{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:20:59Z","timestamp":1793089259825,"version":"4.5.0"},"reference-count":182,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Acute lung injury(ALI)\/acute respiratory distress syndrome(ARDS) is a severe clinical syndrome characterized by high morbidity and mortality, primarily due to lung injury. However, the pathogenesis of ALI\/ARDS remains a complex issue. In recent years, the role of macrophage pyroptosis in lung injury has garnered extensive attention worldwide. This paper reviews the mechanism of macrophage pyroptosis, discusses its role in ALI\/ARDS, and introduces several drugs and intervening measures that can regulate macrophage pyroptosis to influence the progression of ALI\/ARDS. By doing so, we aim to enhance the understanding of the mechanism of macrophage pyroptosis in ALI\/ARDS and provide novel insights for its treatment.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1530849","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:10:56Z","timestamp":1739491856000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Macrophage pyroptosis and its crucial role in ALI\/ARDS"],"prefix":"10.3389","volume":"16","author":[{"given":"Yuju","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luorui","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifeng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1608077","article-title":"Acute respiratory distress syndrome","volume":"377","author":"Thompson","year":"2017","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/01.Ccm.0000057904.62683.2b","article-title":"Epidemiology of acute lung injury","volume":"31","author":"Rubenfeld","year":"2003","journal-title":"Crit Care Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1001\/jama.2016.0291","article-title":"Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries","volume":"315","author":"Bellani","year":"2016","journal-title":"Jama"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e076612","DOI":"10.1136\/bmj-2023-076612","article-title":"Acute respiratory distress syndrome","volume":"387","author":"Wick","year":"2024","journal-title":"Bmj"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2024.05.012","article-title":"Interplay between pulmonary epithelial stem cells and innate immune cells contribute to the repair and regeneration of ALI\/ARDS","volume":"272","author":"Wang","year":"2024","journal-title":"Transl Res"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13408","article-title":"Inflammasome-mediated pyroptosis in defense against pathogenic bacteria","volume":"329","author":"Oh","year":"2024","journal-title":"Immunol Rev"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2024.102489","article-title":"Inflammasomes and their role in PANoptosomes","volume":"91","author":"Nadella","year":"2024","journal-title":"Curr Opin Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1330461","article-title":"The dance of macrophage death: the interplay between the inevitable and the microenvironment","volume":"15","author":"Makuch","year":"2024","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101239","article-title":"Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos","volume":"26","author":"Robinson","year":"2019","journal-title":"Redox Biol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(67)90168-7","article-title":"Acute respiratory distress in adults","volume":"2","author":"Ashbaugh","year":"1967","journal-title":"Lancet"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.3.7509706","article-title":"The American-European Consensus Conference on ARDS. 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