":"2020","journal-title":"Sci Rep"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1007\/BF02935630","article-title":"Ganglioside function in the development and repair of the nervous system. From basic science to clinical application","volume":"3","author":"Skaper","year":"1989","journal-title":"Mol Neurobiol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/0014-4886(89)90163-5","article-title":"Monosialoganglioside GM1 protects against anoxia-induced neuronal death in vitro","volume":"106","author":"Skaper","year":"1989","journal-title":"Exp Neurol"},{"key":"B74","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.97.20.10954","article-title":"Microglial activation precedes acute neurodegeneration in Sandhoff disease and is suppressed by bone marrow transplantation","volume":"97","author":"Wada","year":"2000","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.45","article-title":"Acid sphingomyelinase activity triggers microparticle release from glial cells","volume":"28","author":"Bianco","year":"2009","journal-title":"EMBO J"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01154-06","article-title":"Acid sphingomyelinase deficiency increases susceptibility to fatal alphavirus encephalomyelitis","volume":"80","author":"Ng","year":"2006","journal-title":"J Virol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060921","article-title":"Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases","volume":"203","author":"Gadola","year":"2006","journal-title":"J Exp Med"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00422","article-title":"DAMPs from cell death to new life","volume":"6","author":"Venereau","year":"2015","journal-title":"Front Immunol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"578180","DOI":"10.1016\/j.jneuroim.2023.578180","article-title":"Microglia mediated neuroinflammation in neurodegenerative diseases: A review on the cell signaling pathways involved in microglial activation","volume":"383","author":"Biswas","year":"2023","journal-title":"J\u00a0Neuroimmunol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06457-11","article-title":"Melanoma differentiation-associated gene 5 is critical for protection against Theiler\u2019s virus-induced demyelinating disease","volume":"86","author":"Jin","year":"2012","journal-title":"J Virol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2009.04.030","article-title":"Generation and characterization of a polyclonal antibody for the detection of Theiler\u2019s murine encephalomyelitis virus by light and electron microscopy","volume":"160","author":"Kummerfeld","year":"2009","journal-title":"J Virol Methods"}],"updated-by":[{"DOI":"10.3389\/fimmu.2025.1610299","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000}}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1467207\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:36:29Z","timestamp":1745555789000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1467207\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,9]]},"references-count":81,"alternative-id":["10.3389\/fimmu.2025.1467207"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1467207","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,9]]},"article-number":"1467207"}}