{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:50:09Z","timestamp":1792029009748,"version":"4.4.0"},"reference-count":168,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020784","name":"Gannan Medical University","doi-asserted-by":"publisher","award":["QD202336, ZD201918"],"award-info":[{"award-number":["QD202336, ZD201918"]}],"id":[{"id":"10.13039\/501100020784","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020205","name":"Health Commission of Jiangxi Province","doi-asserted-by":"publisher","award":["SKJP220236344"],"award-info":[{"award-number":["SKJP220236344"]}],"id":[{"id":"10.13039\/501100020205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>As an immune and metabolic organ, the liver affects the progression and prognosis of sepsis. Despite the severe adverse effects of sepsis liver injury on the body, treatment options remain limited. Sphingosine-1-phosphate (S1P) is a widely distributed lipid signaling molecule that binds to five sphingosine-1-phosphate receptors (S1PR) to regulate downstream signaling pathways involved in the pathophysiological processes of sepsis, including endothelial permeability, cytokine release, and vascular tone. This review summarizes current research on the role of S1P in normal liver biology and describes the mechanisms by which changes in S1P\/S1PR affect the development of liver-related diseases. At the same time, the pathological processes underlying liver injury, as evidenced by clinical manifestations during sepsis, were comprehensively reviewed. This paper focused on the mechanistic pathways through which S1P and its receptors modulate immunity, bile acid metabolism, and liver-intestinal circulation in septic liver injury. Finally, the relationships between S1P and its receptors with liver inflammation and metabolism and the use of related drugs for the treatment of liver injury were examined. By elucidating the role of S1P and its receptor in the pathogenesis of sepsis liver injury, this review established a molecular targeting framework, providing novel insights into clinical and drug development.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1489015","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T06:45:19Z","timestamp":1738046719000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Regulatory role of S1P and its receptors in sepsis-induced liver injury"],"prefix":"10.3389","volume":"16","author":[{"given":"Bin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangfeng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongquan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i1585","article-title":"Sepsis: pathophysiology and clinical management","volume":"353","author":"Gotts","year":"2016","journal-title":"BMJ"},{"key":"B2","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1001\/jama.2016.20328","article-title":"Prognostic accuracy of the SOFA score, SIRS criteria, and qSOFA score for in-hospital mortality among adults with suspected infection admitted to the intensive care unit","volume":"317","author":"Raith","year":"2017","journal-title":"JAMA"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations","volume":"193","author":"Fleischmann","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-022-04374-2","article-title":"Incidence, predictors and outcome of sepsis-associated liver injury in children: a prospective observational study","volume":"181","author":"Saini","year":"2022","journal-title":"Eur J Pediatr"},{"key":"B5","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3109\/08830185.2014.889129","article-title":"The role of the liver in sepsis","volume":"33","author":"Yan","year":"2014","journal-title":"Int Rev Immunol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201508-1660LE","article-title":"Liver dysfunction is associated with long-term mortality in septic shock","volume":"193","author":"Nesseler","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/68363","article-title":"Liver dysfunction in sepsis","volume":"27","author":"Wo\u017anica","year":"2018","journal-title":"Adv Clin Exp Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s00134-015-4054-0","article-title":"Cholestatic liver (dys)function during sepsis and other critical illnesses","volume":"42","author":"Jenniskens","year":"2016","journal-title":"Intensive Care Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1186\/s13054-022-04090-1","article-title":"The gut-liver axis in sepsis: interaction mechanisms and therapeutic potential","volume":"26","author":"Zhang","year":"2022","journal-title":"Crit Care"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxz037","article-title":"Sphingosine 1-phosphate and inflammation","volume":"31","author":"Obinata","year":"2019","journal-title":"Int Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6741-1_1","article-title":"An overview of sphingolipid metabolism: from synthesis to breakdown","volume":"688","author":"Gault","year":"2010","journal-title":"Adv Exp Med Biol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104775","article-title":"Sphingosine-1-phosphate and its receptors in vascular endothelial and lymphatic barrier function","volume":"299","author":"Weigel","year":"2023","journal-title":"J Biol Chem"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104793","article-title":"Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology","volume":"156","author":"Jozefczuk","year":"2020","journal-title":"Pharmacol Res"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-081519-083952","article-title":"Finding a way out: S1P signaling and immune cell migration","volume":"38","author":"Baeyens","year":"2020","journal-title":"Annu Rev Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvs090","article-title":"The functional roles of S1P in immunity","volume":"152","author":"Hisano","year":"2012","journal-title":"J Biochem"},{"key":"B16","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1186\/s13054-015-1089-0","article-title":"Decreased serum concentrations of sphingosine-1-phosphate in sepsis","volume":"19","author":"Winkler","year":"2015","journal-title":"Crit Care"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113341","article-title":"Sphingosine 1-phosphate receptor, a new therapeutic direction in different diseases","volume":"153","author":"Chen","year":"2022","journal-title":"BioMed Pharmacother"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.3390\/cells11132058","article-title":"Sphingosine-1-phosphate (S1P) and S1P signaling pathway modulators, from current insights to future perspectives","volume":"11","author":"Bravo","year":"2022","journal-title":"Cells"},{"key":"B19","article-title":"The role of sphingosine 1-phosphate in immunity and sepsis","volume":"1","author":"Gr\u00e4ler","year":"2012","journal-title":"Am J Clin Exp Immunol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1641750","article-title":"Apolipoprotein M protects lipopolysaccharide-treated mice from death and organ injury","volume":"118","author":"Kurano","year":"2018","journal-title":"Thromb Haemost"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000814","article-title":"Sphingosine-1-phosphate: A potential biomarker and therapeutic target for endothelial dysfunction and sepsis","volume":"47","author":"Winkler","year":"2017","journal-title":"Shock"},{"key":"B22","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s13054-021-03545-1","article-title":"Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS","volume":"25","author":"Piotti","year":"2021","journal-title":"Crit Care"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12831","article-title":"Sphingosine 1-phosphate and its carrier apolipoprotein M in human sepsis and in Escherichia coli sepsis in baboons","volume":"20","author":"Frej","year":"2016","journal-title":"J Cell Mol Med"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00390","article-title":"Design, synthesis, and in vitro and in vivo evaluation of an (18)F-labeled sphingosine 1-phosphate receptor 1 (S1P1) PET tracer","volume":"59","author":"Rosenberg","year":"2016","journal-title":"J Med Chem"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110912","article-title":"Aralia saponin A isolated from Achyranthes bidentata Bl. ameliorates LPS\/D-GalN induced acute liver injury via SPHK1\/S1P\/S1PR1 pathway in vivo and in vitro","volume":"124","author":"Zeng","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646417","article-title":"Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis","volume":"46","author":"Hemdan","year":"2016","journal-title":"Eur J Immunol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1080\/10409238.2017.1337706","article-title":"Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology","volume":"52","author":"Rohrbach","year":"2017","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8606878","article-title":"Sphingosine-1-phosphate signaling in immune cells and inflammation: roles and therapeutic potential","volume":"2016","author":"Aoki","year":"2016","journal-title":"Mediators Inflamm"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-05879-5_4","article-title":"S1P control of endothelial integrity","volume":"378","author":"Xiong","year":"2014","journal-title":"Curr Top Microbiol Immunol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.043","article-title":"Communication by extracellular vesicles: where we are and where we need to go","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v4.27066","article-title":"Biological properties of extracellular vesicles and their physiological functions","volume":"4","author":"Y\u00e1\u00f1ez-M\u00f3","year":"2015","journal-title":"J Extracell Vesicles"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02980","article-title":"Hepatocyte-derived lipotoxic extracellular vesicle sphingosine 1-phosphate induces macrophage chemotaxis","volume":"9","author":"Liao","year":"2018","journal-title":"Front Immunol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.07.030","article-title":"Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate","volume":"64","author":"Nojima","year":"2016","journal-title":"J Hepatol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103187108","article-title":"Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M","volume":"108","author":"Christoffersen","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.3390\/ijms18081636","article-title":"A novel perspective on the apoM-S1P axis, highlighting the metabolism of apoM and its role in liver fibrosis and neuroinflammation","volume":"18","author":"Hajny","year":"2017","journal-title":"Int J Mol Sci"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.631101","article-title":"Uncleaved ApoM signal peptide is required for formation of large ApoM\/sphingosine 1-phosphate (S1P)-enriched HDL particles","volume":"290","author":"Liu","year":"2015","journal-title":"J Biol Chem"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.121.316725","article-title":"Apolipoprotein M and sphingosine-1-phosphate receptor 1 promote the transendothelial transport of high-density lipoprotein","volume":"41","author":"Velagapudi","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2014.07.013","article-title":"Systemic distribution, subcellular localization and differential expression of sphingosine-1-phosphate receptors in benign and Malignant human tissues","volume":"97","author":"Wang","year":"2014","journal-title":"Exp Mol Pathol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.06.011","article-title":"Sphingosine kinase-1 inhibition protects primary rat hepatocytes against bile salt-induced apoptosis","volume":"1832","author":"Karimian","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29076","article-title":"The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice","volume":"65","author":"Wang","year":"2017","journal-title":"Hepatology"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(24)00246-7","article-title":"Cenerimod, a sphingosine-1-phosphate receptor modulator, versus placebo in patients with moderate-to-severe systemic lupus erythematosus (CARE): an international, double-blind, randomised, placebo-controlled, phase 2 trial","volume":"7","author":"Askanase","year":"2025","journal-title":"Lancet Rheumatol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"14065","DOI":"10.3390\/ijms232214065","article-title":"Sphingosine 1-phosphate and apolipoprotein M levels and their correlations with inflammatory biomarkers in patients with untreated familial hypercholesterolemia","volume":"23","author":"Juh\u00e1sz","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2023.2273963","article-title":"Roles of sphingosine kinase and sphingosine-1-phosphate receptor 2 in endotoxin-induced acute retinal inflammation","volume":"32","author":"Ahmed","year":"2024","journal-title":"Ocul Immunol Inflamm"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1405622","article-title":"S1PR2 participates in intestinal injury in severe acute pancreatitis by regulating macrophage pyroptosis","volume":"15","author":"Lin","year":"2024","journal-title":"Front Immunol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2024.119877","article-title":"Targeting SphK1\/S1PR3 axis ameliorates sepsis-induced multiple organ injury via orchestration of macrophage polarization and glycolysis","volume":"1872","author":"Wang","year":"2025","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.80256","article-title":"Sphingosine-1-phosphate receptor 4 attenuates neutrophilic airway inflammation in experimental asthma via repressing proinflammatory macrophage activation","volume":"19","author":"Wang","year":"2023","journal-title":"Int J Biol Sci"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2016.1153614","article-title":"Pro-phagocytic effects of thymoquinone on cigarette smoke-exposed macrophages occur by modulation of the sphingosine-1-phosphate signalling system","volume":"13","author":"Barnawi","year":"2016","journal-title":"COPD"},{"key":"B48","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1080\/21623945.2021.2021700","article-title":"S1P\/S1PR3 signalling axis protects against obesity-induced metabolic dysfunction","volume":"11","author":"Chakrabarty","year":"2022","journal-title":"Adipocyte"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-12806-4","article-title":"Conjugated bile acids accelerate progression of pancreatic cancer metastasis via S1PR2 signaling in cholestasis","volume":"30","author":"Sarkar","year":"2023","journal-title":"Ann Surg Oncol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200148RR","article-title":"Intestinal aberrant sphingolipid metabolism shaped-gut microbiome and bile acids metabolome in the development of hepatic steatosis","volume":"36","author":"Miao","year":"2022","journal-title":"FASEB J"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-168351","article-title":"Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression","volume":"25","author":"Osawa","year":"2011","journal-title":"FASEB J"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.2337\/db19-0811","article-title":"Protection against insulin resistance by apolipoprotein M\/sphingosine-1-phosphate","volume":"69","author":"Kurano","year":"2020","journal-title":"Diabetes"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.12.012","article-title":"Sphk2-\/- mice are protected from obesity and insulin resistance","volume":"1865","author":"Ravichandran","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R069286","article-title":"The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases","volume":"57","author":"Nagahashi","year":"2016","journal-title":"J Lipid Res"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-051116-052415","article-title":"Immune responses in the liver","volume":"36","author":"Kubes","year":"2018","journal-title":"Annu Rev Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c120011","article-title":"Liver immunology","volume":"3","author":"Bogdanos","year":"2013","journal-title":"Compr Physiol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"52","DOI":"10.4254\/wjh.v15.i1.52","article-title":"Liver immunity, autoimmunity, and inborn errors of immunity","volume":"15","author":"Parlar","year":"2023","journal-title":"World J Hepatol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/s41586-019-1373-2","article-title":"A human liver cell atlas reveals heterogeneity and epithelial progenitors","volume":"572","author":"Aizarani","year":"2019","journal-title":"Nature"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2024.109587","article-title":"Calorie restriction mimetic, resveratrol, attenuates hepatic ischemia and reperfusion injury through enhancing efferocytosis of macrophages via AMPK\/STAT3\/S1PR1 pathway","volume":"126","author":"Yao","year":"2024","journal-title":"J Nutr Biochem"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100479","article-title":"Lipid alterations in chronic liver disease and liver cancer","volume":"4","author":"Paul","year":"2022","journal-title":"JHEP Rep"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0471-x","article-title":"SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition","volume":"27","author":"Li","year":"2020","journal-title":"Cell Death Differ"},{"key":"B62","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12957-016-0884-7","article-title":"The SphKs\/S1P\/S1PR1 axis in immunity and cancer: more ore to be mined","volume":"14","author":"Jin","year":"2016","journal-title":"World J Surg Oncol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31321","article-title":"Inhibition of sphingosine-1-phosphate-induced th17 cells ameliorates alcohol-associated steatohepatitis in mice","volume":"73","author":"Chu","year":"2021","journal-title":"Hepatology"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i45.12778","article-title":"New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury","volume":"21","author":"Sano","year":"2015","journal-title":"World J Gastroenterol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.02.021","article-title":"Sphingosine kinase\/sphingosine 1-phosphate (S1P)\/S1P receptor axis is involved in liver fibrosis-associated angiogenesis","volume":"59","author":"Yang","year":"2013","journal-title":"J Hepatol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.03.022","article-title":"Sphingosine-1-phosphate prevents egress of hematopoietic stem cells from liver to reduce fibrosis","volume":"153","author":"King","year":"2017","journal-title":"Gastroenterology"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.08.028","article-title":"Sphingosine 1-phosphate (S1P)\/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility","volume":"54","author":"Li","year":"2011","journal-title":"J Hepatol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41419-020-2582-1","article-title":"Neutrophils undergo switch of apoptosis to NETosis during murine fatty liver injury via S1P receptor 2 signaling","volume":"11","author":"Zhao","year":"2020","journal-title":"Cell Death Dis"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2020.104243","article-title":"Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)\/S1P receptors during chronic liver injury","volume":"359","author":"Zhao","year":"2021","journal-title":"Cell Immunol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"4537","DOI":"10.3390\/ijms25084537","article-title":"NLRP3 inflammasome in acute and chronic liver diseases","volume":"25","author":"Sayaf","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-020-02032-4","article-title":"NLRP3 inflammasome priming and activation in cholestatic liver injury via the sphingosine 1-phosphate\/S1P receptor 2\/G\u03b1(12\/13)\/MAPK signaling pathway","volume":"99","author":"Hou","year":"2021","journal-title":"J Mol Med (Berl)"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00222.2016","article-title":"Inhibition of sphingosine 1-phosphate signaling ameliorates murine nonalcoholic steatohepatitis","volume":"312","author":"Mauer","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"19716","DOI":"10.1038\/s41598-023-46011-4","article-title":"Effect of FTY720P on lipid accumulation in HEPG2 cells","volume":"13","author":"Rida","year":"2023","journal-title":"Sci Rep"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M063511","article-title":"SphK1 mediates hepatic inflammation in a mouse model of NASH induced by high saturated fat feeding and initiates proinflammatory signaling in hepatocytes","volume":"56","author":"Geng","year":"2015","journal-title":"J Lipid Res"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20960","article-title":"Serum autotaxin is independently associated with hepatic steatosis in women with severe obesity","volume":"23","author":"Rachakonda","year":"2015","journal-title":"Obes (Silver Spring)"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02666.x","article-title":"Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P\/EDG1 axis in hepatocellular carcinoma","volume":"32","author":"Bao","year":"2012","journal-title":"Liver Int"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-05-0021","article-title":"Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma","volume":"4","author":"Ho","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S156328","article-title":"Targeted co-delivery of Beclin 1 siRNA and FTY720 to hepatocellular carcinoma by calcium phosphate nanoparticles for enhanced anticancer efficacy","volume":"13","author":"Wu","year":"2018","journal-title":"Int J Nanomedicine"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032380","article-title":"FTY720 suppresses liver tumor metastasis by reducing the population of circulating endothelial progenitor cells","volume":"7","author":"Li","year":"2012","journal-title":"PloS One"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2621","article-title":"FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling","volume":"68","author":"Hung","year":"2008","journal-title":"Cancer Res"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181b9ca69","article-title":"Suppression of hepatocellular carcinoma recurrence after rat liver transplantation by FTY720, a sphingosine-1-phosphate analog","volume":"88","author":"Ushitora","year":"2009","journal-title":"Transplantation"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000259462.97164.A0","article-title":"Incidence and prognosis of early hepatic dysfunction in critically ill patients\u2013a prospective multicenter study","volume":"35","author":"Kramer","year":"2007","journal-title":"Crit Care Med"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2020.75.4.182","article-title":"Liver dysfunction in sepsis","volume":"75","author":"Kim","year":"2020","journal-title":"Korean J Gastroenterol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1042\/CS20230522","article-title":"Inflammatory liver diseases and susceptibility to sepsis","volume":"138","author":"Lu","year":"2024","journal-title":"Clin Sci (Lond)"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001338","article-title":"Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis","volume":"9","author":"Recknagel","year":"2012","journal-title":"PloS Med"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2022.10.004","article-title":"Clinical characteristics and construction of a predictive model for patients with sepsis related liver injury","volume":"537","author":"Xie","year":"2022","journal-title":"Clin Chim Acta"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20646","article-title":"Liver perfusion in sepsis, septic shock, and multiorgan failure","volume":"291","author":"Spapen","year":"2008","journal-title":"Anat Rec (Hoboken)"},{"key":"B88","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/cc11381","article-title":"Clinical review: The liver in sepsis","volume":"16","author":"Nesseler","year":"2012","journal-title":"Crit Care"},{"key":"B89","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1186\/s13054-020-03327-1","article-title":"Gut-liver crosstalk in sepsis-induced liver injury","volume":"24","author":"Sun","year":"2020","journal-title":"Crit Care"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(02)00178-6","article-title":"EDG receptors and hepatic pathophysiology of LPA and S1P: EDG-ology of liver injury","volume":"1582","author":"Svetlov","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.102","article-title":"Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation","volume":"90","author":"Park","year":"2010","journal-title":"Lab Invest"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.3","article-title":"Liver immunology and its role in inflammation and homeostasis","volume":"13","author":"Robinson","year":"2016","journal-title":"Cell Mol Immunol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.4103\/2321-3868.132689","article-title":"Advances in sepsis-associated liver dysfunction","volume":"2","author":"Wang","year":"2014","journal-title":"Burns Trauma"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00137.2005","article-title":"Endotoxin-induced acute lung injury requires interaction with the liver","volume":"289","author":"Siore","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i46.13055","article-title":"Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells","volume":"21","author":"Lei","year":"2015","journal-title":"World J Gastroenterol"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i48.13438","article-title":"Sphingosine kinase 1 dependent protein kinase C-\u03b4 activation plays an important role in acute liver failure in mice","volume":"21","author":"Lei","year":"2015","journal-title":"World J Gastroenterol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202256635","article-title":"Enhancing Spns2\/S1P in macrophages alleviates hyperinflammation and prevents immunosuppression in sepsis","volume":"24","author":"Fang","year":"2023","journal-title":"EMBO Rep"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2023-0075OC","article-title":"Lack of S1PR2 in macrophage ameliorates sepsis-associated lung injury through inducing IL-33-mediated type 2 immunity","volume":"70","author":"Gong","year":"2024","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000725","article-title":"Sphingosine 1-phosphate receptor 2 signaling suppresses macrophage phagocytosis and impairs host defense against sepsis","volume":"123","author":"Hou","year":"2015","journal-title":"Anesthesiology"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01149","article-title":"Macrophage sphingosine 1-phosphate receptor 2 blockade attenuates liver inflammation and fibrogenesis triggered by NLRP3 inflammasome","volume":"11","author":"Hou","year":"2020","journal-title":"Front Immunol"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1090202","article-title":"Inhibition of sphingosine-1-phosphate receptor 3 suppresses ATP-induced NLRP3 inflammasome activation in macrophages via TWIK2-mediated potassium efflux","volume":"14","author":"Wang","year":"2023","journal-title":"Front Immunol"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22725","article-title":"NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and Kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis","volume":"49","author":"Hou","year":"2009","journal-title":"Hepatology"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.899725","article-title":"Immune regulation of intrahepatic regulatory T cells in fibrotic livers of mice","volume":"23","author":"Zhang","year":"2017","journal-title":"Med Sci Monit"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01854.x","article-title":"Activation of human T cells with NK cell markers by staphylococcal enterotoxin A via IL-12 but not via IL-18","volume":"128","author":"Ami","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202149733","article-title":"Dendritic cells Trigger IFN-\u03b3 secretion by NK cells independent of IL-12 and IL-18","volume":"52","author":"Abdi","year":"2022","journal-title":"Eur J Immunol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1182\/blood-2011-02-337980","article-title":"Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo","volume":"120","author":"Tang","year":"2012","journal-title":"Blood"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.7.3500","article-title":"Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor","volume":"171","author":"Dorsam","year":"2003","journal-title":"J Immunol"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090525","article-title":"T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow","volume":"206","author":"Jenne","year":"2009","journal-title":"J Exp Med"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det339","article-title":"Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration","volume":"28","author":"Zhang","year":"2013","journal-title":"Hum Reprod"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1038\/ni1523","article-title":"Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor","volume":"8","author":"Walzer","year":"2007","journal-title":"Nat Immunol"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.08.125","article-title":"Bone marrow-derived mesenchymal stem cells suppress NK cell recruitment and activation in PolyI:C-induced liver injury","volume":"466","author":"Qu","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.08.021","article-title":"Involvement of natural killer cells in PolyI:C-induced liver injury","volume":"41","author":"Dong","year":"2004","journal-title":"J Hepatol"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-022-00935-7","article-title":"Bile acids and their receptors: modulators and therapeutic targets in liver inflammation","volume":"44","author":"Bertolini","year":"2022","journal-title":"Semin Immunopathol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.S091959","article-title":"New insights into functions of the sphingosine-1-phosphate transporter SPNS2","volume":"60","author":"Spiegel","year":"2019","journal-title":"J Lipid Res"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1042\/BST20150132","article-title":"Lipid flopping in the liver","volume":"43","author":"Linton","year":"2015","journal-title":"Biochem Soc Trans"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50100","article-title":"Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes","volume":"124","author":"Spirl\u00ec","year":"2003","journal-title":"Gastroenterology"},{"key":"B117","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S1089-3261(03)00134-X","article-title":"Sepsis and cholestasis","volume":"8","author":"Moseley","year":"2004","journal-title":"Clin Liver Dis"},{"key":"B118","doi-asserted-by":"publisher","first-page":"9606","DOI":"10.3390\/ijms23179606","article-title":"Sphingosine-1-phosphate (S1P) lyase inhibition aggravates atherosclerosis and induces plaque rupture in apoE-\/-mice","volume":"23","author":"Keul","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M088443","article-title":"Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages","volume":"60","author":"Vaidya","year":"2019","journal-title":"J Lipid Res"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.03.007","article-title":"Farnesoid X receptor regulation of the NLRP3 inflammasome underlies cholestasis-associated sepsis","volume":"25","author":"Hao","year":"2017","journal-title":"Cell Metab"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.25516","article-title":"Proinflammatory cytokines inhibit secretion in rat bile duct epithelium","volume":"121","author":"Spirl\u00ec","year":"2001","journal-title":"Gastroenterology"},{"key":"B122","doi-asserted-by":"publisher","first-page":"e16744","DOI":"10.7717\/peerj.16744","article-title":"Reversal of cholestatic liver disease by the inhibition of sphingosine 1-phosphate receptor 2 signaling","volume":"12","author":"Cao","year":"2024","journal-title":"PeerJ"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.01.020","article-title":"Interactions between the intestinal microbiome and liver diseases","volume":"146","author":"Schnabl","year":"2014","journal-title":"Gastroenterology"},{"key":"B124","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nrgastro.2016.168","article-title":"Liver - guardian, modifier and target of sepsis","volume":"14","author":"Strnad","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.03.005","article-title":"The intestinal microenvironment in sepsis","volume":"1863","author":"Fay","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-018-1178-5","article-title":"Gut-origin sepsis in the critically ill patient: pathophysiology and treatment","volume":"46","author":"Assimakopoulos","year":"2018","journal-title":"Infection"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.767456","article-title":"IL-1\u03b2 and the intestinal epithelial tight junction barrier","volume":"12","author":"Kaminsky","year":"2021","journal-title":"Front Immunol"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00891","article-title":"Challenge to the intestinal mucosa during sepsis","volume":"10","author":"Haussner","year":"2019","journal-title":"Front Immunol"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2019.1629235","article-title":"Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner","volume":"11","author":"Stephens","year":"2020","journal-title":"Gut Microbes"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1151728","article-title":"Circulating sepsis-related metabolite sphinganine could protect against intestinal damage during sepsis","volume":"14","author":"Wang","year":"2023","journal-title":"Front Immunol"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1235656","article-title":"The role of sphingosine-1-phosphate in the gut mucosal microenvironment and inflammatory bowel diseases","volume":"14","author":"Zou","year":"2023","journal-title":"Front Physiol"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2021.1940069","article-title":"Barrier maintenance by S1P during inflammation and sepsis","volume":"9","author":"Ziegler","year":"2021","journal-title":"Tissue Barriers"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2020.105819","article-title":"HDL-S1P protects endothelial function and reduces lung injury during sepsis in vivo and in vitro","volume":"126","author":"Fan","year":"2020","journal-title":"Int J Biochem Cell Biol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.14670\/HH-18-428","article-title":"Sphingosine 1-phosphate and its regulatory role in vascular endothelial cells","volume":"37","author":"Qiu","year":"2022","journal-title":"Histol Histopathol"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.2174\/138945007780362719","article-title":"Novel therapies for microvascular permeability in sepsis","volume":"8","author":"Jacobson","year":"2007","journal-title":"Curr Drug Targets"},{"key":"B136","doi-asserted-by":"publisher","first-page":"4176","DOI":"10.3390\/nu15194176","article-title":"Red rice seed coat targeting SPHK2 ameliorated alcoholic liver disease via restored intestinal barrier and improved gut microbiota in mice","volume":"15","author":"Chen","year":"2023","journal-title":"Nutrients"},{"key":"B137","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1165\/rcmb.2009-0223OC","article-title":"Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung","volume":"43","author":"Sammani","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B138","article-title":"The drug development based on sphingosine-1-phosphate signaling pathway","volume":"51","author":"Bai","year":"2016","journal-title":"Yao Xue Xue Bao"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-017-0565-4","article-title":"Sphingosine 1-phosphate receptor modulators for the treatment of multiple sclerosis","volume":"14","author":"Chaudhry","year":"2017","journal-title":"Neurotherapeutics"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1177\/0091270004274288","article-title":"FTY720 pharmacokinetics in mild to moderate hepatic impairment","volume":"45","author":"Kovarik","year":"2005","journal-title":"J Clin Pharmacol"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2020.07.020","article-title":"Fingolimod-induced remission in a patient with ulcerative colitis and multiple sclerosis","volume":"44","author":"Ladr\u00f3n Abia","year":"2021","journal-title":"Gastroenterol Hepatol"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00574-7","article-title":"Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel disease","volume":"19","author":"Verstockt","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12897","article-title":"FTY-720 alleviates diabetes-induced liver injury by inhibiting oxidative stress and inflammation","volume":"37","author":"Ye","year":"2023","journal-title":"Fundam Clin Pharmacol"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.018","article-title":"Hepatopulmonary syndrome is associated with low sphingosine-1-phosphate levels and can be ameliorated by the functional agonist fingolimod","volume":"79","author":"Baweja","year":"2023","journal-title":"J Hepatol"},{"key":"B145","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3892\/ijmm.2022.5123","article-title":"FTY720 attenuates APAP\u2212induced liver injury via the JAK2\/STAT3 signaling pathway","volume":"49","author":"He","year":"2022","journal-title":"Int J Mol Med"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.repc.2014.11.012","article-title":"Cardiovascular effects of fingolimod: Relevance, detection and approach","volume":"34","author":"Aguiar","year":"2015","journal-title":"Rev Port Cardiol"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.17712\/nsj.2024.3.20240040","article-title":"Assessment of clinician adherence to Fingolimod instructions and its effect on patient safety","volume":"29","author":"Alhubaishi","year":"2024","journal-title":"Neurosci (Riyadh)"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22800","article-title":"Antioxidative effects of silymarin on the reduction of liver complications of fingolimod in patients with relapsing-remitting multiple sclerosis: A clinical trial study","volume":"35","author":"Ghiasian","year":"2021","journal-title":"J Biochem Mol Toxicol"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.52017","article-title":"Sphingosine 1-phosphate receptor modulators in multiple sclerosis treatment: A practical review","volume":"11","author":"Coyle","year":"2024","journal-title":"Ann Clin Transl Neurol"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202300387","article-title":"Structural determinants of sphingosine-1-phosphate receptor selectivity","volume":"356","author":"Wunsch","year":"2023","journal-title":"Arch Pharm (Weinheim)"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-022-01762-8","article-title":"Ozanimod: A review in ulcerative colitis","volume":"82","author":"Paik","year":"2022","journal-title":"Drugs"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2033617","article-title":"Ozanimod as induction and maintenance therapy for ulcerative colitis","volume":"385","author":"Sandborn","year":"2021","journal-title":"N Engl J Med"},{"key":"B153","doi-asserted-by":"publisher","first-page":"12634","DOI":"10.3390\/ijms241612634","article-title":"Immune system and brain\/intestinal barrier functions in psychiatric diseases: is sphingosine-1-phosphate at the helm","volume":"24","author":"Mart\u00edn-Hern\u00e1ndez","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B154","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1186\/s12934-024-02579-8","article-title":"Engineering of Saccharomyces cerevisiae as a platform strain for microbial production of sphingosine-1-phosphate","volume":"23","author":"Jang","year":"2024","journal-title":"Microb Cell Fact"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2024.115732","article-title":"High-resolution targeted mass spectrometry for comprehensive quantification of sphingolipids: clinical applications and characterization of extracellular vesicles","volume":"698","author":"Felippe","year":"2024","journal-title":"Anal Biochem"},{"key":"B156","article-title":"Macrophage polarization involved the inflammation of chronic obstructive pulmonary disease by S1P\/HDAC1 signaling","volume":"13","author":"Zhang","year":"2023","journal-title":"Am J Cancer Res"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01085.x","article-title":"The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo","volume":"5","author":"Lan","year":"2005","journal-title":"Am J Transplant"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.6.3437","article-title":"Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3","volume":"178","author":"Maeda","year":"2007","journal-title":"J Immunol"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2014-0271","article-title":"S1PR4 is required for plasmacytoid dendritic cell differentiation","volume":"396","author":"Dillmann","year":"2015","journal-title":"Biol Chem"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2669","article-title":"S1PR5 regulates NK cell responses in preventing graft-versus-host disease while preserving graft-versus-tumour activity in a murine allogeneic haematopoietic stem cell transplantation model","volume":"38","author":"Wang","year":"2020","journal-title":"Hematol Oncol"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1038\/nature02284","article-title":"Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1","volume":"427","author":"Matloubian","year":"2004","journal-title":"Nature"},{"key":"B162","article-title":"Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P","volume":"3","author":"Matsuyuki","year":"2006","journal-title":"Cell Mol Immunol"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1172\/JCI174984","article-title":"S1PR1 inhibition induces proapoptotic signaling in T cells and limits humoral responses within lymph nodes","volume":"134","author":"Dixit","year":"2024","journal-title":"J Clin Invest"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3730fje","article-title":"Type 4 sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration","volume":"19","author":"Wang","year":"2005","journal-title":"FASEB J"},{"key":"B165","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.3390\/ijms23031191","article-title":"In vitro characterization of sphingosine 1-phosphate receptor 1 (S1P1) expression and mediated migration of primary human T and B cells in the context of cenerimod, a novel, selective S1P1 receptor modulator","volume":"23","author":"Schlicher","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B166","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jaut.2016.03.012","article-title":"Fingolimod therapy modulates circulating B cell composition, increases B regulatory subsets and production of IL-10 and TGF\u03b2 in patients with Multiple Sclerosis","volume":"70","author":"Blumenfeld","year":"2016","journal-title":"J Autoimmun"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2047","article-title":"The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement","volume":"12","author":"Green","year":"2011","journal-title":"Nat Immunol"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939858","article-title":"S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development","volume":"40","author":"Donovan","year":"2010","journal-title":"Eur J Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1489015\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T06:45:27Z","timestamp":1738046727000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1489015\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,28]]},"references-count":168,"alternative-id":["10.3389\/fimmu.2025.1489015"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1489015","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,28]]},"article-number":"1489015"}}