{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T01:30:59Z","timestamp":1788226259172,"version":"build-2803163510"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Advanced ovarian cancer (AOC) is prone to recurrence, which can be attributed to drug resistance. Drug resistance may be related to the tumor microenvironment (TME), including the immune and non-immune TME. In the immune TME, the immune effector cells such as dendritic cells (DCs), M1-like tumor-associated macrophages (M1-TAMs), and T cells are inhibited. In contrast, immunosuppressive cells such as M2-like tumor-associated macrophages (M2-TAMs), myeloid-derived suppressor cells (MDSCs), and regulatory T cells (Tregs) are activated. These changes make it difficult to produce immune effects and affect the efficacy of chemo-immunotherapy. In the non-immune TME, mechanisms such as apoptosis inhibition, DNA damage response (DDR), and epithelial-mesenchymal transition (EMT) can promote tumor growth, metastasis, and drug resistance. Despite the challenges posed by the TME in the treatment of AOC, the unique biological advantages of nanoparticles (NPs) make it possible to regulate the TME. NPs can stimulate the immune responses of M1-TAMs, DCs, and T cells while reducing the infiltration of immune suppressive cells such as M2-TAMs and Tregs, thereby regulating the AOC immune TME. In addition, NPs can regulate the non-immune TME by reducing apoptosis in AOC cells, inhibiting homologous recombination (HR) repair, reversing EMT, and achieving the effect of reversing drug resistance. In summary, the application of NPs provides some new venues for clinical treatment in AOC.<\/jats:p>","DOI":"10.3389\/fimmu.2025.1542326","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T07:26:43Z","timestamp":1739345203000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["A new strategy for the treatment of advanced ovarian cancer: utilizing nanotechnology to regulate the tumor microenvironment"],"prefix":"10.3389","volume":"16","author":[{"given":"Zixuan","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuqun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1177\/20417314221088514","article-title":"Establishment of the SIS scaffold-based 3D model of human peritoneum for studying the dissemination of ovarian cancer","volume":"13","author":"Herbert","year":"2022","journal-title":"J Tissue Eng"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15524","article-title":"Metformin inhibits the proliferation and invasion of ovarian cancer cells by suppressing tripartite motif-containing 37-induced tumor necrosis factor receptor-associated factor 2 ubiquitination","volume":"113","author":"Zheng","year":"2022","journal-title":"Cancer Sci"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt333","article-title":"Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","author":"Ledermann","year":"2013","journal-title":"Ann oncology: Off J Eur Soc Med Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jff.2018.09.021","article-title":"Theaflavin-3, 3\u2019-digallate inhibits ovarian cancer stem cells via suppressing Wnt\/\u03b2-Catenin signaling pathway","volume":"50","author":"Pan","year":"2018","journal-title":"J Funct foods"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02210-9","article-title":"AXL: shapers of tumor progression and immunosuppressive microenvironments","volume":"24","author":"Liu","year":"2025","journal-title":"Mol Cancer"},{"key":"B6","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.omto.2021.07.002","article-title":"Development of a seven-gene tumor immune microenvironment prognostic signature for high-risk grade III endometrial cancer","volume":"22","author":"Zheng","year":"2021","journal-title":"Mol Ther oncolytics"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.08.017","article-title":"Challenges for immunotherapy for the treatment of platinum resistant ovarian cancer","volume":"77","author":"Le Saux","year":"2021","journal-title":"Semin Cancer Biol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e20191869","DOI":"10.1084\/jem.20191869","article-title":"Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer","volume":"217","author":"Etzerodt","year":"2020","journal-title":"J Exp Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12951-018-0392-8","article-title":"Nano based drug delivery systems: recent developments and future prospects","volume":"16","author":"Patra","year":"2018","journal-title":"J nanobiotechnology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e2103836","DOI":"10.1002\/advs.202103836","article-title":"Tumor-microenvironment-responsive nanomedicine for enhanced cancer immunotherapy","volume":"9","author":"Peng","year":"2022","journal-title":"Advanced Sci (Weinheim Baden-Wurttemberg Germany)"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1950","article-title":"Nanoparticle drug delivery systems responsive to tumor microenvironment: Promising alternatives in the treatment of triple-negative breast cancer","volume":"16","author":"Cao","year":"2024","journal-title":"Wiley Interdiscip Rev Nanomedicine nanobiotechnology"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202202039","article-title":"Versatile nano-PROTAC-induced epigenetic reader degradation for efficient lung cancer therapy","volume":"9","author":"Zhang","year":"2022","journal-title":"Advanced Sci (Weinheim Baden-Wurttemberg Germany)"},{"key":"B13","doi-asserted-by":"publisher","first-page":"834","DOI":"10.3390\/biom10060834","article-title":"Significance of STAT3 in immune infiltration and drug response in cancer","volume":"10","author":"Chen","year":"2020","journal-title":"Biomolecules"},{"key":"B14","doi-asserted-by":"publisher","first-page":"0","DOI":"10.1126\/sciadv.ade4186","article-title":"PD-L1 methylation restricts PD-L1\/PD-1 interactions to control cancer immune surveillance","volume":"9","author":"Huang","year":"2023","journal-title":"Sci Adv"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2021.108728","article-title":"Atezolizumab and blockade of LncRNA PVT1 attenuate cisplatin resistant ovarian cancer cells progression synergistically via JAK2\/STAT3\/PD-L1 pathway","volume":"227","author":"Chen","year":"2021","journal-title":"Clin Immunol (Orlando Fla.)"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17235","article-title":"Chronic alcohol exposure induces hepatocyte damage by inducing oxidative stress, SATB2 and stem cell-like characteristics, and activating lipogenesis","volume":"26","author":"Yu","year":"2022","journal-title":"J Cell Mol Med"},{"key":"B17","doi-asserted-by":"publisher","first-page":"4675","DOI":"10.3390\/ijms23094675","article-title":"Rotenone-induced 4-HNE aggresome formation and degradation in HL-1 cardiomyocytes: role of autophagy flux","volume":"23","author":"Sharma","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.93","article-title":"Dendritic cells are stressed out in tumor","volume":"25","author":"Maj","year":"2015","journal-title":"Cell Res"},{"key":"B19","doi-asserted-by":"publisher","first-page":"599","DOI":"10.7150\/ijbs.67816","article-title":". Trophoblast-derived lactic acid orchestrates decidual macrophage differentiation via SRC\/LDHA signaling in early pregnancy","volume":"18","author":"Lu","year":"2022","journal-title":"Int J Biol Sci"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116930","article-title":"Macrophage polarization in the tumor microenvironment: Emerging roles and therapeutic potentials","volume":"177","author":"Zhang","year":"2024","journal-title":"Biomedicine pharmacotherapy = Biomedecine pharmacotherapie"},{"key":"B21","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s13045-024-01559-0","article-title":"Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy","volume":"17","author":"Toledo","year":"2024","journal-title":"J Hematol Oncol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126560","article-title":"The impact of the tumor microenvironment on macrophage polarization in cancer metastatic progression","volume":"22","author":"Wang","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B23","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s40425-019-0666-1","article-title":"Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and Malignant phenotypes in 3D engineered microenvironments","volume":"7","author":"Raghavan","year":"2019","journal-title":"J immunotherapy Cancer"},{"key":"B24","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/s41392-021-00670-9","article-title":"Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer","volume":"6","author":"Li","year":"2021","journal-title":"Signal transduction targeted Ther"},{"key":"B25","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s42003-025-07524-y","article-title":"Piezo1 promotes vibration-induced vascular smooth muscle injury by regulating the NF-\u03baB\/p65 axis","volume":"8","author":"Zeng","year":"2025","journal-title":"Commun Biol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1038\/s41467-018-03966-7","article-title":"Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation","volume":"9","author":"Taki","year":"2018","journal-title":"Nat Commun"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010033","article-title":"Synergistic effects of nanomedicine targeting TNFR2 and DNA demethylation inhibitor-an opportunity for cancer treatment","volume":"9","author":"Al-Hatamleh","year":"2019","journal-title":"Cells"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/biom13081253","article-title":"Endometriosis-associated ovarian carcinomas: how PI3K\/AKT\/mTOR pathway affects their pathogenesis","volume":"13","author":"Driva","year":"2023","journal-title":"Biomolecules"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1057198","article-title":"NUF2 overexpression contributes to epithelial ovarian cancer progression via ERBB3-mediated PI3K-AKT and MAPK signaling axes","volume":"12","author":"Leng","year":"2022","journal-title":"Front Oncol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22899","article-title":"MEF2 signaling and human diseases","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S270441","article-title":"Silencing of MEF2D by siRNA loaded selenium nanoparticles for ovarian cancer therapy","volume":"15","author":"Wang","year":"2020","journal-title":"Int J nanomedicine"},{"key":"B32","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/s41419-019-1807-7","article-title":"Inhibition of ZIP4 reverses epithelial-to-mesenchymal transition and enhances the radiosensitivity in human nasopharyngeal carcinoma cells","volume":"10","author":"Zeng","year":"2019","journal-title":"Cell Death Dis"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0253-2727.2019.01.010","article-title":"Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi","volume":"40","author":"Wu","year":"2019","journal-title":"Chin J Hematol."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-beta family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1113\/JP278810","article-title":"Revisiting the Warburg effect: historical dogma versus current understanding","volume":"599","author":"Vaupel","year":"2021","journal-title":"J Physiol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1800190","article-title":"MiR-1180 from bone marrow-derived mesenchymal stem cells induces glycolysis and chemoresistance in ovarian cancer cells by upregulating the Wnt signaling pathway","volume":"20","author":"Gu","year":"2019","journal-title":"J Zhejiang University. Science. B"},{"key":"B37","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s13046-019-1095-1","article-title":"Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype","volume":"38","author":"Zhu","year":"2019","journal-title":"J Exp Clin Cancer research: CR"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2488","article-title":"MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN","volume":"68","author":"Yang","year":"2008","journal-title":"Cancer Res"},{"key":"B39","article-title":"L-Tetrahydropalmatine enhances the sensitivity of human ovarian cancer cells to cisplatin via microRNA-93\/PTEN\/Akt cascade","volume":"24","author":"Gong","year":"2019","journal-title":"J B.U.ON.: Off J Balkan Union Oncol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3892\/or.2020.7571","article-title":"PTEN\/AKT\/mTOR signaling mediates anticancer effects of epigallocatechin-3-gallate in ovarian cancer","volume":"43","author":"Qin","year":"2020","journal-title":"Oncol Rep"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.05.023","article-title":"Interference between copper transport systems and platinum drugs","volume":"76","author":"Arnesano","year":"2021","journal-title":"Semin Cancer Biol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1002\/mc.22971","article-title":"Core fucosylation of copper transporter 1 plays a crucial role in cisplatin-resistance of epithelial ovarian cancer by regulating drug uptake","volume":"58","author":"Lv","year":"2019","journal-title":"Mol carcinogenesis"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110401","article-title":"The contribution of copper efflux transporters ATP7A and ATP7B to chemoresistance and personalized medicine in ovarian cancer","volume":"129","author":"Lukanovi\u0107","year":"2020","journal-title":"Biomedicine pharmacotherapy = Biomedecine pharmacotherapie"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.41246","article-title":"ATM expression is elevated in established radiation-resistant breast cancer cells and improves DNA repair efficiency","volume":"16","author":"Bian","year":"2020","journal-title":"Int J Biol Sci"},{"key":"B45","doi-asserted-by":"publisher","first-page":"6298","DOI":"10.1038\/s41467-020-20140-0","article-title":"Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages","volume":"11","author":"Song","year":"2020","journal-title":"Nat Commun"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-022-03156-x","article-title":"VSSP abrogates murine ovarian tumor-associated myeloid cell-driven immune suppression and induces M1 polarization in tumor-associated macrophages from ovarian cancer patients","volume":"71","author":"Khan","year":"2022","journal-title":"Cancer immunology immunotherapy: CII"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.1c00139","article-title":"Large, anionic liposomes enable targeted intraperitoneal delivery of a TLR 7\/8 agonist to repolarize ovarian tumors\u2019 Microenvironment","volume":"32","author":"Kang","year":"2021","journal-title":"Bioconjugate Chem"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2019.07.002","article-title":"Improved anti-tumor efficacy of paclitaxel in combination with MicroRNA-125b-based tumor-associated macrophage repolarization in epithelial ovarian cancer","volume":"461","author":"Parayath","year":"2019","journal-title":"Cancer Lett"},{"key":"B49","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12951-022-01264-5","article-title":"Exosome-liposome hybrid nanoparticle codelivery of TP and miR497 conspicuously overcomes chemoresistant ovarian cancer","volume":"20","author":"Li","year":"2022","journal-title":"J nanobiotechnology"},{"key":"B50","doi-asserted-by":"publisher","first-page":"101416","DOI":"10.1016\/j.nantod.2022.101416","article-title":"Reactivation of dysfunctional dendritic cells by a stress-relieving nanosystem resets anti-tumor immune landscape","volume":"43","author":"Lu","year":"2022","journal-title":"Nano Today"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.828263","article-title":"Development of a dendritic cell\/tumor cell fusion cell membrane nano-vaccine for the treatment of ovarian cancer","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Immunol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2058653","article-title":"Sonosensitizer nanoplatform-mediated sonodynamic therapy induced immunogenic cell death and tumor immune microenvironment variation","volume":"29","author":"Zheng","year":"2022","journal-title":"Drug delivery"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c07180","article-title":"Cancer-erythrocyte hybrid membrane-camouflaged magnetic nanoparticles with enhanced photothermal-immunotherapy for ovarian cancer","volume":"15","author":"Xiong","year":"2021","journal-title":"ACS nano"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120690","article-title":"Point-source burst of coordination polymer nanoparticles for tri-modality cancer therapy","volume":"270","author":"Ling","year":"2021","journal-title":"Biomaterials"},{"key":"B55","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.jconrel.2021.12.029","article-title":"BiTE secretion from in situ-programmed myeloid cells results in tumor-retained pharmacology","volume":"342","author":"Hao","year":"2022","journal-title":"J Controlled release: Off J Controlled Release Soc"},{"key":"B56","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13046-022-02244-1","article-title":"Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p\/PD-L1 pathway","volume":"41","author":"Li","year":"2022","journal-title":"J Exp Clin Cancer research: CR"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.259036","article-title":"Mesothelin\/CD3 half-life extended bispecific T-cell engager molecule shows specific tumor uptake and distributes to mesothelin and CD3 expressing tissues. Journal of nuclear medicine: official publication","author":"Suurs","year":"2021","journal-title":"Soc Nucl Med"},{"key":"B58","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.mattod.2022.01.025","article-title":"Disabling partners in crime: Gold nanoparticles disrupt multicellular communications within the tumor microenvironment to inhibit ovarian tumor aggressiveness","volume":"56","author":"Zhang","year":"2022","journal-title":"Materials Today (Kidlington England)"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S111279","article-title":"Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy","volume":"11","author":"Zhang","year":"2016","journal-title":"Int J nanomedicine"},{"key":"B60","doi-asserted-by":"publisher","first-page":"e10507","DOI":"10.1002\/btm2.10507","article-title":"Micelle encapsulation zinc-doped copper oxide nanocomposites reverse Olaparib resistance in ovarian cancer by disrupting homologous recombination repair","volume":"8","author":"Yi","year":"2023","journal-title":"Bioengineering Trans Med"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c02552","article-title":"Engineering chemotherapeutic-augmented calcium phosphate nanoparticles for treatment of intraperitoneal disseminated ovarian cancer","volume":"14","author":"Qiu","year":"2022","journal-title":"ACS Appl materials interfaces"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.553576","article-title":"Immune (Cell) derived exosome mimetics (IDEM) as a treatment for ovarian cancer","volume":"8","author":"Pisano","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.05.032","article-title":"Impaired DNA damage response\u2013an Achilles\u2019 heel sensitizing cancer to chemotherapy and radiotherapy","volume":"625","author":"Darzynkiewicz","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1186\/s12951-022-01477-8","article-title":"Nanoparticle classification, physicochemical properties, characterization, and applications: a comprehensive review for biologists","volume":"20","author":"Joudeh","year":"2022","journal-title":"J nanobiotechnology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/s41586-019-1730-1","article-title":"A view on drug resistance in cancer","volume":"575","author":"Vasan","year":"2019","journal-title":"Nature"},{"key":"B66","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1186\/s12951-024-03005-2","article-title":"Targeting the tumor microenvironment with biomaterials for enhanced immunotherapeutic efficacy","volume":"22","author":"Feng","year":"2024","journal-title":"J nanobiotechnology"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.7150\/thno.91814","article-title":"Current evidence and therapeutic implication of PANoptosis in cancer","volume":"14","author":"Ocansey","year":"2024","journal-title":"Theranostics"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115696","article-title":"The emerging role of PANoptosis in cancer treatment","volume":"168","author":"Xiong","year":"2023","journal-title":"Biomedicine pharmacotherapy = Biomedecine pharmacotherapie"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01999-3","article-title":"Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism","volume":"25","author":"Peralta","year":"2024","journal-title":"Nat Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1542326\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T07:26:46Z","timestamp":1739345206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2025.1542326\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,12]]},"references-count":69,"alternative-id":["10.3389\/fimmu.2025.1542326"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2025.1542326","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,12]]},"article-number":"1542326"}}